Applications of Porous Scaffolds in Muscle Tissue Engineering_Journal of Biomedical Engineering

Authors：

SUNYan ^1,2 , ZOULing ^1,2 ,  LIUJun ^1,3

1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China;
2. Department of Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;
3. Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;

Corresponding author：

LIUJun, Email: junliu@scu.edu.cn

Keywords：

muscle regeneration; tissue engineering; porous scaffolds

DOI：

10.7507/1001-5515.20150237

Video：

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Scaffold is one of the key elements required for tissue engineering. Porous scaffolds have several special advantages for muscle tissue engineering, and they are beneficial to cell survival, myogenic differentiation, and vascular ingrowth. The performance of porous scaffolds is closely related to the property of the biomaterials used. Additionally, the pore size and porosity may affect cell adhesion, proliferation, and differentiation. This review focuses on the application of porous scaffolds in muscle tissue engineering, including their categories, application, and advantages.

Citation： SUNYan, ZOULing, LIUJun. Applications of Porous Scaffolds in Muscle Tissue Engineering. Journal of Biomedical Engineering, 2015, 32(6): 1343-1347. doi: 10.7507/1001-5515.20150237 Copy

1.	CAMERON A R, FRITH J E, GOMEZ G A, et al. The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells[J]. Biomaterials, 2014, 35(6):1857-1868.
2.	方易冰, 廖斌.心肌组织工程支架材料研究进展[J].中国修复重建外科杂志, 2011, 25(3):361-364.
3.	LAU T T, WANG D A. Bioresponsive hydrogel scaffolding systems for 3D constructions in tissue engineering and regenerative medicine[J]. Nanomedicine, 2013, 8(4):655-668.
4.	GUO H D, WANG H J, TAN Y Z, et al. Transplantation of Marrow-Derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction[J]. Tissue Eng Part A, 2011, 17(1/2):45-58.
5.	DULING R R, DUPAIX R B, KATSUBE N, et al. Mechanical characterization of electrospun polycaprolactone(PCL):a potential scaffold for tissue engineering[J]. J Biomech Eng, 2008, 130(1):011006.
6.	POK S, MYERS J D, MADIHALLY S V, et al. A multi-layered scaffold of a chitosan and gelatin hydrogel supported by a PCL core for cardiac tissue engineering[J]. Acta Biomater, 2013, 9(3):5630-5642.
7.	SHAH R, READY D, KNOWLES J C, et al. Sequential identification of a degradable phosphate glass scaffold for skeletal muscle regeneration[J]. J Tissue Eng Regen Med, 2012.
8.	ALEKSEEVA T, ABOU NEEL E A, KNOWLES J C. Development of conical soluble phosphate glass fibers for directional tissue growth[J]. J Biomater Appl, 2012, 26(6):733-744.
9.	董教明, 莫秀梅, 李雨, 等.天然组织去细胞技术的研究进展[J].生物医学工程学杂志, 2012, 29(5):1007-1013.
10.	吕晶同, 项舟.肌腱组织工程生物衍生支架材料[J].生物医学工程学杂志, 2013, 30(2):451-454.
11.	LIU J, XU H H, ZHOU H Z, et al. Human umbilical cord stem cell encapsulation in novel macroporous and injectable fibrin for muscle tissue engineering[J]. Acta Biomater, 2013, 9(1):4688-4697.
12.	罗会涛, 赵婧, 范兴平, 等.不同类型多孔结构生物材料支架制备及其性能优化[J].中国材料进展, 2012, 31(5):30-39.
13.	GONG X, TANG C Y, ZHANG Y, et al. Fabrication of graded macroporous poly(lactic acid)scaffold by a progressive solvent casting/porogen leaching approach[J]. J Appl Polym Sci, 2012, 125(1):571-577.
14.	LEE M, WU B M, DUNN J C. Effect of scaffold architecture and pore size on smooth muscle cell growth[J]. J Biomed Mater Res A, 2008, 87A(4):1010-1016.
15.	KROEHNE V, HESCHEL I, SCHUEGNER F, et al. Use of a novel collagen matrix with oriented pore structure for muscle cell differentiation in cell culture and in grafts[J]. J Cell Mol Med, 2008, 12(5A):1640-1648.
16.	QIAN L, ZHANG H F. Controlled freezing and freeze drying:a versatile route for porous and micro-/nano-structured materials[J]. J Chem Tech Biotech, 2011, 86(2):172-184.
17.	AVISS K J, GOUGH J E, DOWNES S. aligned electrospun polymer fibres for skeletal muscle regeneration[J]. Eur Cell Mater, 2010, 19:193-204.
18.	BLAKENEY B A, TAMBRALLI A, ANDERSON J M, et al. Cell infiltration and growth in a low density, uncompressed three-dimensional electrospun nanofibrous scaffold[J]. Biomaterials, 2011, 32(6):1583-1590.
19.	HWANG C M, SANT S, MASAELI M, et al. Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering[J]. Biofabrication, 2010, 2(3):035003.
20.	DERBY B. Printing and prototyping of tissues and scaffolds[J]. Science, 2012, 338(619):921-926.
21.	LEE J Y, CHOI B, WU B, et al. Customized biomimetic scaffolds created by indirect three-dimensional printing for tissue engineering[J]. Biofabrication, 2013, 5(4):045003.
22.	JI C, KHADEMHOSSEINI A, DEHGHANI F. Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications[J]. Biomaterials, 2011, 32(36):9719-9729.
23.	NG S S, SU K, LI C, et al. Biomechanical study of the edge outgrowth phenomenon of encapsulated chondrocytic isogenous groups in the surface layer of hydrogel scaffolds for cartilage tissue engineering[J]. Acta Biomater, 2012, 8(1):244-252.
24.	LIU J, ZHOU H Z, WEIR M D, et al. Fast-Degradable microbeads encapsulating human umbilical cord stem cells in alginate for muscle tissue engineering[J]. Tissue Eng Part A, 2012, 18(21/22):2303-2314.
25.	LEE J, ABDEEN A A, HUANG T H, et al. Controlling cell geometry on substrates of variable stiffness can tune the degree of osteogenesis in human mesenchymal stem cells[J]. J Mech Behav Biomed Mater, 2014, 38:209-218.
26.	KU S H, LEE S H, PARK C B. Synergic effects of nanofiber alignment and electroactivity on myoblast differentiation[J]. Biomaterials, 2012, 33(26):6098-6104.
27.	RICOTTI L, POLINI A, GENCHI G G, et al. Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds[J]. Biomed Mater, 2012, 7(3):035010.
28.	JANA S, COOPER A, ZHANG M Q. Chitosan scaffolds with unidirectional microtubular pores for large skeletal myotube Generation[J]. Adv Healthc Mater, 2013, 2(4):557-561.
29.	NGUYEN L H, ANNABI N, NIKKHAH M, et al. Vascularized bone tissue engineering:approaches for potential improvement[J]. Tissue Eng Part B Rev, 2012, 18(5):363-382.
30.	ARTEL A, MEHDIZADEH H, CHIU Y C, et al. An agent-based model for the investigation of neovascularization within porous scaffolds[J]. Tissue Eng Part A, 2011, 17(17-18):2133-2141.
31.	CHIU Y C, CHENG M H, ENGEL H, et al. The role of pore size on vascularization and tissue remodeling in PEG hydrogels[J]. Biomaterials, 2011, 32(26):6045-6051.
32.	THOMSON K S, KORTE F S, GIACHELLI C M, et al. Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications[J]. Tissue Eng Part A, 2013, 19(7-8):967-977.
33.	BORSELLI C, CEZAR C A, SHVARTSMAN D A, et al. The role of multifunctional delivery scaffold in the ability of cultured myoblasts to promote muscle regeneration[J]. Biomaterials, 2011, 32(34):8905-8914.

1. CAMERON A R, FRITH J E, GOMEZ G A, et al. The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells[J]. Biomaterials, 2014, 35(6):1857-1868.
2. 方易冰, 廖斌.心肌组织工程支架材料研究进展[J].中国修复重建外科杂志, 2011, 25(3):361-364.
3. LAU T T, WANG D A. Bioresponsive hydrogel scaffolding systems for 3D constructions in tissue engineering and regenerative medicine[J]. Nanomedicine, 2013, 8(4):655-668.
4. GUO H D, WANG H J, TAN Y Z, et al. Transplantation of Marrow-Derived cardiac stem cells carried in fibrin improves cardiac function after myocardial infarction[J]. Tissue Eng Part A, 2011, 17(1/2):45-58.
5. DULING R R, DUPAIX R B, KATSUBE N, et al. Mechanical characterization of electrospun polycaprolactone(PCL):a potential scaffold for tissue engineering[J]. J Biomech Eng, 2008, 130(1):011006.
6. POK S, MYERS J D, MADIHALLY S V, et al. A multi-layered scaffold of a chitosan and gelatin hydrogel supported by a PCL core for cardiac tissue engineering[J]. Acta Biomater, 2013, 9(3):5630-5642.
7. SHAH R, READY D, KNOWLES J C, et al. Sequential identification of a degradable phosphate glass scaffold for skeletal muscle regeneration[J]. J Tissue Eng Regen Med, 2012.
8. ALEKSEEVA T, ABOU NEEL E A, KNOWLES J C. Development of conical soluble phosphate glass fibers for directional tissue growth[J]. J Biomater Appl, 2012, 26(6):733-744.
9. 董教明, 莫秀梅, 李雨, 等.天然组织去细胞技术的研究进展[J].生物医学工程学杂志, 2012, 29(5):1007-1013.
10. 吕晶同, 项舟.肌腱组织工程生物衍生支架材料[J].生物医学工程学杂志, 2013, 30(2):451-454.
11. LIU J, XU H H, ZHOU H Z, et al. Human umbilical cord stem cell encapsulation in novel macroporous and injectable fibrin for muscle tissue engineering[J]. Acta Biomater, 2013, 9(1):4688-4697.
12. 罗会涛, 赵婧, 范兴平, 等.不同类型多孔结构生物材料支架制备及其性能优化[J].中国材料进展, 2012, 31(5):30-39.
13. GONG X, TANG C Y, ZHANG Y, et al. Fabrication of graded macroporous poly(lactic acid)scaffold by a progressive solvent casting/porogen leaching approach[J]. J Appl Polym Sci, 2012, 125(1):571-577.
14. LEE M, WU B M, DUNN J C. Effect of scaffold architecture and pore size on smooth muscle cell growth[J]. J Biomed Mater Res A, 2008, 87A(4):1010-1016.
15. KROEHNE V, HESCHEL I, SCHUEGNER F, et al. Use of a novel collagen matrix with oriented pore structure for muscle cell differentiation in cell culture and in grafts[J]. J Cell Mol Med, 2008, 12(5A):1640-1648.
16. QIAN L, ZHANG H F. Controlled freezing and freeze drying:a versatile route for porous and micro-/nano-structured materials[J]. J Chem Tech Biotech, 2011, 86(2):172-184.
17. AVISS K J, GOUGH J E, DOWNES S. aligned electrospun polymer fibres for skeletal muscle regeneration[J]. Eur Cell Mater, 2010, 19:193-204.
18. BLAKENEY B A, TAMBRALLI A, ANDERSON J M, et al. Cell infiltration and growth in a low density, uncompressed three-dimensional electrospun nanofibrous scaffold[J]. Biomaterials, 2011, 32(6):1583-1590.
19. HWANG C M, SANT S, MASAELI M, et al. Fabrication of three-dimensional porous cell-laden hydrogel for tissue engineering[J]. Biofabrication, 2010, 2(3):035003.
20. DERBY B. Printing and prototyping of tissues and scaffolds[J]. Science, 2012, 338(619):921-926.
21. LEE J Y, CHOI B, WU B, et al. Customized biomimetic scaffolds created by indirect three-dimensional printing for tissue engineering[J]. Biofabrication, 2013, 5(4):045003.
22. JI C, KHADEMHOSSEINI A, DEHGHANI F. Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications[J]. Biomaterials, 2011, 32(36):9719-9729.
23. NG S S, SU K, LI C, et al. Biomechanical study of the edge outgrowth phenomenon of encapsulated chondrocytic isogenous groups in the surface layer of hydrogel scaffolds for cartilage tissue engineering[J]. Acta Biomater, 2012, 8(1):244-252.
24. LIU J, ZHOU H Z, WEIR M D, et al. Fast-Degradable microbeads encapsulating human umbilical cord stem cells in alginate for muscle tissue engineering[J]. Tissue Eng Part A, 2012, 18(21/22):2303-2314.
25. LEE J, ABDEEN A A, HUANG T H, et al. Controlling cell geometry on substrates of variable stiffness can tune the degree of osteogenesis in human mesenchymal stem cells[J]. J Mech Behav Biomed Mater, 2014, 38:209-218.
26. KU S H, LEE S H, PARK C B. Synergic effects of nanofiber alignment and electroactivity on myoblast differentiation[J]. Biomaterials, 2012, 33(26):6098-6104.
27. RICOTTI L, POLINI A, GENCHI G G, et al. Proliferation and skeletal myotube formation capability of C2C12 and H9c2 cells on isotropic and anisotropic electrospun nanofibrous PHB scaffolds[J]. Biomed Mater, 2012, 7(3):035010.
28. JANA S, COOPER A, ZHANG M Q. Chitosan scaffolds with unidirectional microtubular pores for large skeletal myotube Generation[J]. Adv Healthc Mater, 2013, 2(4):557-561.
29. NGUYEN L H, ANNABI N, NIKKHAH M, et al. Vascularized bone tissue engineering:approaches for potential improvement[J]. Tissue Eng Part B Rev, 2012, 18(5):363-382.
30. ARTEL A, MEHDIZADEH H, CHIU Y C, et al. An agent-based model for the investigation of neovascularization within porous scaffolds[J]. Tissue Eng Part A, 2011, 17(17-18):2133-2141.
31. CHIU Y C, CHENG M H, ENGEL H, et al. The role of pore size on vascularization and tissue remodeling in PEG hydrogels[J]. Biomaterials, 2011, 32(26):6045-6051.
32. THOMSON K S, KORTE F S, GIACHELLI C M, et al. Prevascularized microtemplated fibrin scaffolds for cardiac tissue engineering applications[J]. Tissue Eng Part A, 2013, 19(7-8):967-977.
33. BORSELLI C, CEZAR C A, SHVARTSMAN D A, et al. The role of multifunctional delivery scaffold in the ability of cultured myoblasts to promote muscle regeneration[J]. Biomaterials, 2011, 32(34):8905-8914.

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