Research Progress of Collagen-based Three-dimensional Porous Scaffolds Used in Skin Tissue Engineering_Journal of Biomedical Engineering

Authors：

ZHANGJing , TANGQiwei , ZHOUAimei ,  YANGShulin

Institute of Biotechnology, Nanjing University of Science and Technology, Nanjing 210094, China;

Corresponding author：

YANGShulin, Email: yshulin@mail.njust.edu.cn

Keywords：

collagen; three-dimensional porous scaffold; skin tissue engineering

DOI：

10.7507/1001-5515.20150165

Video：

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Collagen is a kind of natural biomedical material and collagen based three-dimensional porous scaffolds have been widely used in skin tissue engineering. However, these scaffolds do not meet the requirements for artificial skin substitutes in terms of their poor mechanical properties, short supply, and rejection in the bodies. All of these factors limit their further application in skin tissue engineering. A variety of methods have been chosen to meliorate the situation, such as cross linking and blending other substance for improving mechanical properties. The highly biomimetic scaffolds either in structure or in function can be prepared through culturing cells and loading growth factors. To avoid the drawbacks of unsafety attributing to animals, investigators have fixed their eyes on the recombinant collagen. This paper reviews the the progress of research and application of collagen-based 3-dimensional porous scaffolds in skin tissue engineering.

Citation： ZHANGJing, TANGQiwei, ZHOUAimei, YANGShulin. Research Progress of Collagen-based Three-dimensional Porous Scaffolds Used in Skin Tissue Engineering. Journal of Biomedical Engineering, 2015, 32(4): 924-928. doi: 10.7507/1001-5515.20150165 Copy

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2.	MCCLUREA M J,SIMPSONB D G,BOWLIN G L.Tri-layered vascular grafts composed of polycaprolactone,elastin,collagen,and silk:Optimization of graft properties[J].J Mech Behav Biomed Mater,2012,10:48-61.
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6.	POWELL H M,SUPP D M,BOYCE S T.Influence of electrospun collagen on wound contraction of engineered skin substitutes[J].Biomaterials,2008,29(7):834-843.
7.	ZHANG Q,LU H X,KAWAZOE N,et al.Preparation of collagen porous scaffolds with a gradient pore size structure using ice particulates[J].Mater Lett,2013,107(5):280-283.
8.	WANG X,GHASRI P,AMIR M,et al.Topical application of recombinant type VⅡ collagen incorporates into the dermal-epidermal junction and promotes wound closure[J].Mol Ther,2013,21(7):1335-1344.
9.	RAJAM A M,JITHENDRA P,ROSE C,et al.In vitro evaluation of dual growth factor-incorporated chitosan nanoparticle impregnated collagen-chitosan scaffold for tissue engineering[J].J Bioact Compat Polym,2012,27(3):265-278.
10.	AHNA J I,KUFFOVA L,MERRETTA K,et al.Crosslinked collagen hydrogels as corneal implants:Effects of sterically bulky vs.non-bulky carbodiimides as crosslinkers[J].Acta Biomater,2013,9(8):7796-7805.
11.	SARGEANT T D,DESAI A P,BANERJEE S,et al.An in situ forming collagen-PEG hydrogel for tissue regeneration[J].Acta Biomater,2012,8(1):124-132.
12.	CHEN X,PENG L H,SHAN Y H,et al.Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery[J].Int J Pharm,2013,447(1-2):171-181.
13.	AKTURK O,TEZCANER A,BILGILI H,et al.Evaluation of sericin/collagen membranes as prospective wound dressing biomaterial[J].J Biosci Bioeng,2011,12(3):279-288.
14.	VAN DER SMISSEN A,HINTZE V,SCHARNWEBER D,et al.Growth promoting substrates for human dermal fibroblasts provided by artificial extracellular matrices composed of collagen I and sulfated glycosaminoglycans[J].Biomaterials,2011,32(34):8938-8946.
15.	PEI Y,YANG J,LIU P,et al.Fabrication,properties and bioapplications of cellulose/collagen hydrolysate composite films[J].Carbohydr Polym,2013,92(2):1752-1760.
16.	RUSTAD K C,WONG V W,SORKIN M,et al.Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold[J].Biomaterials,2012,33(1):80-90.
17.	HASHEMI S M,SOUDI S,SHABANI I,et al.The promotion of stemness and pluripotency following feeder-free culture of embryonic stem cells on collagen-grafted 3-dimensional nanofibrous scaffold[J].Biomaterials,2011,32(30):7363-7374.
18.	CAVES J M,CUI W,WEN J,et al.Elastin-like protein matrix reinforced with collagen microfibers for soft tissue repair[J].Biomaterials,2011,32(23):5371-5379.
19.	BARNES C P,SELL S A,BOLAND E D,et al.Nanofiber technology:designing the next Generation of tissue engineering scaffolds[J].Adv Drug Deliv Rev,2007,59(14):1413-1433.
20.	HUANG C,FU X,LIU J,et al.The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skinfi broblasts on anisotropic collagen-containing nanofibers[J].Biomaterials,2012,33(6):1791-1800.
21.	YAN L P,WANG Y J,REN L,et al.Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications[J].J Biomed Mater Res A,2010,95(2):465-475.
22.	REICH M S,AKKUS O.Sporicidal efficacy of genipin:a potential theoretical alternative for biomaterial and tissue graft sterilization[J].Cell Tissue Bank,2013,14(3):381-393.
23.	HUANG C H,CHI C Y,CHEN Y S,et al.Evaluation of proanthocyanidin-crosslinked electrospun gelatin nanofibers for drug delivering system[J].Materials Science and Engineering C,2012,32(8):2476-2483.
24.	WANG X,YOU C,HUA X,et al.The roles of knitted mesh-reinforced collagen-chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats[J].Acta Biomater,2013,9(8):7822-7832.
25.	LAI V K,LAKE S P,FREY C R,et al.Mechanical behavior of collagen-fibrin co-gels reflects transition from series to parallel interactions with increasing collagen content[J].J Biomech Eng,2012,134(1):011004.
26.	KEMPF M,MIYAMURA Y,LIU P Y,et al.A denatured collagen microfiber scaffold seeded with human fibroblasts and keratinocytes for skin grafting[J].Biomaterials,2011,32(21):4782-4792.
27.	HUANG S,XU Y,WU C,et al.In vitro constitution and in vivo implantation of engineered skin constructs with sweat glands[J].Biomaterials,2010,31(21):5520-5525.
28.	HWANG Y S,CHO J,TAY F,et al.The use of murine embryonic stem cells,alginate encapsulation,and rotary microgravity bioreactor in bone tissue engineering[J].Biomaterials,2009,30(4):499-507.
29.	ANSARI S,MOSHAVERINIA A,PI S H.Functionalization of scaffolds with chimeric anti-BMP-2 monoclonal antibodies for osseous regeneration[J].Biomaterials,2013,34(38):10191-10198.
30.	CHEN F M,ZHANG M,WU Z F.Toward delivery of multiple growth factors in tissue engineering[J].Biomaterials,2010,31(24):6279-6308.
31.	WERKMEISTER J A,RAMSHAW J A.Recombinant protein scaffolds for tissue engineering[J].Biomed Mater,2012,7(1):012002.
32.	PULKKINEN H J,TⅡTU V,VALONEN P,et al.Repair of osteochondral defects with recombinant human type Ⅱ collagen gel and autologous chondrocytes in rabbit[J].Osteoarthritis Cartilage,2013,21(3):481-490.
33.	ZHU C,FAN D,DUAN Z,et al.Initial investigation of novel human-like collagen/chitosan scaffold for vascular tissue engineering[J].J Biomed Mater Res A,2009,89(3):829-840.

1. KORIA P.Delivery of growth factors for tissue regeneration and wound healing[J].BioDrugs,2012,26(3):163-175.
2. MCCLUREA M J,SIMPSONB D G,BOWLIN G L.Tri-layered vascular grafts composed of polycaprolactone,elastin,collagen,and silk:Optimization of graft properties[J].J Mech Behav Biomed Mater,2012,10:48-61.
3. GUO R,XU S,MA L,et al.The healing of full-thickness burns treated by using plasmid DNA encoding VEGF-165 activated collagene-chitosan dermal equivalents[J].Biomaterials,2011,32(4):1019-1031.
4. LI Q,TAO L,CHEN B,et al.Extrahepatic bile duct regeneration in pigs using collagen scaffolds loaded with human collagen-binding bFGF[J].Biomaterials,2012,33(17):4298-4308.
5. CHEN L,XIAO Z,MENG Y,et al.The enhancement of cancer stem cell properties of MCF-7 cells in 3D collagen scaffolds for modeling of cancer and anti-cancer drugs[J].Biomaterials,2012,33(5):1437-1444.
6. POWELL H M,SUPP D M,BOYCE S T.Influence of electrospun collagen on wound contraction of engineered skin substitutes[J].Biomaterials,2008,29(7):834-843.
7. ZHANG Q,LU H X,KAWAZOE N,et al.Preparation of collagen porous scaffolds with a gradient pore size structure using ice particulates[J].Mater Lett,2013,107(5):280-283.
8. WANG X,GHASRI P,AMIR M,et al.Topical application of recombinant type VⅡ collagen incorporates into the dermal-epidermal junction and promotes wound closure[J].Mol Ther,2013,21(7):1335-1344.
9. RAJAM A M,JITHENDRA P,ROSE C,et al.In vitro evaluation of dual growth factor-incorporated chitosan nanoparticle impregnated collagen-chitosan scaffold for tissue engineering[J].J Bioact Compat Polym,2012,27(3):265-278.
10. AHNA J I,KUFFOVA L,MERRETTA K,et al.Crosslinked collagen hydrogels as corneal implants:Effects of sterically bulky vs.non-bulky carbodiimides as crosslinkers[J].Acta Biomater,2013,9(8):7796-7805.
11. SARGEANT T D,DESAI A P,BANERJEE S,et al.An in situ forming collagen-PEG hydrogel for tissue regeneration[J].Acta Biomater,2012,8(1):124-132.
12. CHEN X,PENG L H,SHAN Y H,et al.Astragaloside IV-loaded nanoparticle-enriched hydrogel induces wound healing and anti-scar activity through topical delivery[J].Int J Pharm,2013,447(1-2):171-181.
13. AKTURK O,TEZCANER A,BILGILI H,et al.Evaluation of sericin/collagen membranes as prospective wound dressing biomaterial[J].J Biosci Bioeng,2011,12(3):279-288.
14. VAN DER SMISSEN A,HINTZE V,SCHARNWEBER D,et al.Growth promoting substrates for human dermal fibroblasts provided by artificial extracellular matrices composed of collagen I and sulfated glycosaminoglycans[J].Biomaterials,2011,32(34):8938-8946.
15. PEI Y,YANG J,LIU P,et al.Fabrication,properties and bioapplications of cellulose/collagen hydrolysate composite films[J].Carbohydr Polym,2013,92(2):1752-1760.
16. RUSTAD K C,WONG V W,SORKIN M,et al.Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold[J].Biomaterials,2012,33(1):80-90.
17. HASHEMI S M,SOUDI S,SHABANI I,et al.The promotion of stemness and pluripotency following feeder-free culture of embryonic stem cells on collagen-grafted 3-dimensional nanofibrous scaffold[J].Biomaterials,2011,32(30):7363-7374.
18. CAVES J M,CUI W,WEN J,et al.Elastin-like protein matrix reinforced with collagen microfibers for soft tissue repair[J].Biomaterials,2011,32(23):5371-5379.
19. BARNES C P,SELL S A,BOLAND E D,et al.Nanofiber technology:designing the next Generation of tissue engineering scaffolds[J].Adv Drug Deliv Rev,2007,59(14):1413-1433.
20. HUANG C,FU X,LIU J,et al.The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skinfi broblasts on anisotropic collagen-containing nanofibers[J].Biomaterials,2012,33(6):1791-1800.
21. YAN L P,WANG Y J,REN L,et al.Genipin-cross-linked collagen/chitosan biomimetic scaffolds for articular cartilage tissue engineering applications[J].J Biomed Mater Res A,2010,95(2):465-475.
22. REICH M S,AKKUS O.Sporicidal efficacy of genipin:a potential theoretical alternative for biomaterial and tissue graft sterilization[J].Cell Tissue Bank,2013,14(3):381-393.
23. HUANG C H,CHI C Y,CHEN Y S,et al.Evaluation of proanthocyanidin-crosslinked electrospun gelatin nanofibers for drug delivering system[J].Materials Science and Engineering C,2012,32(8):2476-2483.
24. WANG X,YOU C,HUA X,et al.The roles of knitted mesh-reinforced collagen-chitosan hybrid scaffold in the one-step repair of full-thickness skin defects in rats[J].Acta Biomater,2013,9(8):7822-7832.
25. LAI V K,LAKE S P,FREY C R,et al.Mechanical behavior of collagen-fibrin co-gels reflects transition from series to parallel interactions with increasing collagen content[J].J Biomech Eng,2012,134(1):011004.
26. KEMPF M,MIYAMURA Y,LIU P Y,et al.A denatured collagen microfiber scaffold seeded with human fibroblasts and keratinocytes for skin grafting[J].Biomaterials,2011,32(21):4782-4792.
27. HUANG S,XU Y,WU C,et al.In vitro constitution and in vivo implantation of engineered skin constructs with sweat glands[J].Biomaterials,2010,31(21):5520-5525.
28. HWANG Y S,CHO J,TAY F,et al.The use of murine embryonic stem cells,alginate encapsulation,and rotary microgravity bioreactor in bone tissue engineering[J].Biomaterials,2009,30(4):499-507.
29. ANSARI S,MOSHAVERINIA A,PI S H.Functionalization of scaffolds with chimeric anti-BMP-2 monoclonal antibodies for osseous regeneration[J].Biomaterials,2013,34(38):10191-10198.
30. CHEN F M,ZHANG M,WU Z F.Toward delivery of multiple growth factors in tissue engineering[J].Biomaterials,2010,31(24):6279-6308.
31. WERKMEISTER J A,RAMSHAW J A.Recombinant protein scaffolds for tissue engineering[J].Biomed Mater,2012,7(1):012002.
32. PULKKINEN H J,TⅡTU V,VALONEN P,et al.Repair of osteochondral defects with recombinant human type Ⅱ collagen gel and autologous chondrocytes in rabbit[J].Osteoarthritis Cartilage,2013,21(3):481-490.
33. ZHU C,FAN D,DUAN Z,et al.Initial investigation of novel human-like collagen/chitosan scaffold for vascular tissue engineering[J].J Biomed Mater Res A,2009,89(3):829-840.

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