Preparation and Property Evaluation of Graphene Oxide Based Silver Nanoparticles Composite Materials_Journal of Biomedical Engineering

Authors：

 SHENYupu ¹ , HEJiantai ¹ , ZHANGYangde ¹ , SHENYukun ^1,2 , ZHANGLongjiao ¹

1. National Hepatobiliary and Enteric Surgery Research Center, Ministry of Health, Central South University, Changsha 410008, China;
2. Changzhi Medical College, Changzhi 046000, China;

Corresponding author：

SHENYupu, Email: shenyupu@qq.com

Keywords：

graphene; silver nanoparticles; polyethyleneimine; composite material

DOI：

10.7507/1001-5515.20140067

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We prepared silver nanoparticles/polyethyleneimine-reduction graphene oxide (AgNP/rGO-PEI) composite materials, and evaluated their quality performance in our center. Firstly, we prepared AgNP/rGO-PEI, and then analysed its stability, antibacterial activity, and cellular toxicity by comparing the AgNP/rGO-PEI with the silver nanoparticles (PVP/AgNP) modified by polyvinylpyrrolidone. We found in the study that silver nanoparticles (AgNP) distributed relatively uniformly in AgNP/rGO-PEI surface, silver nanoparticles mass fraction was 4.5%, and particle size was 6-13 nm. In dark or in low illumination light intensity of 3 000 lx meter environment (lux) for 10 days, PVP/AgNP aggregation was more obvious, but the AgNP/rGO-PEI had good dispersibility and its aggregation was not obvious; AgNP/rGO-PEI had a more excellent antibacterial activity, biological compatibility and relatively low biological toxicity. It was concluded that AgNP/rGO-PEI composite materials had reliable quality and good performance, and would have broad application prospects in the future.

Citation： SHENYupu, HEJiantai, ZHANGYangde, SHENYukun, ZHANGLongjiao. Preparation and Property Evaluation of Graphene Oxide Based Silver Nanoparticles Composite Materials. Journal of Biomedical Engineering, 2014, 31(2): 357-360. doi: 10.7507/1001-5515.20140067 Copy

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1. DAS M R,SARMA R K,SAIKIA R,et al.Synthesis of silver nanoparticles in an aqueous suspension of graphene oxide sheets and its antimicrobial activity[J].Colloids Surf B Biointerfaces,2011,83(1):16-22.
2. LIU Y S,CHEN S M,ZHONG L,et al.Preparation of high-stable silver nanoparticle dispersion by using sodium alginate as a stabilizer under gamma radiation[J].Rad Phys Chem,2009,78(4):251-255.
3. AKHAVAN O,GHADERI E.Toxicity of graphene and graphene oxidenanowalls against bacteria[J].ACS Nano,2010,4(10):5731-5736.
4. GEIM A K,NOVOSELOV K S.The rise of grapheme[J].Nat Mater,2007,6:183-191.
5. ASHARANI P V,LOW KAH MUN G,VALIYAVEETTIL S,et al.Cytotoxicity and genotoxicity of silver nanoparticles in human cells[J].ACS Nano,2009,3(2):279-290.
6. 黄毅,陈永胜.石墨烯的功能化及其相关应用[J].中国科学B辑:化学,2009,39(9):887-896.
7. WILLIAM JR H S,OFFEMAN R E.Preparation of graphitic oxide[J].J Am Chem Soc,1958,80(6):1339.
8. 王昕,施嬿萍,朱雪涛,等.MTT法评价医用高分子材料的细胞毒性[J].山东生物医学工程,2003,1:46-47.
9. 唐秋莎,张东生,顾宁,等.聚乙烯亚胺在锰锌铁氧体纳米粒子表面定量吸附[J].东南大学学报(自然科学版),2007,37(5):867-872.

Journal of Biomedical Engineering

Preparation and Property Evaluation of Graphene Oxide Based Silver Nanoparticles Composite Materials

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