Simulation research on magnetoacoustic B-scan imaging of magnetic nanoparticles_Journal of Biomedical Engineering

Authors：

SHI Xiaoyu ^1,2 ,  LIU Guoqiang ^2,3 , YAN Xiaoheng ¹ , LI Yanhong ²

1. Faculty of Electrical and Control Engineering, Liaoning Technical University, Huludao, Liaoning 125105, P.R.China;
2. Institute of Electrical Engineering Chinese Academy of Sciences, Beijing 100190, P.R.China;
3. School of Electronic Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101407, P.R.China;

Corresponding author：

LIU Guoqiang, Email: liuguoqiang@mail.iee.ac.cn

Keywords：

magnetic nanoparticles; pulsed magnetic field; magnetoacoustic effect; acoustic signal; B-scan imaging

DOI：

10.7507/1001-5515.202001025

Video：

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Abstract Full text Figures/Tables Video References Cited by

As drug carriers, magnetic nanoparticles can specifically bind to tumors and have the potential for targeted therapy. It is of great significance to explore non-invasive imaging methods that can detect the distribution of magnetic nanoparticles. Based on the mechanism that magnetic nanoparticles can generate ultrasonic waves through the pulsed magnetic field excitation, the sound pressure wave equation containing the concentration information of magnetic nanoparticles was derived. Using the finite element method and the analytical solution, the consistent transient pulsed magnetic field was obtained. A three-dimensional simulation model was constructed for the coupling calculation of electromagnetic field and sound field. The simulation results verified that the sound pressure waveform at the detection point reflected the position of magnetic nanoparticles in biological tissue. Using the sound pressure data detected by the ultrasonic transducer, the B-scan imaging of the magnetic nanoparticles was achieved. The maximum error of the target area position was 1.56%, and the magnetic nanoparticles regions with different concentrations were distinguished by comparing the amplitude of the boundary signals in the image. Studies in this paper indicate that B-scan imaging can quickly and accurately obtain the dimensional and positional information of the target region and is expected to be used for the detection of magnetic nanoparticles in targeted therapy.

Citation： SHI Xiaoyu, LIU Guoqiang, YAN Xiaoheng, LI Yanhong. Simulation research on magnetoacoustic B-scan imaging of magnetic nanoparticles. Journal of Biomedical Engineering, 2020, 37(5): 786-792, 801. doi: 10.7507/1001-5515.202001025 Copy

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19.	Li Yuanyuan, Liu Guoqiang, Sun Zhishen, et al. Magneto-acousto-electrical tomography for high resolution electrical conductivity contrast imaging. J Med Imaging Health Inf, 2018, 8(7): 1402-1407.
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22.	夏慧, 刘国强, 黄欣, 等. 注入电流式磁声成像平面模型的逆问题研究. 电工技术学报, 2017, 32(4): 147-153.

1. Zou M, Xu P, Wang L, et al. Design and construction of a magnetic targeting pro-coagulant protein for embolic therapy of solid tumors. Artif Cells Nanomed Biotechnol, 2020, 48(1): 116-128.
2. Hedayatnasab Z, Abnisa F, Daud W M A W. Review on magnetic nanoparticles for magnetic nanofluid hyperthermia application. Mater Design, 2017, 123: 174-196.
3. Akbarzadeh A, Khiabani A S, Farshbaf M, et al. Magnetic nanoparticles: preparation methods, applications in cancer diagnosis and cancer therapy. Artif Cells, 2016, 45(1): 6-17.
4. Yue Xiuli, Ma Fang, Dai Zhifei. Multifunctional magnetic nanoparticles for magnetic resonance image-guided photothermal therapy for cancer. Chin Phys B, 2014, 23(4): 044301.
5. Zhao Xiaohe, Liu Guoqiang, Yan Xiaoheng, et al. The influence on acoustic frequency characteristics of conductivity gradual-varying tissue in magnetoacoustic tomography (MAT). Comput Biol Med, 2019, 104: 105-110.
6. Oh J, Feldman M D, Kim J, et al. Detection of magnetic nanoparticles in tissue using magneto-motive ultrasound. Nanotechnology, 2006, 17(16): 4183-4190.
7. Mehrmohammadi M, Shin T H, Qu M, et al. In vivo pulsed magneto-motive ultrasound imaging using high-performance magnetoactive contrast nanoagents. Nanotechnology, 2013, 5(22): 11179-11186.
8. Mehrmohammadi M, Oh J, Mallidi S, et al. Pulsed magneto-motive ultrasound imaging using ultrasmall magnetic nanoprobes. Mol Imaging, 2011, 10(2): 102-110.
9. Mehrmohammadi M, Qu M, Ma L L, et al. Pulsed magneto-motive ultrasound imaging to detect intracellular accumulation of magnetic nanoparticles. Nanotechnology, 2011, 22(41): 415105.
10. Hu G, He B. Magnetoacoustic imaging of magnetic iron oxide nanoparticles embedded in biological tissues with microsecond magnetic stimulation. Appl Phys Lett, 2012, 100(1): 013704.
11. Steinberg I, Ben-David M, Gannot I. A new method for tumor detection using induced acoustic waves from tagged magnetic nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2012, 8(5): 569-579.
12. Tsalach A, Steinberg I, Gannot I. Tumor localization using magnetic nanoparticle-induced acoustic signals. IEEE Trans Biomed Eng, 2014, 61(8): 2313-2323.
13. Mariappan L, Shao Qi, Jiang Chunlan, et al. Magneto acoustic tomography with short pulsed magnetic field for in-vivo imaging of magnetic iron oxide nanoparticles. Nanomedicine, 2016, 12(3): 689-699.
14. 张帅, 李子秀, 张雪莹, 等. 基于时间反演的磁动力超声成像仿真与实验. 电工技术学报, 2019, 34(16): 3303-3310.
15. 房大伟. 磁感应磁声纳米传感技术研究. 南京: 南京师范大学, 2014.
16. 杨红双. 纳米粒子磁动力超声成像理论研究. 天津: 河北工业大学, 2016.
17. Zou X, Ma Z, Zhao X, et al. B-scan ultrasound imaging measurement of suspended sediment concentration and its vertical distribution. Meas Sci Technol, 2014, 25(11): 115303.
18. Grasland-Mongrain P, Mari J M, Chapelon J Y, et al. Lorentz force electrical impedance tomography. IRBM, 2013, 34(4-5): 357-360.
19. Li Yuanyuan, Liu Guoqiang, Sun Zhishen, et al. Magneto-acousto-electrical tomography for high resolution electrical conductivity contrast imaging. J Med Imaging Health Inf, 2018, 8(7): 1402-1407.
20. Weizenecker J, Borgert J, Gleich B. A simulation study on the resolution and sensitivity of magnetic particle imaging. Phys Med Biol, 2007, 52(21): 6363.
21. Brandl M, Mayer M, Hartmann J, et al. Theoretical analysis of ferromagnetic microparticles in streaming liquid under the influence of external magnetic forces. J Magn Magn Mater, 2010, 322(17): 2454-2464.
22. 夏慧, 刘国强, 黄欣, 等. 注入电流式磁声成像平面模型的逆问题研究. 电工技术学报, 2017, 32(4): 147-153.

Journal of Biomedical Engineering

Simulation research on magnetoacoustic B-scan imaging of magnetic nanoparticles

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