Comparison Study of Left Ventricular Function Assessment by <sup>18</sup>F-FDG PET, Gated SPECT and 2D-Echocardiography in Patients with Myocardial Infarction_Journal of Biomedical Engineering

Authors：

LIFanglan , HUANGRui , OUXiaohong ,  LILin

Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

LILin, Email: lilinhuaxi@sina.com

Keywords：

positron emission tomography; gated single photon emission computed tomography; echocardiography; left ventricular function; myocardial infarction

DOI：

10.7507/1001-5515.20150193

Video：

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The aim of this study is to analyze the concordance between EDV, ESV and LVEF values derived from ¹⁸F-FDG PET, GSPECT and ECHO in patients with myocardial infarction. Sixty-four patients with coronary artery disease (CAD) and myocardial infarction were enrolled in the study.. Each patient underwent at least two of the above mentioned studies within 2 weeks. LVEF、 EDV and ESV values were analyzed with dedicated software. Statistical evaluation of correlation and agreement was carried out EDV was overestimated by ¹⁸F-FDG PET compared with GSPECT [(137.98±61.71) mL and (125.35±59.34) mL]; ESV was overestimated by ¹⁸F-FDG PET (85.89±55.21) mL and GSPECT (82.39±55.56) mL compared with ECHO (68.22±41.37) mL; EF was overestimated by ¹⁸F-FDG PET (41.96%±15.08%) and ECHO (52.18%±13.87%) compared with GSPECT (39.75%±15.64%), and EF was also overestimated by ¹⁸F-FDG PET compared with GSPECT. The results of linear regression analysis showed good correlation between EDV, ESV and LVEF values derived from ¹⁸F-FDG PET, GSPECT and ECHO (r=0.643-0.873, P=0.000). Bland-Altman analysis indicated that ¹⁸F-FDG PET correlated well with ECHO in the Left ventricular function parameters. While GSPECT correlated well with ¹⁸F-FDG PET in ESV, GSPECT had good correlation with Echo in respect of EDV and EF; whereas GSPECT had poor correlation with PET/ECHO in the remaining left ventricular function parameters. Therefore, the clinical physicians should decide whether they would use the method according to the patients' situation and diagnostic requirements.

Citation： LIFanglan, HUANGRui, OUXiaohong, LILin. Comparison Study of Left Ventricular Function Assessment by ¹⁸F-FDG PET, Gated SPECT and 2D-Echocardiography in Patients with Myocardial Infarction. Journal of Biomedical Engineering, 2015, 32(5): 1090-1095. doi: 10.7507/1001-5515.20150193 Copy

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10.	PFEFFER M A, BRAUNWALD E, MOYE L A, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction:results of the survival and ventricular enlargement trial-the SAVE Investigators[J]. N Engl J Med, 1992, 327(10):669-677.
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13.	田丛娜.门控心肌灌注SPECT显像及门控心肌代谢PET显像评价左心室室壁瘤患者左心室功能的价值[D].北京:中国协和医学院/中国医学科学院,2013.
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15.	DEMIR H, TAN Y Z, KOZDAG G, et al. Comparison of gated SPECT, echocardiography and cardiac magnetic resonance imaging for the assessment of left ventricular ejection fraction and volumes[J]. Ann Saudi Med, 2007, 27(6):415-420.

1. STEGGER L, HEIJMAN E, SCH? FERS K P, et al. Quantification of left ventricular volumes and ejection fraction in mice using PET, compared with MRI[J]. J Nucl Med, 2009, 50(1):132-138.
2. KHORSAND A, GYÖNGYÖSI M, SOCHOR H, et al. Assessment of left ventricular volumes, ejection fraction and mass. Comparison of model-based analysis of ECG-gated (⁹⁹m)Tc-SPECT and ¹⁸F-FDG-PET[J]. Nuklearmedizin, 2011, 50(1):9-14.
3. BEANLANDS R S, YOUSSEF G. Diagnosis and prognosis of coronary artery disease:PET is superior to SPECT:Pro[J]. J Nucl Cardiol, 2010, 17(4):683-695.
4. 萨建,刘桂芬.定量测量结果的一致性评价及Bland-Altman法的应用[J].中国卫生统计,2011,28(4):409-413.
5. HUTYRA M, SKALA T, KAMINEK M, et al. Comparison of left ventricular volumes and ejection fraction assessment by two-dimensional echocardiography compared with gated myocardial spect in patients with ischemic cardiomyopathy[J]. Biomed Pap Med FacUnivPalacky Olomouc Czech Repub, 2010, 154(1):47-54.
6. SAAB G, DEKEMP R A, UKKONEN H, et al. Gated fluorine 18 fluorodeoxy glucose positron emission tomography:determination of global and regional left ventricular function and myocardial tissue characterization[J]. J Nucl Cardiol, 2003,10(3):297-303.
7. SCHAEFER W M, LIPKE C S, NOWAK B, et al. Validation of QGS and 4D-MSPECT for quantification of left ventricular volumes and ejection fraction from gated ¹⁸F-FDG PET:comparison with cardiac MRI[J]. J Nucl Med, 2004, 45(1):74-79.
8. 刘晓洁.¹⁸F-FDG PET心肌代谢显像的方法学研究及其评估心肌活性的应用价值[D].合肥:安徽医科大学,2011.
9. COSYNS B, HABERMAN D, DROOGMANS S, et al. Comparison of contrast enhanced three dimensional echocardiography with MIBI gated SPECT for the evaluationof left ventricular function[J]. Cardiovasc Ultrasound, 2009, 7:27.
10. PFEFFER M A, BRAUNWALD E, MOYE L A, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction:results of the survival and ventricular enlargement trial-the SAVE Investigators[J]. N Engl J Med, 1992, 327(10):669-677.
11. LONGMORE D B, UNDERW OOD S R, HOUNSFIELD G N, et al. Dimensional accuracy of magnetic resonance in studies of the heart[J]. Lancet, 1985, 1(8442):1360-1362.
12. SAKUMA H, FUJITA N, FOO T K, et al. Evaluation of left ventricular volume and mass with breathhold cine M R imaging[J]. Radiology, 1993, 188(2):377-380.
13. 田丛娜.门控心肌灌注SPECT显像及门控心肌代谢PET显像评价左心室室壁瘤患者左心室功能的价值[D].北京:中国协和医学院/中国医学科学院,2013.
14. YAMAKAWA Y, TAKAHASHI N, ISHIKAWA T, et al. Clinical usefulness of ECG-gated ¹⁸F-FDG PET combined with ^99mTC-MIBI gated SPECT for evaluating myocardial viability and function[J]. Ann Nucl Med, 2004, 18(5):375-383.
15. DEMIR H, TAN Y Z, KOZDAG G, et al. Comparison of gated SPECT, echocardiography and cardiac magnetic resonance imaging for the assessment of left ventricular ejection fraction and volumes[J]. Ann Saudi Med, 2007, 27(6):415-420.

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Comparison Study of Left Ventricular Function Assessment by ¹⁸F-FDG PET, Gated SPECT and 2D-Echocardiography in Patients with Myocardial Infarction

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Comparison Study of Left Ventricular Function Assessment by ¹⁸F-FDG PET, Gated SPECT and 2D-Echocardiography in Patients with Myocardial Infarction