Research Progress of Brain Functional Magnetic Resonance Imaging in Post-traumatic Stress Disorder_Journal of Biomedical Engineering

Authors：

WANGTing ¹ ,  ZHANGJunran ^1,2 , HUANGHua ¹ , GONGQiyong ²

1. Department of Medical Information Engineering, School of Electrical Engineering and Information, Sichuan University, Chengdu 610065, China;
2. Huaxi Research Center, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

ZHANGJunran, Email: zhangjunran@126.com

Keywords：

post-traumatic stress disorder; task-related functional magnetic resonance imaging; resting-state functional magnetic resonance imaging

DOI：

10.7507/1001-5515.20140129

Video：

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Post-traumatic stress disorder (PTSD) is a mental disorder causing great distress to individuals, families and even society, and there is not yet effective way of unified prevention and treatment up till now. Lots of neuroimaging techniques, however, such as the magnetic resonance imaging, are widely used to the study of the pathogenesis of PTSD with the development of medical imaging. Functional magnetic resonance imaging (fMRI) can be applied to detect the abnormalities not only of the brain morphology but also of the function of various cerebral areas and neural circuit, and plays an important role in studying the pathogenesis of psychiatric diseases. In this paper, we mainly review the task-related and resting-state functional magnetic resonance imaging studies of the PTSD, and finally suggest possible directions for future research.

Citation： WANGTing, ZHANGJunran, HUANGHua, GONGQiyong. Research Progress of Brain Functional Magnetic Resonance Imaging in Post-traumatic Stress Disorder. Journal of Biomedical Engineering, 2014, 31(3): 691-697. doi: 10.7507/1001-5515.20140129 Copy

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2.	王志阳,汤月芬,施慎逊.创伤后应激障碍国内研究现状[J].上海精神医学,2006,18(6):372-374.
3.	WANG Z,NEYLAN T C,MUELLER S G,et al.Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder[J].Arch Gen Psychiatry,2010,67(3):296-303.
4.	朱丞,赵虎,孙晓海,等.创伤后应激障碍患者海马体积及代谢物水平变化的在体研究[J].全科医学临床与教育,2011,9(6):619-621.
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6.	BROHAWN K H,OFFRINGA R,PFAFF D L,et al.The neural correlates of emotional memory in posttraumatic stress disorder[J].Biol Psychiatry,2010,68(11):1023-1030.
7.	JURUENA M F,GIAMPIETRO V P,SMITH S D,et al.Amygdala activation to masked happy facial expressions[J].J Int Neuropsychol Soc,2010,16(2):383-387.
8.	HAYES J P,LABAR K S,MCCARTHY G,et al.Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD[J].J Psychiatr Res,2011,45(5):660-669.
9.	陈树林,李凌江,汪永光,等.前扣带回与创伤后应激障碍关系的功能磁共振成像研究[J].中国神经精神疾病杂志,2008,34(7):406-409.
10.	CARRION V G,HAAS B W,GARRETT A,et al.Reduced hippocampal activity in youth with posttraumatic stress symptoms:an FMRI study[J].J Pediatr Psychol,2010,35(5):559-569.
11.	张丽,郑会蓉,李卫晖,等.慢性创伤后应激障碍患者的脑功能磁共振研究[J].中国临床心理学杂志,2011,19(1):4-9.
12.	KIM M J,CHEY J,CHUNG A,et al.Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder[J].J Psychiatr Res,2008,42(4):268-277.
13.	邹吉林,周仁来,张环,等.情绪记忆权衡效应:对复杂情绪刺激的记忆[J].心理科学进展,2011,19(10):1460-1470.
14.	张丽,李卫晖,李凌江,等.慢性创伤后应激障碍患者对短期记忆提取任务的脑功能磁共振研究[J].中国临床心理学杂志,2011,19(2):143-145.
15.	STRIGO I A,SIMMONS A N,MATTHEWS S C,et al.Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence[J].Biol Psychiatry,2010,68(5):442-450.
16.	黄清玲,唐勇,王沛弟,等.创伤后应激障碍患者杏仁核为主的边缘系统静息态脑功能磁共振研究[J].中国神经精神疾病杂志,2011,37(12):705-709.
17.	FRINGS L,WAGNER K,QUISKE A,et al.Precuneus is involved in allocentric spatial location encoding and recognition[J].Exp Brain Res,2006,173(4):661-672.
18.	YIN Y,LI L,JIN C,et al.Abnormal baseline brain activity in posttraumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Lett,2011,498(3):185-189.
19.	YIN Y,JIN C,EYLER L T,et al.Altered regional homogeneity in post-traumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Bull,2012,28(5):541-549.
20.	尧德中,罗程,雷旭,等.脑成像与脑连接[J].中国生物医学工程学报,2011,30(1):6-10.
21.	张晔,邱明国,谢兵,等.创伤后应激障碍患者静息状态下脑默认网络研究[J].第三军医大学学报,2011,33(21):2271-2273.
22.	武瑞芝,张俊然,邱昌建,等.地震创伤后应激障碍患者脑静息态默认网络研究[J].四川大学学报(医学版),2011,42(3):397-400.
23.	SRIPADA R K,KING A P,GARFINKEL S N,et al.Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder[J].J Psychiatry Neurosci,2012,37(4):241-249.
24.	YIN Y,JIN C,HU X,et al.Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder:a functional magnetic resonance imaging study[J].Brain Res,2011,1411(2011):98-107.
25.	ZHOU Y,WANG Z,QIN L D,et al.Early altered resting-state functional connectivity predicts the severity of post-traumatic stress disorder symptoms in acutely traumatized subjects[J].PloS one,2012,7(10):1-6.
26.	蒋田仔,刘勇,李永辉.脑网络:从脑结构到脑功能[J].生命科学,2009,21(2):181-188.
27.	BLUHM R L,WILLIAMSON P C,OSUCH E A,et al.Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma[J].J Psychiatry Neurosci,2009,34(3):187-194.
28.	SRIPADA R K,KING A P,WELSH R C,et al.Neural dysregulation in posttraumatic stress disorder:evidence for disrupted equilibrium between salience and default mode brain networks[J].Psychosom Med,2012,74(9):904-911.
29.	MOREY R A,GOLD A L,LABAR K S,et al.Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group[J].Arch Gen Psychiatry,2012,69(11):1169-1178.
30.	王小玲,李松蔚,钱铭怡.创伤后应激障碍患者情绪记忆优势研究述评[J].心理科学进展,2012,20(2):248-255.

1. 戚荣丰,卢光明.创伤后应激障碍脑功能神经影像学研究和进展[J].医学影像学杂志,2012,22(6):1023-1026.
2. 王志阳,汤月芬,施慎逊.创伤后应激障碍国内研究现状[J].上海精神医学,2006,18(6):372-374.
3. WANG Z,NEYLAN T C,MUELLER S G,et al.Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder[J].Arch Gen Psychiatry,2010,67(3):296-303.
4. 朱丞,赵虎,孙晓海,等.创伤后应激障碍患者海马体积及代谢物水平变化的在体研究[J].全科医学临床与教育,2011,9(6):619-621.
5. KLEISER R,STAEMPFLI P,VALAVANIS A,et al.Impact of fMRI-guided advanced DTI fiber tracking techniques on their clinical applications in patients with brain tumors[J].Neuroradiology,2010,52(1):37-46.
6. BROHAWN K H,OFFRINGA R,PFAFF D L,et al.The neural correlates of emotional memory in posttraumatic stress disorder[J].Biol Psychiatry,2010,68(11):1023-1030.
7. JURUENA M F,GIAMPIETRO V P,SMITH S D,et al.Amygdala activation to masked happy facial expressions[J].J Int Neuropsychol Soc,2010,16(2):383-387.
8. HAYES J P,LABAR K S,MCCARTHY G,et al.Reduced hippocampal and amygdala activity predicts memory distortions for trauma reminders in combat-related PTSD[J].J Psychiatr Res,2011,45(5):660-669.
9. 陈树林,李凌江,汪永光,等.前扣带回与创伤后应激障碍关系的功能磁共振成像研究[J].中国神经精神疾病杂志,2008,34(7):406-409.
10. CARRION V G,HAAS B W,GARRETT A,et al.Reduced hippocampal activity in youth with posttraumatic stress symptoms:an FMRI study[J].J Pediatr Psychol,2010,35(5):559-569.
11. 张丽,郑会蓉,李卫晖,等.慢性创伤后应激障碍患者的脑功能磁共振研究[J].中国临床心理学杂志,2011,19(1):4-9.
12. KIM M J,CHEY J,CHUNG A,et al.Diminished rostral anterior cingulate activity in response to threat-related events in posttraumatic stress disorder[J].J Psychiatr Res,2008,42(4):268-277.
13. 邹吉林,周仁来,张环,等.情绪记忆权衡效应:对复杂情绪刺激的记忆[J].心理科学进展,2011,19(10):1460-1470.
14. 张丽,李卫晖,李凌江,等.慢性创伤后应激障碍患者对短期记忆提取任务的脑功能磁共振研究[J].中国临床心理学杂志,2011,19(2):143-145.
15. STRIGO I A,SIMMONS A N,MATTHEWS S C,et al.Neural correlates of altered pain response in women with posttraumatic stress disorder from intimate partner violence[J].Biol Psychiatry,2010,68(5):442-450.
16. 黄清玲,唐勇,王沛弟,等.创伤后应激障碍患者杏仁核为主的边缘系统静息态脑功能磁共振研究[J].中国神经精神疾病杂志,2011,37(12):705-709.
17. FRINGS L,WAGNER K,QUISKE A,et al.Precuneus is involved in allocentric spatial location encoding and recognition[J].Exp Brain Res,2006,173(4):661-672.
18. YIN Y,LI L,JIN C,et al.Abnormal baseline brain activity in posttraumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Lett,2011,498(3):185-189.
19. YIN Y,JIN C,EYLER L T,et al.Altered regional homogeneity in post-traumatic stress disorder:a resting-state functional magnetic resonance imaging study[J].Neurosci Bull,2012,28(5):541-549.
20. 尧德中,罗程,雷旭,等.脑成像与脑连接[J].中国生物医学工程学报,2011,30(1):6-10.
21. 张晔,邱明国,谢兵,等.创伤后应激障碍患者静息状态下脑默认网络研究[J].第三军医大学学报,2011,33(21):2271-2273.
22. 武瑞芝,张俊然,邱昌建,等.地震创伤后应激障碍患者脑静息态默认网络研究[J].四川大学学报(医学版),2011,42(3):397-400.
23. SRIPADA R K,KING A P,GARFINKEL S N,et al.Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder[J].J Psychiatry Neurosci,2012,37(4):241-249.
24. YIN Y,JIN C,HU X,et al.Altered resting-state functional connectivity of thalamus in earthquake-induced posttraumatic stress disorder:a functional magnetic resonance imaging study[J].Brain Res,2011,1411(2011):98-107.
25. ZHOU Y,WANG Z,QIN L D,et al.Early altered resting-state functional connectivity predicts the severity of post-traumatic stress disorder symptoms in acutely traumatized subjects[J].PloS one,2012,7(10):1-6.
26. 蒋田仔,刘勇,李永辉.脑网络:从脑结构到脑功能[J].生命科学,2009,21(2):181-188.
27. BLUHM R L,WILLIAMSON P C,OSUCH E A,et al.Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma[J].J Psychiatry Neurosci,2009,34(3):187-194.
28. SRIPADA R K,KING A P,WELSH R C,et al.Neural dysregulation in posttraumatic stress disorder:evidence for disrupted equilibrium between salience and default mode brain networks[J].Psychosom Med,2012,74(9):904-911.
29. MOREY R A,GOLD A L,LABAR K S,et al.Amygdala volume changes in posttraumatic stress disorder in a large case-controlled veterans group[J].Arch Gen Psychiatry,2012,69(11):1169-1178.
30. 王小玲,李松蔚,钱铭怡.创伤后应激障碍患者情绪记忆优势研究述评[J].心理科学进展,2012,20(2):248-255.

Journal of Biomedical Engineering

Research Progress of Brain Functional Magnetic Resonance Imaging in Post-traumatic Stress Disorder

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