MUC4 Research Progress in Tumor Molecular Markers_Journal of Biomedical Engineering

Authors：

ZHUHua ,  YOUJinhui

Department of Nuclear Medicine, the Affiliated Hospital of North Sichuan Medical College;Medical Imaging Key Laboratory of Sichuan Province, Nanchong 637007, China;

Corresponding author：

YOUJinhui, Email: youjh@126.com

Keywords：

mucin antigen 4 (MUC4); malignant tumor; marker; radioimmunoimaging; molecular imaging

DOI：

10.7507/1001-5515.20140044

Video：

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Mucin antigen 4 (MUC4) is a molecular marker for some malignant tumors for early tumor diagnosis, prognosis and targeted therapy. It provides a new research direction in tumor diagnosis and treatment that will have a wide application prospect. In recent years, there has been a large number of research reports on the basic and clinical studies about MUC4, but the molecular imaging study about MUC4 is seldom reported. In this paper the recent research about MUC4 on basic and clinical studies is briefly reviewed, and it is expected to promote the development of tumor molecular imaging.

Citation： ZHUHua, YOUJinhui. MUC4 Research Progress in Tumor Molecular Markers. Journal of Biomedical Engineering, 2014, 31(1): 233-236. doi: 10.7507/1001-5515.20140044 Copy

1.	JULIAN J, CARSON D D.Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells[J]. Biochem Biophys Res Commun,2002,293(4):1183-1190.
2.	姜争,武林枫. 胰腺癌中MUC4表达的作用及临床意义[J]. 国际遗传学杂志,2006,29(2):127-129,158.
3.	陈健,王鲁平. 癌基因MUC4研究进展[J].国外医学肿瘤学分册,2004,31(增刊):24-27.
4.	王伟艺,项炜,唐文皓,等. 胰腺癌的表达及其临床相关影响因素的分析[J]. 外科理论与实践,2012,17(3):243-247.
5.	金钢,胡先贵,应康,等. 基因表达谱芯片在胰腺癌相关基因筛选中的应用研究[J].第二军医大学学报2000,21(9):819-822.
6.	陈健,王鲁平,郭瑞峰,等. 食管癌中癌基因MUC4的变化及临床病理意义[J]. 诊断病理学杂志,2004,11(2):49-51.
7.	ZHU Y,ZHANG J J,ZHU R,et al.The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma[J]. Med Oncol, 2011,28 (Suppl 1):S175-S184.
8.	徐信兰,张玲玲,孔祥,等.卵巢上皮性肿瘤组织中 MUC4,MUC16 蛋白的表达及临床意义[J].肿瘤防治研究,2010,37(3):333-335.
9.	JEON J M,LEE H W, PARK J Y,et al. Expression of MUC1 and MUC4 and its prognostic significance in non-small cell lung carcinoma[J].Korean J Pathol, 2010,44(4):397-403.
10.	陈智勇,景在平,郑建民,等.Mucin4在胰腺癌组织中的表达及其临床意义[J]. 胰腺病学,2005,5(4):220-223.
11.	陈衍,韩晟,薛妍,等.人MUC4启动子驱动HSV-TK腺病毒靶向杀伤胃癌细胞的研究[J].现代肿瘤医学,2012,20(3):442-445.
12.	龚道元,伏红霞,彭艳,等.血清粘蛋白抗原4对胰腺癌的诊断价值研究[J].临床检验杂志,2011,29(7):533-537.
13.	WANG G,LIPERT R J,JAIN M,et al.Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering[J].Anal Chem,2011,83(7):2554-2561.
14.	ZHANG J, ZHANG X, ZHU Y,et al.Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells[J]. Mol Biol Rep,2010,37(6):2797-2802.
15.	SRIVASTAVA S K,BHARDWAJ A,SINGH S,et al. MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells[J]. Carcinogenesis,2011,32(12):1832-1839.
16.	苏悦,韩素萍.黏附分子和血管内皮生长因子在卵巢上皮性肿瘤中的表达及临床意义[J].实用临床医药杂志,2010,4(11):8-11.
17.	徐信兰,张玲玲,卢丹,等. 卵巢上皮性肿瘤组织中粘蛋白抗原4和核因子-κB/p65蛋白表达及临床意义[J].实用临床医药杂志,2011,15(11):8-10.
18.	PONNUSAMY M P,LAKSHMANAN I,JAIN M,et al. MUC4 mucin-induced epithelial to mesenchymal transition:a novel mechanism for metastasis of human ovarian cancer cells[J]. Oncogene, 2010,29(42):5741-5754.
19.	BRUYÈRE E,JONCKHEERE N,FRÉNOIS F,et al.The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties:implication for S100A4 protein[J].Biochem Biophys Res Commun, 2011,413(2):325-329.
20.	CHANDRAKUMAR S, JHALA N C,VENKAT R K, et al. Prognostic value of mucin 4 expression in colorectal adenocarcinomas[J].Cancer, 2010,116(15):3577-3586.
21.	TOMOFUMI H,TSUNENOBU W,MAYUMI M,et al. MUC4:a novel prognostic factor of oral squamous cell carcinoma[J].Int J Cancer,2012,130(8):1768-1776.
22.	SINGH A P,MONIAUX N,CHAUHAN S C,et al. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis[J].Cancer Res,2004,64(2):622-630.
23.	JAIN M,VENKATRAMAN G,MONIAUX N,et al. Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer[J].PLoS One, 2011,6(8):233-244.
24.	翟士军,章斌,袁航,等.Iodogen法¹²⁵I标记单克隆抗体10D9[J].核技术,2009,32(5):371-374.
25.	LI J, SHI L, WANG C, et al. Preliminary biological evaluation of 125I-labeled anti-carbonic anhydrase Ⅸ monoclonal antibody in the mice bearing HT-29 tumors[J]. Nucl Med Commun, 2011,32(12):1190-1193.
26.	CHOPRA A.¹¹¹In/¹²⁵/¹³¹I-Labeled anti-mucin-1 murine, chimeric or humanized antibody hPAM4[DB/OL].Molecular Imaging and Contrast Agent Database. National Center for Biotechnology Information (NCBI)(2011-07-26)[2012-09-12].http://www.ncbi.nlm.nih.gov/books/NBK57127/.

1. JULIAN J, CARSON D D.Formation of MUC1 metabolic complex is conserved in tumor-derived and normal epithelial cells[J]. Biochem Biophys Res Commun,2002,293(4):1183-1190.
2. 姜争,武林枫. 胰腺癌中MUC4表达的作用及临床意义[J]. 国际遗传学杂志,2006,29(2):127-129,158.
3. 陈健,王鲁平. 癌基因MUC4研究进展[J].国外医学肿瘤学分册,2004,31(增刊):24-27.
4. 王伟艺,项炜,唐文皓,等. 胰腺癌的表达及其临床相关影响因素的分析[J]. 外科理论与实践,2012,17(3):243-247.
5. 金钢,胡先贵,应康,等. 基因表达谱芯片在胰腺癌相关基因筛选中的应用研究[J].第二军医大学学报2000,21(9):819-822.
6. 陈健,王鲁平,郭瑞峰,等. 食管癌中癌基因MUC4的变化及临床病理意义[J]. 诊断病理学杂志,2004,11(2):49-51.
7. ZHU Y,ZHANG J J,ZHU R,et al.The increase in the expression and hypomethylation of MUC4 gene with the progression of pancreatic ductal adenocarcinoma[J]. Med Oncol, 2011,28 (Suppl 1):S175-S184.
8. 徐信兰,张玲玲,孔祥,等.卵巢上皮性肿瘤组织中 MUC4,MUC16 蛋白的表达及临床意义[J].肿瘤防治研究,2010,37(3):333-335.
9. JEON J M,LEE H W, PARK J Y,et al. Expression of MUC1 and MUC4 and its prognostic significance in non-small cell lung carcinoma[J].Korean J Pathol, 2010,44(4):397-403.
10. 陈智勇,景在平,郑建民,等.Mucin4在胰腺癌组织中的表达及其临床意义[J]. 胰腺病学,2005,5(4):220-223.
11. 陈衍,韩晟,薛妍,等.人MUC4启动子驱动HSV-TK腺病毒靶向杀伤胃癌细胞的研究[J].现代肿瘤医学,2012,20(3):442-445.
12. 龚道元,伏红霞,彭艳,等.血清粘蛋白抗原4对胰腺癌的诊断价值研究[J].临床检验杂志,2011,29(7):533-537.
13. WANG G,LIPERT R J,JAIN M,et al.Detection of the potential pancreatic cancer marker MUC4 in serum using surface-enhanced Raman scattering[J].Anal Chem,2011,83(7):2554-2561.
14. ZHANG J, ZHANG X, ZHU Y,et al.Transcriptional regulation of human mucin gene MUC4 in pancreatic cancer cells[J]. Mol Biol Rep,2010,37(6):2797-2802.
15. SRIVASTAVA S K,BHARDWAJ A,SINGH S,et al. MicroRNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancer cells[J]. Carcinogenesis,2011,32(12):1832-1839.
16. 苏悦,韩素萍.黏附分子和血管内皮生长因子在卵巢上皮性肿瘤中的表达及临床意义[J].实用临床医药杂志,2010,4(11):8-11.
17. 徐信兰,张玲玲,卢丹,等. 卵巢上皮性肿瘤组织中粘蛋白抗原4和核因子-κB/p65蛋白表达及临床意义[J].实用临床医药杂志,2011,15(11):8-10.
18. PONNUSAMY M P,LAKSHMANAN I,JAIN M,et al. MUC4 mucin-induced epithelial to mesenchymal transition:a novel mechanism for metastasis of human ovarian cancer cells[J]. Oncogene, 2010,29(42):5741-5754.
19. BRUYÈRE E,JONCKHEERE N,FRÉNOIS F,et al.The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties:implication for S100A4 protein[J].Biochem Biophys Res Commun, 2011,413(2):325-329.
20. CHANDRAKUMAR S, JHALA N C,VENKAT R K, et al. Prognostic value of mucin 4 expression in colorectal adenocarcinomas[J].Cancer, 2010,116(15):3577-3586.
21. TOMOFUMI H,TSUNENOBU W,MAYUMI M,et al. MUC4:a novel prognostic factor of oral squamous cell carcinoma[J].Int J Cancer,2012,130(8):1768-1776.
22. SINGH A P,MONIAUX N,CHAUHAN S C,et al. Inhibition of MUC4 expression suppresses pancreatic tumor cell growth and metastasis[J].Cancer Res,2004,64(2):622-630.
23. JAIN M,VENKATRAMAN G,MONIAUX N,et al. Monoclonal antibodies recognizing the non-tandem repeat regions of the human mucin MUC4 in pancreatic cancer[J].PLoS One, 2011,6(8):233-244.
24. 翟士军,章斌,袁航,等.Iodogen法¹²⁵I标记单克隆抗体10D9[J].核技术,2009,32(5):371-374.
25. LI J, SHI L, WANG C, et al. Preliminary biological evaluation of 125I-labeled anti-carbonic anhydrase Ⅸ monoclonal antibody in the mice bearing HT-29 tumors[J]. Nucl Med Commun, 2011,32(12):1190-1193.
26. CHOPRA A.¹¹¹In/¹²⁵/¹³¹I-Labeled anti-mucin-1 murine, chimeric or humanized antibody hPAM4[DB/OL].Molecular Imaging and Contrast Agent Database. National Center for Biotechnology Information (NCBI)(2011-07-26)[2012-09-12].http://www.ncbi.nlm.nih.gov/books/NBK57127/.

Journal of Biomedical Engineering

MUC4 Research Progress in Tumor Molecular Markers

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