Magnetic induced phase shift detection system based on a novel sensor for cerebral hemorrhage_Journal of Biomedical Engineering

Authors：

LIU Jie , YAN Lian , QIN Mingxin , ZHANG Haisheng ,  CHEN Mingsheng

Department of Biomedical Engineering and Imaging Medicine, Army Medical University, Chongqing 400038, P. R. China;

Corresponding author：

CHEN Mingsheng, Email: chenms83@tmmu.edu.cn

Keywords：

Cerebral hemorrhage; Magnetic induced phase shift; Helmholtz birdcage sensor

DOI：

10.7507/1001-5515.202305048

Video：

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The main magnetic field, generated by the excitation coil of the magnetic induction phase shift technology detection system, is mostly dispersed field with small field strength, and the offset effect needs to be further improved, which makes the detection signal weak and the detection system difficult to achieve quantitative detection, thus the technology is rarely used in vivo experiments and clinical trials. In order to improve problems mentioned above, a new Helmholtz birdcage sensor was designed. Stimulation experiment was carried out to analyze the main magnetic field in aspects of intensity and magnetic distribution, then different bleeding volume and bleeding rates experiments were conducted to compared with traditional sensors. The results showed that magnetic field intensity in detection region was 2.5 times than that of traditional sensors, cancellation effect of the main magnetic field was achieved, the mean value of phase difference of 10 mL rabbit blood was (–3.34 ± 0.21)°, and exponential fitting adjusted R² between phase difference and bleeding volumes and bleeding rates were both 0.99. The proposed Helmholtz birdcage sensor has a uniform magnetic field with a higher field strength, enable more accurate quantification of hemorrhage and monitored change of bleeding rates, providing significance in magnetic induced technology research for cerebral hemorrhage detection.

Citation： LIU Jie, YAN Lian, QIN Mingxin, ZHANG Haisheng, CHEN Mingsheng. Magnetic induced phase shift detection system based on a novel sensor for cerebral hemorrhage. Journal of Biomedical Engineering, 2024, 41(3): 455-460. doi: 10.7507/1001-5515.202305048 Copy

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2.	Feigin V L, Lawes C M, Bennett D A, et al. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol, 2003, 2(1): 43-53.
3.	Jolink W M, Klijn C J, Brouwers P J, et al. Time trends in incidence, case fatality, and mortality of intracerebral hemorrhage. Neurology, 2015, 85(15): 1318-1324.
4.	GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol, 2021, 20(10): 795-820.
5.	Sun J, Jin G, Qin M X, et al. Detection of acute cerebral hemorrhage in rabbits by magnetic induction. Braz J Med Biol Res, 2014, 47(2): 144-150.
6.	Pan W, Yan Q, Qin M, et al. Detection of cerebral hemorrhage in rabbits by time-difference magnetic inductive phase shift spectroscopy. PLoS One, 2015, 10(5): e128127.
7.	Pan W, Zhuang W, Chong Y, et al. Noninvasive real-time detection of cerebral blood perfusion in hemorrhagic shock rabbits based on whole-brain magnetic induction phase shift: an experimental study. Physiol Meas, 2020, 41(9): 95004.
8.	Sun J, Jin G, Qin M, et al. The detection of chronic cerebral hemorrhage in rabbits with magnetic induction. J Phys Conf Ser, 2012, 407: 12014.
9.	Zhuang W, Pan W, Xu L, et al. A preliminary study on the feasibility of detecting global acute cerebral ischemia by the MIPS method. IEEE Access, 2020, 8: 32290-32296.
10.	Zhao S, Li G, Gu S, et al. An experimental study of relationship between magnetic induction phase shift and brain parenchyma volume with brain edema in traumatic brain injury. IEEE Access, 2019, 7: 20974-20983.
11.	Yang J, Zhao H, Li G, et al. An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system. Peer J, 2019, 7: e6717.
12.	彭斌, 唐庆华, 孙健, 等. 脑出血磁感应实时监测系统的建立. 生物医学工程学杂志, 2015, 32(2): 440-445.
13.	潘文才, 秦明新, 金贵, 等. 基于特征频带磁感应相移谱检测家兔脑出血的实验研究. 生物医学工程学杂志, 2015, 32(3): 569-574.
14.	Yan Q, Jin G, Qin M, et al. Experimental study on the detection of rabbit intracranial hemorrhage using four coil structures based on magnetic induction phase shift. Biomed Tech, 2017, 62(1): 23-36.
15.	Jin G, Sun J, Qin M, et al. A new method for detecting cerebral hemorrhage in rabbits by magnetic inductive phase shift. Biosens Bioelectron, 2014, 52: 374-378.
16.	Zhao S L, Jin G, Bai Z L, et al. Twenty-four-hour real-time continuous monitoring of acute focal cerebral ischemia in rabbits based on magnetic inductive phase shift. Biomed Eng Online, 2020, 19(1): 83.
17.	Chen J, Li G, Chen M, et al. A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction. Peer J, 2020, 8: e10079.
18.	Xiao Z, Tan C, Dong F. 3-D hemorrhage imaging by cambered magnetic induction tomography. IEEE T Instrum Meas, 2019, 68(7): 2460-2468.
19.	Chen Y, Tan C, Dong F. Combined planar magnetic induction tomography for local detection of intracranial hemorrhage. IEEE T Instrum Meas, 2021, 70: 1-11.
20.	Xiang J, Dong Y, Zhang M, et al. Design of a magnetic induction tomography system by gradiometer coils for conductive fluid imaging. IEEE Access, 2019, 7: 56733-56744.
21.	Griffiths H, Stewart W R, Gough W. Magnetic induction tomography: a measuring system for biological tissues. Ann N Y Acad Sci, 1999, 873(1): 335-345.
22.	Barai A, Watson S, Griffiths H, et al. Magnetic induction spectroscopy: non-contact measurement of the electrical conductivity spectra of biological samples. Meas Sci Technol, 2012, 23(8): 85501.
23.	Fujita H, Braum W O, Morich M A. Novel quadrature birdcage coil for a vertical B0 field open MRI system. Magn Reson Med, 2000, 44(4): 633-640.
24.	Chin C, Collins C M, Li S, et al. BirdcageBuilder: design of specified-geometry birdcage coils with desired current pattern and resonant frequency. Concept Magn Reson, 2002, 15(2): 156-163.
25.	He Z, Chen J, Chen M, et al. A novel sensor system to detect cerebral hemorrhage in rabbits through MIPS. Med Phys, 2023, 50(4): 2565-2576.
26.	Chen Y, Tan C, Zhao S, et al. Intracranial hemorrhage detection by open MIT sensor array. IEEE T Instrum Meas, 2022, 71: 1-11.

1. Greenberg S M, Ziai W C, Cordonnier C, et al. 2022 Guideline for The Management of Patients with Spontaneous Intracerebral Hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke, 2022, 53(7): e282-e361.
2. Feigin V L, Lawes C M, Bennett D A, et al. Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol, 2003, 2(1): 43-53.
3. Jolink W M, Klijn C J, Brouwers P J, et al. Time trends in incidence, case fatality, and mortality of intracerebral hemorrhage. Neurology, 2015, 85(15): 1318-1324.
4. GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol, 2021, 20(10): 795-820.
5. Sun J, Jin G, Qin M X, et al. Detection of acute cerebral hemorrhage in rabbits by magnetic induction. Braz J Med Biol Res, 2014, 47(2): 144-150.
6. Pan W, Yan Q, Qin M, et al. Detection of cerebral hemorrhage in rabbits by time-difference magnetic inductive phase shift spectroscopy. PLoS One, 2015, 10(5): e128127.
7. Pan W, Zhuang W, Chong Y, et al. Noninvasive real-time detection of cerebral blood perfusion in hemorrhagic shock rabbits based on whole-brain magnetic induction phase shift: an experimental study. Physiol Meas, 2020, 41(9): 95004.
8. Sun J, Jin G, Qin M, et al. The detection of chronic cerebral hemorrhage in rabbits with magnetic induction. J Phys Conf Ser, 2012, 407: 12014.
9. Zhuang W, Pan W, Xu L, et al. A preliminary study on the feasibility of detecting global acute cerebral ischemia by the MIPS method. IEEE Access, 2020, 8: 32290-32296.
10. Zhao S, Li G, Gu S, et al. An experimental study of relationship between magnetic induction phase shift and brain parenchyma volume with brain edema in traumatic brain injury. IEEE Access, 2019, 7: 20974-20983.
11. Yang J, Zhao H, Li G, et al. An experimental study on the early diagnosis of traumatic brain injury in rabbits based on a noncontact and portable system. Peer J, 2019, 7: e6717.
12. 彭斌, 唐庆华, 孙健, 等. 脑出血磁感应实时监测系统的建立. 生物医学工程学杂志, 2015, 32(2): 440-445.
13. 潘文才, 秦明新, 金贵, 等. 基于特征频带磁感应相移谱检测家兔脑出血的实验研究. 生物医学工程学杂志, 2015, 32(3): 569-574.
14. Yan Q, Jin G, Qin M, et al. Experimental study on the detection of rabbit intracranial hemorrhage using four coil structures based on magnetic induction phase shift. Biomed Tech, 2017, 62(1): 23-36.
15. Jin G, Sun J, Qin M, et al. A new method for detecting cerebral hemorrhage in rabbits by magnetic inductive phase shift. Biosens Bioelectron, 2014, 52: 374-378.
16. Zhao S L, Jin G, Bai Z L, et al. Twenty-four-hour real-time continuous monitoring of acute focal cerebral ischemia in rabbits based on magnetic inductive phase shift. Biomed Eng Online, 2020, 19(1): 83.
17. Chen J, Li G, Chen M, et al. A noninvasive flexible conformal sensor for accurate real-time monitoring of local cerebral edema based on electromagnetic induction. Peer J, 2020, 8: e10079.
18. Xiao Z, Tan C, Dong F. 3-D hemorrhage imaging by cambered magnetic induction tomography. IEEE T Instrum Meas, 2019, 68(7): 2460-2468.
19. Chen Y, Tan C, Dong F. Combined planar magnetic induction tomography for local detection of intracranial hemorrhage. IEEE T Instrum Meas, 2021, 70: 1-11.
20. Xiang J, Dong Y, Zhang M, et al. Design of a magnetic induction tomography system by gradiometer coils for conductive fluid imaging. IEEE Access, 2019, 7: 56733-56744.
21. Griffiths H, Stewart W R, Gough W. Magnetic induction tomography: a measuring system for biological tissues. Ann N Y Acad Sci, 1999, 873(1): 335-345.
22. Barai A, Watson S, Griffiths H, et al. Magnetic induction spectroscopy: non-contact measurement of the electrical conductivity spectra of biological samples. Meas Sci Technol, 2012, 23(8): 85501.
23. Fujita H, Braum W O, Morich M A. Novel quadrature birdcage coil for a vertical B0 field open MRI system. Magn Reson Med, 2000, 44(4): 633-640.
24. Chin C, Collins C M, Li S, et al. BirdcageBuilder: design of specified-geometry birdcage coils with desired current pattern and resonant frequency. Concept Magn Reson, 2002, 15(2): 156-163.
25. He Z, Chen J, Chen M, et al. A novel sensor system to detect cerebral hemorrhage in rabbits through MIPS. Med Phys, 2023, 50(4): 2565-2576.
26. Chen Y, Tan C, Zhao S, et al. Intracranial hemorrhage detection by open MIT sensor array. IEEE T Instrum Meas, 2022, 71: 1-11.

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