Numerical simulation of the focal region modulation to realize uniform temperature distribution during high-intensity focused ultrasound brain tumor therapy_Journal of Biomedical Engineering

Authors：

CHANG Shihui ¹ , WANG Peiguo ² ,  JIAN Xiqi ¹

1. School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin 30070, P.R.China;
2. Cancer Institute and Hospital of Tianjin Medical University, Tianjin 300060, P.R.China;

Corresponding author：

JIAN Xiqi, Email: jianxiqi@tmu.edu.cn

Keywords：

high-intensity focused ultrasound; uniform temperature distribution; focal region modulation

DOI：

10.7507/1001-5515.201802009

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

The temperature during the brain tumor therapy using high-intensity focused ultrasound (HIFU) should be controlled strictly. This research aimed at realizing uniform temperature distribution in the focal region by adjusting driving signals of phased array transducer. The three-dimensional simulation model imitating craniotomy HIFU brain tumor treatment was established based on an 82-element transducer and the computed tomography (CT) data of a volunteer's head was used to calculate and modulate the temperature distributions using the finite difference in time domain (FDTD) method. Two signals which focus at two preset targets with a certain distance were superimposed to emit each transducer element. Then the temperature distribution was modulated by changing the triggering time delay and amplitudes of the two signals. The results showed that when the distance between the two targets was within a certain range, a focal region with uniform temperature distribution could be created. And also the volume of focal region formed by one irradiation could be adjusted. The simulation results would provide theoretical method and reference for HIFU applying in clinical brain tumor treatment safely and effectively.

Citation： CHANG Shihui, WANG Peiguo, JIAN Xiqi. Numerical simulation of the focal region modulation to realize uniform temperature distribution during high-intensity focused ultrasound brain tumor therapy. Journal of Biomedical Engineering, 2018, 35(6): 877-886. doi: 10.7507/1001-5515.201802009 Copy

1.	Kennedy J E. High-intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer, 2005, 5(4): 321-327.
2.	Ter Haar G. Therapeutic applications of ultrasound. Prog Biophys Mol Biol, 2007, 93(1/3): 111-129.
3.	Mcdannold N, Clement G T, Black P, et al. Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery, 2010, 66(2): 323-332.
4.	Elias W J, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med, 2013, 369(7): 640-648.
5.	Chang W S, Jung H H, Kweon E J, et al. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes. J Neurol Neurosurg Psychiatry, 2015, 86(3): 257-264.
6.	Fry F J. Precision high intensity focusing ultrasonic machines for surgery. Am J Phys Med, 1958, 37(3): 152-156.
7.	Fry F J, Kossoff G, Eggleton R C, et al. Threshold ultrasonic dosages for structural changes in the mammalian brain. J Acoust Soc Am, 1970, 48(6b): 1413-1417.
8.	Ram Z, Cohen Z R, Harnof S, et al. Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy. Neurosurgery, 2006, 59(5): 949-955.
9.	Kohler M O, Mougenot C, Quesson B, et al. Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry. Med Phys, 2009, 36(8): 3521-3535.
10.	Partanen A, Tillander M, Yarmolenko P S, et al. Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR-guided high-intensity focused ultrasound mediated mild hyperthermia. Med Phys, 2013, 40(1): 013301.
11.	Zhou Yufeng. Generation of uniform lesions in high intensity focused ultrasound ablation. Ultrasonics, 2013, 53(2): 495-505.
12.	Lee K I, Sim I, Kang G S, et al. Numerical simulation of temperature elevation in soft tissue by high intensity focused ultrasound. Modern Physics Letters B, 2008, 22(11): 803-807.
13.	Westervelt P J. Parametric acoustic array. J Acoust Soc Am, 1963, 35(4): 535-537.
14.	Hallaj I M, Cleveland R O. FDTD simulation of finite-amplitude pressure and temperature fields for biomedical ultrasound. J Acoust Soc Am, 1999, 105(5): L7-L12.
15.	Pennes H H. Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol, 1948, 1(2): 93-122.
16.	Sapareto S A, Dewey W C. Thermal dose determination in cancer-therapy. Int J Radiat Oncol Biol Phys, 1984, 10(6): 787-800.
17.	Ding Xin, Wang Yizhe, Zhang Qian, et al. Modulation of transcranial focusing thermal deposition in nonlinear HIFU brain surgery by numerical simulation. Phys Med Biol, 2015, 60(10): 3975-3998.
18.	Pinton G, Aubry J F, Fink M, et al. Effects of nonlinear ultrasound propagation on high intensity brain therapy. Med Phys, 2011, 38(3): 1207-1216.
19.	Aubry J F, Tanter M, Pernot M, et al. Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans. J Acoust Soc Am, 2003, 113(1): 84-93.
20.	Pernot M, Aubry J F, Tanter M, et al. Prediction of the skull overheating during high intensity focused ultrasound transcranial brain therapy//Ultrasonics Symposium, Montreal: IEEE, 2004(2): 1005-1008.
21.	Ghanouni P, Dobrotwir A, Bazzocchi A A, et al. Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol, 2017, 27(2): 732-740.
22.	Zhang Yanrong, Aubry J F, Zhang Junfeng, et al. Defining the optimal age for focal lesioning in a rat model of transcranial HIFU. Ultrasound in Medicine and Biology, 2015, 41(2): 449-455.
23.	Fan X B, Hynynen K. Ultrasound surgery using multiple sonications-treatment time considerations. Ultrasound in Medicine and Biology, 1996, 22(4): 471-482.
24.	陶敏慧. HIFU经颅脑肿瘤治疗焦域的数值仿真研究. 天津: 天津医科大学, 2016.

1. Kennedy J E. High-intensity focused ultrasound in the treatment of solid tumours. Nat Rev Cancer, 2005, 5(4): 321-327.
2. Ter Haar G. Therapeutic applications of ultrasound. Prog Biophys Mol Biol, 2007, 93(1/3): 111-129.
3. Mcdannold N, Clement G T, Black P, et al. Transcranial magnetic resonance imaging-guided focused ultrasound surgery of brain tumors: initial findings in 3 patients. Neurosurgery, 2010, 66(2): 323-332.
4. Elias W J, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med, 2013, 369(7): 640-648.
5. Chang W S, Jung H H, Kweon E J, et al. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes. J Neurol Neurosurg Psychiatry, 2015, 86(3): 257-264.
6. Fry F J. Precision high intensity focusing ultrasonic machines for surgery. Am J Phys Med, 1958, 37(3): 152-156.
7. Fry F J, Kossoff G, Eggleton R C, et al. Threshold ultrasonic dosages for structural changes in the mammalian brain. J Acoust Soc Am, 1970, 48(6b): 1413-1417.
8. Ram Z, Cohen Z R, Harnof S, et al. Magnetic resonance imaging-guided, high-intensity focused ultrasound for brain tumor therapy. Neurosurgery, 2006, 59(5): 949-955.
9. Kohler M O, Mougenot C, Quesson B, et al. Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry. Med Phys, 2009, 36(8): 3521-3535.
10. Partanen A, Tillander M, Yarmolenko P S, et al. Reduction of peak acoustic pressure and shaping of heated region by use of multifoci sonications in MR-guided high-intensity focused ultrasound mediated mild hyperthermia. Med Phys, 2013, 40(1): 013301.
11. Zhou Yufeng. Generation of uniform lesions in high intensity focused ultrasound ablation. Ultrasonics, 2013, 53(2): 495-505.
12. Lee K I, Sim I, Kang G S, et al. Numerical simulation of temperature elevation in soft tissue by high intensity focused ultrasound. Modern Physics Letters B, 2008, 22(11): 803-807.
13. Westervelt P J. Parametric acoustic array. J Acoust Soc Am, 1963, 35(4): 535-537.
14. Hallaj I M, Cleveland R O. FDTD simulation of finite-amplitude pressure and temperature fields for biomedical ultrasound. J Acoust Soc Am, 1999, 105(5): L7-L12.
15. Pennes H H. Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol, 1948, 1(2): 93-122.
16. Sapareto S A, Dewey W C. Thermal dose determination in cancer-therapy. Int J Radiat Oncol Biol Phys, 1984, 10(6): 787-800.
17. Ding Xin, Wang Yizhe, Zhang Qian, et al. Modulation of transcranial focusing thermal deposition in nonlinear HIFU brain surgery by numerical simulation. Phys Med Biol, 2015, 60(10): 3975-3998.
18. Pinton G, Aubry J F, Fink M, et al. Effects of nonlinear ultrasound propagation on high intensity brain therapy. Med Phys, 2011, 38(3): 1207-1216.
19. Aubry J F, Tanter M, Pernot M, et al. Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans. J Acoust Soc Am, 2003, 113(1): 84-93.
20. Pernot M, Aubry J F, Tanter M, et al. Prediction of the skull overheating during high intensity focused ultrasound transcranial brain therapy//Ultrasonics Symposium, Montreal: IEEE, 2004(2): 1005-1008.
21. Ghanouni P, Dobrotwir A, Bazzocchi A A, et al. Magnetic resonance-guided focused ultrasound treatment of extra-abdominal desmoid tumors: a retrospective multicenter study. Eur Radiol, 2017, 27(2): 732-740.
22. Zhang Yanrong, Aubry J F, Zhang Junfeng, et al. Defining the optimal age for focal lesioning in a rat model of transcranial HIFU. Ultrasound in Medicine and Biology, 2015, 41(2): 449-455.
23. Fan X B, Hynynen K. Ultrasound surgery using multiple sonications-treatment time considerations. Ultrasound in Medicine and Biology, 1996, 22(4): 471-482.
24. 陶敏慧. HIFU经颅脑肿瘤治疗焦域的数值仿真研究. 天津: 天津医科大学, 2016.

Journal of Biomedical Engineering

Numerical simulation of the focal region modulation to realize uniform temperature distribution during high-intensity focused ultrasound brain tumor therapy

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content