Influence of Medication on the Oscillatory and Dynamic Characteristics of Subthalamic Local Field Potentials in Patients with Parkinson’s Disease_Journal of Biomedical Engineering

Authors：

WANGYanan ^1,2,3 , GENGXinyi ^1,3 , HUANGYongzhi ^1,3 ,  WANGShouyan ¹

1. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China;
2. Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China;
3. University of Chinese Academy of Sciences, Beijing 100049, China;

Corresponding author：

WANGShouyan, Email: swang@sibet.ac.cn

Keywords：

local field potentials; neuro-biomarker; Parkinson’s disease; subthalamic nucleus; deep brain stimulation

DOI：

10.7507/1001-5515.20160010

Video：

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The dysfunction of subthalamic nucleus is the main cause of Parkinson’s disease. Local field potentials in human subthalamic nucleus contain rich physiological information. The present study aimed to quantify the oscillatory and dynamic characteristics of local field potentials of subthalamic nucleus, and their modulation by the medication therapy for Parkinson’s disease. The subthalamic nucleus local field potentials were recorded from patients with Parkinson’s disease at the states of on and off medication. The oscillatory features were characterised with the power spectral analysis. Furthermore, the dynamic features were characterised with time-frequency analysis and the coefficient of variation measure of the time-variant power at each frequency. There was a dominant peak at low beta band with medication off. The medication significantly suppressed the low beta component and increased the theta component. The amplitude fluctuation of neural oscillations was measured by the coefficient of variation. The coefficient of variation in 4-7 Hz and 60-66 Hz was increased by medication. These effects proved that medication had significant modulation to subthalamic nucleus neural oscillatory synchronization and dynamic features. The subthalamic nucleus neural activities tend towards stable state under medication. The findings would provide quantitative biomarkers for studying the mechanisms of Parkinson’s disease and clinical treatments of medication or deep brain stimulation.

Citation： WANGYanan, GENGXinyi, HUANGYongzhi, WANGShouyan. Influence of Medication on the Oscillatory and Dynamic Characteristics of Subthalamic Local Field Potentials in Patients with Parkinson’s Disease. Journal of Biomedical Engineering, 2016, 33(1): 49-55. doi: 10.7507/1001-5515.20160010 Copy

1.	GOLDBERG J A, ROKNI U, BORAUD T, et al. Spike synchronization in the cortex/basal-ganglia networks of Parkinsonian primates reflects global dynamics of the local field potentials[J]. J Neurosci, 2004, 24(26): 6003-6010.
2.	MITZDORF U. Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena[J]. Physiol Rev, 1985, 65(1): 37-100.
3.	MAGILL P J, SHAROTT A, BEVAN M D, et al. Synchronous unit activity and local field potentials evoked in the subthalamic nucleus by cortical stimulation[J]. J Neurophysiol, 2004, 92(2): 700-714.
4.	WANG S, CHEN Y, DING M, et al. Revealing the dynamic causal interdependence between neural and muscular signals in Parkinsonian tremor[J]. J Franklin Inst, 2007, 344(3-4): 180-195.
5.	WANG Shouyan, AZIZ T Z, STEIN J F, et al. Physiological and harmonic components in neural and muscular coherence in Parkinsonian tremor[J]. Clin Neurophysiol, 2006, 117(7): 1487-1498.
6.	KVHN A A, KUPSCH A, SCHNEIDER G H, et al. Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson’s disease[J]. Eur J Neurosci, 2006, 23(7): 1956-1960.
7.	KVHN A A, TSUI A, AZIZ T, et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson’s disease relates to both bradykinesia and rigidity[J]. Exp Neurol, 2009, 215(2): 380-387.
8.	EUSEBIO A, THEVATHASAN W, GAYNOR L D, et al. Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients[J]. J Neurol Neurosurg Psychiatry, 2011, 82(5): 569-573.
9.	RAY N J, JENKINSON N, WANG S, et al. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson’s disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation[J]. Exp Neurol, 2008, 213(1): 108-113.
10.	BROWN P, WILLIAMS D. Basal ganglia local field potential activity: character and functional significance in the human[J]. Clin Neurophysiol, 2005, 116(11): 2510-2519.
11.	ALONSO-FRECH F, ZAMARBIDE I, ALEGRE M, et al. Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson’s disease[J]. Brain, 2006, 129(Pt 7): 1748-1757.
12.	LITTLE S, POGOSYAN A, KUHN A A, et al. β band stability over time correlates with parkinsonian rigidity and bradykinesia[J]. Exp Neurol, 2012, 236(2): 383-388.
13.	靳同红, 莫正波, 郑德亮, 等. 时频分析技术及应用研究[J]. 机械科学与技术, 2009, 28(1): 75-78.
14.	LIU X, FORD-DUNN H L, HAYWARD G N, et al. The oscillatory activity in the Parkinsonian subthalamic nucleus investigated using the macro-electrodes for deep brain stimulation[J]. Clin Neurophysiol, 2002, 113(11): 1667-1672.
15.	JOUNDI R A, BRITTAIN J S, GREEN A L, et al. Persistent suppression of subthalamic beta-band activity during rhythmic finger tapping in Parkinson’s disease[J]. Clin Neurophysiol, 2013, 124(3): 565-573.
16.	ANZAK A, GAYNOR L, BEIGI M, et al. Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson’s disease[J]. Neuroimage, 2013, 64(2): 284-289.

1. GOLDBERG J A, ROKNI U, BORAUD T, et al. Spike synchronization in the cortex/basal-ganglia networks of Parkinsonian primates reflects global dynamics of the local field potentials[J]. J Neurosci, 2004, 24(26): 6003-6010.
2. MITZDORF U. Current source-density method and application in cat cerebral cortex: investigation of evoked potentials and EEG phenomena[J]. Physiol Rev, 1985, 65(1): 37-100.
3. MAGILL P J, SHAROTT A, BEVAN M D, et al. Synchronous unit activity and local field potentials evoked in the subthalamic nucleus by cortical stimulation[J]. J Neurophysiol, 2004, 92(2): 700-714.
4. WANG S, CHEN Y, DING M, et al. Revealing the dynamic causal interdependence between neural and muscular signals in Parkinsonian tremor[J]. J Franklin Inst, 2007, 344(3-4): 180-195.
5. WANG Shouyan, AZIZ T Z, STEIN J F, et al. Physiological and harmonic components in neural and muscular coherence in Parkinsonian tremor[J]. Clin Neurophysiol, 2006, 117(7): 1487-1498.
6. KVHN A A, KUPSCH A, SCHNEIDER G H, et al. Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson’s disease[J]. Eur J Neurosci, 2006, 23(7): 1956-1960.
7. KVHN A A, TSUI A, AZIZ T, et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson’s disease relates to both bradykinesia and rigidity[J]. Exp Neurol, 2009, 215(2): 380-387.
8. EUSEBIO A, THEVATHASAN W, GAYNOR L D, et al. Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients[J]. J Neurol Neurosurg Psychiatry, 2011, 82(5): 569-573.
9. RAY N J, JENKINSON N, WANG S, et al. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson’s disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation[J]. Exp Neurol, 2008, 213(1): 108-113.
10. BROWN P, WILLIAMS D. Basal ganglia local field potential activity: character and functional significance in the human[J]. Clin Neurophysiol, 2005, 116(11): 2510-2519.
11. ALONSO-FRECH F, ZAMARBIDE I, ALEGRE M, et al. Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson’s disease[J]. Brain, 2006, 129(Pt 7): 1748-1757.
12. LITTLE S, POGOSYAN A, KUHN A A, et al. β band stability over time correlates with parkinsonian rigidity and bradykinesia[J]. Exp Neurol, 2012, 236(2): 383-388.
13. 靳同红, 莫正波, 郑德亮, 等. 时频分析技术及应用研究[J]. 机械科学与技术, 2009, 28(1): 75-78.
14. LIU X, FORD-DUNN H L, HAYWARD G N, et al. The oscillatory activity in the Parkinsonian subthalamic nucleus investigated using the macro-electrodes for deep brain stimulation[J]. Clin Neurophysiol, 2002, 113(11): 1667-1672.
15. JOUNDI R A, BRITTAIN J S, GREEN A L, et al. Persistent suppression of subthalamic beta-band activity during rhythmic finger tapping in Parkinson’s disease[J]. Clin Neurophysiol, 2013, 124(3): 565-573.
16. ANZAK A, GAYNOR L, BEIGI M, et al. Subthalamic nucleus gamma oscillations mediate a switch from automatic to controlled processing: a study of random number generation in Parkinson’s disease[J]. Neuroimage, 2013, 64(2): 284-289.

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