Preparation and drug release of curcumin-loaded poly (α-isobutyl cyanoacrylate) microspheres_Journal of Biomedical Engineering

Authors：

SHI Shuxian , LI Qingzhao , CHEN Xiaonong ,  XIA Yuzheng

Key Laboratory of Carbon Fiber and Functional Polymers, Beijing University of Chemical Technology, Beijing 100029, P. R. China;

Corresponding author：

XIA Yuzheng, Email: xyz6262@126.com

Keywords：

curcumin; α-isobutyl cyanoacrylate; drug-loaded microspheres; drug release

DOI：

10.7507/1001-5515.201701045

Video：

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Abstract Full text Figures/Tables Video References Cited by

Curcumin-loaded poly (α-isobutyl cyanoacrylate) microspheres (Cur-HP-β-CD-PiBCA) were prepared by one-step emulsification with α-isobutyl cyanoacrylate as materials, poloxamer 188 as emulsifier, and curcumin complex with hydroxypropyl-β-cyclodextrin (Cur-HP-β-CD) as drug prepared by kneading method. Effects of emulsifier and drug concentration on microspheres size and distribution, drug loading and encapsulation efficiency were investigated in detail. And the curcumin release of drug-loaded microspheres was also studied. Results showed that as the emulsifier concentration increased from 0.01% to 0.07%, particle size of the drug-loaded microspheres decreased while particle size distribution, drug loading and entrapment efficiency increased. The optimized concentration of surfactant was 0.05%. With increasing the concentration of drug from 0.03% to 0.07%, drug loading of Cur-HP-β-CD-PiBCA increased, but encapsulation efficiency decreased. Additionally, the results of drug release experiments revealed that the higher drug loading of Cur-HP-β-CD-PiBCA was, the lower cumulative release percentage was. Drug-loading of cumulative inclusions in HP-β-CD by PiBCA can improve its wettability, and increase the degree of dissolution and bioavailability.

Citation： SHI Shuxian, LI Qingzhao, CHEN Xiaonong, XIA Yuzheng. Preparation and drug release of curcumin-loaded poly (α-isobutyl cyanoacrylate) microspheres. Journal of Biomedical Engineering, 2018, 35(5): 749-753. doi: 10.7507/1001-5515.201701045 Copy

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1. 林琳, 王平, 尹如铁, 等. 姜黄素抗肿瘤机制研究进展. 华西医学, 2009, 24(5): 1320-1322.
2. 韩刚, 霍文, 李秋影. 姜黄素的稳定性研究. 中成药, 2007, 29(2): 291-293.
3. 杨鹏波, 张华. 脂质体的研究新进展. 浙江中医药大学学报, 2013, 37(7): 936-939.
4. 张盛伟, 李湘洲, 李文生, 等. 姜黄素纳米混悬剂的制备及其表征. 林产化学与工业, 2016, 36(2): 109-114.
5. Liu Jieying, Chen Siyuan, Lv Li, et al. Recent progress in studying curcumin and its nano-preparations for cancer therapy. Curr Pharm Des, 2013, 19(11): 1974-1993.
6. Duan Jinghua, Zhang Yangde, Han Shiwei, et al. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm, 2010, 400(1/2): 211-220.
7. Mulik R, Mahadik K, Paradkar A. Development of curcuminoids loaded poly(butyl) cyanoacrylate nanoparticles: Physicochemical characterization and stability study. Eur J Pharm Sci, 2009, 37(3/4): 395-404.
8. Hani U, Shivakumar H G, Srivastava A, et al. Design and optimization of curcumin-HPβCD bioadhesive vaginal tablets by 2³ factorial design: in vitro and in vivo evaluation. J Pharm Innov, 2015, 10(1): 21-35.
9. Doppalapudi S, Jain A, Khan W, et al. Biodegradable polymers—an overview. Polym Adv Technol, 2014, 25(5, SI): 427-435.
10. Ćurić A, Keller B L, Reul R A, et al. Development and lyophilization of itraconazole loaded poly(butyl cyanoacrylate) nanospheres as a drug delivery system. Eur J Pharm Sci, 2015, 78(14): 121-131.
11. Tian Xinhua, Lin Xiaoning, Wei Feng, et al. Enhanced brain targeting of temozolomide in polysorbate-80 coated polybutylcyanoacrylate nanoparticles. Int J Nanomedicine, 2011, 6(6): 445-452.
12. 张强, 廖工铁. 硫酸庆大霉素聚氰基丙烯酸正丁酯毫微球制备工艺研究. 中国药学杂志, 1996, 31(1): 24-27.
13. Maskarinec S A, Hannig J, Lee R C, et al. Direct observation of poloxamer 188 insertion into lipid monolayers. Biophys J, 2002, 82(3): 1453-1459.
14. Mitra A, Lin Senshang. Effect of surfactant on fabrication and characterization of paclitaxel-loaded polybutylcyanoacrylate nanoparticulate delivery systems. J Pharm Pharmacol, 2003, 55(7): 895-902.
15. Illum L, Khan M, Mak E. Evaluation of carrier capacity and release characteristics for poly(butyl 2-cyanoacrylate) nanoparticles. Int J Pharm, 1986, 30(1): 17-28.

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