Experimental study on silicone hand disinfection by a touchable non-thermal plasma_Journal of Biomedical Engineering

Authors：

ZHENG Chao ¹ , KOU Yanqin ¹ ,  LIU Zhen ² , JIANG Hongqiang ¹ , HUANG Yifan ² , YAN Keping ²

1. Zhejiang Center for Medical Device Adverse Event Monitoring and Safety Research, Hangzhou 310009, P.R.China;
2. College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P.R.China;

Corresponding author：

LIU Zhen, Email: zliu@zju.edu.cn

Keywords：

non-thermal plasma; plasma medicine; disinfection and sterilization; hand disinfection

DOI：

10.7507/1001-5515.201605036

Video：

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In this study, silicone hand was disinfected by homemade touchable non-thermal plasma to simulate and evaluate its feasibility of application on human hand. Experimental results showed that there was no significant difference whenEscherichia coli (E. coli),Staphylococcus aureus (S. au),Staphylococcus albus (S. al), andPseudomonas aeruginosa (P. ae) were loaded on the silicone hand surface and treated with plasma. The efficiency of plasma disinfection was higher when the treatment time was prolonged or initial bacterial density was lower. When initial bacterial number was 1.0×10⁶–1.0×10⁷ CFU, the plasma disinfection process mainly occured in the first 5 s and more than 99% of bacteria could be disinfected. This study can provide guidelines for the development of a new plasma device for human hand disinfection.

Citation： ZHENG Chao, KOU Yanqin, LIU Zhen, JIANG Hongqiang, HUANG Yifan, YAN Keping. Experimental study on silicone hand disinfection by a touchable non-thermal plasma. Journal of Biomedical Engineering, 2017, 34(2): 303-307. doi: 10.7507/1001-5515.201605036 Copy

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4.	郑超, 徐羽贞, 黄逸凡, 等. 低温等离子体灭菌及生物医药技术研究进展. 化工进展, 2013, 32(9): 2185-2193.
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19.	Boekema B K H L, Vlig M, Guijt D. A new flexible DBD device for treating infected wounds:in vitro andex vivo evaluation and comparison with a RF argon plasma jet. Journal of Physics D: Applied Physics, 2016, 49: 044001.

1. 于骁, 周再发, 李伟华, 等. 等离子体刻蚀工艺模型研究进展. 微电子学, 2015, 45(1): 94-99.
2. 苏葆辉, 冉均国, 苟立, 等. 等离子体活化羟基磷灰石(HA)的机理研究. 生物医学工程学杂志, 2005, 22(4): 711-714.
3. 胡国庆. 我国过氧化氢低温等离子体灭菌技术应用现状与管理. 中国消毒学杂志, 2011, 28(3): 353-355.
4. 郑超, 徐羽贞, 黄逸凡, 等. 低温等离子体灭菌及生物医药技术研究进展. 化工进展, 2013, 32(9): 2185-2193.
5. Fridman G, Friedman G, Gutsol A, et al. Applied plasma medicine. Plasma Processes and Polymers, 2008, 5(6): 503-533.
6. Julak J, Schlotz V. Decontamination of human skin by low-temperature plasma produced by cometary discharge. Clinical Plasma Medicine, 2013, 1: 31-34.
7. Isbary G, Stolz W, Shimizu T, et al. Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: Results of an open retrospective randomized controlled study in vivo. Clinical Plasma Medicine, 2013, 1: 25-30.
8. Chen C Y, Fan H W, Kuo S P, et al. Blood clotting by low-temperature air plasma. IEEE Transactions on Plasma Science, 2009, 37(6): 993-999.
9. Mirpour S, Ghomi H, Piroozmand S A, et al. The selective characterization of nonthermal atmospheric pressure plasma jet on treatment of human breast cancer and normal cells. IEEE Transactions on Plasma Science, 2014, 42(2): 315-322.
10. Vasilets V N, Shekhter A B, Guller A E, et al. Air plasma-generated nitric oxide in treatment of skin scars and articular musculoskeletal disorders: Preliminary review of observations. Clinical Plasma Medicine, 2015, 3: 32-39.
11. 卢新培. 等离子体射流及其医学应用. 高电压技术, 2011, 37(6): 1416-1425.
12. Alster T S, Konda S. Plasma skin resurfacing for regeneration of neck, chest, and hands: investigation of a novel device. Dermato-logic Surgery, 2007, 33(11): 1315-1321.
13. 中华人民共和国国家质量监督检验检疫总局. GB 15982-2012医院消毒卫生标准. 北京: 中国标准出版社, 2012.
14. 中华人民共和国卫生部. WS/T 313-2009医务人员手卫生规范. 北京: 中国标准出版社, 2009.
15. 中华人民共和国卫生部. GB 27950-2011手消毒剂卫生要求. 北京: 中国标准出版社, 2012.
16. Lademann O, Richter H, Patzelt A, et al. Application of a plasma-jet for skin antisepsis: analysis of the thermal action of the plasma by laser scanning microscopy. Laser Physics Letters, 2010, 7(6): 458-462.
17. Morfill G E, Shimizu T, Steffes B, et al. Nosocomial infections--a new approach towards preventive medicine using plasmas. New Journal of Physics, 2009, 11: 115019 (10pp).
18. 刘新定, 李嘉丰, 马致臻, 等. 空气沿面介质阻挡放电活性粒子成分及其影响因素. 高电压技术, 2016, 42(2): 421-427.
19. Boekema B K H L, Vlig M, Guijt D. A new flexible DBD device for treating infected wounds:in vitro andex vivo evaluation and comparison with a RF argon plasma jet. Journal of Physics D: Applied Physics, 2016, 49: 044001.

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