Study on Relationship between Assessment of Vascular Function Using Digital Fingertip Thermal Monitoring and Pulse Wave Velocity_Journal of Biomedical Engineering

Authors：

WANGXinxin ¹ ,  LIXia ^1,2 , CHUXi ³ , DONGQing ¹ , ZHAOXiaojing ¹ , CHENHui ^1,2 , ZHANGKuan ^1,2

1. School of Biomedical Engineering, Capital Medical University, Beijing 100069, China;
2. Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China;
3. Xuanwu Hospital, Capital Medical University, Beijing 100069, China;

Corresponding author：

LIXia, Email: xiali@ccmu.edu.cn

Keywords：

fingertip digital thermal monitor; pulse wave velocity; Logistic regression model

DOI：

10.7507/1001-5515.20160173

Video：

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Abstract Full text Figures/Tables Video References Cited by

Early detection of vascular function plays an important role in the prevention and treatment of cardiovascular diseases (CVDs). This paper reports the main studies of the effectiveness of fingertip temperature curve in digital thermal monitoring (DTM) for predicting CVDs, as well as the relationship between parameters from DTM and pulse wave velocity (PWV) detection. A total of 112 subjects [age (42.18±12.28) years, 50% male, 37 with known CVDs] underwent DTM and PWV detection. Results showed that most of parameters related to CVDs were from the declining stage of the digital thermal signal. Binary Logistic regression models were built, and the best one was chosen by ten-fold validation to predict CVDs. Consistency was great between the detection result of PWV and that of the Logistic model of DTM parameters. Parameters from DTM also contained information for early detecting of vascular stiffness. This study indicates that the fingertip temperature curve in DTM has a potential application for predication of CVDs, and it would be used to access vascular function in the initial stage of CVDs.

Citation： WANGXinxin, LIXia, CHUXi, DONGQing, ZHAOXiaojing, CHENHui, ZHANGKuan. Study on Relationship between Assessment of Vascular Function Using Digital Fingertip Thermal Monitoring and Pulse Wave Velocity. Journal of Biomedical Engineering, 2016, 33(6): 1084-1089. doi: 10.7507/1001-5515.20160173 Copy

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4.	AHMADI N, HAJSADEGHI F, GUL K, et al. Relations between digital thermal monitoring of vascular function, the Framingham risk score, and coronary artery calcium score[J]. J Cardiovasc Comput Tomogr, 2008, 2(6): 382-388.
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7.	MUNAKATA M. Brachial-ankle pulse wave velocity in the measurement of arterial stiffness: recent evidence and clinical applications[J]. Curr Hypertens Rev, 2014, 10(1): 49-57.
8.	MCENIERY C M, WALLACE S, MACKENZIE I S, et al. Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans[J]. Hypertension, 2006, 48(4): 602-608.
9.	SCHIER R, HINKELBEIN J, MARCUS H, et al. A novel technique for the assessment of preoperative cardiovascular risk: reactive hyperemic response to short-term exercise[J]. Biomed Res Int, 2013: 837130.
10.	SCHIER R, MARCUS H E, MANSUR E, et al. Evaluation of digital thermal monitoring as a tool to assess perioperative vascular reactivity[J]. J Atheroscler Thromb, 2013, 20(3): 277-286.
11.	董晴, 李霞,万云高,等.基于指温变化的血管功能无创检测方法的初步研究[J].生物医学工程学杂志,2016,33(1):144-148.
12.	KIM E K, CHANG Sunga, JANG S Y, et al. Brachial-ankle pulse wave velocity as a screen for arterial stiffness: a comparison with cardiac magnetic resonance[J]. Yonsei Med J, 2015, 56(3): 617-624.
13.	TURIN T C, KITA Y, RUMANA N, et al. Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan[J]. Hypertens Res, 2010, 33(9): 922-925.
14.	STONER L, YOUNG J M, FRYER S. Assessments of arterial stiffness and endothelial function using pulse wave analysis[J]. Int J Vasc Med, 2012: 903107.
15.	GUL K M, AHMADI N, WANG Zhiying, et al. Digital thermal monitoring of vascular function: a novel tool to improve cardiovascular risk assessment[J]. Vasc Med, 2009, 14(2): 143-148.
16.	LARIJANI V N, AHMADI N, ZEB I, et al. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial[J]. Nutrition, 2013, 29(1): 71-75.
17.	SCHWARTZ B G, ECONOMIDES C, MAYEDA G S, et al. The endothelial cell in health and disease: its function, dysfunction, measurement and therapy[J]. Int J Impot Res, 2010, 22(2): 77-90.
18.	AKHTAR M W, KLEIS S J, METCALFE R W, et al. Sensitivity of digital thermal monitoring parameters to reactive hyperemia[J]. J Biomech Eng, 2010, 132(5): 051005.

1. 陈伟伟, 高润霖,刘力生,等.《中国心血管病报告2014》概要[J].中国循环杂志,2015,07(7):617-622.
2. YUSUF S, WOOD D, RALSTON J, et al. The World Heart Federation's vision for worldwide cardiovascular disease prevention[J]. Lancet, 2015, 386(9991): 399-402.
3. AHMADI N, MCQUILKIN G L, AKHTAR M W, et al. Reproducibility and variability of digital thermal monitoring of vascular reactivity[J]. Clin Physiol Funct Imaging, 2011, 31(6): 422-428.
4. AHMADI N, HAJSADEGHI F, GUL K, et al. Relations between digital thermal monitoring of vascular function, the Framingham risk score, and coronary artery calcium score[J]. J Cardiovasc Comput Tomogr, 2008, 2(6): 382-388.
5. AHMADI N, NABAVI V, NUGURI V, et al. Low fingertip temperature rebound measured by digital thermal monitoring strongly correlates with the presence and extent of coronary artery disease diagnosed by 64-slice multi-detector computed tomography[J]. Int J Cardiovasc Imaging, 2009, 25(7): 725-738.
6. SUGAWARA J, HAYASHI K, YOKOI T, et al. Brachial-ankle pulse wave velocity: an index of central arterial stiffness?[J]. J Hum Hypertens, 2005, 19(5): 401-406.
7. MUNAKATA M. Brachial-ankle pulse wave velocity in the measurement of arterial stiffness: recent evidence and clinical applications[J]. Curr Hypertens Rev, 2014, 10(1): 49-57.
8. MCENIERY C M, WALLACE S, MACKENZIE I S, et al. Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans[J]. Hypertension, 2006, 48(4): 602-608.
9. SCHIER R, HINKELBEIN J, MARCUS H, et al. A novel technique for the assessment of preoperative cardiovascular risk: reactive hyperemic response to short-term exercise[J]. Biomed Res Int, 2013: 837130.
10. SCHIER R, MARCUS H E, MANSUR E, et al. Evaluation of digital thermal monitoring as a tool to assess perioperative vascular reactivity[J]. J Atheroscler Thromb, 2013, 20(3): 277-286.
11. 董晴, 李霞,万云高,等.基于指温变化的血管功能无创检测方法的初步研究[J].生物医学工程学杂志,2016,33(1):144-148.
12. KIM E K, CHANG Sunga, JANG S Y, et al. Brachial-ankle pulse wave velocity as a screen for arterial stiffness: a comparison with cardiac magnetic resonance[J]. Yonsei Med J, 2015, 56(3): 617-624.
13. TURIN T C, KITA Y, RUMANA N, et al. Brachial-ankle pulse wave velocity predicts all-cause mortality in the general population: findings from the Takashima study, Japan[J]. Hypertens Res, 2010, 33(9): 922-925.
14. STONER L, YOUNG J M, FRYER S. Assessments of arterial stiffness and endothelial function using pulse wave analysis[J]. Int J Vasc Med, 2012: 903107.
15. GUL K M, AHMADI N, WANG Zhiying, et al. Digital thermal monitoring of vascular function: a novel tool to improve cardiovascular risk assessment[J]. Vasc Med, 2009, 14(2): 143-148.
16. LARIJANI V N, AHMADI N, ZEB I, et al. Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial[J]. Nutrition, 2013, 29(1): 71-75.
17. SCHWARTZ B G, ECONOMIDES C, MAYEDA G S, et al. The endothelial cell in health and disease: its function, dysfunction, measurement and therapy[J]. Int J Impot Res, 2010, 22(2): 77-90.
18. AKHTAR M W, KLEIS S J, METCALFE R W, et al. Sensitivity of digital thermal monitoring parameters to reactive hyperemia[J]. J Biomech Eng, 2010, 132(5): 051005.

Journal of Biomedical Engineering

Study on Relationship between Assessment of Vascular Function Using Digital Fingertip Thermal Monitoring and Pulse Wave Velocity

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