Relationship between Platelet Parameters and Traumatic Cerebral Infarction in Acute Phase of Craniocerebral Injury_West China Medical Journal

Authors：

DAN Bing ,  YU Shui , ZENG Lingchun , PENG Zongqing , ZENG Yijun , DU Deming , ZHENG Feng , WANG Qiangping

Department of Neurosurgery, People’s Hospital of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;

Corresponding author：

YU Shui, Email: apollo-22@163.com

Keywords：

颅脑损伤; 血小板; 预后

DOI：

10.7507/1002-0179.20130002

Video：

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目的　探讨颅脑损伤急性期血小板（PLT）参数与外伤性脑梗死（TCI）的关系。方法　选取2010年9月－2012年1月符合纳入除标准的颅脑损伤患者191例。将伤后14 d内发生脑梗死的患者划入观察组，余为对照组。分别于伤后第24、48小时，第3、7、14天，采集肘静脉血对PLT计数、PLT平均体积（MPV）、PLT体积分布宽度（PDW）；伤后24 h行格拉斯哥昏迷评分（GCS），伤后6个月随访行格拉斯哥结果评分（GOS）。分别分析脑梗死与上述PLT参数的关系、PLT参数与颅脑损伤病情轻重的关系以及与预后的关系。结果　观察组PLT计数降低、MPV升高、PDW升高；观察组患者GCS/GOS与PLT计数呈正相关，与MPV、PDW呈负相关。结论　PLT计数、MPV、PDW均与TCI有关，三者中PLT最具临床意义。PLT计数越低、MPV和PDW越高，脑梗死可能性越大，颅脑损伤可能越严重，预后可能越差。

Citation： DAN Bing,YU Shui,ZENG Lingchun,PENG Zongqing,ZENG Yijun,DU Deming,ZHENG Feng,WANG Qiangping. Relationship between Platelet Parameters and Traumatic Cerebral Infarction in Acute Phase of Craniocerebral Injury. West China Medical Journal, 2013, 28(1): 7-10. doi: 10.7507/1002-0179.20130002 Copy

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2.	Tian HL, Geng Z, Cui YH, et al. Risk factors for posttraumatic cerebral infarction in patients with moderate or severe head trauma[J]. Neurosurg Rev, 2008, 31(4): 431-436; discussion 436-437.
3.	Ham HY, Lee JK, Jang JW, et al. Decompressive hemicraniectomy for the treatment of traumatic brain injury[J]. J Korean Neurosurg Soc, 2011, 50(4): 370-376.
4.	Oertel M, Kelly DF, Mcarthur D, et al. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injuey[J]. J Neurosurg, 2002， 96(1): 109-116.
5.	刘卫平, 章翔, 易声禹, 等. 大鼠急性颅脑损伤后脓微循环的变化[J]. 第四军医大学学报， 2000, 21(12) : 1506-1509.
6.	Matters M, Vemieri F, Troisi E, el al. Early cerebral heodynamic changes during passive movements and motor recovery after stroke [J]. J Neuml, 2003, 250(7): 810-817.
7.	Clark RS, Schiding JK, Kaczorowski SL, et al. Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models[J]. J Neurotrauma, 1994, 11(5): 499-506.
8.	邓树荣, 粱涛, 李洪韬, 等. 急性脑血管病血小板参数变化及临床意义 [J]. 广西医科大学报, 2004, 21(5): 70l-703.
9.	Kurabayashi H, Tamura J, Naruse T, et al. Possible existence of platelet activation before the onset of cerebral infarction[J]. Atherosclerosis, 2000, 153(1): 203-207.
10.	Akisu M, Huseyinov A, Yalaz M, et al. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia [J]. Prostaglandins Leukot Essent Fatty Acids, 2003, 69(1): 45-50.
11.	Talving P, Lustenberger T, Lam L, et al. Coagulopathy after isolated severe traumatic brain injury in children [J]. J Trauma, 2011, 71(5): 1205-1210.
12.	Saggar V, Mittal RS, Vyas MC. Hemostatic abnormalities in patients with closed head injuries and their role in predicting early mortality [J]. J Neurotrauma, 2009, 26(10): 1665-1668.
13.	Talving P, Benfield R, Hadjizacharia P, et al. Coagulopathy in severe traumatic brain injury: a prospective study [J]. J Trauma, 2009, 66(1): 55-61.
14.	姚晓腾，荆国杰，谢乙团，等. 重型颅脑损伤患者亚低温治疗凝血功能指标的变化与预后[J]. 中国实用神经疾病杂志, 2011, 14(21): 3-7.
15.	曲东锋. 脑出血后的抗血小板治疗[J]. 国际脑血管病杂志, 2006, 14(3): 196.

1. 　Tawil I, Stein DM, Mirvis SE, et al. Osttraumatic cerebral infarction: incidence, outcome, and risk factors[J]. J Trauma, 2008, 64(4): 849-853.
2. 　Tian HL, Geng Z, Cui YH, et al. Risk factors for posttraumatic cerebral infarction in patients with moderate or severe head trauma[J]. Neurosurg Rev, 2008, 31(4): 431-436; discussion 436-437.
3. 　Ham HY, Lee JK, Jang JW, et al. Decompressive hemicraniectomy for the treatment of traumatic brain injury[J]. J Korean Neurosurg Soc, 2011, 50(4): 370-376.
4. 　Oertel M, Kelly DF, Mcarthur D, et al. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injuey[J]. J Neurosurg, 2002， 96(1): 109-116.
5. 　刘卫平, 章翔, 易声禹, 等. 大鼠急性颅脑损伤后脓微循环的变化[J]. 第四军医大学学报， 2000, 21(12) : 1506-1509.
6. 　Matters M, Vemieri F, Troisi E, el al. Early cerebral heodynamic changes during passive movements and motor recovery after stroke [J]. J Neuml, 2003, 250(7): 810-817.
7. 　Clark RS, Schiding JK, Kaczorowski SL, et al. Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models[J]. J Neurotrauma, 1994, 11(5): 499-506.
8. 　邓树荣, 粱涛, 李洪韬, 等. 急性脑血管病血小板参数变化及临床意义 [J]. 广西医科大学报, 2004, 21(5): 70l-703.
9. 　Kurabayashi H, Tamura J, Naruse T, et al. Possible existence of platelet activation before the onset of cerebral infarction[J]. Atherosclerosis, 2000, 153(1): 203-207.
10. 　Akisu M, Huseyinov A, Yalaz M, et al. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia [J]. Prostaglandins Leukot Essent Fatty Acids, 2003, 69(1): 45-50.
11. 　Talving P, Lustenberger T, Lam L, et al. Coagulopathy after isolated severe traumatic brain injury in children [J]. J Trauma, 2011, 71(5): 1205-1210.
12. 　Saggar V, Mittal RS, Vyas MC. Hemostatic abnormalities in patients with closed head injuries and their role in predicting early mortality [J]. J Neurotrauma, 2009, 26(10): 1665-1668.
13. 　Talving P, Benfield R, Hadjizacharia P, et al. Coagulopathy in severe traumatic brain injury: a prospective study [J]. J Trauma, 2009, 66(1): 55-61.
14. 　姚晓腾，荆国杰，谢乙团，等. 重型颅脑损伤患者亚低温治疗凝血功能指标的变化与预后[J]. 中国实用神经疾病杂志, 2011, 14(21): 3-7.
15. 　曲东锋. 脑出血后的抗血小板治疗[J]. 国际脑血管病杂志, 2006, 14(3): 196.

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West China Medical Journal

Relationship between Platelet Parameters and Traumatic Cerebral Infarction in Acute Phase of Craniocerebral Injury

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