Research Advancement on the Carriers and Controlled-release Systems of Bone Morphogenetic Proteins_Journal of Biomedical Engineering

Authors：

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University, Guangzhou 510140, China;

Corresponding author：

Keywords：

bone morphogenetic protein; carrier; controlled-release system; bone regeneration

DOI：

10.7507/1001-5515.20160131

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Bone morphogenetic protein (BMPs) has been so far regarded as one of the highly potent osteoinductive growth factors. Recombinant human bone morphogenetic proteins have been utilized extensively in the disciplines of orthopedics, stomatology, etc. For clinical application, BMPs are usually loaded in carriers with a controlled-release system, to maintain concentration to induce de novo bone formation at the desired site. In this article, the research advancements of the carriers and release systems of BMP are reviewed.

Citation： LIShuyi, ZHOUMiao. Research Advancement on the Carriers and Controlled-release Systems of Bone Morphogenetic Proteins. Journal of Biomedical Engineering, 2016, 33(4): 812-815. doi: 10.7507/1001-5515.20160131 Copy

1.	KIM H C, SONG J M, KIM C J, et al. Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects[J]. Maxillofac Plast Reconstr Surg, 2015, 37(1):16.
2.	ZHANG Qingchun, TAN Ke, ZHANG Yan, et al. In situ controlled release of rhBMP-2 in gelatin-coated 3D porous poly(ε-caprolactone) scaffolds for homogeneous bone tissue formation[J]. Biomacromolecules, 2014, 15(1):84-94.
3.	DE GUZMAN R C, SAUL J M, ELLENBURG M D, et al. Bone regeneration with BMP-2 delivered from keratose scaffolds[J]. Biomaterials, 2013, 34(6):1644-1656.
4.	NATH S D, ABUEVA C, KIM B, et al. Chitosan-hyaluronic acid polyelectrolyte complex scaffold crosslinked with genipin for immobilization and controlled release of BMP-2[J]. Carbohydr Polym, 2015, 115:160-169.
5.	SHRIVATS A R, MCDERMOTT M C, HOLLINGER J O. Bone tissue engineering:state of the union[J]. Drug Discov Today, 2014, 19(6):781-786.
6.	CARREIRA A C, LOJUDICE F H, HALCSIK E, et al. Bone morphogenetic proteins:facts, challenges, and future perspectives[J]. J Dent Res, 2014, 93(4):335-345.
7.	LI Fengqian, WU Wen, XIANG Li, et al. Sustained release of VH and rhBMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair[J]. Int J Nanomedicine, 2015, 10:4071-4080.
8.	HINSENKAMP M, COLLARD J F. Growth factors in orthopaedic surgery:demineralized bone matrix versus recombinant bone morphogenetic proteins[J]. Int Orthop, 2015, 39(1):137-147.
9.	HÄNSELER P, EHRBAR M, KRUSE A, et al. Delivery of BMP-2 by two clinically available apatite materials:in vitro and in vivo comparison[J]. J Biomed Mater Res A, 2015, 103(2):628-638.
10.	CHO H J, PERIKAMANA S K, LEE J H, et al. Effective immobilization of BMP-2 mediated by polydopamine coating on biodegradable nanofibers for enhanced in vivo bone formation[J]. ACS Appl Mater Interfaces, 2014, 6(14):11225-11235.
11.	WINK J D, GERETY P A, SHERIF R D, et al. Sustained deliveryof rhBMP-2 by means of poly(lactic-co-glycolic acid)microspheres:cranial bone regeneration without heterotopic ossification or craniosynostosis[J]. Plast Reconstr Surg, 2014, 134(1):51-59.
12.	SHEKARAN Asha, GARCÍA J R, CLARK A Y, et al. Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle[J]. Biomaterials, 2014, 35(21):5453-5461.
13.	JO J H, CHOI S W, CHOI J W, et al. Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration[J]. Biomed Mater, 2015, 10(4):0450071.
14.	SARKAR S K, LEE B T. Hard tissue regeneration using bone substitutes:an update on innovations in materials[J]. Korean J Intern Med, 2015, 30(3):279-293.
15.	ABARRATEGI A, MORENO-VICENTE C, MARTÍNEZ-VÁZQUEZ F J, et al. Biological properties of solid free form designed ceramic scaffolds with BMP-2:in vitro and in vivo evaluation[J]. PLoS One, 2012, 7(3):e34117.
16.	ZIEGLER J, ANGER D, KRUMMENAUER F, et al. Biological activity of recombinant human growth factors released from biocompatible bone implants[J]. J Biomed Mater Res A, 2008, 86(1):89-97.
17.	LIU Tie, WU Gang, WISMEIJER D, et al. Deproteinized bovine bone functionalized with the slow delivery of BMP-2 for the repair of critical-sized bone defects in sheep[J]. Bone, 2013, 56(1):110-118.
18.	ZHENG Yuanna, WU Gang, LIU Tie, et al. A novel BMP2-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particle:a biodegradable and highly efficient osteoinducer[J]. Clin Implant Dent Relat Res, 2014, 16(5):643-654.
19.	HOLLINGER J O, SCHMITT J M, BUCK D C, et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration[J]. Journal of Biomedical Materials Research, 1998, 43(4):356-364.
20.	GARCÍA-GARETA E, COATHUP M J, BLUNN G W. Osteoinduction of bone grafting materials for bone repair and regeneration[J]. Bone, 2015, 81(2015):112-121.
21.	CHEN Bing, LIN Hang, WANG Jianhua, et al. Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2[J]. Biomaterials, 2007, 28(6):1027-1035.
22.	LI Qin, WANG Xianliu, LOU Xiangxin, et al. Genipin-crosslinked electrospun chitosan nanofibers:Determination of crosslinking conditions and evaluation of cytocompatibility[J]. Carbohydr Polym, 2015, 130(2015):166-174.
23.	王晏, 笪琳萃, 谢艳, 等.京尼平作为交联剂在天然生物材料改性中的应用[J].中国修复重建外科杂志, 2013, 27(5):580-585.
24.	RAHMAN C V, BEN-DAVID D, DHILLON A, et al. Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model[J]. J Tissue Eng Regen Med, 2014, 8(1):59-66.
25.	ORYAN A, ALIDADI S, MOSHIRI A, et al. Bone regenerative medicine:classic options, novel strategies, and future directions[J]. J Orthop Surg Res, 2014, 9(1):18.
26.	HE Xiaoning, LIU Yang, YUAN Xue, et al. Enhanced healing of rat calvarial defects with MSCs loaded on BMP-2 releasing chitosan/alginate/hydroxyapatite scaffolds[J]. PLoS One, 2014, 9(8):e104061.
27.	LIU Yuelian, WU Gang, DE GROOT K. Biomimetic coatings for bone tissue engineering of critical-sized defects[J]. J R Soc Interface, 2010, 7(Suppl 5):S631-S647.
28.	SHI Zhilong, NEOH K G, KANG En-tang, et al. Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions[J]. Tissue Eng Part A, 2009, 15(2):417-426.
29.	HANNINK G, GEUTJES P J, DAAMEN W F, et al. Evaluation of collagen/heparin coated TCP/HA granules for long-term delivery of BMP-2[J]. J Mater Sci Mater Med, 2013, 24(2):325-332.
30.	SIGKOU O, LABBAF S, STEVENS M M, et al. Monodispersed bioactive glass submicron particles and their effect on bone marrow and adipose tissue-derived stem cells[J]. Adv Healthc Mater, 2014, 3(1):115-125.

1. KIM H C, SONG J M, KIM C J, et al. Combined effect of bisphosphonate and recombinant human bone morphogenetic protein 2 on bone healing of rat calvarial defects[J]. Maxillofac Plast Reconstr Surg, 2015, 37(1):16.
2. ZHANG Qingchun, TAN Ke, ZHANG Yan, et al. In situ controlled release of rhBMP-2 in gelatin-coated 3D porous poly(ε-caprolactone) scaffolds for homogeneous bone tissue formation[J]. Biomacromolecules, 2014, 15(1):84-94.
3. DE GUZMAN R C, SAUL J M, ELLENBURG M D, et al. Bone regeneration with BMP-2 delivered from keratose scaffolds[J]. Biomaterials, 2013, 34(6):1644-1656.
4. NATH S D, ABUEVA C, KIM B, et al. Chitosan-hyaluronic acid polyelectrolyte complex scaffold crosslinked with genipin for immobilization and controlled release of BMP-2[J]. Carbohydr Polym, 2015, 115:160-169.
5. SHRIVATS A R, MCDERMOTT M C, HOLLINGER J O. Bone tissue engineering:state of the union[J]. Drug Discov Today, 2014, 19(6):781-786.
6. CARREIRA A C, LOJUDICE F H, HALCSIK E, et al. Bone morphogenetic proteins:facts, challenges, and future perspectives[J]. J Dent Res, 2014, 93(4):335-345.
7. LI Fengqian, WU Wen, XIANG Li, et al. Sustained release of VH and rhBMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair[J]. Int J Nanomedicine, 2015, 10:4071-4080.
8. HINSENKAMP M, COLLARD J F. Growth factors in orthopaedic surgery:demineralized bone matrix versus recombinant bone morphogenetic proteins[J]. Int Orthop, 2015, 39(1):137-147.
9. HÄNSELER P, EHRBAR M, KRUSE A, et al. Delivery of BMP-2 by two clinically available apatite materials:in vitro and in vivo comparison[J]. J Biomed Mater Res A, 2015, 103(2):628-638.
10. CHO H J, PERIKAMANA S K, LEE J H, et al. Effective immobilization of BMP-2 mediated by polydopamine coating on biodegradable nanofibers for enhanced in vivo bone formation[J]. ACS Appl Mater Interfaces, 2014, 6(14):11225-11235.
11. WINK J D, GERETY P A, SHERIF R D, et al. Sustained deliveryof rhBMP-2 by means of poly(lactic-co-glycolic acid)microspheres:cranial bone regeneration without heterotopic ossification or craniosynostosis[J]. Plast Reconstr Surg, 2014, 134(1):51-59.
12. SHEKARAN Asha, GARCÍA J R, CLARK A Y, et al. Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle[J]. Biomaterials, 2014, 35(21):5453-5461.
13. JO J H, CHOI S W, CHOI J W, et al. Effects of different rhBMP-2 release profiles in defect areas around dental implants on bone regeneration[J]. Biomed Mater, 2015, 10(4):0450071.
14. SARKAR S K, LEE B T. Hard tissue regeneration using bone substitutes:an update on innovations in materials[J]. Korean J Intern Med, 2015, 30(3):279-293.
15. ABARRATEGI A, MORENO-VICENTE C, MARTÍNEZ-VÁZQUEZ F J, et al. Biological properties of solid free form designed ceramic scaffolds with BMP-2:in vitro and in vivo evaluation[J]. PLoS One, 2012, 7(3):e34117.
16. ZIEGLER J, ANGER D, KRUMMENAUER F, et al. Biological activity of recombinant human growth factors released from biocompatible bone implants[J]. J Biomed Mater Res A, 2008, 86(1):89-97.
17. LIU Tie, WU Gang, WISMEIJER D, et al. Deproteinized bovine bone functionalized with the slow delivery of BMP-2 for the repair of critical-sized bone defects in sheep[J]. Bone, 2013, 56(1):110-118.
18. ZHENG Yuanna, WU Gang, LIU Tie, et al. A novel BMP2-coprecipitated, layer-by-layer assembled biomimetic calcium phosphate particle:a biodegradable and highly efficient osteoinducer[J]. Clin Implant Dent Relat Res, 2014, 16(5):643-654.
19. HOLLINGER J O, SCHMITT J M, BUCK D C, et al. Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration[J]. Journal of Biomedical Materials Research, 1998, 43(4):356-364.
20. GARCÍA-GARETA E, COATHUP M J, BLUNN G W. Osteoinduction of bone grafting materials for bone repair and regeneration[J]. Bone, 2015, 81(2015):112-121.
21. CHEN Bing, LIN Hang, WANG Jianhua, et al. Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2[J]. Biomaterials, 2007, 28(6):1027-1035.
22. LI Qin, WANG Xianliu, LOU Xiangxin, et al. Genipin-crosslinked electrospun chitosan nanofibers:Determination of crosslinking conditions and evaluation of cytocompatibility[J]. Carbohydr Polym, 2015, 130(2015):166-174.
23. 王晏, 笪琳萃, 谢艳, 等.京尼平作为交联剂在天然生物材料改性中的应用[J].中国修复重建外科杂志, 2013, 27(5):580-585.
24. RAHMAN C V, BEN-DAVID D, DHILLON A, et al. Controlled release of BMP-2 from a sintered polymer scaffold enhances bone repair in a mouse calvarial defect model[J]. J Tissue Eng Regen Med, 2014, 8(1):59-66.
25. ORYAN A, ALIDADI S, MOSHIRI A, et al. Bone regenerative medicine:classic options, novel strategies, and future directions[J]. J Orthop Surg Res, 2014, 9(1):18.
26. HE Xiaoning, LIU Yang, YUAN Xue, et al. Enhanced healing of rat calvarial defects with MSCs loaded on BMP-2 releasing chitosan/alginate/hydroxyapatite scaffolds[J]. PLoS One, 2014, 9(8):e104061.
27. LIU Yuelian, WU Gang, DE GROOT K. Biomimetic coatings for bone tissue engineering of critical-sized defects[J]. J R Soc Interface, 2010, 7(Suppl 5):S631-S647.
28. SHI Zhilong, NEOH K G, KANG En-tang, et al. Titanium with surface-grafted dextran and immobilized bone morphogenetic protein-2 for inhibition of bacterial adhesion and enhancement of osteoblast functions[J]. Tissue Eng Part A, 2009, 15(2):417-426.
29. HANNINK G, GEUTJES P J, DAAMEN W F, et al. Evaluation of collagen/heparin coated TCP/HA granules for long-term delivery of BMP-2[J]. J Mater Sci Mater Med, 2013, 24(2):325-332.
30. SIGKOU O, LABBAF S, STEVENS M M, et al. Monodispersed bioactive glass submicron particles and their effect on bone marrow and adipose tissue-derived stem cells[J]. Adv Healthc Mater, 2014, 3(1):115-125.

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