Application of cardiac assist device and its biomechanics research for heart failure_Journal of Biomedical Engineering

Authors：

CHEN Ying ^1,2 , YIN Zhongjie ² ,  TAN Wenchang ^1,2

1. Shenzhen Graduate School, Peking University, Shenzhen, Guangdong 518055, P.R.China;
2. College of Engineering, Peking University, Beijing 100871, P.R.China;

Corresponding author：

Keywords：

cardiac assist device; heart failure; biomechanics; hemodynamics

DOI：

10.7507/1001-5515.201904041

Video：

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As an important means of treating heart failure (HF), cardiac assist device has been widely used in clinic. This paper reviews the application status, existing problems and future development trend of cardiac assist devices, including the classification of cardiac assist devices, representative research achievements and indications of the assist devices. It also summarizes the biomechanical indexes of the heart and the new approaches and methods for treating heart failure, as well as the hemodynamic studies of cardiac assist devices in recent years. The research findings provide references for further optimization of cardiac assist device structure and clinical application of the device.

Citation： CHEN Ying, YIN Zhongjie, TAN Wenchang. Application of cardiac assist device and its biomechanics research for heart failure. Journal of Biomedical Engineering, 2019, 36(6): 1043-1047. doi: 10.7507/1001-5515.201904041 Copy

1.	Oeing C U, Tschöpe C, Pieske B. The new ESC guidelines for acute and chronic heart failure 2016. Herz, 2016, 41(8): 655-663.
2.	Huang Jun, Yin Hongjun, Zhang Milun, et al. Understanding the economic burden of heart failure in China: impact on disease management and resource utilization. J Med Econ, 2017, 20(5): 549-553.
3.	武文芳, 吴兵. 人工心脏的历史及研究进展. 中国医学装备, 2008, 5(3): 55-58.
4.	Lim H S, Howell N, Ranasinghe A. The physiology of Continuous-Flow left ventricular assist devices. J Card Fail, 2017, 23(2): 169-180.
5.	黄鹏辉, 黄柊喻, 党维国, 等. 用于心室辅助装置血流动力学性能评价的体外模拟循环系统技术进展. 医用生物力学, 2018, 33(4): 365-371.
6.	Krishnamoorthy A, Devore A D, Sun J L, et al. The impact of a failing right heart in patients supported by intra-aortic balloon counter pulsation. Eur Heart J Acute Cardiovasc Care, 2017, 6(8): 709-718.
7.	王旭. 儿童心室辅助装置对心脏功能的辅助. 中国小儿急救医学, 2018, 25(6): 407-410.
8.	连淑芬. J-Valve 介入人工生物心脏瓣膜临床应用. 影像研究与医学应用, 2019, 3(12): 150-152.
9.	Imamura T, Chung B, Nguyen A, et al. Clinical implications of hemodynamic assessment during left ventricular assist device therapy. J Cardiol, 2018, 71(4): 352-358.
10.	Mehra M R, Naka Yoshifumi, Uriel N, et al. A fully magnetically levitated circulatory pump for advanced heart failure. N Engl J Med, 2017, 376(5): 440-450.
11.	郭潇雅. 国产人工心脏开启医学新时代. 中国医院院长, 2018, 12: 28-29.
12.	Ponikowski P, Voors A A, Anker S D, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail, 2016, 18(8): 891-975.
13.	朱奇. 心室辅助装置电磁兼容性评价. 科技与创新, 2019, 02: 61-62.
14.	张金丽, 程云章, 郑淇文. 连续型血泵溶血性能评价方法分析. 中国医学物理学杂志, 2018, 35(9): 1087-1093.
15.	Szwast M, Moskal A, Piatkiewicz W. A new method for assessing haemolysis in a rotary blood pump using large eddy simulations (LES). Chemical and Process Engineering, 2017, 38(2): 231-239.
16.	Ju M, Leo H L, Kim S. Numerical investigation on red blood cell dynamics in microflow: effect of cell deformability. Clin Hemorheol Microcirc, 2017, 65(2): 105-117.
17.	Mirsky I, Parmley W W. Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ Res, 1973, 33(2): 233-243.
18.	王静, 刘鹏飞. 心脏磁共振成像对右心疾病的研究. 心血管病学进展, 2018, 29(12): 1078-1082.
19.	唐晓晓, 司效东. 超声相关生物力学技术在评价糖尿病患者左心室收缩功能中的应用. 医学综述, 2017, 23(18): 3704-3712.
20.	Anyanwu E C, Bhatia A, Tehrani D M, et al. The accuracy of physical exam compared to RHC in LVAD patients. Journal of Heart and Lung Transplantation, 2017, 36(4, S): S341-S342.
21.	Sun Xiaotian, Li Jun, Zhao Weipeng, et al. Early assistance with left ventricular assist device limits left ventricular remodeling after acute myocardial infarction in a swine model. Artif Organs, 2016, 40(3): 243-251.
22.	Couperus L E, Delgado V, Khidir M J, et al. Pump speed optimization in stable patients with a left ventricular assist device. ASAIO J, 2017, 63(3): 266-272.
23.	Uriel N, Kim G, Burkhoff D. Myocardial recovery after LVAD implantation: a vision or simply an illusion?. J Am Coll Cardiol, 2017, 70(3): 355-357.
24.	常宇, 张亚歌, 谷凯云, 等. 人工心脏植入方式对主动脉内微栓运动规律的血流动力学影响. 北京工业大学学报, 2016, 42(4): 620-627.
25.	黄柊喻, 党维国, 陈琛, 等. 完全磁悬浮心室辅助装置的体外模拟循环系统实验研究. 医用生物力学, 2017, 32(2): 174-180.
26.	廖晓倩, 周晓辉. 非血液接触式心室辅助装置的现状及展望. 中国医疗设备, 2018, 33(11): 113-117.
27.	Hydren J R, Kithas A C, Park S H, et al. Targeting peripheral vascular pulsatility in heart failure patients with continuous-flow left ventricular assist devices: the impact of pump speed. ASAIO J, 2019, 4(4): 1-9.
28.	Ahmad Bakir A, Al Abed A, Stevens M C, et al. A multiphysics biventricular cardiac model: simulations with a Left-Ventricular assist device. Front Physiol, 2018, 9: 1259.
29.	Sacks L D, Hollander S A, ZHANG Yulin, et al. Vasoplegia after pediatric cardiac transplantation in patients supported with a continuous flow ventricular assist device. J Thorac Cardiovasc Surg, 2019, 157(6): 2433-2440.
30.	Yang Y J, Huo Y, Xu Y W, et al. Percutaneous ventricular restoration therapy using the parachute device in Chinese patients with ischemic heart failure: three month primary endpoint results of PARACHUTE China Study. Chin Med J, 2016, 129(17): 2058-2062.
31.	江佩, 张平洋, 马小五, 等. 左心室心肌力学参数预测心脏再同步化治疗效果的临床研究. 临床医学, 2017, 37(18): 945-946.

1. Oeing C U, Tschöpe C, Pieske B. The new ESC guidelines for acute and chronic heart failure 2016. Herz, 2016, 41(8): 655-663.
2. Huang Jun, Yin Hongjun, Zhang Milun, et al. Understanding the economic burden of heart failure in China: impact on disease management and resource utilization. J Med Econ, 2017, 20(5): 549-553.
3. 武文芳, 吴兵. 人工心脏的历史及研究进展. 中国医学装备, 2008, 5(3): 55-58.
4. Lim H S, Howell N, Ranasinghe A. The physiology of Continuous-Flow left ventricular assist devices. J Card Fail, 2017, 23(2): 169-180.
5. 黄鹏辉, 黄柊喻, 党维国, 等. 用于心室辅助装置血流动力学性能评价的体外模拟循环系统技术进展. 医用生物力学, 2018, 33(4): 365-371.
6. Krishnamoorthy A, Devore A D, Sun J L, et al. The impact of a failing right heart in patients supported by intra-aortic balloon counter pulsation. Eur Heart J Acute Cardiovasc Care, 2017, 6(8): 709-718.
7. 王旭. 儿童心室辅助装置对心脏功能的辅助. 中国小儿急救医学, 2018, 25(6): 407-410.
8. 连淑芬. J-Valve 介入人工生物心脏瓣膜临床应用. 影像研究与医学应用, 2019, 3(12): 150-152.
9. Imamura T, Chung B, Nguyen A, et al. Clinical implications of hemodynamic assessment during left ventricular assist device therapy. J Cardiol, 2018, 71(4): 352-358.
10. Mehra M R, Naka Yoshifumi, Uriel N, et al. A fully magnetically levitated circulatory pump for advanced heart failure. N Engl J Med, 2017, 376(5): 440-450.
11. 郭潇雅. 国产人工心脏开启医学新时代. 中国医院院长, 2018, 12: 28-29.
12. Ponikowski P, Voors A A, Anker S D, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur J Heart Fail, 2016, 18(8): 891-975.
13. 朱奇. 心室辅助装置电磁兼容性评价. 科技与创新, 2019, 02: 61-62.
14. 张金丽, 程云章, 郑淇文. 连续型血泵溶血性能评价方法分析. 中国医学物理学杂志, 2018, 35(9): 1087-1093.
15. Szwast M, Moskal A, Piatkiewicz W. A new method for assessing haemolysis in a rotary blood pump using large eddy simulations (LES). Chemical and Process Engineering, 2017, 38(2): 231-239.
16. Ju M, Leo H L, Kim S. Numerical investigation on red blood cell dynamics in microflow: effect of cell deformability. Clin Hemorheol Microcirc, 2017, 65(2): 105-117.
17. Mirsky I, Parmley W W. Assessment of passive elastic stiffness for isolated heart muscle and the intact heart. Circ Res, 1973, 33(2): 233-243.
18. 王静, 刘鹏飞. 心脏磁共振成像对右心疾病的研究. 心血管病学进展, 2018, 29(12): 1078-1082.
19. 唐晓晓, 司效东. 超声相关生物力学技术在评价糖尿病患者左心室收缩功能中的应用. 医学综述, 2017, 23(18): 3704-3712.
20. Anyanwu E C, Bhatia A, Tehrani D M, et al. The accuracy of physical exam compared to RHC in LVAD patients. Journal of Heart and Lung Transplantation, 2017, 36(4, S): S341-S342.
21. Sun Xiaotian, Li Jun, Zhao Weipeng, et al. Early assistance with left ventricular assist device limits left ventricular remodeling after acute myocardial infarction in a swine model. Artif Organs, 2016, 40(3): 243-251.
22. Couperus L E, Delgado V, Khidir M J, et al. Pump speed optimization in stable patients with a left ventricular assist device. ASAIO J, 2017, 63(3): 266-272.
23. Uriel N, Kim G, Burkhoff D. Myocardial recovery after LVAD implantation: a vision or simply an illusion?. J Am Coll Cardiol, 2017, 70(3): 355-357.
24. 常宇, 张亚歌, 谷凯云, 等. 人工心脏植入方式对主动脉内微栓运动规律的血流动力学影响. 北京工业大学学报, 2016, 42(4): 620-627.
25. 黄柊喻, 党维国, 陈琛, 等. 完全磁悬浮心室辅助装置的体外模拟循环系统实验研究. 医用生物力学, 2017, 32(2): 174-180.
26. 廖晓倩, 周晓辉. 非血液接触式心室辅助装置的现状及展望. 中国医疗设备, 2018, 33(11): 113-117.
27. Hydren J R, Kithas A C, Park S H, et al. Targeting peripheral vascular pulsatility in heart failure patients with continuous-flow left ventricular assist devices: the impact of pump speed. ASAIO J, 2019, 4(4): 1-9.
28. Ahmad Bakir A, Al Abed A, Stevens M C, et al. A multiphysics biventricular cardiac model: simulations with a Left-Ventricular assist device. Front Physiol, 2018, 9: 1259.
29. Sacks L D, Hollander S A, ZHANG Yulin, et al. Vasoplegia after pediatric cardiac transplantation in patients supported with a continuous flow ventricular assist device. J Thorac Cardiovasc Surg, 2019, 157(6): 2433-2440.
30. Yang Y J, Huo Y, Xu Y W, et al. Percutaneous ventricular restoration therapy using the parachute device in Chinese patients with ischemic heart failure: three month primary endpoint results of PARACHUTE China Study. Chin Med J, 2016, 129(17): 2058-2062.
31. 江佩, 张平洋, 马小五, 等. 左心室心肌力学参数预测心脏再同步化治疗效果的临床研究. 临床医学, 2017, 37(18): 945-946.

Journal of Biomedical Engineering

Application of cardiac assist device and its biomechanics research for heart failure

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