Study of Event related Brain Potential in Children with Attention Deficit Hyperactivity Disorder_Journal of Biomedical Engineering

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School of Information Engineering, Nanchang University, Nanchang 330031, China;

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Keywords：

attention deficit hyperactivity disorder; event related potential; spectrum; visual continuous performance test

DOI：

10.7507/1001-5515.20160029

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This study aims to explore the differences of event related potential (ERP) between attention deficit hyperactivity disorder (ADHD) and normal children, so that these differences provide scientific basis for the diagnosis of ADHD. Eight children were identified to be ADHD group by the diagnostic criteria of DSM IV (diagnostic and statistical manual of mental disorders IV), and the control group also consisted of 8 normal children. Modified visual continuous performance test (CPT) was used as the experiment paradigm. The experiment included two major conditions, i.e. Go and NoGo. All the 16 subjects participated in the study. A high density EEG acquisition instrument was used to record the EEG signal and processed these EEG data by means of ERP and spectrum analysis. P2 N2 peak peak value and spectral peak around 11 Hz were analyzed between ADHD subjects and those in the control group, and then statistical tests were applied to these two groups. Results showed that: ① Under the condition of Go, ADHD group had a significant lower P2 N2 peak peak value than the values in the control group ( P< 0.05); but under the condition of NoGo there was no significant difference in between. ② Compared with the control group, the ADHD group had significant lower spectral amplitude around 11 Hz under the condition of NoGo ( P< 0.05). However, under the condition of Go the difference was insignificant. In conclusion, there is certain cognitive dysfunction in ADHD children. P2-N2 peak-peak value and spectral peak around 11 Hz could be considered as clinical evaluation indexes of ADHD children′s cognitive function. These two objective indexes provide an early diagnosis and effective treatment of ADHD .

Citation： ZHULi, ZENGQuan, JIANGYangting, CHENJia, ZHANGLiying. Study of Event related Brain Potential in Children with Attention Deficit Hyperactivity Disorder. Journal of Biomedical Engineering, 2016, (): 161-166. doi: 10.7507/1001-5515.20160029 Copy

1.	POLANCZYK G, ROHDE L A. Epidemiology of attention deficit/hyperactivity disorder across the lifespan[J]. Curr Opin Psychiatry, 2007, 20(4): 386-392.
2.	BECK L H, BRANSOME E D, MIRSKY A F, et al. A continuous performance test of brain damage[J]. J Consult Psychol, 1956, 20(5): 343-350.
3.	KOEHLER S, LAUER P, SCHREPPEL T, et al. Increased EEG power density in alpha and theta bands in adult ADHD patients[J]. J Neural Transm, 2009, 116(1): 97-104.
4.	SAKAGAMI M, TSUTSUI K. The hierarchical organization of decision making in the primate prefrontal cortex[J]. Neurosci Res, 1999, 34(2): 79-89.
5.	WILLCUTT E G. The prevalence of DSM IV attention deficit/hyperactivity disorder: a meta analytic review[J]. Neurotherapeutics, 2012, 9(3): 490-499.
6.	万小姣,王苏弘,高小榕,等.基于改进的视觉CPT范式对注意缺陷多动障碍患儿额区ERPs的研究[J].中国生物医学工程学报,2014,33(4):385-391.
7.	WANG Suhong, YANG Yilin, XING Wei, et al. Altered neural circuits related to sustained attention and executive control in children with ADHD: an event related fMRI study[J]. Clin Neurophysiol, 2013, 124(11): 2181-2190.
8.	BARRY R J, JOHNSTONE S J, CLARKE A R. A review of electrophysiology in attention deficit/hyperactivity disorder: Ⅱ. Event related potentials[J]. Clin Neurophysiol, 2003, 114(2): 184 198.
9.	EPNER J E, LEVENBERG P B, SCHOENY M E. Primary care providers′ responsiveness to health risk behaviors reported by adolescent patients[J]. Arch Pediatr Adolesc Med, 1998, 152(8): 774-780.
10.	NIELSON K A, LANGENECKER S A, GARAVAN H. Differences in the functional neuroanatomy of inhibitory control across the adult Life span[J]. Psychol Aging, 2002, 17(1): 56-71.
11.	RICHARDSON F M, THOMAS M S. The benefits of computational modeling for the study of developmental disorders: Extending the Triesch et al. model to ADHD[J]. Dev Sci, 2006, 9(2): 151-155.
12.	WILD WALL N, OADES R D, SCHMIDT WESSELS M, et al. Neural activity associated with executive functions in adolescents with attention deficit/hyperactivity disorder (ADHD)[J]. Int J Psychophysiol, 2009, 74(1): 19-27.
13.	BOCQUILLON P, BOURRIEZ J L, PALMERO SOLER E, et al. The spatiotemporal dynamics of early attention processes: A high resolution electroencephalographic study of N2 subcomponent sources[J]. Neuroscience, 2014, 271(15): 9-22.〖JP〗.
14.	RUCKLIDGE J J, JOHNSTONE J, KAPLAN B J. Nutrient supplementation approaches in the treatment of ADHD[J]. Expert Rev Neurother, 2009, 9(4): 461-476.
15.	YANEZ TELLEZ G, ROMERO ROMERO H, RIVERA GARCIA L, et al. Cognitive and executive functions in ADHD[J]. Actas Esp Psiquiatri, 2012, 40(6): 293-298.
16.	杨红梅,张振强.病理生理学. [M].第7版.西安:第四军医大学出版社,2005:1-172.
17.	VOGT F, KLIMESCH W, DOPPELMAYR M. High frequency components in the alpha band and memory performance[J]. J Clin Neurophysiol, 1998, 15(2): 167-172.
18.	BRADLEY J C. The learning revolution[J]. Nature, 2009, 457(7226): 151-152.
19.	王浩,陈志华,邹飒枫,等.基于Morlet小波变换的EEG信号α波持续性的分析[J].生物医学工程学杂志,2010,27(4):746-748,752.
20.	李捷.运动技能形成自组织理论的建构及其实证研究[D].北京:北京体育大学,1999.
21.	KLIMESCH W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis[J]. Brain Res Rev, 1999, 29(2-3): 169-195.
22.	罗跃嘉,魏景汉,翁旭初,等.汉字视听再认的ERP效应与记忆提取脑机制[J].心理学报,2001,33(6):489-494.

1. POLANCZYK G, ROHDE L A. Epidemiology of attention deficit/hyperactivity disorder across the lifespan[J]. Curr Opin Psychiatry, 2007, 20(4): 386-392.
2. BECK L H, BRANSOME E D, MIRSKY A F, et al. A continuous performance test of brain damage[J]. J Consult Psychol, 1956, 20(5): 343-350.
3. KOEHLER S, LAUER P, SCHREPPEL T, et al. Increased EEG power density in alpha and theta bands in adult ADHD patients[J]. J Neural Transm, 2009, 116(1): 97-104.
4. SAKAGAMI M, TSUTSUI K. The hierarchical organization of decision making in the primate prefrontal cortex[J]. Neurosci Res, 1999, 34(2): 79-89.
5. WILLCUTT E G. The prevalence of DSM IV attention deficit/hyperactivity disorder: a meta analytic review[J]. Neurotherapeutics, 2012, 9(3): 490-499.
6. 万小姣,王苏弘,高小榕,等.基于改进的视觉CPT范式对注意缺陷多动障碍患儿额区ERPs的研究[J].中国生物医学工程学报,2014,33(4):385-391.
7. WANG Suhong, YANG Yilin, XING Wei, et al. Altered neural circuits related to sustained attention and executive control in children with ADHD: an event related fMRI study[J]. Clin Neurophysiol, 2013, 124(11): 2181-2190.
8. BARRY R J, JOHNSTONE S J, CLARKE A R. A review of electrophysiology in attention deficit/hyperactivity disorder: Ⅱ. Event related potentials[J]. Clin Neurophysiol, 2003, 114(2): 184 198.
9. EPNER J E, LEVENBERG P B, SCHOENY M E. Primary care providers′ responsiveness to health risk behaviors reported by adolescent patients[J]. Arch Pediatr Adolesc Med, 1998, 152(8): 774-780.
10. NIELSON K A, LANGENECKER S A, GARAVAN H. Differences in the functional neuroanatomy of inhibitory control across the adult Life span[J]. Psychol Aging, 2002, 17(1): 56-71.
11. RICHARDSON F M, THOMAS M S. The benefits of computational modeling for the study of developmental disorders: Extending the Triesch et al. model to ADHD[J]. Dev Sci, 2006, 9(2): 151-155.
12. WILD WALL N, OADES R D, SCHMIDT WESSELS M, et al. Neural activity associated with executive functions in adolescents with attention deficit/hyperactivity disorder (ADHD)[J]. Int J Psychophysiol, 2009, 74(1): 19-27.
13. BOCQUILLON P, BOURRIEZ J L, PALMERO SOLER E, et al. The spatiotemporal dynamics of early attention processes: A high resolution electroencephalographic study of N2 subcomponent sources[J]. Neuroscience, 2014, 271(15): 9-22.〖JP〗.
14. RUCKLIDGE J J, JOHNSTONE J, KAPLAN B J. Nutrient supplementation approaches in the treatment of ADHD[J]. Expert Rev Neurother, 2009, 9(4): 461-476.
15. YANEZ TELLEZ G, ROMERO ROMERO H, RIVERA GARCIA L, et al. Cognitive and executive functions in ADHD[J]. Actas Esp Psiquiatri, 2012, 40(6): 293-298.
16. 杨红梅,张振强.病理生理学. [M].第7版.西安:第四军医大学出版社,2005:1-172.
17. VOGT F, KLIMESCH W, DOPPELMAYR M. High frequency components in the alpha band and memory performance[J]. J Clin Neurophysiol, 1998, 15(2): 167-172.
18. BRADLEY J C. The learning revolution[J]. Nature, 2009, 457(7226): 151-152.
19. 王浩,陈志华,邹飒枫,等.基于Morlet小波变换的EEG信号α波持续性的分析[J].生物医学工程学杂志,2010,27(4):746-748,752.
20. 李捷.运动技能形成自组织理论的建构及其实证研究[D].北京:北京体育大学,1999.
21. KLIMESCH W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis[J]. Brain Res Rev, 1999, 29(2-3): 169-195.
22. 罗跃嘉,魏景汉,翁旭初,等.汉字视听再认的ERP效应与记忆提取脑机制[J].心理学报,2001,33(6):489-494.

Journal of Biomedical Engineering

Study of Event related Brain Potential in Children with Attention Deficit Hyperactivity Disorder

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