Numerical analysis of the influence of otitis media on the hearing compensation performance of round-window stimulation_Journal of Biomedical Engineering

Authors：

XUE Lin ¹ ,  LIU Houguang ¹ , WANG Zhihua ¹ , YANG Jianhua ¹ , YANG Shanguo ¹ , HUANG Xinsheng ² , ZHANG Hu ¹

1. School of Mechatronic Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, P.R.China;
2. Department of Otorhinolaryngology, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, P.R.China;

Corresponding author：

LIU Houguang, Email: liuhg@cumt.edu.cn

Keywords：

round-window stimulation; otitis media; tympanic membrane lesion; ossicular erosion; finite element analysis

DOI：

10.7507/1001-5515.201809056

Video：

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In order to study the influence of tympanic membrane lesion and ossicular erosion caused by otitis media on the hearing compensation performance of round-window stimulation, a human ear finite element model including cochlear asymmetric structure was established by computed tomography (CT) technique and reverse engineering technique. The reliability of the model was verified by comparing with the published experimental data. Based on this model, the tympanic membrane lesion and ossicular erosion caused by otitis media were simulated by changing the corresponding tissue structure. Besides, these simulated diseases’ effects on the round-window stimulation were studied by comparing the corresponding basilar-membrane’s displacement at the frequency-dependent characteristic position. The results show that the thickening and the hardening of the tympanic membrane mainly deteriorated the hearing compensation performance of round-window stimulation in the low frequency; tympanic membrane perforation and the minor erosion of ossicle with ossicular chain connected slightly effected the hearing compensation performance of round-window stimulation. Whereas, different from the influence of the aforementioned lesions, the ossicular erosion involving the ossicular chain detachment increased its influence on performance of round-window stimulation at the low frequency. Therefore, the effect of otitis media on the hearing compensation performance of round-window stimulation should be considered comprehensively when designing its actuator, especially the low-frequency deterioration caused by the thickening and the hardening of the tympanic membrane; the actuator’s low-frequency output should be enhanced accordingly to ensure its postoperative hearing compensation performance.

Citation： XUE Lin, LIU Houguang, WANG Zhihua, YANG Jianhua, YANG Shanguo, HUANG Xinsheng, ZHANG Hu. Numerical analysis of the influence of otitis media on the hearing compensation performance of round-window stimulation. Journal of Biomedical Engineering, 2019, 36(5): 745-754. doi: 10.7507/1001-5515.201809056 Copy

1.	Stevens G, Flaxman S, Brunskill E, et al. Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countries. Eur J Public Health, 2013, 23(1): 146-152.
2.	Moore B C J. Cochlear hearing loss: physiological, physiological and technical issues. 2nd ed. Chichester: John Wiley & Sons, 2007.
3.	Liu Houguang, Cheng Jinlei, Yang Jianhua, et al. Concept and evaluation of a new piezoelectric transducer for an implantable middle ear hearing device. Sensors, 2017, 17(11): E2515.
4.	Song Yulin, Jian J T, Chen Weizen, et al. The development of a non-surgical direct drive hearing device with a wireless actuator coupled to the tympanic membrane. Appl Acoust, 2013, 74(12): 1511-1518.
5.	Colletti L, Mandala M, Colletti V. Long-term outcome of round window Vibrant SoundBridge implantation in extensive ossicular chain defects. Otolaryngol Head Neck Surg, 2013, 149(1): 134-141.
6.	Colletti V, Soli S D, Carner M, et al. Treatment of mixed hearing losses via implantation of a vibratory transducer on the round window. Int J Audiol, 2006, 45(10): 600-608.
7.	Sprinzl G M, Wolf-Magele A, Schnabl J, et al. The active middle ear implant for the rehabilitation of sensorineural, mixed and conductive hearing losses. Laryngorhinootologie, 2011, 90(9): 560-569.
8.	Arnold A, Stieger C, Candreia C, et al. Factors improving the vibration transfer of the floating mass transducer at the round window. Otol Neurotol, 2010, 31(1): 122-128.
9.	Schraven S P, Hirt B, Goll E, et al. Conditions for highly efficient and reproducible round-window stimulation in humans. Audiol Neurootol, 2012, 17(2): 133-138.
10.	张虎, 刘后广, 赵禹, 等. 初始压力与支撑刚度对圆窗激振听力补偿影响的数值研究. 生物医学工程学杂志, 2018, 35(2): 191-197.
11.	刘迎曦, 李生, 孙秀珍. 人耳传声数值模型. 力学学报, 2008, 40(1): 107-113.
12.	姚文娟, 李武, 付黎杰, 等. 中耳结构数值模拟及传导振动分析. 系统仿真学报, 2009, 21(3): 651-654.
13.	Wang Xuelin, Wang Liling, Zhou Jianjun, et al. Finite element modelling of human auditory periphery including a feed-forward amplification of the cochlea. Comput Methods Biomech Biomed Engin, 2014, 17(10): 1096-1107.
14.	Zhou Lei, Feng Miaolin, Wang Wei, et al. Study on the role of ossicular joint using finite element method. J Mech Med Biol, 2016, 16(4): 1650041.
15.	Wysocki J. Dimensions of the human vestibular and tympanic scalae. Hear Res, 1999, 135(1/2): 39-46.
16.	Wever E G. Theory of hearing. New York: John Wiley & Sons, 1949.
17.	Tian J, Huang X, Rao Z, et al. Finite element analysis of the effcet of actuator coupling conditions on round window stimulation. J Mech Med Biol, 2015, 15(4): 1550048.
18.	Gentil F, Parente M, Martins P, et al. The influence of the mechanical behaviour of the middle ear ligaments: a finite element analysis. Proc Inst Mech Eng H, 2011, 225(1): 68-76.
19.	Homma K, Shimizu Y, Kim N, et al. Effects of ear-canal pressurization on middle-ear bone- and air-conduction responses. Hear Res, 2010, 263(1/2, SI): 204-215.
20.	刘后广. 新型人工中耳压电振子听力补偿的理论与实验研究. 上海: 上海交通大学, 2011.
21.	Liu Houguang, Xu Dan, Yang Jianhua, et al. Analysis of the influence of the transducer and its coupling layer on round window stimulation. Acta Bioeng Biomech, 2017, 19(2): 103-111.
22.	王学林, 胡于进. 蜗窗激励评价的有限元计算模型研究. 力学学报, 2012, 44(3): 622-630.
23.	王振龙, 王学林, 胡于进, 等. 基于中耳与耳蜗集成有限元模型的耳声传递模拟. 中国生物医学工程学报, 2011, 30(1): 60-66.
24.	王丹妮, 赵守琴, 李轶, 等. 先天性前庭窗闭锁的圆窗模式振动声桥植入(附9例报告). 临床耳鼻咽喉头颈外科杂志, 2017, 31(8): 588-591.
25.	Bornitz M, Hardtke H J, Zahnert T. Evaluation of implantable actuators by means of a middle ear simulation model. Hear Res, 2010, 263(1/2): 145-151.
26.	Gan R Z, Feng Bin, Sun Qunli. Three-dimensional finite element modeling of human ear for sound transmission. Ann Biomed Eng, 2004, 32(6): 847-859.
27.	Koike T, Wada H, Kobayashi T. Effect of depth of conical-shaped tympanic membrane on middle-ear sound transmission. JSME International Journal Series C, 2001, 44(4): 1097-1102.
28.	Lee C F, Chen J H, Chou Y F, et al. Optimal graft thickness for different sizes of tympanic membrane perforation in cartilage myringoplasty: A finite element analysis. Laryngoscope, 2007, 117(4): 725-730.
29.	Varshney S, Nangia A, Bist S S, et al. Ossicular chain status in chronic suppurative otitis media in adults. Indian J Otolaryngol Head Neck Surg, 2010, 62(4): 421-426.
30.	Mohammadi G, Naderpour M, Mousaviagdas M. Ossicular erosion in patients requiring surgery for cholesteatoma. Iran J otorhinolaryngol, 2012, 24(68): 125-128.
31.	Bekesy G V. Experiments in hearing. New York: McGraw-Hill, 1960.
32.	Kringlebotn M, Gundersen T, Krokstad A, et al. Noise-induced hearing losses. Can they be explained by basilar membrane movement? Acta Otolaryngol, 1979, 86(Suppl 360): 98-101.
33.	Gundersen T, Skarstein O, Sikkeland T. A study of the vibration of the basilar membrane in human temporal bone preparations by the use of the mossbauer effect. Acta Otolaryngol, 1978, 86(1/6): 225-232.
34.	Stenfelt S, Puria S, Hato N, et al. Basilar membrane and osseous spiral lamina motion in human cadavers with air and bone conduction stimuli. Hear Res, 2003, 181(1/2): 131-143.
35.	Aibara R, Welsh J T, Puria S, et al. Human middle-ear sound transfer function and cochlear input impedance. Hear Res, 2001, 152(1): 100-109.
36.	Puria S, Peake W T, Rosowski J J. Sound-pressure measurements in the cochlear vestibule of human-cadaver ears. J Acoust Soc Am, 1997, 101(5): 2754-2770.
37.	Merchant S N, Ravicz M E, Rosowski J J. Acoustic input impedance of the stapes and cochlea in human temporal bones. Hear Res, 1996, 97(1/2): 30-45.
38.	孙秀珍, 李生, 刘迎曦. 人耳鼓膜穿孔对中耳传声影响的数值模拟. 计算力学学报, 2010, 27(6): 1102-1106.
39.	Steele C R. Stiffness of Reissner’s membrane. J Acoust Soc Am, 1974, 56(4): 1252-1257.
40.	Holmes M H, Cole J D. Cochlear mechanics: analysis for a pure tone. J Acoust Soc Am, 1984, 76(3): 767-778.
41.	Steele C R, Zais J G. Effect of coiling in a cochlear model. J Acoust Soc Am, 1985, 77(5): 1849-1852.
42.	Gan R Z, Reeves B P, Wang Xuelin. Modeling of sound transmission from ear canal to cochlea. Ann Biomed Eng, 2007, 35(12): 2180-2195.
43.	Manoussaki D, Dimitriadis E K, Chadwick R S. Cochlea's graded curvature effect on low frequency waves. Phys Rev Lett, 2006, 96(8): 88701.
44.	朱富高, 孙美红, 华辉. 慢性化脓性中耳炎的听骨链病变及对听力的影响. 临床耳鼻咽喉头颈外科杂志, 2008, 22(7): 312-314.
45.	刘迎曦, 李生, 孙秀珍. 人耳鼓膜病变数值分析. 医用生物力学, 2008, 23(4): 275-278.
46.	甘超孙, 姚文娟, 郭翠萍, 等. 细菌生物膜厚度和面积对人耳听力的影响. 中国生物医学工程学报, 2015, 34(4): 421-428.
47.	Liu Yingxi, Li Sheng, Sun Xiuzhen. Numerical analysis of ossicular chain lesion of human ear. Acta Mechanica Sinica, 2009, 25(2): 241-247.

1. Stevens G, Flaxman S, Brunskill E, et al. Global and regional hearing impairment prevalence: an analysis of 42 studies in 29 countries. Eur J Public Health, 2013, 23(1): 146-152.
2. Moore B C J. Cochlear hearing loss: physiological, physiological and technical issues. 2nd ed. Chichester: John Wiley & Sons, 2007.
3. Liu Houguang, Cheng Jinlei, Yang Jianhua, et al. Concept and evaluation of a new piezoelectric transducer for an implantable middle ear hearing device. Sensors, 2017, 17(11): E2515.
4. Song Yulin, Jian J T, Chen Weizen, et al. The development of a non-surgical direct drive hearing device with a wireless actuator coupled to the tympanic membrane. Appl Acoust, 2013, 74(12): 1511-1518.
5. Colletti L, Mandala M, Colletti V. Long-term outcome of round window Vibrant SoundBridge implantation in extensive ossicular chain defects. Otolaryngol Head Neck Surg, 2013, 149(1): 134-141.
6. Colletti V, Soli S D, Carner M, et al. Treatment of mixed hearing losses via implantation of a vibratory transducer on the round window. Int J Audiol, 2006, 45(10): 600-608.
7. Sprinzl G M, Wolf-Magele A, Schnabl J, et al. The active middle ear implant for the rehabilitation of sensorineural, mixed and conductive hearing losses. Laryngorhinootologie, 2011, 90(9): 560-569.
8. Arnold A, Stieger C, Candreia C, et al. Factors improving the vibration transfer of the floating mass transducer at the round window. Otol Neurotol, 2010, 31(1): 122-128.
9. Schraven S P, Hirt B, Goll E, et al. Conditions for highly efficient and reproducible round-window stimulation in humans. Audiol Neurootol, 2012, 17(2): 133-138.
10. 张虎, 刘后广, 赵禹, 等. 初始压力与支撑刚度对圆窗激振听力补偿影响的数值研究. 生物医学工程学杂志, 2018, 35(2): 191-197.
11. 刘迎曦, 李生, 孙秀珍. 人耳传声数值模型. 力学学报, 2008, 40(1): 107-113.
12. 姚文娟, 李武, 付黎杰, 等. 中耳结构数值模拟及传导振动分析. 系统仿真学报, 2009, 21(3): 651-654.
13. Wang Xuelin, Wang Liling, Zhou Jianjun, et al. Finite element modelling of human auditory periphery including a feed-forward amplification of the cochlea. Comput Methods Biomech Biomed Engin, 2014, 17(10): 1096-1107.
14. Zhou Lei, Feng Miaolin, Wang Wei, et al. Study on the role of ossicular joint using finite element method. J Mech Med Biol, 2016, 16(4): 1650041.
15. Wysocki J. Dimensions of the human vestibular and tympanic scalae. Hear Res, 1999, 135(1/2): 39-46.
16. Wever E G. Theory of hearing. New York: John Wiley & Sons, 1949.
17. Tian J, Huang X, Rao Z, et al. Finite element analysis of the effcet of actuator coupling conditions on round window stimulation. J Mech Med Biol, 2015, 15(4): 1550048.
18. Gentil F, Parente M, Martins P, et al. The influence of the mechanical behaviour of the middle ear ligaments: a finite element analysis. Proc Inst Mech Eng H, 2011, 225(1): 68-76.
19. Homma K, Shimizu Y, Kim N, et al. Effects of ear-canal pressurization on middle-ear bone- and air-conduction responses. Hear Res, 2010, 263(1/2, SI): 204-215.
20. 刘后广. 新型人工中耳压电振子听力补偿的理论与实验研究. 上海: 上海交通大学, 2011.
21. Liu Houguang, Xu Dan, Yang Jianhua, et al. Analysis of the influence of the transducer and its coupling layer on round window stimulation. Acta Bioeng Biomech, 2017, 19(2): 103-111.
22. 王学林, 胡于进. 蜗窗激励评价的有限元计算模型研究. 力学学报, 2012, 44(3): 622-630.
23. 王振龙, 王学林, 胡于进, 等. 基于中耳与耳蜗集成有限元模型的耳声传递模拟. 中国生物医学工程学报, 2011, 30(1): 60-66.
24. 王丹妮, 赵守琴, 李轶, 等. 先天性前庭窗闭锁的圆窗模式振动声桥植入(附9例报告). 临床耳鼻咽喉头颈外科杂志, 2017, 31(8): 588-591.
25. Bornitz M, Hardtke H J, Zahnert T. Evaluation of implantable actuators by means of a middle ear simulation model. Hear Res, 2010, 263(1/2): 145-151.
26. Gan R Z, Feng Bin, Sun Qunli. Three-dimensional finite element modeling of human ear for sound transmission. Ann Biomed Eng, 2004, 32(6): 847-859.
27. Koike T, Wada H, Kobayashi T. Effect of depth of conical-shaped tympanic membrane on middle-ear sound transmission. JSME International Journal Series C, 2001, 44(4): 1097-1102.
28. Lee C F, Chen J H, Chou Y F, et al. Optimal graft thickness for different sizes of tympanic membrane perforation in cartilage myringoplasty: A finite element analysis. Laryngoscope, 2007, 117(4): 725-730.
29. Varshney S, Nangia A, Bist S S, et al. Ossicular chain status in chronic suppurative otitis media in adults. Indian J Otolaryngol Head Neck Surg, 2010, 62(4): 421-426.
30. Mohammadi G, Naderpour M, Mousaviagdas M. Ossicular erosion in patients requiring surgery for cholesteatoma. Iran J otorhinolaryngol, 2012, 24(68): 125-128.
31. Bekesy G V. Experiments in hearing. New York: McGraw-Hill, 1960.
32. Kringlebotn M, Gundersen T, Krokstad A, et al. Noise-induced hearing losses. Can they be explained by basilar membrane movement? Acta Otolaryngol, 1979, 86(Suppl 360): 98-101.
33. Gundersen T, Skarstein O, Sikkeland T. A study of the vibration of the basilar membrane in human temporal bone preparations by the use of the mossbauer effect. Acta Otolaryngol, 1978, 86(1/6): 225-232.
34. Stenfelt S, Puria S, Hato N, et al. Basilar membrane and osseous spiral lamina motion in human cadavers with air and bone conduction stimuli. Hear Res, 2003, 181(1/2): 131-143.
35. Aibara R, Welsh J T, Puria S, et al. Human middle-ear sound transfer function and cochlear input impedance. Hear Res, 2001, 152(1): 100-109.
36. Puria S, Peake W T, Rosowski J J. Sound-pressure measurements in the cochlear vestibule of human-cadaver ears. J Acoust Soc Am, 1997, 101(5): 2754-2770.
37. Merchant S N, Ravicz M E, Rosowski J J. Acoustic input impedance of the stapes and cochlea in human temporal bones. Hear Res, 1996, 97(1/2): 30-45.
38. 孙秀珍, 李生, 刘迎曦. 人耳鼓膜穿孔对中耳传声影响的数值模拟. 计算力学学报, 2010, 27(6): 1102-1106.
39. Steele C R. Stiffness of Reissner’s membrane. J Acoust Soc Am, 1974, 56(4): 1252-1257.
40. Holmes M H, Cole J D. Cochlear mechanics: analysis for a pure tone. J Acoust Soc Am, 1984, 76(3): 767-778.
41. Steele C R, Zais J G. Effect of coiling in a cochlear model. J Acoust Soc Am, 1985, 77(5): 1849-1852.
42. Gan R Z, Reeves B P, Wang Xuelin. Modeling of sound transmission from ear canal to cochlea. Ann Biomed Eng, 2007, 35(12): 2180-2195.
43. Manoussaki D, Dimitriadis E K, Chadwick R S. Cochlea's graded curvature effect on low frequency waves. Phys Rev Lett, 2006, 96(8): 88701.
44. 朱富高, 孙美红, 华辉. 慢性化脓性中耳炎的听骨链病变及对听力的影响. 临床耳鼻咽喉头颈外科杂志, 2008, 22(7): 312-314.
45. 刘迎曦, 李生, 孙秀珍. 人耳鼓膜病变数值分析. 医用生物力学, 2008, 23(4): 275-278.
46. 甘超孙, 姚文娟, 郭翠萍, 等. 细菌生物膜厚度和面积对人耳听力的影响. 中国生物医学工程学报, 2015, 34(4): 421-428.
47. Liu Yingxi, Li Sheng, Sun Xiuzhen. Numerical analysis of ossicular chain lesion of human ear. Acta Mechanica Sinica, 2009, 25(2): 241-247.

Journal of Biomedical Engineering

Numerical analysis of the influence of otitis media on the hearing compensation performance of round-window stimulation

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