Related Research on Mechanical Property of Valve Membrane in Transcatheter Bioprosthesis Valve Based on the Chemical Modification and Cutting Technology_Journal of Biomedical Engineering

Authors：

 CHENDakai ^1,2,3 , LIYu ¹ , LUOQiyi ¹ , LIUBaolin ² , CHENKangmin ³

1. Shanghai MicroPort Medical(Group) Co., Ltd., Shanghai 201203, China;
2. Modern Mciroport Medical Instrument and Technology Research Center of Ministry of Education, College of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;
3. College of Energy and Power Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China;

Corresponding author：

CHENDakai, Email: kseventiger@hotmail.com

Keywords：

transcatheter bioprosthetic valve; valve membrane; carbodiimide; suture force

DOI：

10.7507/1001-5515.20140150

Video：

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Abstract Full text Figures/Tables Video References Cited by

The aim of this research is to investigate the preparation method of valve membrane in transcatheter bioprosthetic valve, and to study the effect of chemical modification and cutting technology to tensile property and suture force property of valve membrane. We carried out a series of processes to perform the tests, such as firstly to test the crosslinking degree of valve membrane using ninhydrin method, then to test the tensile property and suture force property by using Instron's biomechanical testing equipment, and then to observe the collagen fiber orientation in valve membrane using Instron's biomechanical testing equipment and using field emission scanning electron microscopy. The study indicated that after the chemical modification, the crosslinking degree, tensile strength and suture force strength increasing rate of valve membrane were 93.78%±3.2%, (8.24±0.79) MPa, 102%, respectively. The valve membrane had a better biomechanical property and would be expected to become valve membrane in transcatheter bioprosthesis valve.

Citation： CHENDakai, LIYu, LUOQiyi, LIUBaolin, CHENKangmin. Related Research on Mechanical Property of Valve Membrane in Transcatheter Bioprosthesis Valve Based on the Chemical Modification and Cutting Technology. Journal of Biomedical Engineering, 2014, 31(4): 801-805. doi: 10.7507/1001-5515.20140150 Copy

1.	GREVE A M, BOMAN K, GOHLKE-BAERWOLF C, et al. Clinical implications of electrocardiographic left ventricular strain and hypertrophy in asymptomatic patients with aortic stenosis: the simvastatin and ezetimibe in aortic stenosis study[J]. Circulation, 2012, 125(2): 346-353.
2.	EWE S H, MURATORI M, DELGADO V, et al. Hemodynamic and clinical impact of prosthesis-patient mismatch after transcatheter aortic valve implantation[J]. J Am Coll Cardiol, 2011, 58(18): 1910-1918.
3.	史嘉玮,董念国,孙宗全.RGD肽对天然瓣膜支架细胞黏附性能的影响[J].生物医学工程学杂志,2008,25(2):388-392.
4.	PIAZZA N, DE JAEGERE P, SCHULTZ C, et al. Anatomy of the aortic valvar complex and its implications for transcatheter implantation of the aortic valve[J]. Circ Cardiovasc Interv, 2008, 1(1): 74-81.
5.	KLAABORG K E, EGEBLAD H, JAKOBSEN C J, et al. Transapical transcatheter treatment of a stenosed aortic valve bioprosthesis using the edwards SAPIEN transcatheter heart valve[J]. Ann Thorac Surg, 2009, 87(6): 1943-1946.
6.	BAPAT V, THOMAS M, HANCOCK J, et al. First successful trans-catheter aortic valve implantation through ascending aorta using Edwards SAPIEN THV system[J]. Eur J Cardiothorac Surg, 2010, 38(6): 811-813.
7.	SHERIF M A, ABDEL-WAHAB M, STÖCKER B, et al. Anatomic and procedural predictors of paravalvular aortic regurgitation after implantation of the Medtronic CoreValve bioprosthesis[J]. J Am Coll Cardiol, 2010, 56(20): 1623-1629.
8.	JILAIHAWI H, CHIN D, SPYT T, et al. Prosthesis-patient mismatch after transcatheter aortic valve implantation with the Medtronic-Corevalve bioprosthesis[J]. Eur Heart J, 2010, 31(7): 857-864.
9.	EGGEBRECHT H, KAHLERT P, PATSALIS P, et al. Developments in transcatheter heart valves for patients with severe aortic stenosis[J]. Int Cardiol, 2011, 6(1): 58-61.
10.	刘有军,乔爱科.基于血流动力学仿真的心血管外科手术规划进展[J].医用生物力学,2009,24(6):395-400,407.
11.	SUNG H, CHANG W, MA C, et al. Crosslinking of biological tissues using genipin and/or carbodiimide[J]. J Biomed Mater Res A, 2003, 64A(3): 427-438.
12.	SIMIONESCU D, SIMIONESCU A, DEAC R. Mapping of glutaraldehyde-treated bovine pericardium and tissue selection for bioprosthetic heart valves[J]. J Biomed Mater Res A, 1993, 27(6): 697-704.
13.	SUNG H W, CHANG Y, CHIU C T, et al. Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent[J]. Biomaterials, 1999, 20(19): 1759-1772.
14.	MIRNAJAFI A, RAYMER J, SCOTT M J, et al. The effects of collagen fiber orientation on the flexural properties of pericardial heterograft biomaterials[J]. Biomaterials, 2005, 26(7): 795-804.
15.	VAN ZUIJLEN P P, DE VRIES H J, LAMME E N, et al. Morphometry of dermal collagen orientation by Fourier analysis is superior to multi-observer assessment[J]. J Pathol, 2002, 198(3): 284-291.

1. GREVE A M, BOMAN K, GOHLKE-BAERWOLF C, et al. Clinical implications of electrocardiographic left ventricular strain and hypertrophy in asymptomatic patients with aortic stenosis: the simvastatin and ezetimibe in aortic stenosis study[J]. Circulation, 2012, 125(2): 346-353.
2. EWE S H, MURATORI M, DELGADO V, et al. Hemodynamic and clinical impact of prosthesis-patient mismatch after transcatheter aortic valve implantation[J]. J Am Coll Cardiol, 2011, 58(18): 1910-1918.
3. 史嘉玮,董念国,孙宗全.RGD肽对天然瓣膜支架细胞黏附性能的影响[J].生物医学工程学杂志,2008,25(2):388-392.
4. PIAZZA N, DE JAEGERE P, SCHULTZ C, et al. Anatomy of the aortic valvar complex and its implications for transcatheter implantation of the aortic valve[J]. Circ Cardiovasc Interv, 2008, 1(1): 74-81.
5. KLAABORG K E, EGEBLAD H, JAKOBSEN C J, et al. Transapical transcatheter treatment of a stenosed aortic valve bioprosthesis using the edwards SAPIEN transcatheter heart valve[J]. Ann Thorac Surg, 2009, 87(6): 1943-1946.
6. BAPAT V, THOMAS M, HANCOCK J, et al. First successful trans-catheter aortic valve implantation through ascending aorta using Edwards SAPIEN THV system[J]. Eur J Cardiothorac Surg, 2010, 38(6): 811-813.
7. SHERIF M A, ABDEL-WAHAB M, STÖCKER B, et al. Anatomic and procedural predictors of paravalvular aortic regurgitation after implantation of the Medtronic CoreValve bioprosthesis[J]. J Am Coll Cardiol, 2010, 56(20): 1623-1629.
8. JILAIHAWI H, CHIN D, SPYT T, et al. Prosthesis-patient mismatch after transcatheter aortic valve implantation with the Medtronic-Corevalve bioprosthesis[J]. Eur Heart J, 2010, 31(7): 857-864.
9. EGGEBRECHT H, KAHLERT P, PATSALIS P, et al. Developments in transcatheter heart valves for patients with severe aortic stenosis[J]. Int Cardiol, 2011, 6(1): 58-61.
10. 刘有军,乔爱科.基于血流动力学仿真的心血管外科手术规划进展[J].医用生物力学,2009,24(6):395-400,407.
11. SUNG H, CHANG W, MA C, et al. Crosslinking of biological tissues using genipin and/or carbodiimide[J]. J Biomed Mater Res A, 2003, 64A(3): 427-438.
12. SIMIONESCU D, SIMIONESCU A, DEAC R. Mapping of glutaraldehyde-treated bovine pericardium and tissue selection for bioprosthetic heart valves[J]. J Biomed Mater Res A, 1993, 27(6): 697-704.
13. SUNG H W, CHANG Y, CHIU C T, et al. Mechanical properties of a porcine aortic valve fixed with a naturally occurring crosslinking agent[J]. Biomaterials, 1999, 20(19): 1759-1772.
14. MIRNAJAFI A, RAYMER J, SCOTT M J, et al. The effects of collagen fiber orientation on the flexural properties of pericardial heterograft biomaterials[J]. Biomaterials, 2005, 26(7): 795-804.
15. VAN ZUIJLEN P P, DE VRIES H J, LAMME E N, et al. Morphometry of dermal collagen orientation by Fourier analysis is superior to multi-observer assessment[J]. J Pathol, 2002, 198(3): 284-291.

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Related Research on Mechanical Property of Valve Membrane in Transcatheter Bioprosthesis Valve Based on the Chemical Modification and Cutting Technology

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