Potential Medical Applications of Nanoscale Particles of Viruses_Journal of Biomedical Engineering

Authors：

 LIKai ¹ , ZHANGJinling ¹ , WANGQian ² , SUNJun ¹ , TIANGuoning ¹ , GAOYan ¹ , FANGLingjun ³

1. Weifang Entry-Exit Inspection and Quarantine Bureau, Weifang 261041, China;
2. University of South Carolina, SC, Columbia, 29208, USA;
3. Binzhou Liuhe Longda Farming Limited, Binzhou 256600, China;

Corresponding author：

LIKai, Email: likai2003@gmail.com

Keywords：

viral nanoparticles; biomaterial; protein assemblies; virus-based therapeutics

DOI：

10.7507/1001-5515.20140134

Video：

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The study of viruses traditionally focused on their roles as infectious agents and as tools for understanding cell biology. Recently, however, with the development of structural biology, viruses have now been receiving particular attention in nanotechnology. By chemical methods or by gene modification, viruses have been functionalized as potential building blocks for several applications, such as drug/gene delivery vehicles, advanced vaccine vehicles, and special inorganic or organic nanomaterials. Here we highlight some of the recent progresses in the medical applications of viruses.

Citation： LIKai, ZHANGJinling, WANGQian, SUNJun, TIANGuoning, GAOYan, FANGLingjun. Potential Medical Applications of Nanoscale Particles of Viruses. Journal of Biomedical Engineering, 2014, 31(3): 718-722. doi: 10.7507/1001-5515.20140134 Copy

1.	LI K, NGUYEN H G, LU X, et al. Viruses and their potential in bioimaging and biosensing applications[J]. Analyst (Lond), 2010, 135(1):21-27.
2.	CHATTERJI A, BURNS L L, TAYLOR S S, et al. Cowpea Mosaic virus:from the presentation of antigenic peptides to the display of active biomaterials[J]. Intervirology, 2002, 45(4-6):362-370.
3.	LIN T. Structural genesis of the chemical addressability in a viral nano-block[J]. J Mater Chem, 2006, 16(37):3673-3681.
4.	NAM K T, KIM D W, YOO P J, et al. Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes[J]. Science, 2006, 312(5775):885-888.
5.	KHALIL A S, FERRER J M, BRAU R R, et al. Single M13 bacteriophage tethering and stretching[J]. Proc Natl Acad Sci U S A, 2007, 104(12):4892-4897.
6.	LI K, CHEN Y, LI S, et al. Chemical modification of M13 bacteriophage and its application in cancer cell imaging[J]. Bioconjug Chem, 2010, 21(7):1369-1377.
7.	BRUCKMAN M A, LIU J, KOLEY G, et al. Tobacco mosaic virus based thin film sensor for detection of volatile organic compounds[J]. J Mater Chem, 2010, 20(27):5715-5719.
8.	LAGA R, KONÁK C, SUBR V, et al. Chemical conjugation of cowpea Mosaic viruses with reactive HPMA-based polymers[J]. J Biomater Sci Polym Ed, 2010, 21(12):1669-1685.
9.	SOTO C M, BLUM A S, VORA G J, et al. Fluorescent signal amplification of carbocyanine dyes using engineered viral nanoparticles[J]. J Am Chem Soc, 2006, 128(15):5184-5189.
10.	BARNHILL H N, REUTHER R, FERGUSON P L, et al. Turnip yellow Mosaic virus as a chemoaddressable bionanoparticle[J]. Bioconjug Chem, 2007, 18(3):852-859.
11.	LEONG H S, STEINMETZ N F, ABLACK A, et al. Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles[J]. Nat Protoc, 2010, 5(8):1406-1417.
12.	RAE C S, KHOR I W, WANG Q, et al. Systemic trafficking of plant virus nanoparticles in mice via the oral route[J]. Virology, 2005, 343(2):224-235.
13.	LEWIS J D, DESTITO G, ZIJLSTRA A, et al. Viral nanoparticles as tools for intravital vascular imaging[J]. Nat Med, 2006, 12(3):354-360.
14.	SINGH P, DESTITO G, SCHNEEMANN A, et al. Canine parvovirus-like particles, a novel nanomaterial for tumor targeting[J]. J Nanobiotechnology, 2006, 4:2.
15.	CHEN L, ZURITA A J, ARDELT P U, et al. Design and validation of a bifunctional ligand display system for receptor targeting[J]. Chem Biol, 2004, 11(8):1081-1091.
16.	PRASUHN D E JR, YEH R M, OBENAUS A, et al. Viral MRI contrast agents:coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition[J]. Chem Commun (Camb), 2007(12):1269-1271.
17.	MELDRUM T, SEIM K L, BAJAJ V S, et al. A xenon-based molecular sensor assembled on an MS2 viral capsid scaffold[J]. J Am Chem Soc, 2010, 132(17):5936-5937.
18.	HOOKER J M, O'NEIL J P, ROMANINI D W, et al. Genome-free viral capsids as carriers for positron emission tomography radiolabels[J]. Mol Imaging Biol, 2008, 10(4):182-191.
19.	HUANG R K, STEINMETZ N F, FU C Y, et al. Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells[J]. Nanomedicine (Lond), 2011, 6(1):55-68.
20.	BRUNEL F M, LEWIS J D, DESTITO G, et al. Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting[J]. Nano Lett, 2010, 10(3):1093-1097.
21.	SUTHIWANGCHAROEN N, LI T, LI K, et al. M13 bacteriophage-polymer nanoassemblies as drug delivery vehicles[J]. Nano Res, 2011, 4(5):483-493.
22.	YACOBY I, SHAMIS M, BAR H, et al. Targeting antibacterial agents by using drug-carrying filamentous bacteriophages[J]. Antimicrob Agents Chemother, 2006, 50(6):2087-2097.
23.	STEINMETZ N F, HONG V, SPOERKE E D, et al. Buckyballs meet viral nanoparticles:candidates for biomedicine[J]. J Am Chem Soc, 2009, 131(47):17093-17095.
24.	SUCI P A, VARPNESS Z, GILLITZER E, et al. Targeting and photodynamic killing of a microbial pathogen using protein cage architectures functionalized with a photosensitizer[J]. Langmuir, 2007, 23(24):12280-12286.
25.	STEPHANOPOULOS N, TONG G J, HSIAO S C, et al. Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells[J]. ACS Nano, 2010, 4(10):6014-6020.
26.	PLUMMER E M, MANCHESTER M. Viral nanoparticles and virus-like particles:platforms for contemporary vaccine design[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2010, 3(2):174-196.
27.	RONG J, LEE L A, LI K, et al. Oriented cell growth on self-assembled bacteriophage M13 thin films[J]. Chem Commun (Camb), 2008,41:5185-5187.
28.	YOO S Y, KOBAYASHI M, LEE P P, et al. Early osteogenic differentiation of mouse preosteoblasts induced by collagen-derived DGEA-peptide on nanofibrous phage tissue matrices[J]. Biomacromolecules, 2011, 12(4):987-996.
29.	WU L, LEE L A, NIU Z, et al. Visualizing cell extracellular matrix (ECM) deposited by cells cultured on aligned bacteriophage M13 thin films[J]. Langmuir, 2011, 27(15):9490-9496.

1. LI K, NGUYEN H G, LU X, et al. Viruses and their potential in bioimaging and biosensing applications[J]. Analyst (Lond), 2010, 135(1):21-27.
2. CHATTERJI A, BURNS L L, TAYLOR S S, et al. Cowpea Mosaic virus:from the presentation of antigenic peptides to the display of active biomaterials[J]. Intervirology, 2002, 45(4-6):362-370.
3. LIN T. Structural genesis of the chemical addressability in a viral nano-block[J]. J Mater Chem, 2006, 16(37):3673-3681.
4. NAM K T, KIM D W, YOO P J, et al. Virus-enabled synthesis and assembly of nanowires for lithium ion battery electrodes[J]. Science, 2006, 312(5775):885-888.
5. KHALIL A S, FERRER J M, BRAU R R, et al. Single M13 bacteriophage tethering and stretching[J]. Proc Natl Acad Sci U S A, 2007, 104(12):4892-4897.
6. LI K, CHEN Y, LI S, et al. Chemical modification of M13 bacteriophage and its application in cancer cell imaging[J]. Bioconjug Chem, 2010, 21(7):1369-1377.
7. BRUCKMAN M A, LIU J, KOLEY G, et al. Tobacco mosaic virus based thin film sensor for detection of volatile organic compounds[J]. J Mater Chem, 2010, 20(27):5715-5719.
8. LAGA R, KONÁK C, SUBR V, et al. Chemical conjugation of cowpea Mosaic viruses with reactive HPMA-based polymers[J]. J Biomater Sci Polym Ed, 2010, 21(12):1669-1685.
9. SOTO C M, BLUM A S, VORA G J, et al. Fluorescent signal amplification of carbocyanine dyes using engineered viral nanoparticles[J]. J Am Chem Soc, 2006, 128(15):5184-5189.
10. BARNHILL H N, REUTHER R, FERGUSON P L, et al. Turnip yellow Mosaic virus as a chemoaddressable bionanoparticle[J]. Bioconjug Chem, 2007, 18(3):852-859.
11. LEONG H S, STEINMETZ N F, ABLACK A, et al. Intravital imaging of embryonic and tumor neovasculature using viral nanoparticles[J]. Nat Protoc, 2010, 5(8):1406-1417.
12. RAE C S, KHOR I W, WANG Q, et al. Systemic trafficking of plant virus nanoparticles in mice via the oral route[J]. Virology, 2005, 343(2):224-235.
13. LEWIS J D, DESTITO G, ZIJLSTRA A, et al. Viral nanoparticles as tools for intravital vascular imaging[J]. Nat Med, 2006, 12(3):354-360.
14. SINGH P, DESTITO G, SCHNEEMANN A, et al. Canine parvovirus-like particles, a novel nanomaterial for tumor targeting[J]. J Nanobiotechnology, 2006, 4:2.
15. CHEN L, ZURITA A J, ARDELT P U, et al. Design and validation of a bifunctional ligand display system for receptor targeting[J]. Chem Biol, 2004, 11(8):1081-1091.
16. PRASUHN D E JR, YEH R M, OBENAUS A, et al. Viral MRI contrast agents:coordination of Gd by native virions and attachment of Gd complexes by azide-alkyne cycloaddition[J]. Chem Commun (Camb), 2007(12):1269-1271.
17. MELDRUM T, SEIM K L, BAJAJ V S, et al. A xenon-based molecular sensor assembled on an MS2 viral capsid scaffold[J]. J Am Chem Soc, 2010, 132(17):5936-5937.
18. HOOKER J M, O'NEIL J P, ROMANINI D W, et al. Genome-free viral capsids as carriers for positron emission tomography radiolabels[J]. Mol Imaging Biol, 2008, 10(4):182-191.
19. HUANG R K, STEINMETZ N F, FU C Y, et al. Transferrin-mediated targeting of bacteriophage HK97 nanoparticles into tumor cells[J]. Nanomedicine (Lond), 2011, 6(1):55-68.
20. BRUNEL F M, LEWIS J D, DESTITO G, et al. Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting[J]. Nano Lett, 2010, 10(3):1093-1097.
21. SUTHIWANGCHAROEN N, LI T, LI K, et al. M13 bacteriophage-polymer nanoassemblies as drug delivery vehicles[J]. Nano Res, 2011, 4(5):483-493.
22. YACOBY I, SHAMIS M, BAR H, et al. Targeting antibacterial agents by using drug-carrying filamentous bacteriophages[J]. Antimicrob Agents Chemother, 2006, 50(6):2087-2097.
23. STEINMETZ N F, HONG V, SPOERKE E D, et al. Buckyballs meet viral nanoparticles:candidates for biomedicine[J]. J Am Chem Soc, 2009, 131(47):17093-17095.
24. SUCI P A, VARPNESS Z, GILLITZER E, et al. Targeting and photodynamic killing of a microbial pathogen using protein cage architectures functionalized with a photosensitizer[J]. Langmuir, 2007, 23(24):12280-12286.
25. STEPHANOPOULOS N, TONG G J, HSIAO S C, et al. Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells[J]. ACS Nano, 2010, 4(10):6014-6020.
26. PLUMMER E M, MANCHESTER M. Viral nanoparticles and virus-like particles:platforms for contemporary vaccine design[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2010, 3(2):174-196.
27. RONG J, LEE L A, LI K, et al. Oriented cell growth on self-assembled bacteriophage M13 thin films[J]. Chem Commun (Camb), 2008,41:5185-5187.
28. YOO S Y, KOBAYASHI M, LEE P P, et al. Early osteogenic differentiation of mouse preosteoblasts induced by collagen-derived DGEA-peptide on nanofibrous phage tissue matrices[J]. Biomacromolecules, 2011, 12(4):987-996.
29. WU L, LEE L A, NIU Z, et al. Visualizing cell extracellular matrix (ECM) deposited by cells cultured on aligned bacteriophage M13 thin films[J]. Langmuir, 2011, 27(15):9490-9496.

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