Study on the application of aptamers in the screening of tumor serum markers_Journal of Biomedical Engineering

Authors：

MA Shuling ,  ZENG Jiayu

College of Life Science, Northwest Normal University, Lanzhou 730070, P.R.China;

Corresponding author：

Keywords：

aptamer; tumor serum biomarker; tumor diagnosis

DOI：

10.7507/1001-5515.201710026

Video：

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The nucleic acid adapters of tumor serum markers are oligonucleotide molecules with high specificity and high affinity with tumor serum markers obtained by in vitro screening with systematic evolution of ligands by exponential enrichment (SELEX). Researchers take the advantage of the nucleic acid adapter to explore new tumor serum markers that have more diagnostic value for tumor diagnosis. Recently, some achievements have been achieved in the research of liver cancer and stomach cancer. This paper has reviewed nucleic acid adapter and its research in the serum tumor marker screening, and discussed the value of the nucleic acid adapter of serum tumor markers in the diagnosis, as well as current problems existing in the research. This paper is very useful to help people better understand the screening of nucleic acid adapters of tumor serum markers, and to provide help in discovering new tumor serum markers.

Citation： MA Shuling, ZENG Jiayu. Study on the application of aptamers in the screening of tumor serum markers. Journal of Biomedical Engineering, 2018, 35(2): 320-323. doi: 10.7507/1001-5515.201710026 Copy

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11.	陈弘炜, 王开宇, 兰小鹏. 金黄色葡萄球菌毒性休克综合征毒素1核酸适配体的筛选. 生物技术通讯, 2016, 27(1): 86-89.
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15.	Gobin R, Bogard D, Chauvin N, et al. International fusion materials irradiation facility injector acceptance tests at CEA/Saclay: 140 mA/100 keV deuteron beam characterization. Review of Scientific Instruments, 2015, 85(2):02A918.
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20.	葸玉琴, 赵运旺, 李东东, 等. 胃癌血清适配体的筛选及其鉴定. 南京医科大学学报:自然科学版, 2016, 36(11): 1306-1312.
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23.	万波. 癌胚抗原特异性单克隆抗体核酸适配体的筛选. 兰州: 西北师范大学, 2015.
24.	Gold L, Ayers D, Bertino J, et al. Aptamer-Based multiplexed proteomic technology for biomarker discovery. PLoS One, 2010, 5(12): 15004.
25.	Ostroff R M, Bigbee W L, Franklin W, et al. Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. PLoS One, 2010, 5(12): 15003.

1. Fitzmaurice C, Allen C, Barber R M, et al. Global, regional, and National cancer incidence, mortality, years of Life lost, years lived with disability, and Disability-Adjusted life-years for 32 cancer groups, 1990 to 2015 a systematic analysis for the global burden of disease study. JAMA Oncology, 2017, 3(4): 524-548.
2. Chen Wanqing, Zheng Rongshou, Baade P D, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2): 115-132.
3. 李林海. 常见肿瘤标志物的临床应用及进展. 中华检验医学杂志, 2016, 39(12): 995-998.
4. 张永, 李晓勇, 宋瑜, 等. 优化肿瘤标志物群建立的决策树模型对肝癌辅助诊断的价值. 郑州大学学报: 医学版, 2015, 50(6): 794-797.
5. Alsalloom A A. An update of biochemical markers of hepatocellular carcinoma. Int J Health Sci (Qassim), 2016, 10(1): 121-136.
6. Veli C Q, Gulay B, Zehra E, et al. Pathogen detection in complex samples by quartz crystal microbalance sensor coupled to aptamer functionalized core-shell type magnetic separation. Anal Chim Acta, 2015, 853(3): 533-540.
7. Zhao Bianjun, Wu Ping, Zhang Hui, et al. Designing activatable aptamer probes for simultaneous detection of multiple tumor-related proteins in living cancer cells. Biosens Bioelectron, 2015, 68(2): 763-770.
8. 靳贵晓, 李娟, 杨黄浩. 核酸适体的筛选及其在生物医学领域的研究进展. 福州大学学报, 2016, 44(6):919-935.
9. 杨歌, 魏强, 赵新颖, 等. 蛋白质的核酸适配体筛选的研究进展. 色谱, 2016, 34(4): 370-381.
10. 曾家豫, 万波, 马瑾, 等. 癌胚抗原特异性单克隆抗体(Anti-CEA)核酸适配体的筛选. 南京医科大学学报: 自然科学版, 2015, 35(6): 782-786.
11. 陈弘炜, 王开宇, 兰小鹏. 金黄色葡萄球菌毒性休克综合征毒素1核酸适配体的筛选. 生物技术通讯, 2016, 27(1): 86-89.
12. Chen Ye, Gao Shegan, Chen Jianmin, et al. Serum CA242, CA199, CA125, CEA, and TSGF are biomarkers for the efficacy and prognosis of cryoablation in pancreatic cancer patients. Cell Biochem Biophys, 2015, 71(3): 1287-1291.
13. Chen B, Wu G R, Yang W Y, et al. Diagnostic value of HE4 CYFRA21-1 in combination with and TPS for early diagnosis of non-small cell lung cancer. Journal of Practical Medicine, 2016, 22(1): 734-736.
14. Chen L. Analysis on the value of combined detection of CYFRA21-1, NSE, CEA, CA125 in lung carcinoma. International Journal of Laboratory Medicine, 2016, 37(8): 1057-1059.
15. Gobin R, Bogard D, Chauvin N, et al. International fusion materials irradiation facility injector acceptance tests at CEA/Saclay: 140 mA/100 keV deuteron beam characterization. Review of Scientific Instruments, 2015, 85(2):02A918.
16. Coleman C. Early detection and screening for breast cancer. Semin Oncol Nurs, 2017, 33(2): 141-155.
17. Berezovski M V, Lechmann M, Musheev M U, et al. Aptamer-facilitated biomarker discovery (AptaBiD). J Am Chem Soc, 2008, 130(28): 9137-9143.
18. 陈文学. 肝癌血清核酸适配体的筛选及其鉴定. 南昌: 南昌大学, 2011.
19. 张洪丽. 胃癌血清适配子对胃癌诊断价值的研究. 南昌: 南昌大学, 2015.
20. 葸玉琴, 赵运旺, 李东东, 等. 胃癌血清适配体的筛选及其鉴定. 南京医科大学学报:自然科学版, 2016, 36(11): 1306-1312.
21. Mi Jing, Liu Yingmiao, Rabbani Z N, et al. In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol, 2010, 6(1): 22-24.
22. 方念. AFP-L3核酸适配子的筛选鉴定及其对肝细胞癌诊断价值的初步研究. 南昌: 南昌大学, 2008.
23. 万波. 癌胚抗原特异性单克隆抗体核酸适配体的筛选. 兰州: 西北师范大学, 2015.
24. Gold L, Ayers D, Bertino J, et al. Aptamer-Based multiplexed proteomic technology for biomarker discovery. PLoS One, 2010, 5(12): 15004.
25. Ostroff R M, Bigbee W L, Franklin W, et al. Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer. PLoS One, 2010, 5(12): 15003.

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