Analysis of Influence on Single Eythrocyte Injury Caused by Oscillating Boundary Flow Field_Journal of Biomedical Engineering

Authors：

 YUNZhong , XIANGChuang , CAIChao , XUJunrui

College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China;

Corresponding author：

YUNZhong, Email: yunzhong@126.com

Keywords：

oscillating boundary flow field; erythrocyte; injury

DOI：

10.7507/1001-5515.20160015

Video：

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The implantable axial blood pump, driven by external electromagnet, is studied recently. It oscillats when it is running because of the elastic implanted environment and driving force disequilibrium, etc. In this paper, a model of single erythrocyte in vibrated flow field was built to simulate the deformation and force of the erythrocyte. By using the mechanical injury principle of blood in blood pump, we studied the injury of a single erythrocyte resulted from oscillating boundary flow field. The research results indicated that the shape of the erythrocyte, force and velocity field nearby, which are affected by oscillating boundary flow field, all cause injury to the erythrocyte. All the researches shown in the present paper are expected to provide theoretical foundation for lightening hemolysis by the blood pump.

Citation： YUNZhong, XIANGChuang, CAIChao, XUJunrui. Analysis of Influence on Single Eythrocyte Injury Caused by Oscillating Boundary Flow Field. Journal of Biomedical Engineering, 2016, 33(1): 78-82. doi: 10.7507/1001-5515.20160015 Copy

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1. KIM S H, HASHI S, ISHIYAMA K. Centrifugal force based magnetic micro-pump driven by rotating magnetic fields[J]. J Phys Conf Ser, 2011, 266: 1-5.
2. TIMMS D. A review of clinical ventricular assist devices[J]. Med Eng Phys, 2011, 33(9): 1041-1047.
3. FAN Huimin, HONG Fangwen, ZHANG Guoping, et al. Applications of CFD technique in the design and flow analysis of implantable axial flow blood pump[J]. J Hydrodynam B, 2010, 22(4): 518-525.
4. QIAN Kunxi, WU Qinlin, WANG Fangqun. Numerical analysis and hemolysis prediction in an implantable aortic valve-pump[C]//2010 3rd International Conference on Biomedical Engineering and Informatics (BMEI 2010). Yantai:2010, 4: 1536-1539.
5. 张宝宁, 张扬军, 吴玉林, 等. 应用CFD对人工血泵流场进行数值仿真[J]. 中国生物医学工程学报, 2002, 21(1):41-45.
6. BEHBAHANI M, BEHR M, HORMES M, et al. A review of computational fluid dynamics analysis of blood pump[J]. Eur J Appl Math, 2009, 20(4): 363-397.
7. 许焰, 谭建平, 李谭喜, 等. 行波磁场驱动的大间隙磁力传动系统方案设计[J]. 机械科学与技术, 2009, 28(4):446-449.
8. THOMPSON J F, WEATHERILL N P. Aspects of numerical grid generation: current science and art[R]. AIAA-93-3539-CP, 1993: 1029-1070.
9. 王亚伟, 韩广才, 刘莹, 等. 双曲面对称体红细胞模型的光散射虚拟仿真[J]. 中国激光, 2007, 34(12):1676-1681.
10. 云忠, 徐军瑞, 向闯, 等. 磁力驱动血泵泵体径向振动分析[J]. 机械设计与研究, 2015, 31(1):58-61,77.
11. 云忠, 谭建平. 基于血液剪切损伤机理的高速螺旋血泵仿真分析[J]. 中山大学学报:自然科学版, 2008, 47(1):47-50.
12. EVANS J, GRATZER W, MOHANDAS N, et al. Fluctuations of the red blood cell membrane: relation to mechanical properties and lack of ATP dependence[J]. Biophys J, 2008, 94(10): 4134-4144.
13. 张世鹏, 倪明玖. VOF法模拟剪切流动下液滴的变形和断裂运动[J]. 工程热物理学报, 2011, 32(4):609-611.
14. 云忠. 血液机械损伤机理及高速螺旋血泵结构优化研究[D]. 长沙:中南大学, 2007.
15. NARSIMHAN G, NEJFELT G, RAMKRISHNA D. Breakage functions of droplets in agitated liquid-liquid dispersion[J]. AIChE Journal, 1984, 30(3): 457-467.

Journal of Biomedical Engineering

Analysis of Influence on Single Eythrocyte Injury Caused by Oscillating Boundary Flow Field

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