Research Progress of Silk Fibroin As a Drug Delivery Materials_Journal of Biomedical Engineering

Authors：

JILijing , KEJing , JIALan , GUOLi ,  ZHUJingxin

College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China;

Corresponding author：

ZHUJingxin, Email: zhujingxin@tyut.edu.cn

Keywords：

silk fibroin; drug release; carrier

DOI：

10.7507/1001-5515.20150241

Video：

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Recently, drug delivery materials have become the hotspot of medical study. Suitable delivery material plays an important role in constructing an excellent drug delivery system. Silk fibroin is a naturally occurring protein polymer with excellent biocompatibility, remarkable mechanical properties, biodegradability and outstanding processability. Due to its unique properties, silk fibroin has become a favorable carrier material for the incorporation and delivery of a range of therapeutic agents. Based on the structure and characteristics of silk fibroin, this article provides an overview of the recent research progress of silk fibroin used as drug delivery materials.

Citation： JILijing, KEJing, JIALan, GUOLi, ZHUJingxin. Research Progress of Silk Fibroin As a Drug Delivery Materials. Journal of Biomedical Engineering, 2015, 32(6): 1364-1368. doi: 10.7507/1001-5515.20150241 Copy

1.	袁青青.再生丝蛋白材料的制备及其结构与性能的研究[D].上海:复旦大学, 2010.
2.	INOUE S, TANAKA K, ARISAKA F, et al. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with 6:6:1 molar ratio[J]. J Biol Chem, 2000, 275(51):40517-40528.
3.	韦俏娜, 马林, 黄爱民, 等.甲醇-水混合溶剂后处理制备丝素蛋白膜及其药物释放研究[J].化学学报, 2012, 70(6):714-720.
4.	黄溪, 王芋骁, 董燕, 等.丝素蛋白/聚乙二醇薄膜结构性质和药物释放研究[J].广西大学学报:自然科学版, 2013, 38(3):576-583.
5.	SEIB F P, KAPLAN D L. Doxorubicin-loaded silk films:Drug-silk interactions and in vivo performance in human orthotopic breast cancer[J]. Biomaterials, 2012, 33(33):8442-8450.
6.	PRITCHARD E M, SZYBALA C, BOISON D, et al. Silk fibroin encapsulated powder reservoirs for sustained release of adenosine[J]. J Contr Rel, 2010, 144(2):159-167.
7.	ZHOU Jian, FANG Taolin, WEN Jianchuan, et al. Silk coating on poly(epsilon-caprolactone) microspheres for the delayed release of vancomycin[J]. J Microencapsul, 2011, 28(2):99-107.
8.	PRITCHARD E M, VALENTIN T, PANILAITIS B A, et al. Antibiotic-releasing silk biomaterials for infection prevention and treatment[J]. Adv Funct Mater, 2013, 23(7):854-861.
9.	ZHAO Zheng, CHEN Aizheng, LI Yi, et al. Fabrication of silk fibroin nanoparticles for controlled drug delivery[J]. J Nanopart Res, 2012, 14(4):1-10.
10.	吴豪翔.一种丝素微球的制备方法:中国, 201310228078.4[P].2013-10-09.
11.	黄永利, 吕强, 李明忠, 等.电场调控载药丝素蛋白微球的制备[J].科学通报, 2011, 56(13):1013-1018.
12.	PARK C H, JEONG L, CHO D, et al. Effect of methylcellulose on the formation and drug release behavior of silk fibroin hydrogel[J]. Carbohydr Polym, 2013, 98(1):1179-1185.
13.	马晓晔, 施丽君, 周涓, 等.聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能[J].有机化学, 2013, 33(5):1080-1087.
14.	SEIB F P, PRITCHARD E M, KAPLAN D L. Self-Assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer[J]. Adv Funct Mater, 2013, 23(1):58-65.
15.	王立新, 张幼珠, 何莉.静电纺再生丝素纳米纤维载药体系研究[J].丝绸, 2007(6):17-19.
16.	ELAKKIYA T, MALARVIZHI G, RAJIV S A. Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery[J]. Polym Int, 2014, 63(1):100-105.
17.	SHENG Xiaoyue, FAN Linpeng, HE Chuanglong, et al. Vitamin E-loaded silk fibroin nanofibrous mats fabricated by green process for skin care application[J]. Int J Biol Macromol, 2013, 56:49-56.
18.	KASOJU N, BORA U. Fabrication and characterization of curcumin-releasing silk fibroin scaffold[J]. J Biomed Mater Res B Appl Biomater, 2012, 100B(7):1854-1866.
19.	马寅孙, 蔡玉荣, 刘琳, 等.肝素化丝素支架作为骨形态发生蛋白-2缓释载体的研究[J].化学学报, 2012, 70(4):479-484.
20.	ZHANG Yufeng, CHENG Ning, MIRON R, et al. Delivery of PDGF-B and BMP-7 by mesoporous bioglass/silk fibrin scaffolds for the repair of osteoporotic defects[J]. Biomaterials, 2012, 33(28):6698-6708.
21.	NUMATA K, YAMAZAKI S, NAGA N. Biocompatible and biodegradable dual-drug release system based on silk hydrogel containing silk nanoparticles[J]. Biomacromolecules, 2012, 13(5):1383-1389.
22.	WILZ A, PRITCHARD E M, LI Tianfu, et al. Silk polymer-based adenosine release:therapeutic potential for epilepsy[J]. Biomaterials, 2008, 29(26):3609-3616.
23.	FAROKHI M, MOTTAGHITALAB F, AI J, et al. Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold[J]. Int J Pharm, 2013, 454(1):216-225.
24.	YOU Xueqiu, CHANG J H, JU B K, et al. Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng C Mater Biol Appl, 2011, 31(8):1632-1636.
25.	DEMUTH P C, MIN Y, IRVINE D J, et al. Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization[J]. Adv Healthc Mater, 2014, 3(1):47-58.
26.	SHCHEPELINA O, DRACHUK I, GUPTA M K, et al. Silk-on-silk layer-by-layer microcapsules[J]. Advanced Materials, 2011, 23(40):4655-4660.
27.	ZARKOOB S, EBY R K, RENEKER D H, et al. Structure and morphology of electrospun silk nanofibers[J]. Polymer (Guildf), 2004, 45(11):3973-3977.
28.	柯靖, 朱晶心, 马彦龙, 等.不同矿化方式下丝素蛋白电纺纤维的仿生矿化[J].丝绸, 2014, 51(5):1-6.
29.	游学秋, 卢家宾, 王晓诚.一种丝素微针系统和丝素纳米颗粒及制备:中国, 201210048238.2[P].2012-07-18.

1. 袁青青.再生丝蛋白材料的制备及其结构与性能的研究[D].上海:复旦大学, 2010.
2. INOUE S, TANAKA K, ARISAKA F, et al. Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with 6:6:1 molar ratio[J]. J Biol Chem, 2000, 275(51):40517-40528.
3. 韦俏娜, 马林, 黄爱民, 等.甲醇-水混合溶剂后处理制备丝素蛋白膜及其药物释放研究[J].化学学报, 2012, 70(6):714-720.
4. 黄溪, 王芋骁, 董燕, 等.丝素蛋白/聚乙二醇薄膜结构性质和药物释放研究[J].广西大学学报:自然科学版, 2013, 38(3):576-583.
5. SEIB F P, KAPLAN D L. Doxorubicin-loaded silk films:Drug-silk interactions and in vivo performance in human orthotopic breast cancer[J]. Biomaterials, 2012, 33(33):8442-8450.
6. PRITCHARD E M, SZYBALA C, BOISON D, et al. Silk fibroin encapsulated powder reservoirs for sustained release of adenosine[J]. J Contr Rel, 2010, 144(2):159-167.
7. ZHOU Jian, FANG Taolin, WEN Jianchuan, et al. Silk coating on poly(epsilon-caprolactone) microspheres for the delayed release of vancomycin[J]. J Microencapsul, 2011, 28(2):99-107.
8. PRITCHARD E M, VALENTIN T, PANILAITIS B A, et al. Antibiotic-releasing silk biomaterials for infection prevention and treatment[J]. Adv Funct Mater, 2013, 23(7):854-861.
9. ZHAO Zheng, CHEN Aizheng, LI Yi, et al. Fabrication of silk fibroin nanoparticles for controlled drug delivery[J]. J Nanopart Res, 2012, 14(4):1-10.
10. 吴豪翔.一种丝素微球的制备方法:中国, 201310228078.4[P].2013-10-09.
11. 黄永利, 吕强, 李明忠, 等.电场调控载药丝素蛋白微球的制备[J].科学通报, 2011, 56(13):1013-1018.
12. PARK C H, JEONG L, CHO D, et al. Effect of methylcellulose on the formation and drug release behavior of silk fibroin hydrogel[J]. Carbohydr Polym, 2013, 98(1):1179-1185.
13. 马晓晔, 施丽君, 周涓, 等.聚丙烯酸钠和丝素蛋白自膨胀水凝胶的制备及其释药性能[J].有机化学, 2013, 33(5):1080-1087.
14. SEIB F P, PRITCHARD E M, KAPLAN D L. Self-Assembling doxorubicin silk hydrogels for the focal treatment of primary breast cancer[J]. Adv Funct Mater, 2013, 23(1):58-65.
15. 王立新, 张幼珠, 何莉.静电纺再生丝素纳米纤维载药体系研究[J].丝绸, 2007(6):17-19.
16. ELAKKIYA T, MALARVIZHI G, RAJIV S A. Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery[J]. Polym Int, 2014, 63(1):100-105.
17. SHENG Xiaoyue, FAN Linpeng, HE Chuanglong, et al. Vitamin E-loaded silk fibroin nanofibrous mats fabricated by green process for skin care application[J]. Int J Biol Macromol, 2013, 56:49-56.
18. KASOJU N, BORA U. Fabrication and characterization of curcumin-releasing silk fibroin scaffold[J]. J Biomed Mater Res B Appl Biomater, 2012, 100B(7):1854-1866.
19. 马寅孙, 蔡玉荣, 刘琳, 等.肝素化丝素支架作为骨形态发生蛋白-2缓释载体的研究[J].化学学报, 2012, 70(4):479-484.
20. ZHANG Yufeng, CHENG Ning, MIRON R, et al. Delivery of PDGF-B and BMP-7 by mesoporous bioglass/silk fibrin scaffolds for the repair of osteoporotic defects[J]. Biomaterials, 2012, 33(28):6698-6708.
21. NUMATA K, YAMAZAKI S, NAGA N. Biocompatible and biodegradable dual-drug release system based on silk hydrogel containing silk nanoparticles[J]. Biomacromolecules, 2012, 13(5):1383-1389.
22. WILZ A, PRITCHARD E M, LI Tianfu, et al. Silk polymer-based adenosine release:therapeutic potential for epilepsy[J]. Biomaterials, 2008, 29(26):3609-3616.
23. FAROKHI M, MOTTAGHITALAB F, AI J, et al. Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold[J]. Int J Pharm, 2013, 454(1):216-225.
24. YOU Xueqiu, CHANG J H, JU B K, et al. Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng C Mater Biol Appl, 2011, 31(8):1632-1636.
25. DEMUTH P C, MIN Y, IRVINE D J, et al. Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization[J]. Adv Healthc Mater, 2014, 3(1):47-58.
26. SHCHEPELINA O, DRACHUK I, GUPTA M K, et al. Silk-on-silk layer-by-layer microcapsules[J]. Advanced Materials, 2011, 23(40):4655-4660.
27. ZARKOOB S, EBY R K, RENEKER D H, et al. Structure and morphology of electrospun silk nanofibers[J]. Polymer (Guildf), 2004, 45(11):3973-3977.
28. 柯靖, 朱晶心, 马彦龙, 等.不同矿化方式下丝素蛋白电纺纤维的仿生矿化[J].丝绸, 2014, 51(5):1-6.
29. 游学秋, 卢家宾, 王晓诚.一种丝素微针系统和丝素纳米颗粒及制备:中国, 201210048238.2[P].2012-07-18.

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