Broadband subharmonic active cavitation imaging with high cavitation to tissue ratio_Journal of Biomedical Engineering

Authors：

MA Xuejin ^1,2 , GAO Kun ¹ , WANG Na ¹ ,  ZHONG Hui ¹

1. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P.R.China;
2. Imaging Department, The Third Affiliated Hospital of Zunyi Medical University, The First People’s Hospital of Zunyi, Zunyi, Guizhou 563000, P.R.China;

Corresponding author：

ZHONG Hui, Email: bmezhonghui@mail.xjtu.edu.cn

Keywords：

high-intensity focused ultrasound; cavitation-to-tissue ratio; pulse inversion technology; broadband subharmonic cavitation imaging

DOI：

10.7507/1001-5515.201812053

Video：

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Abstract Full text Figures/Tables Video References Cited by

To improve the cavitation-to-tissue ratio (CTR) of cavitation imaging during the treatment with high-intensity focused ultrasound (HIFU), we proposed a pulse inversion based broadband subharmonic cavitation imaging method (PIBSHI). Due to the fact that the subharmonic signal is a unique nonlinear vibration characteristic of cavitation bubbles, we extracted the broadband subharmonic signal to get a high-CTR cavitation imaging. The simulation showed that the subharmonic signal produced by cavitating bubbles with different sizes varied, and the signal was stronger than other subharmonics when the bubbles’ resonant frequency was close to 1/2 subharmonic frequency. Further experiment results demonstrated that compared with the conventional B-mode images, broadband subharmonic cavitation imaging (BSHI) has improved the CTR by 5.7 dB, and the CTR was further improved by 3.4 dB when combined with pulse inversion (PI) technology. Moreover, when the bandwidth was set to 100%~140% of the 1/2 subharmonic frequency in PIBSHI, the CTR was the highest and the imaging showed the optimal quality. The study may have reference value for the development of precise cavitation imaging during HIFU treatment, and contribute to improve the safety of HIFU treatment.

Citation： MA Xuejin, GAO Kun, WANG Na, ZHONG Hui. Broadband subharmonic active cavitation imaging with high cavitation to tissue ratio. Journal of Biomedical Engineering, 2019, 36(6): 938-944. doi: 10.7507/1001-5515.201812053 Copy

1.	陈楚怡, 于洁, 陈功, 等. B模式实时成像定量监控超声空化时空行为的研究. 声学学报, 2015, 40(4): 563-568.
2.	张春兵, 滕风猛, 张家辉, 等. 超声空化增强川芎嗪对脑缺血再灌注损伤保护作用机制的研究. 声学学报, 2016, 41(5): 739-743.
3.	刘娟, 吴凤林. 超声激励微泡" 空化效应”在肿瘤治疗方面的研究进展. 重庆医学, 2014, 43(3): 358-361.
4.	Liu Runna, Xu Shanshan, Hu Hong, et al. Wavelet-transform-based active imaging of cavitation bubbles in tissues induced by high intensity focused ultrasound. J Acoust Soc Am, 2016, 140(2): 798.
5.	Vignon F, Shi W T, Powers J E, et al. Microbubble cavitation imaging. IEEE Trans Ultrason Ferroelectr Freq Control, 2013, 60(4): 661-670.
6.	Ter Haar G, Sinnett D, Rivens I. High intensity focused ultrasound--a surgical technique for the treatment of discrete liver tumours. Phys Med Biol, 1989, 34(11): 1743-1750.
7.	Zhong Hui, Ding Guanhua, She Yanmin, et al. The study of Sub-harmonic cavitation imaging based on pulse inversion technique for the monitoring of high intensity focused ultrasound therapies. Journal of Medical Imaging and Health Informatics, 2014, 4(3): 410-415.
8.	Zhong Hui, Ma Xuejin, Wan Mingxi. Differential PI-based subharmonic cavitation imaging during pulsed high intensity focused ultrasound exposures. Journal of Medical Imaging and Health Informatics, 2017, 7(5): 922-927.
9.	Forsberg F, Shi W T, Goldberg B B. Subharmonic imaging of contrast agents. Ultrasonics, 2000, 38(1): 93-98.
10.	吴凤林, 李颖嘉, 侯连兵. 经静脉二次谐波造影鉴别脂肪肝中低回声病灶的研究. 中国超声医学杂志, 2002, 18(4): 292-295.
11.	凌涛, 郑海荣. 超声造影微泡非线性声学特性与成像研究进展. 中国介入影像与治疗学, 2009, 6(4): 392-396.
12.	章希睿, 张明博, 桑茂栋, 等. 医学超声造影成像的新技术研究进展. 中国生物医学工程学报, 2016, 35(2): 225-233.
13.	王成会, 莫润阳, 胡静, 等. 泡群内气泡振动特性分析. 中国科学:物理学力学天文学, 2017(2): 59-67.
14.	Frohly J, Labouret S, Bruneel C, et al. Ultrasonic cavitation monitoring by acoustic noise power measurement. Journal of the Acoustical Society of America, 2000, 108(5): 2012-2020.
15.	Neppiras E A. Subharmonic and other low-frequency signals from sound-irradiated liquids. J Sound Vib, 1969, 10(2): 176-186.
16.	Leighton T G. The acoustic bubble. London: Academic Press, 1994, 96 (4): 301-306.
17.	Lide D R. CRC handbook of chemistry and physics. 82th ed., Boca Raton: The Chemical Rubber Company, 2001, 257 (6): 349, 1100-1167.
18.	Hu Hong, Xu Shanshan, Yuan Yuan, et al. Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy. J Acoust Soc Am, 2015, 137(5): 2563-2572.

1. 陈楚怡, 于洁, 陈功, 等. B模式实时成像定量监控超声空化时空行为的研究. 声学学报, 2015, 40(4): 563-568.
2. 张春兵, 滕风猛, 张家辉, 等. 超声空化增强川芎嗪对脑缺血再灌注损伤保护作用机制的研究. 声学学报, 2016, 41(5): 739-743.
3. 刘娟, 吴凤林. 超声激励微泡" 空化效应”在肿瘤治疗方面的研究进展. 重庆医学, 2014, 43(3): 358-361.
4. Liu Runna, Xu Shanshan, Hu Hong, et al. Wavelet-transform-based active imaging of cavitation bubbles in tissues induced by high intensity focused ultrasound. J Acoust Soc Am, 2016, 140(2): 798.
5. Vignon F, Shi W T, Powers J E, et al. Microbubble cavitation imaging. IEEE Trans Ultrason Ferroelectr Freq Control, 2013, 60(4): 661-670.
6. Ter Haar G, Sinnett D, Rivens I. High intensity focused ultrasound--a surgical technique for the treatment of discrete liver tumours. Phys Med Biol, 1989, 34(11): 1743-1750.
7. Zhong Hui, Ding Guanhua, She Yanmin, et al. The study of Sub-harmonic cavitation imaging based on pulse inversion technique for the monitoring of high intensity focused ultrasound therapies. Journal of Medical Imaging and Health Informatics, 2014, 4(3): 410-415.
8. Zhong Hui, Ma Xuejin, Wan Mingxi. Differential PI-based subharmonic cavitation imaging during pulsed high intensity focused ultrasound exposures. Journal of Medical Imaging and Health Informatics, 2017, 7(5): 922-927.
9. Forsberg F, Shi W T, Goldberg B B. Subharmonic imaging of contrast agents. Ultrasonics, 2000, 38(1): 93-98.
10. 吴凤林, 李颖嘉, 侯连兵. 经静脉二次谐波造影鉴别脂肪肝中低回声病灶的研究. 中国超声医学杂志, 2002, 18(4): 292-295.
11. 凌涛, 郑海荣. 超声造影微泡非线性声学特性与成像研究进展. 中国介入影像与治疗学, 2009, 6(4): 392-396.
12. 章希睿, 张明博, 桑茂栋, 等. 医学超声造影成像的新技术研究进展. 中国生物医学工程学报, 2016, 35(2): 225-233.
13. 王成会, 莫润阳, 胡静, 等. 泡群内气泡振动特性分析. 中国科学:物理学力学天文学, 2017(2): 59-67.
14. Frohly J, Labouret S, Bruneel C, et al. Ultrasonic cavitation monitoring by acoustic noise power measurement. Journal of the Acoustical Society of America, 2000, 108(5): 2012-2020.
15. Neppiras E A. Subharmonic and other low-frequency signals from sound-irradiated liquids. J Sound Vib, 1969, 10(2): 176-186.
16. Leighton T G. The acoustic bubble. London: Academic Press, 1994, 96 (4): 301-306.
17. Lide D R. CRC handbook of chemistry and physics. 82th ed., Boca Raton: The Chemical Rubber Company, 2001, 257 (6): 349, 1100-1167.
18. Hu Hong, Xu Shanshan, Yuan Yuan, et al. Spatial-temporal ultrasound imaging of residual cavitation bubbles around a fluid-tissue interface in histotripsy. J Acoust Soc Am, 2015, 137(5): 2563-2572.

Journal of Biomedical Engineering

Broadband subharmonic active cavitation imaging with high cavitation to tissue ratio

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