Research on mental fatigue information transmission integration mechanism based on theta-gamma phase amplitude coupling_Journal of Biomedical Engineering

Authors：

YANG Shuo ^1,2 , JI Yakun ^1,2 , LI Runze ^1,2 ,  WANG Lei ^1,2 , XU Guizhi ^1,2

1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, P.R.China;
2. Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, P.R.China;

Corresponding author：

WANG Lei, Email: murhythm@qq.com

Keywords：

mental fatigue; phase amplitude coupling; electroencephalogram

DOI：

10.7507/1001-5515.201703067

Video：

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Mental fatigue is a subjective fatigue state caused by long-term brain activity, which is the core of health problems among brainworkers. However, its influence on the process of brain information transmission integration is not clear. In this paper, phase amplitude coupling (PAC) between theta and gamma rhythm was used to study the electroencephalogram (EEG) data recorded before and after mental fatigue, so as to explain the effect of mental fatigue on brain information transmission mechanism. The experiment used a 4-hour professional English reading to induce brain fatigue. EEG signals of 14 male undergraduate volunteers before and after mental fatigue were recorded by Neuroscan EEG system. Phase amplitude coupling value was calculated and analyzed. t test was used to compare the results between two states. The results showed that theta phase of more than 90% of the electrodes in the whole brain area jointly modulated gamma amplitude of the right central area and the right parietal area, and the coupling effect among different brain regions significantly decreased (P < 0.05) when participants had felt mental fatigue. This paper shows that phase amplitude coupling can explain the influence of mental fatigue on information transmission mechanism. It could be an important indicator for mental fatigue detection. On the other hand, the results also provide a new measure to evaluate the effect of neuromodulation in relieving mental fatigue.

Citation： YANG Shuo, JI Yakun, LI Runze, WANG Lei, XU Guizhi. Research on mental fatigue information transmission integration mechanism based on theta-gamma phase amplitude coupling. Journal of Biomedical Engineering, 2018, 35(5): 672-678. doi: 10.7507/1001-5515.201703067 Copy

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11.	Holz E M, Glennon M, Prendergast K, et al. Theta-gamma phase synchronization during memory matching in visual working memory. Neuroimage, 2010, 52(1): 326-335.
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13.	Belluscio M A, Mizuseki K, Schmidt R A, et al. Cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus. J Neurosci, 2012, 32(2): 423-435.
14.	Tort A B, Kramer M A, Thorn C, et al. Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task. Proc Natl Acad Sci U S A, 2008, 105(51): 20517-20522.
15.	Pahor A, Jaušovec N. Theta–gamma cross-frequency coupling relates to the level of human intelligence. Intelligence, 2014, 46: 283-290.
16.	Foster B L, Parvizi J. Resting oscillations and cross-frequency coupling in the human posteromedial cortex. Neuroimage, 2012, 60(1): 384-391.
17.	Axmacher N, Henseler M M, Jensen O, et al. Cross-frequency coupling supports multi-item working memory in the human hippocampus. Proc Natl Acad Sci U S A, 2010, 107(7): 3228-3233.
18.	Cohen M X, Elger C E, Fell J. Oscillatory activity and phase-amplitude coupling in the human medial frontal cortex during decision making. J Cogn Neurosci, 2009, 21(2): 390-402.
19.	Canolty R T, Knight R T. The functional role of cross-frequency coupling. Trends Cogn Sci, 2010, 14(11): 506-515.
20.	Kendrick K M, Zhan Yang, Fischer H, et al. Learning alters theta amplitude, theta-gamma coupling and neuronal synchronization in inferotemporal cortex. BMC Neurosci, 2011, 12(1): 55-78.
21.	李群, 程宁, 张涛. 基于神经网络的振荡模式分析及其应用. 生理学报, 2015, (2): 143-154.
22.	Mormann F, Fell J, Axmacher N, et al. Phase/amplitude reset and theta-gamma interaction in the human medial temporal lobe during a continuous word recognition memory task. Hippocampus, 2005, 15(7): 890-900.
23.	Tort A B, Komorowski R W, Manns J R, et al. Theta-gamma coupling increases during the learning of item-context associations. Proc Natl Acad Sci U S A, 2009, 106(49): 20942-20947.
24.	van der Linden D, Frese M, Meijman T F. Mental fatigue and the control of cognitive processes: effects on perseveration and planning. Acta Psychol (Amst), 2003, 113(1): 45-65.
25.	杨博. 长时间持续警戒任务下脑力疲劳对前注意和注意加工能力影响的ERP研究. 西安: 第四军医大学, 2013.
26.	Antonakakis M, Dimitriadis S I, Zervakis M, et al. Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury. Int J Psychophysiol, 2016, 102: 1-11.
27.	Sun Y, Giacobbe P, Tang C W, et al. Deep brain stimulation modulates gamma oscillations and theta-gamma coupling in treatment resistant depression. Brain Stimul, 2015, 8(6): 1033-1042.

1. Boksem M A S, Tops M. Mental fatigue: Costs and benefits. Brain Res Rev, 2008, 59(1): 125-139.
2. Boksem M A S, Meijman T F, Lorist M M. Effects of mental fatigue on attention: An ERP study. Cogn Brain Res, 2005, 25(1): 107-116.
3. Boksem M A S, Kostermans E, Tops M, et al. Individual differences in asymmetric resting-state frontal cortical activity modulate ERPs and performance in a global-local attention task. J Psychophysiol, 2012, 26(2): 51-62.
4. 张崇, 郑崇勋, 裴晓梅, 等. 生理性精神疲劳的多参数脑电功率谱分析. 生物医学工程学杂志, 2009, 26(1): 162-166, 172.
5. Jirsa V, Müller V. Cross-frequency coupling in real and virtual brain networks. Front Comput Neurosci, 2013, 7(78): 78-103.
6. Liu Jianping, Zhang Chong, Zheng Chongxun. EEG-based estimation of mental fatigue by using KPCA-HMM and complexity parameters. Biomed Signal Process Control, 2010, 5(2): 124-130.
7. Käthner I, Wriessnegger S C, Müller-Putz G R, et al. Effects of mental workload and fatigue on the P300, alpha and theta band power during operation of an ERP (P300) brain-computer interface. Biol Psychol, 2014, 102(5): 118-129.
8. 程宁, 徐霞霞, 李群, 等. 神经振荡交叉节律耦合的生理学意义及在神经工程基础研究中的应用. 纳米技术与精密工程, 2015, 13(5): 324-332.
9. Saleh M, Reimer J, Penn R, et al. Fast and slow oscillations in human primary motor cortex predict oncoming behaviorally relevant cues. Neuron, 2010, 65(4): 461-471.
10. Besle J, Lakatos P, Schevon C A, et al. Entrainment of neuronal oscillations as a mechanism of attentional selection. Science, 2008, 320(5872): 110-113.
11. Holz E M, Glennon M, Prendergast K, et al. Theta-gamma phase synchronization during memory matching in visual working memory. Neuroimage, 2010, 52(1): 326-335.
12. Lisman J E, Jensen O. The theta-gamma neural code. Neuron, 2013, 77(6): 1002-1016.
13. Belluscio M A, Mizuseki K, Schmidt R A, et al. Cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus. J Neurosci, 2012, 32(2): 423-435.
14. Tort A B, Kramer M A, Thorn C, et al. Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task. Proc Natl Acad Sci U S A, 2008, 105(51): 20517-20522.
15. Pahor A, Jaušovec N. Theta–gamma cross-frequency coupling relates to the level of human intelligence. Intelligence, 2014, 46: 283-290.
16. Foster B L, Parvizi J. Resting oscillations and cross-frequency coupling in the human posteromedial cortex. Neuroimage, 2012, 60(1): 384-391.
17. Axmacher N, Henseler M M, Jensen O, et al. Cross-frequency coupling supports multi-item working memory in the human hippocampus. Proc Natl Acad Sci U S A, 2010, 107(7): 3228-3233.
18. Cohen M X, Elger C E, Fell J. Oscillatory activity and phase-amplitude coupling in the human medial frontal cortex during decision making. J Cogn Neurosci, 2009, 21(2): 390-402.
19. Canolty R T, Knight R T. The functional role of cross-frequency coupling. Trends Cogn Sci, 2010, 14(11): 506-515.
20. Kendrick K M, Zhan Yang, Fischer H, et al. Learning alters theta amplitude, theta-gamma coupling and neuronal synchronization in inferotemporal cortex. BMC Neurosci, 2011, 12(1): 55-78.
21. 李群, 程宁, 张涛. 基于神经网络的振荡模式分析及其应用. 生理学报, 2015, (2): 143-154.
22. Mormann F, Fell J, Axmacher N, et al. Phase/amplitude reset and theta-gamma interaction in the human medial temporal lobe during a continuous word recognition memory task. Hippocampus, 2005, 15(7): 890-900.
23. Tort A B, Komorowski R W, Manns J R, et al. Theta-gamma coupling increases during the learning of item-context associations. Proc Natl Acad Sci U S A, 2009, 106(49): 20942-20947.
24. van der Linden D, Frese M, Meijman T F. Mental fatigue and the control of cognitive processes: effects on perseveration and planning. Acta Psychol (Amst), 2003, 113(1): 45-65.
25. 杨博. 长时间持续警戒任务下脑力疲劳对前注意和注意加工能力影响的ERP研究. 西安: 第四军医大学, 2013.
26. Antonakakis M, Dimitriadis S I, Zervakis M, et al. Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury. Int J Psychophysiol, 2016, 102: 1-11.
27. Sun Y, Giacobbe P, Tang C W, et al. Deep brain stimulation modulates gamma oscillations and theta-gamma coupling in treatment resistant depression. Brain Stimul, 2015, 8(6): 1033-1042.

Journal of Biomedical Engineering

Research on mental fatigue information transmission integration mechanism based on theta-gamma phase amplitude coupling

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