Wang Runsheng 1 , Lei Tao 1 , Wang Yi 2 , Zheng Yi 2 , Du Shanshuang 1 , Qiao Qiubo 3 , Yang Yunpeng 3 , Wei Junli 3
  • 1. Department of Ophtalmology, The Fourth Hospital of Xi’an, Xi’an 710004, China;
  • 2. Intervention Department, The Fourth Hospital of Xi’an, Xi’an 710004, China;
  • 3. Department of Neurology, The Fourth Hospital of Xi’an, Xi’an 710004, China;
Wang Runsheng, Email: wangrun-sheng0602@sohu.com
Retinal artery occlusion; Ciliary arteries occlusion; Cerebral artery occlusion; Facial cosmetic injection
10.3760/cma.j.issn.1005-1015.2019.05.009
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Objective To observe the clinical characteristics of ophthalmic and cerebral artery occlusion after facial cosmetic injection.Methods A retrospective case study. Twenty patients (20 eyes) with ophthalmic and cerebral artery occlusion in Department of Ophtalmology, The Fourth Hospital of Xi’an from February 2014 to December 2016 were enrolled in this study. There were 2 males (2 eyes) and 18 females (18 eyes). They aged from 21 to 41 years, with the mean age of 29.8±1.4 years. The disease courses was ranged from 3.5 hours to 21 days, with the mean of 40 hours. Facial cosmetic injections of all patients were performed at out-of-hospital beauty institutions. The visual impairment was associated with eyelid pain 1 to 10 minutes after injection.There were 12 right eyes and 8 left eyes.The injection materials, 18 patients were hyaluronic acid and 2 patients were autologous fat, respectively. At the injection site, 13 patients were sacral, 4 patients were nasal, and 3 patients were frontal. The concentration and dose of the injected filler were not known. All patients underwent vision, slit lamp microscope, fundus color photography, visual field, FFA, OCT, and brain CT, magnetic resonance angiography (MRA) examination.Results The visual acuity was ranged from no light perception to 1.0. Among the 20 eyes, 3 eyes (15%) were obstructed by simple ophthalmic artery; 5 eyes (25%) were obstructed by ophthalmic artery combined with cerebral artery; 7 eyes (35%) were obstructed by simple retinal artery occlusion (RAO) alone, which including central RAO (CRAO, 4 eyes), hemi-lateral artery obstruction (1 eye) and branch RAO (2 eyes); 1 eye (5%) was CRAO with ciliary artery branch obstruction; 1 eye (5%) was branch artery occlusion with ischemic optic neuropathy; 2 eyes (10%) were CRAO with nasal dorsal artery occlusion; 1 eye (5%) was CRAO, posterior ciliary artery obstruction and right middle cerebral artery occlusion. Among 20 patients, 4 patients (20%) had eye movement disorder and eyelid skin bun; 2 patients (10%) had facial pain and nasal skin ischemic necrosis. MRA revealed 6 patients (30%) of new intracranial ischemic lesions. Among them, 5 patients of hyaluronic acid injection showed asymptomatic small blood vessel embolization; 1 patient of autologous fat injection showed ophthalmary artery occlusion, cerebral artery occlusion, ipsilateral eye blindness, eye movement disorder and contralateral limb hemiplegia.Conclusion Facial cosmetic injection can cause severe iatrogenic complications such as RAO, ciliary artery occlusion, ischemic optic neuropathy, ophthalmic artery occlusion, and cerebral artery occlusion.

Citation： Wang Runsheng, Lei Tao, Wang Yi, Zheng Yi, Du Shanshuang, Qiao Qiubo, Yang Yunpeng, Wei Junli. Analysis of clinical features of ophthalmic and cerebral artery occlusion after facial cosmetic injection. Chinese Journal of Ocular Fundus Diseases, 2019, 35(5): 470-474. doi: 10.3760/cma.j.issn.1005-1015.2019.05.009 Copy

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