Present status and prospects of injectable hydrogels for treatment of myocardial infarction_Journal of Biomedical Engineering

Authors：

WEN Ying ^1,2,3 [综述] ,  JIANG Xuejun ^1,2,3 [审校]

1. Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, P.R.China;
2. Cardiovascular Research Institute, Wuhan University, Wuhan 430060, P.R.China;
3. Hubei Key Laboratory of Cardiology, Wuhan 430060, P.R.China;

Corresponding author：

JIANG Xuejun, Email: xjjiang@whu.edu.cn

Keywords：

myocardial infarction; ventricular remodeling; extracellular matrix; injectable hydrogels; in situ myocardial tissue engineering

DOI：

10.7507/1001-5515.201508044

Video：

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Survivors from myocardial infarction (MI) eventually develop heart failure due to the post-infarct ventricular remodeling which could not be suppressed by existing treatments. Currently, coronary heart disease has become the major cause of heart failure instead of rheumatic heart disease in China. For this reason, seeking effective treatment to prevent post-infarct ventricular remodeling is urgent. Intramyocardial injection of hydrogels as a new strategy for MI treatment has made great progress recently. This review discusses the principle, present status, mechanisms and prospects of injectable hydrogel therapies for MI.

Citation： WENYing, JIANGXuejun. Present status and prospects of injectable hydrogels for treatment of myocardial infarction. Journal of Biomedical Engineering, 2017, 34(1): 156-160. doi: 10.7507/1001-5515.201508044 Copy

1.	陈伟伟, 高润霖, 刘力生, 等. 中国心血管病报告2013概要. 中国循环杂志, 2014, 29(7): 487-491.
2.	Mozaffarian D, Benjamin E J, Go A S, et al. Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation, 2015, 131(4): e29-322.
3.	Zamilpa R, Navarro M, Flores I, et al. Stem cell mechanisms during left ventricular remodeling post-myocardial infarction: Repair and regeneration. World J Cardiol, 2014, 6(7): 610-620.
4.	Marion M, Bax N, Spreeuwel A, et al. Material-based engineering strategies for cardiac regeneration. Curr Pharm Des, 2014, 20(12): 2057-2068.
5.	Ahmed E. Hydrogel: preparation, characterization, and applications: a review. Journal of Advanced Research, 2015, 6(2): 105-121.
6.	Kamimura W, Koyama H, Miyata T, et al. Sugar-based crosslinker forms a stable atelocollagen hydrogel that is a favorable microenvironment for 3D cell culture. J Biomed Mater Res A, 2014, 102(12): 4309-4316.
7.	Sun X, Nunes S. Overview of hydrogel-based strategies for application in cardiac tissue regeneration. Biomed Mater, 2015, 10(3): 034005.
8.	Nguyen M, Gianneschi N, Christman K. Developing injectable nanomaterials to repair the heart. Curr Opin Biotechnol, 2015, 34: 225-231.
9.	Iwakura A, Fujita M, Kataoka K, et al. Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model. Heart Vessels, 2003, 18(2): 93-99.
10.	Shu Y, Hao T, Yao F, et al. RoY peptide-modified chitosan-based hydrogel to improve angiogenesis and cardiac repair under hypoxia. ACS Appl Mater Interfaces, 2015, 7(12): 6505-6517.
11.	Abdalla S, Makhoul G, Duong M, et al. Hyaluronic acid-based hydrogel induces neovascularization and improves cardiac function in a rat model of myocardial infarction. Interact Cardiovasc Thorac Surg, 2013, 17(5): 767-772.
12.	O'connor D, Naresh N, Piras B, et al. A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction. Physiol Rep, 2015, 3(3): doi:10.14814/phy2.12351.
13.	Yi X, Li X, Ren S, et al. A novel, biodegradable, thermoresponsive hydrogel attenuates ventricular remodeling and improves cardiac function following myocardial infarction - a review. Curr Pharm Des, 2014, 20(12): 2040-2047.
14.	Boopathy A V, Martinez M D, Smith A W, et al. Intramyocardial delivery of notch Ligand-Containing hydrogels improves cardiac function and angiogenesis following infarction. Tissue Eng Part A, 2015, 21(17/18): 2315-2322.
15.	Koudstaal S, Bastings M, Feyen D, et al. Sustained delivery of insulin-like growth factor-1/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart. J Cardiovasc Transl Res, 2014, 7(2): 232-241.
16.	Projahn D, Simsekyilmaz S, Singh S, et al. Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction. J Cell Mol Med, 2014, 18(5): 790-800.
17.	Yao X, Liu Y, Gao J, et al. Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials, 2015, 60: 130-140.
18.	Chen C, CHANG Ming, Wang S, et al. Injection of autologous bone marrow cells in hyaluronan hydrogel improves cardiac performance after infarction in pigs. Am J Physiol Heart Circ Physiol, 2014, 306(7): H1078-H1086.
19.	Boopathy A V, CHE Paolin, Somasuntharam I, et al. The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation. Biomaterials, 2014, 35(28): 8103-8112.
20.	Wan Wei, Jiang Xue, Li Xiao, et al. Enhanced cardioprotective effects mediated by plasmid containing the short-hairpin RNA of angiotensin converting enzyme with a biodegradable hydrogel after myocardial infarction. J Biomed Mater Res A, 2014, 102(10): 3452-3458.
21.	Paul A, Hasan A, Kindi H, et al. Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano, 2014, 8(8): 8050-8062.
22.	Ruvinov E, Cohen S. Alginate biomaterial for the treatment of myocardial infarction: Progress, translational strategies, and clinical outlook: From ocean algae to patient bedside. Adv Drug Deliv Rev, 2016, 96: 54-76.
23.	Lee L, Wall S, Klepach D, et al. Algisyl-LVR^TM with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart. Int J Cardiol, 2013, 168(3): 2022-2028.
24.	Anker S, Coats A, Cristian G, et al. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial) Eur Heart J, 2015, 36(34): 2297-2309.
25.	Leor J, Tuvia S, Guetta V, et al. Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11): 1014-1023.
26.	Frey N, Linke A, Süselbeck T, et al. Intracoronary delivery of injectable bioabsorbable scaffold (IK-5001) to treat left ventricular remodeling after ST-elevation myocardial infarction: a first-in-man study. Circ Cardiovasc Interv, 2014, 7(6): 806-812.
27.	Llc B B. IK-5001 for the prevention of remodeling of the ventricle and congestive heart failure after acute myocardial infarction(PRESERVATION 1) [DB]. Study NCT012265 63 Available at: http://www.ClinicalTrials.gov 2010 (Accessed July 16, 2015).
28.	Wang R, Christman K. Decellularized myocardial matrix hydrogels: In basic research and preclinical studies. Adv Drug Deliv Rev, 2016, 96: 77-82.
29.	Reis L, Chiu L, Wu J, et al. Hydrogels with integrin-binding angiopoietin-1-derived peptide, QHREDGS, for treatment of acute myocardial infarction. Circ Heart Fail, 2015, 8(2): 333-341.
30.	Singelyn J, Sundaramurthy P, Johnson T, et al. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J Am Coll Cardiol, 2012, 59(8): 751-763.
31.	Tsur-Gang O, Ruvinov E, Landa N, et al. The effects of peptide-based modification of alginate on left ventricular remodeling and function after myocardial infarction. Biomaterials, 2009, 30(2): 189-195.
32.	Nelson D, Ma Z, Fujimoto K, et al. Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges. Acta Biomater, 2011, 7(1): 1-15.
33.	Miller R, Davies N H, Kortsmit J, et al. Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution. Int j numer method biomed eng, 2013, 29(8): 870-884.
34.	Kichula E, Wang H, Dorsey S, et al. Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection. Ann Biomed Eng, 2014, 42(7): 1546-1556.
35.	Plotkin M, Vaibavi S, Rufaihah A, et al. The effect of matrix stiffness of injectable hydrogels on the preservation of cardiac function after a heart attack. Biomaterials, 2014, 35(5): 1429-1438.
36.	Ren S, Jiang X, Li Z, et al. Physical properties of poly(N-isopropylacrylamide) hydrogel promote its effects on cardiac protection after myocardial infarction. J Int Med Res, 2012, 40(6): 2167-2182.
37.	Kadner K, Dobner S, Franz T, et al. The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction. Biomaterials, 2012, 33(7): 2060-2066.
38.	Yoon S, Hong S, FANG Yong, et al. Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel. J Biosci Bioeng, 2014, 118(4): 461-468.
39.	Blackburn N, Sofrenovic T, Kuraitis D, et al. Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction. Biomaterials, 2015, 39: 182-192.
40.	Dobner S, Bezuidenhout D, Govender P, et al. A synthetic non-degradable polyethylene glycol hydrogel retards adverse post-infarct left ventricular remodeling. J Card Fail, 2009, 15(7): 629-636.
41.	LI C, Faulkner-Jones A, DUN Ar, et al. DNA-based gel for printing organs. Nature, 2015, 518: 458.

1. 陈伟伟, 高润霖, 刘力生, 等. 中国心血管病报告2013概要. 中国循环杂志, 2014, 29(7): 487-491.
2. Mozaffarian D, Benjamin E J, Go A S, et al. Heart disease and stroke statistics--2015 update: a report from the American Heart Association. Circulation, 2015, 131(4): e29-322.
3. Zamilpa R, Navarro M, Flores I, et al. Stem cell mechanisms during left ventricular remodeling post-myocardial infarction: Repair and regeneration. World J Cardiol, 2014, 6(7): 610-620.
4. Marion M, Bax N, Spreeuwel A, et al. Material-based engineering strategies for cardiac regeneration. Curr Pharm Des, 2014, 20(12): 2057-2068.
5. Ahmed E. Hydrogel: preparation, characterization, and applications: a review. Journal of Advanced Research, 2015, 6(2): 105-121.
6. Kamimura W, Koyama H, Miyata T, et al. Sugar-based crosslinker forms a stable atelocollagen hydrogel that is a favorable microenvironment for 3D cell culture. J Biomed Mater Res A, 2014, 102(12): 4309-4316.
7. Sun X, Nunes S. Overview of hydrogel-based strategies for application in cardiac tissue regeneration. Biomed Mater, 2015, 10(3): 034005.
8. Nguyen M, Gianneschi N, Christman K. Developing injectable nanomaterials to repair the heart. Curr Opin Biotechnol, 2015, 34: 225-231.
9. Iwakura A, Fujita M, Kataoka K, et al. Intramyocardial sustained delivery of basic fibroblast growth factor improves angiogenesis and ventricular function in a rat infarct model. Heart Vessels, 2003, 18(2): 93-99.
10. Shu Y, Hao T, Yao F, et al. RoY peptide-modified chitosan-based hydrogel to improve angiogenesis and cardiac repair under hypoxia. ACS Appl Mater Interfaces, 2015, 7(12): 6505-6517.
11. Abdalla S, Makhoul G, Duong M, et al. Hyaluronic acid-based hydrogel induces neovascularization and improves cardiac function in a rat model of myocardial infarction. Interact Cardiovasc Thorac Surg, 2013, 17(5): 767-772.
12. O'connor D, Naresh N, Piras B, et al. A novel cardiac muscle-derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction. Physiol Rep, 2015, 3(3): doi:10.14814/phy2.12351.
13. Yi X, Li X, Ren S, et al. A novel, biodegradable, thermoresponsive hydrogel attenuates ventricular remodeling and improves cardiac function following myocardial infarction - a review. Curr Pharm Des, 2014, 20(12): 2040-2047.
14. Boopathy A V, Martinez M D, Smith A W, et al. Intramyocardial delivery of notch Ligand-Containing hydrogels improves cardiac function and angiogenesis following infarction. Tissue Eng Part A, 2015, 21(17/18): 2315-2322.
15. Koudstaal S, Bastings M, Feyen D, et al. Sustained delivery of insulin-like growth factor-1/hepatocyte growth factor stimulates endogenous cardiac repair in the chronic infarcted pig heart. J Cardiovasc Transl Res, 2014, 7(2): 232-241.
16. Projahn D, Simsekyilmaz S, Singh S, et al. Controlled intramyocardial release of engineered chemokines by biodegradable hydrogels as a treatment approach of myocardial infarction. J Cell Mol Med, 2014, 18(5): 790-800.
17. Yao X, Liu Y, Gao J, et al. Nitric oxide releasing hydrogel enhances the therapeutic efficacy of mesenchymal stem cells for myocardial infarction. Biomaterials, 2015, 60: 130-140.
18. Chen C, CHANG Ming, Wang S, et al. Injection of autologous bone marrow cells in hyaluronan hydrogel improves cardiac performance after infarction in pigs. Am J Physiol Heart Circ Physiol, 2014, 306(7): H1078-H1086.
19. Boopathy A V, CHE Paolin, Somasuntharam I, et al. The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation. Biomaterials, 2014, 35(28): 8103-8112.
20. Wan Wei, Jiang Xue, Li Xiao, et al. Enhanced cardioprotective effects mediated by plasmid containing the short-hairpin RNA of angiotensin converting enzyme with a biodegradable hydrogel after myocardial infarction. J Biomed Mater Res A, 2014, 102(10): 3452-3458.
21. Paul A, Hasan A, Kindi H, et al. Injectable graphene oxide/hydrogel-based angiogenic gene delivery system for vasculogenesis and cardiac repair. ACS Nano, 2014, 8(8): 8050-8062.
22. Ruvinov E, Cohen S. Alginate biomaterial for the treatment of myocardial infarction: Progress, translational strategies, and clinical outlook: From ocean algae to patient bedside. Adv Drug Deliv Rev, 2016, 96: 54-76.
23. Lee L, Wall S, Klepach D, et al. Algisyl-LVR^TM with coronary artery bypass grafting reduces left ventricular wall stress and improves function in the failing human heart. Int J Cardiol, 2013, 168(3): 2022-2028.
24. Anker S, Coats A, Cristian G, et al. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial) Eur Heart J, 2015, 36(34): 2297-2309.
25. Leor J, Tuvia S, Guetta V, et al. Intracoronary injection of in situ forming alginate hydrogel reverses left ventricular remodeling after myocardial infarction in Swine. J Am Coll Cardiol, 2009, 54(11): 1014-1023.
26. Frey N, Linke A, Süselbeck T, et al. Intracoronary delivery of injectable bioabsorbable scaffold (IK-5001) to treat left ventricular remodeling after ST-elevation myocardial infarction: a first-in-man study. Circ Cardiovasc Interv, 2014, 7(6): 806-812.
27. Llc B B. IK-5001 for the prevention of remodeling of the ventricle and congestive heart failure after acute myocardial infarction(PRESERVATION 1) [DB]. Study NCT012265 63 Available at: http://www.ClinicalTrials.gov 2010 (Accessed July 16, 2015).
28. Wang R, Christman K. Decellularized myocardial matrix hydrogels: In basic research and preclinical studies. Adv Drug Deliv Rev, 2016, 96: 77-82.
29. Reis L, Chiu L, Wu J, et al. Hydrogels with integrin-binding angiopoietin-1-derived peptide, QHREDGS, for treatment of acute myocardial infarction. Circ Heart Fail, 2015, 8(2): 333-341.
30. Singelyn J, Sundaramurthy P, Johnson T, et al. Catheter-deliverable hydrogel derived from decellularized ventricular extracellular matrix increases endogenous cardiomyocytes and preserves cardiac function post-myocardial infarction. J Am Coll Cardiol, 2012, 59(8): 751-763.
31. Tsur-Gang O, Ruvinov E, Landa N, et al. The effects of peptide-based modification of alginate on left ventricular remodeling and function after myocardial infarction. Biomaterials, 2009, 30(2): 189-195.
32. Nelson D, Ma Z, Fujimoto K, et al. Intra-myocardial biomaterial injection therapy in the treatment of heart failure: Materials, outcomes and challenges. Acta Biomater, 2011, 7(1): 1-15.
33. Miller R, Davies N H, Kortsmit J, et al. Outcomes of myocardial infarction hydrogel injection therapy in the human left ventricle dependent on injectate distribution. Int j numer method biomed eng, 2013, 29(8): 870-884.
34. Kichula E, Wang H, Dorsey S, et al. Experimental and computational investigation of altered mechanical properties in myocardium after hydrogel injection. Ann Biomed Eng, 2014, 42(7): 1546-1556.
35. Plotkin M, Vaibavi S, Rufaihah A, et al. The effect of matrix stiffness of injectable hydrogels on the preservation of cardiac function after a heart attack. Biomaterials, 2014, 35(5): 1429-1438.
36. Ren S, Jiang X, Li Z, et al. Physical properties of poly(N-isopropylacrylamide) hydrogel promote its effects on cardiac protection after myocardial infarction. J Int Med Res, 2012, 40(6): 2167-2182.
37. Kadner K, Dobner S, Franz T, et al. The beneficial effects of deferred delivery on the efficiency of hydrogel therapy post myocardial infarction. Biomaterials, 2012, 33(7): 2060-2066.
38. Yoon S, Hong S, FANG Yong, et al. Differential regeneration of myocardial infarction depending on the progression of disease and the composition of biomimetic hydrogel. J Biosci Bioeng, 2014, 118(4): 461-468.
39. Blackburn N, Sofrenovic T, Kuraitis D, et al. Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction. Biomaterials, 2015, 39: 182-192.
40. Dobner S, Bezuidenhout D, Govender P, et al. A synthetic non-degradable polyethylene glycol hydrogel retards adverse post-infarct left ventricular remodeling. J Card Fail, 2009, 15(7): 629-636.
41. LI C, Faulkner-Jones A, DUN Ar, et al. DNA-based gel for printing organs. Nature, 2015, 518: 458.

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