Effect of Caveolae/Caveolin-1 on Osteogenic Differentiation of Mesenchymal Stem Cells_Journal of Biomedical Engineering

Authors：

Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China;

Corresponding author：

Keywords：

caveolin-1; mesenchymal stem cells; osteogenesis differentiation

DOI：

10.7507/1001-5515.20160133

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Mesenchymal stem cells (MSCs) have the property of osteogenic induction. As a result, using the property of MSCs to treat the fractures and bone defects has become a new treatment modality with the development of cell and tissue engineering technology. Caveolae is a flask-shaped membrane microdomain in cell membrane, which composed primarily of cholesterol, sphingolipids and proteins. Caveolin-1 is one of the main protein component. Caveolae is the integrator of cell signals, and many signal molecules gather here to bind with caveolin-1 protein to regulate cell proliferation, differentiation and other life activities. This paper presents a review about Caveolae/Caveolin-1 biologic effects on cell differentiation of MSCs.

Citation： YANGYang, ZHANGGang. Effect of Caveolae/Caveolin-1 on Osteogenic Differentiation of Mesenchymal Stem Cells. Journal of Biomedical Engineering, 2016, 33(4): 821-824. doi: 10.7507/1001-5515.20160133 Copy

1.	MA S, XIE N, LI W, et al. Immunobiology of mesenchymal stem cells[J]. Cell Death and Differentiation, 2014, 21(2):216-225.
2.	KOVTUN O, TILLU V A, ARIOTTI N, et al. Cavin family proteins and the assembly of caveolae[J]. J Cell Sci, 2015, 128(7):1269-1278.
3.	MARTINEAU C, MARTIN-FALSTRAULT L, BRISSETTE L, et al. The atherogenic Scarb1 null mouse model shows a high bone mass phenotype[J]. Am J Physiol Endocrinol Metab, 2014, 306(1):E48-E57.
4.	DE LA GARZA-RODEA A S, BOERSMA H, DAMBROT C, et al. Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration[J]. World J Exp Med, 2015, 5(2):140-153.
5.	FRIDOLFSSON H N, ROTH D M, INSEL P A, et al. Regulation of intracellular signaling and function by caveolin[J]. FASEB J, 2014, 28(9):3823-3831.
6.	WAGERS A J. Systemic regulation of aging phenotypes in mammalian tissues[J]. Exp Gerontol, 2015, 68(3):94-102.
7.	张勤勤, 孙润广, 李连启.Caveolae及其蛋白家族的生物学结构和功能的研究现状[J].北京生物医学工程, 2011, 30(2):215-220.
8.	ZHU Liuluan, CUI Ying, CHANG Yongsheng, et al. A second protein marker of caveolae:caveolin-2[J]. Chinese Medical Sciences Journal, 2010, 25(2):119-124.
9.	LEE Y D, YOON S H, PARK C K, et al. Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner[J]. J Biol Chem, 2015, 290(10):6522-6530.
10.	BAKER N, ZHANG Guofeng, YOU Yang, et al. Caveolin-1 regulates proliferation and osteogenic differentiation of human mesenchymal stem cells[J]. J Cell Biochem, 2012, 113(12):3773-3787.
11.	ZHANG Jian, LAZARENKO O P, BLACKBURN M L, et al. Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways[J]. FASEB J, 2014, 28(7):3134-3145.
12.	WANG Zhiyu, WANG Neng, LI Wenping, et al. Caveolin-1 mediates chemoresistance in breast cancer stem cells via beta-catenin/ABCG2 signaling pathway[J]. Carcinogenesis, 2014, 35(10):2346-2356.
13.	CBHONDE R R, SHESHADRI P, SHARMA S, et al. Making surrogate β-cells from mesenchymal stromal cells:perspectives and future endeavors[J]. Int J Biochem Cell Biol, 2014, 46:90-102.
14.	TAO R, SUN T J, HAN Y Q, et al. Epimorphin-induced differentiation of human umbilical cord mesenchymal stem cells into sweat gland cells[J]. Eur Rev Med Pharmacol Sci, 2014, 18(9):1404-1410.
15.	SOLOMON K R, ADOLPHSON L D, WANK D A, et al. Caveolae in human and murine osteoblasts[J]. J Bone Miner Res, 2000, 15(12):2391-2401.
16.	CASADO J G, TARAZONA R, SANCHEZ-MARGALLO F M. NK and MSCs crosstalk:the sense of immunomodulation and their sensitivity[J]. Stem Cell Rev, 2013, 9(2):184-189.
17.	CHEN Jinran, LAZARENKO O P, BLACKBURN M L, et al. Soy protein isolate inhibits high-fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats[J]. Endocrinology, 2015, 156(2):475-487.
18.	TERRA S R, CARDOSO J C, FÉLIX R C, et al. STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition[J]. Mol Cell Endocrinol, 2015, 403:78-87.
19.	MOSEYCHUK O, AKKIRAJU H, DUTTA J, et al. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes[J]. J Cell Commun Signal, 2013, 7(4):265-278.
20.	ULLAH I, SUBBARAO R B, RHO G J. Human mesenchymal stem cells-current trends and future prospective[J]. Biosci Rep, 2015, 35(2):1-18.
21.	ZHAO Hui, NING Linlin, WANG Zhiyu, et al. Calcitonin gene-related peptide inhibits osteolytic factors induced by osteoblast in co-culture system with breast cancer[J]. Cell Biochem Biophys, 2014, 70(2):1097-1104.
22.	TANG Jiangqiong, SUN Fei, WANG Yuhua, et al. The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells[J]. Biochemistry and Cell Biology, 2013, 91(5):357-360.
23.	TIAN Gang, ZHANG Gang, TAN Yinghui. Calcitonin gene-related peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells in vitro[J]. Acta Pharmacol Sin, 2013, 34(11):1467-1474.
24.	OTSURU S, HOFMANN T J, OLSON T S, et al. Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filter device[J]. Cytotherapy, 2013, 15(2):146-153.
25.	SAIDAK Z, LE HENAFF C, AZZI S, et al. Wnt/β-catenin signaling mediates osteoblast differentiation triggered by peptide-induced α5β1 integrin priming in mesenchymal skeletal cells[J]. J Biol Chem, 2015, 290(11):6903-6912.
26.	刘光源, 田发明, 张柳, 等.BMP2信号通路与经典Wnt信号通路及相互交联对成骨分化的调控[J].中国骨质疏松杂志, 2014, 20(5):551-556, 561.
27.	LI C J, MADHU V, BALIAN G, et al. Cross-Talk between VEGF and BMP-6 pathways accelerates osteogenic differentiation of human adipose-derived stem cells[J]. J Cell Physiol, 2015, 230(11):2671-2682.
28.	BAKER N, TUAN R S. The less-often-traveled surface of stem cells:caveolin-1 and caveolae in stem cells, tissue repair and regeneration[J]. Stem Cell Res Ther, 2013, 4(4):90.

1. MA S, XIE N, LI W, et al. Immunobiology of mesenchymal stem cells[J]. Cell Death and Differentiation, 2014, 21(2):216-225.
2. KOVTUN O, TILLU V A, ARIOTTI N, et al. Cavin family proteins and the assembly of caveolae[J]. J Cell Sci, 2015, 128(7):1269-1278.
3. MARTINEAU C, MARTIN-FALSTRAULT L, BRISSETTE L, et al. The atherogenic Scarb1 null mouse model shows a high bone mass phenotype[J]. Am J Physiol Endocrinol Metab, 2014, 306(1):E48-E57.
4. DE LA GARZA-RODEA A S, BOERSMA H, DAMBROT C, et al. Barriers in contribution of human mesenchymal stem cells to murine muscle regeneration[J]. World J Exp Med, 2015, 5(2):140-153.
5. FRIDOLFSSON H N, ROTH D M, INSEL P A, et al. Regulation of intracellular signaling and function by caveolin[J]. FASEB J, 2014, 28(9):3823-3831.
6. WAGERS A J. Systemic regulation of aging phenotypes in mammalian tissues[J]. Exp Gerontol, 2015, 68(3):94-102.
7. 张勤勤, 孙润广, 李连启.Caveolae及其蛋白家族的生物学结构和功能的研究现状[J].北京生物医学工程, 2011, 30(2):215-220.
8. ZHU Liuluan, CUI Ying, CHANG Yongsheng, et al. A second protein marker of caveolae:caveolin-2[J]. Chinese Medical Sciences Journal, 2010, 25(2):119-124.
9. LEE Y D, YOON S H, PARK C K, et al. Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner[J]. J Biol Chem, 2015, 290(10):6522-6530.
10. BAKER N, ZHANG Guofeng, YOU Yang, et al. Caveolin-1 regulates proliferation and osteogenic differentiation of human mesenchymal stem cells[J]. J Cell Biochem, 2012, 113(12):3773-3787.
11. ZHANG Jian, LAZARENKO O P, BLACKBURN M L, et al. Soy protein isolate down-regulates caveolin-1 expression to suppress osteoblastic cell senescence pathways[J]. FASEB J, 2014, 28(7):3134-3145.
12. WANG Zhiyu, WANG Neng, LI Wenping, et al. Caveolin-1 mediates chemoresistance in breast cancer stem cells via beta-catenin/ABCG2 signaling pathway[J]. Carcinogenesis, 2014, 35(10):2346-2356.
13. CBHONDE R R, SHESHADRI P, SHARMA S, et al. Making surrogate β-cells from mesenchymal stromal cells:perspectives and future endeavors[J]. Int J Biochem Cell Biol, 2014, 46:90-102.
14. TAO R, SUN T J, HAN Y Q, et al. Epimorphin-induced differentiation of human umbilical cord mesenchymal stem cells into sweat gland cells[J]. Eur Rev Med Pharmacol Sci, 2014, 18(9):1404-1410.
15. SOLOMON K R, ADOLPHSON L D, WANK D A, et al. Caveolae in human and murine osteoblasts[J]. J Bone Miner Res, 2000, 15(12):2391-2401.
16. CASADO J G, TARAZONA R, SANCHEZ-MARGALLO F M. NK and MSCs crosstalk:the sense of immunomodulation and their sensitivity[J]. Stem Cell Rev, 2013, 9(2):184-189.
17. CHEN Jinran, LAZARENKO O P, BLACKBURN M L, et al. Soy protein isolate inhibits high-fat diet-induced senescence pathways in osteoblasts to maintain bone acquisition in male rats[J]. Endocrinology, 2015, 156(2):475-487.
18. TERRA S R, CARDOSO J C, FÉLIX R C, et al. STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition[J]. Mol Cell Endocrinol, 2015, 403:78-87.
19. MOSEYCHUK O, AKKIRAJU H, DUTTA J, et al. Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes[J]. J Cell Commun Signal, 2013, 7(4):265-278.
20. ULLAH I, SUBBARAO R B, RHO G J. Human mesenchymal stem cells-current trends and future prospective[J]. Biosci Rep, 2015, 35(2):1-18.
21. ZHAO Hui, NING Linlin, WANG Zhiyu, et al. Calcitonin gene-related peptide inhibits osteolytic factors induced by osteoblast in co-culture system with breast cancer[J]. Cell Biochem Biophys, 2014, 70(2):1097-1104.
22. TANG Jiangqiong, SUN Fei, WANG Yuhua, et al. The role of caveolae in regulating calcitonin receptor-like receptor subcellular distribution in vascular smooth muscle cells[J]. Biochemistry and Cell Biology, 2013, 91(5):357-360.
23. TIAN Gang, ZHANG Gang, TAN Yinghui. Calcitonin gene-related peptide stimulates BMP-2 expression and the differentiation of human osteoblast-like cells in vitro[J]. Acta Pharmacol Sin, 2013, 34(11):1467-1474.
24. OTSURU S, HOFMANN T J, OLSON T S, et al. Improved isolation and expansion of bone marrow mesenchymal stromal cells using a novel marrow filter device[J]. Cytotherapy, 2013, 15(2):146-153.
25. SAIDAK Z, LE HENAFF C, AZZI S, et al. Wnt/β-catenin signaling mediates osteoblast differentiation triggered by peptide-induced α5β1 integrin priming in mesenchymal skeletal cells[J]. J Biol Chem, 2015, 290(11):6903-6912.
26. 刘光源, 田发明, 张柳, 等.BMP2信号通路与经典Wnt信号通路及相互交联对成骨分化的调控[J].中国骨质疏松杂志, 2014, 20(5):551-556, 561.
27. LI C J, MADHU V, BALIAN G, et al. Cross-Talk between VEGF and BMP-6 pathways accelerates osteogenic differentiation of human adipose-derived stem cells[J]. J Cell Physiol, 2015, 230(11):2671-2682.
28. BAKER N, TUAN R S. The less-often-traveled surface of stem cells:caveolin-1 and caveolae in stem cells, tissue repair and regeneration[J]. Stem Cell Res Ther, 2013, 4(4):90.

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