Experimental study on temperature dependence of dielectric properties of biological tissues at 2 450 MHz_Journal of Biomedical Engineering

Authors：

LIU Hongxing , CHENG Yanyan , ZHANG Meng , TIAN Zhen ,  NAN Qun

College of Life Science and Chemistry, The Faculty of Environment and Life Science, Beijing University of Technology; Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, P.R.China;

Corresponding author：

NAN Qun, Email: nanqun@bjut.edu.cn

Keywords：

biological tissue; dielectric properties; temperature dependence; dielectric model; thermal ablation

DOI：

10.7507/1001-5515.202005027

Video：

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The temperature dependence of relative permittivity and conductivity of ex-vivo pig liver, lung and heart at 2 450 MHz was studied. The relative permittivity and conductivity of three kinds of biological tissues were measured by the open-end coaxial line method. The dielectric model was fitted according to the principle of least square method. The results showed that the relative permittivity and conductivity of pig liver, pig lung and pig heart decreased with the increase of tissue temperature from 20 to 80 ℃. The relative permittivity and conductivity models of pig liver, pig lung and pig heart were established to reflect the law of dielectric properties of biological tissue changing with temperature and provide a reference for the parameters setting of thermal ablation temperature field.

Citation： LIU Hongxing, CHENG Yanyan, ZHANG Meng, TIAN Zhen, NAN Qun. Experimental study on temperature dependence of dielectric properties of biological tissues at 2 450 MHz. Journal of Biomedical Engineering, 2021, 38(4): 703-708. doi: 10.7507/1001-5515.202005027 Copy

1.	陈凯, 方主亭. 热消融在肺癌中的应用和展望. 中华介入放射学电子杂志, 2019, 7(2): 126-129.
2.	Gao Xiang, Tian Zhen, Cheng Yanyan, et al. Experimental and numerical study of microwave ablation on ex-vivo porcine lung. Electromagn Biol Med, 2019, 38(4): 249-261.
3.	嵇敏洁, 印佳, 杨悦, 等. 肿瘤热疗无损测温方法的研究进展. 北京生物医学工程, 2019, 38(1): 96-101.
4.	罗光彩. 2450 MHz微波消融离体猪肺组织的实验研究. 山东: 泰山医学院, 2014.
5.	高翔, 陈仕林, 刘静纨, 等. 基于CT的兔肺肿瘤微波消融的温度场研究. 北京生物医学工程, 2020, 39(4): 372-379.
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7.	南群, 郭雪梅, 翟飞, 等. 血管对肝脏微波消融温度场的影响. 北京工业大学学报, 2014, 40(12): 1917-1922.
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9.	田甄, 程妍妍, 高翔, 等. 微波消融联合液体注射的温度场. 北京工业大学学报, 2020, 46(7): 803-811.
10.	曾海萍, 韩继钧, 辛学刚. 生物组织介电特性测量研究进展. 中国医疗设备, 2016, 31(5): 5-11.
11.	赵金哲, 王娟, 沐勇杰, 等. 肝癌微波消融中热损伤参数分析. 北京生物医学工程, 2019, 38(4): 392-399.
12.	Fu Fanrui, Xin Xuegang, Chen Wufan. Temperature and frequency-dependent dielectric properties of biological tissues within the temperature and frequency ranges typically used for magnetic resonance imaging-guided focused ultrasound surgery. Int J Hyperther, 2014, 30(1): 56-65.
13.	张立彬, 胥芳, 计时鸣, 等. 苹果内部品质自动化无损检测系统的原理与实现(英文). 农业工程学报, 2001, 17(1): 140-145.
14.	陈蕊. 基于动态扫频介电常数的测量研究. 西安: 西安电子科技大学, 2009.
15.	傅世强, 姜家宏, 李婵娟. 基于谐振腔微扰理论的电介质测量创新实验设计. 实验科学与技术, 2015, 13(5): 25-28.
16.	王秀丽, 陈彦, 贾明全. 介电常数的实地测量装置的研制. 电子测量技术, 2010, 33(9): 4-7.
17.	La G A, Porter E, Merunka I, et al. Open-ended coaxial probe technique for dielectric measurement of biological tissues: Challenges and common practices. Diagnostics, 2018, 8(2): 40-48.
18.	陈妙良, 陈建国, 魏珊珊, 等. 基于开端同轴射频组织介电特性测量技术的乳腺癌及癌周组织鉴别检测实验研究. 生物医学工程学杂志, 2016, 33(5): 958-962.
19.	贾晔. 用同轴探针法测量部分生物材料的复介电常数. 真空电子技术, 2011(2): 54-57.
20.	冯健. 生物组织介电特性测量及模拟材料研究. 广州: 南方医科大学, 2015.
21.	Trujillo M, Berjano E. Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation. Int J Hyperther, 2013, 29(6): 590-597.
22.	Etoz S, Brace C L. Development of water content dependent tissue dielectric property models. IEEE J Electromagn RF Microw Med Biol, 2019, 3(2): 105-110.
23.	Sebek J, Bortel R, Prakash P. Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models. Med Phys, 2019, 46(10): 4291-4303.
24.	Bobowski J S, Johnson T. Permittivity measurements of biological samples by an open-ended coaxial line. Prog Electromang Res, 2012, 40(2): 159-183.
25.	Gregory A P, Clarke R N. Tables of the complex permittivity of dielectric reference liquids at frequencies up to 5 GHz. Teddington: Nation Physical Laboratory, 2012.
26.	陈曦, 王伟. 基于Matlab的电介质介电常数测量试验数据处理. 教育教学论坛, 2018, 10(10): 267-268.
27.	吕喜明, 李明远. 最小二乘法曲线拟合的Matlab实现. 内蒙古民族大学学报, 2009, 24(2): 125-127.
28.	陈军. 数据的正态性检验及Excel/SPSS/Stata软件的实操应用. 四川职业技术学院学报, 2019, 29(3): 157-161.
29.	刘涛. 水果表面农药残留快速检测方法及模型研究. 南昌: 华东交通大学, 2011.
30.	Liu Dong. Characterization and modeling of tissue contraction during thermal ablation. Madison: University of Wisconsin-Madison, 2016.
31.	Zhen Ji, Christopher L B. Expanded modeling of temperature-dependent dielectric properties for microwave thermal ablation. Phys Med Biol, 2011, 56(10): 5249-5264.
32.	胡昊, 田甄, 南群. 肺肿瘤微波消融治疗效果影响因素的研究现状. 北京生物医学工程, 2020, 39(6): 643-649.

1. 陈凯, 方主亭. 热消融在肺癌中的应用和展望. 中华介入放射学电子杂志, 2019, 7(2): 126-129.
2. Gao Xiang, Tian Zhen, Cheng Yanyan, et al. Experimental and numerical study of microwave ablation on ex-vivo porcine lung. Electromagn Biol Med, 2019, 38(4): 249-261.
3. 嵇敏洁, 印佳, 杨悦, 等. 肿瘤热疗无损测温方法的研究进展. 北京生物医学工程, 2019, 38(1): 96-101.
4. 罗光彩. 2450 MHz微波消融离体猪肺组织的实验研究. 山东: 泰山医学院, 2014.
5. 高翔, 陈仕林, 刘静纨, 等. 基于CT的兔肺肿瘤微波消融的温度场研究. 北京生物医学工程, 2020, 39(4): 372-379.
6. Carberry G A, Nocerino E, Cristescu M M, et al. Microwave ablation of the lung in a porcine model: vessel diameter predicts pulmonary artery occlusion. Cardiovasc Inter Rad, 2017, 40(10): 1609-1616.
7. 南群, 郭雪梅, 翟飞, 等. 血管对肝脏微波消融温度场的影响. 北京工业大学学报, 2014, 40(12): 1917-1922.
8. Cheng Gui, Shi Liangrong, Qiang Weiguang, et al. The safety and efficacy of microwave ablation for the treatment of CRC pulmonary metastases. Int J Hyperther, 2018, 34(4): 486-491.
9. 田甄, 程妍妍, 高翔, 等. 微波消融联合液体注射的温度场. 北京工业大学学报, 2020, 46(7): 803-811.
10. 曾海萍, 韩继钧, 辛学刚. 生物组织介电特性测量研究进展. 中国医疗设备, 2016, 31(5): 5-11.
11. 赵金哲, 王娟, 沐勇杰, 等. 肝癌微波消融中热损伤参数分析. 北京生物医学工程, 2019, 38(4): 392-399.
12. Fu Fanrui, Xin Xuegang, Chen Wufan. Temperature and frequency-dependent dielectric properties of biological tissues within the temperature and frequency ranges typically used for magnetic resonance imaging-guided focused ultrasound surgery. Int J Hyperther, 2014, 30(1): 56-65.
13. 张立彬, 胥芳, 计时鸣, 等. 苹果内部品质自动化无损检测系统的原理与实现(英文). 农业工程学报, 2001, 17(1): 140-145.
14. 陈蕊. 基于动态扫频介电常数的测量研究. 西安: 西安电子科技大学, 2009.
15. 傅世强, 姜家宏, 李婵娟. 基于谐振腔微扰理论的电介质测量创新实验设计. 实验科学与技术, 2015, 13(5): 25-28.
16. 王秀丽, 陈彦, 贾明全. 介电常数的实地测量装置的研制. 电子测量技术, 2010, 33(9): 4-7.
17. La G A, Porter E, Merunka I, et al. Open-ended coaxial probe technique for dielectric measurement of biological tissues: Challenges and common practices. Diagnostics, 2018, 8(2): 40-48.
18. 陈妙良, 陈建国, 魏珊珊, 等. 基于开端同轴射频组织介电特性测量技术的乳腺癌及癌周组织鉴别检测实验研究. 生物医学工程学杂志, 2016, 33(5): 958-962.
19. 贾晔. 用同轴探针法测量部分生物材料的复介电常数. 真空电子技术, 2011(2): 54-57.
20. 冯健. 生物组织介电特性测量及模拟材料研究. 广州: 南方医科大学, 2015.
21. Trujillo M, Berjano E. Review of the mathematical functions used to model the temperature dependence of electrical and thermal conductivities of biological tissue in radiofrequency ablation. Int J Hyperther, 2013, 29(6): 590-597.
22. Etoz S, Brace C L. Development of water content dependent tissue dielectric property models. IEEE J Electromagn RF Microw Med Biol, 2019, 3(2): 105-110.
23. Sebek J, Bortel R, Prakash P. Broadband lung dielectric properties over the ablative temperature range: Experimental measurements and parametric models. Med Phys, 2019, 46(10): 4291-4303.
24. Bobowski J S, Johnson T. Permittivity measurements of biological samples by an open-ended coaxial line. Prog Electromang Res, 2012, 40(2): 159-183.
25. Gregory A P, Clarke R N. Tables of the complex permittivity of dielectric reference liquids at frequencies up to 5 GHz. Teddington: Nation Physical Laboratory, 2012.
26. 陈曦, 王伟. 基于Matlab的电介质介电常数测量试验数据处理. 教育教学论坛, 2018, 10(10): 267-268.
27. 吕喜明, 李明远. 最小二乘法曲线拟合的Matlab实现. 内蒙古民族大学学报, 2009, 24(2): 125-127.
28. 陈军. 数据的正态性检验及Excel/SPSS/Stata软件的实操应用. 四川职业技术学院学报, 2019, 29(3): 157-161.
29. 刘涛. 水果表面农药残留快速检测方法及模型研究. 南昌: 华东交通大学, 2011.
30. Liu Dong. Characterization and modeling of tissue contraction during thermal ablation. Madison: University of Wisconsin-Madison, 2016.
31. Zhen Ji, Christopher L B. Expanded modeling of temperature-dependent dielectric properties for microwave thermal ablation. Phys Med Biol, 2011, 56(10): 5249-5264.
32. 胡昊, 田甄, 南群. 肺肿瘤微波消融治疗效果影响因素的研究现状. 北京生物医学工程, 2020, 39(6): 643-649.

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