Research progress of three-dimensional printing technology in liver surgery and hepatotoxicity evaluation_Journal of Biomedical Engineering

Authors：

YAO Feng ,  LIN Rong

Department of Pharmacology, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, P.R.China;

Corresponding author：

Keywords：

three-dimensional printing; liver transplantation; hepatotoxicity; drug metabolism

DOI：

10.7507/1001-5515.201710074

Video：

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Three-dimensional (3D) printing, an emerging rapid prototyping technology, has been widely used in biomedical field. 3D printing was originally used to construct the visualization models and molds in medicine. With the development of 3D printing in biomedical field, the technology was gradually applied in complex tissue regeneration and organ reconstruction. Artificial tissues and organs obtained by 3D printing are expected to be used for organ transplantation, new drug development and drug toxicity evaluation in the field of medicine and health care research. This paper describes the individualized application of 3D printing technology in liver surgery and introduces the research progress of 3D bioprinting technology in liver transplantation, drug metabolism and hepatotoxicity evaluation, and prospects its future development trend to provide a reference for further study.

Citation： YAO Feng, LIN Rong. Research progress of three-dimensional printing technology in liver surgery and hepatotoxicity evaluation. Journal of Biomedical Engineering, 2018, 35(4): 656-660. doi: 10.7507/1001-5515.201710074 Copy

1.	Alkhouri N, Zein N N. Three-dimensional printing and pediatric liver disease. Curr Opin Pediatr, 2016, 28(5): 626-630.
2.	Lee S Y, Kim H J, Choi D. Cell sources, liver support systems and liver tissue engineering: alternatives to liver transplantation. International journal of stem cells, 2015, 8(1): 36-47.
3.	Soon D S, Chae M P, Pilgrim C H, et al. 3D haptic modelling for preoperative planning of hepatic resection: a systematic review. Ann Med Surg, 2016, 10: 1-7.
4.	Igami T, Nakamura Y, Hirose T, et al. Application of a three-dimensional print of a liver in hepatectomy for small tumors invisible by intraoperative ultrasonography: preliminary experience. World J Surg, 2014, 38(12): 3163-3166.
5.	Xiang Nan, Fang Chihua, Fan Yingfang, et al. Application of liver three-dimensional printing in hepatectomy for complex massive hepatocarcinoma with rare variations of portal vein: preliminary experience. Int J Clin Exp Med, 2015, 8(10): 18873-18878.
6.	Oshiro Y, Ohkohchi N. Three-dimensional liver surgery simulation: computer-assisted surgical planning with three-dimensional simulation software and three-dimensional printing. Tissue Eng Part A, 2017, 23(11/12): 474-480.
7.	Witowski J S, Pędziwiatr M, Major P, et al. Cost-effective, personalized, 3D-printed liver model for preoperative planning before laparoscopic liver hemihepatectomy for colorectal cancer metastases. Int J Comput Assist Radiol Surg,, 2017: 1-8.
8.	Choi Y R, Kim J H, Park S J, et al. Therapeutic response assessment using 3D ultrasound for hepatic metastasis from colorectal cancer: application of a personalized, 3D-printed tumor model using CT images. PLoS One, 2017, 12(8): 11-13.
9.	Javan R, Zeman M N. A prototype educational model for hepatobiliary interventions: unveiling the role of graphic designers in medical 3D printing. J Digit Imaging, 2018, 31(1): 133-143.
10.	Javan R, Herrin D, Tangestanipoor A. Understanding spatially complex segmental and branch anatomy using 3D printing: liver, lung, prostate, coronary arteries, and circle of willis. Acad Radiol, 2016, 23(9): 1183-1189.
11.	Jones D B, Sung R, Weinberg C, et al. Three-dimensional modeling may improve surgical education and clinical practice. Surg Innov, 2016, 23(2): 189-195.
12.	Huang Hongyun, Oizumi S, Kojima N, et al. Avidin-biotin binding-based cell seeding and perfusion culture of liver-derived cells in a porous scaffold with a three-dimensional interconnected flow-channel network. Biomaterials, 2007, 28(26): 3815-3823.
13.	Zhong Cheng, Xie Haiyang, Zhou Lin, et al. Human hepatocytes loaded in 3D bioprinting generate mini-liver. Hepatobiliary Pancreatic Diseases International, 2016, 15(5): 512-518.
14.	Wang X H, Yan Y N, Pan Y Q, et al. Generation of three-dimensional hepatocyte/gelatin structures with rapid prototyping system. Tissue Eng, 2006, 12(1): 83-90.
15.	Kang K, Kim Y, Lee S B, et al. Three-dimensional bio-printing of hepatic structures with direct-converted hepatocyte-like cells. Tissue Eng Part A, 2018, 24(7/8): 576-583.
16.	Zein N N, Hanouneh I A, Bishop P D, et al. Three-dimensional print of a liver for preoperative planning in living donor liver transplantation. Liver Transplantation, 2013, 19(12): 1304-1310.
17.	Soejima Y, Taguchi T, Sugimoto M, et al. Three-dimensional printing and bio-texture modeling for preoperative simulation in living donor liver transplantation for small infants. Liver Transpl, 2016, 22(11): 1610-1614.
18.	Nguyen D G, Funk J, Robbins J B, et al. Bioprinted 3D primary liver tissues allow assessment of Organ-Level response to clinical drug induced toxicity in vitro. PLoS One, 2016, 11(7): e0158674.
19.	Jeon H, Kang K, Park S A, et al. Generation of multilayered 3D structures of HepG2 cells using a bio-printing technique. Gut Liver, 2017, 11(1): 121-128.
20.	Bhise N S, Manoharan V, Massa S, et al. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication, 2016, 8(1): 014101.
21.	Kim Y, Kang K, Yoon S, et al. Prolongation of liver-specific function for primary hepatocytes maintenance in 3D printed architectures, 2018: 1-12.
22.	Kizawa H, Nagao E, Shimamura M, et al. Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery. Biochem Biophys Rep, 2017, 10: 186-191.
23.	Ma Xuanyi, Qu Xin, Zhu Wei, et al. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A, 2016, 113(8): 2206-2211.
24.	Rhiannon N H, Deborah G N, Justin R, et al. Functional characterization of 3D human liver tissues generated by an automated bioprinting platform. Faseb Journal, 2015, 29: LB424.
25.	Snyder J E, Hamid Q, Wang C, et al. Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip. Biofabrication, 2011, 3(3, SI): 34112-34120.

1. Alkhouri N, Zein N N. Three-dimensional printing and pediatric liver disease. Curr Opin Pediatr, 2016, 28(5): 626-630.
2. Lee S Y, Kim H J, Choi D. Cell sources, liver support systems and liver tissue engineering: alternatives to liver transplantation. International journal of stem cells, 2015, 8(1): 36-47.
3. Soon D S, Chae M P, Pilgrim C H, et al. 3D haptic modelling for preoperative planning of hepatic resection: a systematic review. Ann Med Surg, 2016, 10: 1-7.
4. Igami T, Nakamura Y, Hirose T, et al. Application of a three-dimensional print of a liver in hepatectomy for small tumors invisible by intraoperative ultrasonography: preliminary experience. World J Surg, 2014, 38(12): 3163-3166.
5. Xiang Nan, Fang Chihua, Fan Yingfang, et al. Application of liver three-dimensional printing in hepatectomy for complex massive hepatocarcinoma with rare variations of portal vein: preliminary experience. Int J Clin Exp Med, 2015, 8(10): 18873-18878.
6. Oshiro Y, Ohkohchi N. Three-dimensional liver surgery simulation: computer-assisted surgical planning with three-dimensional simulation software and three-dimensional printing. Tissue Eng Part A, 2017, 23(11/12): 474-480.
7. Witowski J S, Pędziwiatr M, Major P, et al. Cost-effective, personalized, 3D-printed liver model for preoperative planning before laparoscopic liver hemihepatectomy for colorectal cancer metastases. Int J Comput Assist Radiol Surg,, 2017: 1-8.
8. Choi Y R, Kim J H, Park S J, et al. Therapeutic response assessment using 3D ultrasound for hepatic metastasis from colorectal cancer: application of a personalized, 3D-printed tumor model using CT images. PLoS One, 2017, 12(8): 11-13.
9. Javan R, Zeman M N. A prototype educational model for hepatobiliary interventions: unveiling the role of graphic designers in medical 3D printing. J Digit Imaging, 2018, 31(1): 133-143.
10. Javan R, Herrin D, Tangestanipoor A. Understanding spatially complex segmental and branch anatomy using 3D printing: liver, lung, prostate, coronary arteries, and circle of willis. Acad Radiol, 2016, 23(9): 1183-1189.
11. Jones D B, Sung R, Weinberg C, et al. Three-dimensional modeling may improve surgical education and clinical practice. Surg Innov, 2016, 23(2): 189-195.
12. Huang Hongyun, Oizumi S, Kojima N, et al. Avidin-biotin binding-based cell seeding and perfusion culture of liver-derived cells in a porous scaffold with a three-dimensional interconnected flow-channel network. Biomaterials, 2007, 28(26): 3815-3823.
13. Zhong Cheng, Xie Haiyang, Zhou Lin, et al. Human hepatocytes loaded in 3D bioprinting generate mini-liver. Hepatobiliary Pancreatic Diseases International, 2016, 15(5): 512-518.
14. Wang X H, Yan Y N, Pan Y Q, et al. Generation of three-dimensional hepatocyte/gelatin structures with rapid prototyping system. Tissue Eng, 2006, 12(1): 83-90.
15. Kang K, Kim Y, Lee S B, et al. Three-dimensional bio-printing of hepatic structures with direct-converted hepatocyte-like cells. Tissue Eng Part A, 2018, 24(7/8): 576-583.
16. Zein N N, Hanouneh I A, Bishop P D, et al. Three-dimensional print of a liver for preoperative planning in living donor liver transplantation. Liver Transplantation, 2013, 19(12): 1304-1310.
17. Soejima Y, Taguchi T, Sugimoto M, et al. Three-dimensional printing and bio-texture modeling for preoperative simulation in living donor liver transplantation for small infants. Liver Transpl, 2016, 22(11): 1610-1614.
18. Nguyen D G, Funk J, Robbins J B, et al. Bioprinted 3D primary liver tissues allow assessment of Organ-Level response to clinical drug induced toxicity in vitro. PLoS One, 2016, 11(7): e0158674.
19. Jeon H, Kang K, Park S A, et al. Generation of multilayered 3D structures of HepG2 cells using a bio-printing technique. Gut Liver, 2017, 11(1): 121-128.
20. Bhise N S, Manoharan V, Massa S, et al. A liver-on-a-chip platform with bioprinted hepatic spheroids. Biofabrication, 2016, 8(1): 014101.
21. Kim Y, Kang K, Yoon S, et al. Prolongation of liver-specific function for primary hepatocytes maintenance in 3D printed architectures, 2018: 1-12.
22. Kizawa H, Nagao E, Shimamura M, et al. Scaffold-free 3D bio-printed human liver tissue stably maintains metabolic functions useful for drug discovery. Biochem Biophys Rep, 2017, 10: 186-191.
23. Ma Xuanyi, Qu Xin, Zhu Wei, et al. Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting. Proc Natl Acad Sci U S A, 2016, 113(8): 2206-2211.
24. Rhiannon N H, Deborah G N, Justin R, et al. Functional characterization of 3D human liver tissues generated by an automated bioprinting platform. Faseb Journal, 2015, 29: LB424.
25. Snyder J E, Hamid Q, Wang C, et al. Bioprinting cell-laden matrigel for radioprotection study of liver by pro-drug conversion in a dual-tissue microfluidic chip. Biofabrication, 2011, 3(3, SI): 34112-34120.

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