Effect of Adenosine on Propofol Consumption in Total Intravenous Anesthesia_West China Medical Journal

Authors：

QIN Wenming , WANG Yan.

Department of Anesthesia, Bazhong Central Hospital of Sichuan Province, Bazhong, Sichuan 636000, P. R. China;

Corresponding author：

Keywords：

腺苷; 丙泊酚; 全凭静脉麻醉; 剂量

DOI：

10.7507/1002-0179.20130022

Video：

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目的　探讨全凭静脉麻醉中腺苷对丙泊酚用量的影响。方法　2011年1月－12月期间59例行择期手术的患者全凭静脉麻醉，随机分为腺苷静脉持续输注组（A组）和对照组（B组），A组患者麻醉诱导后持续输注腺苷70 μg/（kg·min），直至术毕。B组麻醉后按常规处理。比较两组患者麻醉时间、苏醒时间、瑞芬太尼用量，麻醉过程中平均动脉压（MAP）、心率，以及麻醉过程中丙泊酚的用量。同时记录使用腺苷过程中的不良反应。结果　两组患者麻醉时间、苏醒时间、瑞芬太尼用量比较均无明显差异，无统计学意义（P＞0.05）。两组患者麻醉过程中MAP、心率比较亦无明显差异，无统计学意义（P＞0.05）。两组患者麻醉过程中丙泊酚平均用量比较，A组明显低于C组，差异有统计学意义（P＜0.05），且不良反应发生率低。结论　腺苷能明显降低全凭静脉麻醉中丙泊酚的使用剂量。

Citation： QIN Wenming,WANG Yan.. Effect of Adenosine on Propofol Consumption in Total Intravenous Anesthesia. West China Medical Journal, 2013, 28(1): 80-82. doi: 10.7507/1002-0179.20130022 Copy

1.	Sawynok J, Zarrindast MR, Reid AR, et al. Adenosine a3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine[J]. Eur J Pharmacol, 1997, 333(1): 1-7.
2.	Donnelly-Roberts D, Mcgaraughty S, Shieh CC, et al. Painful purinergic receptors[J]. J Pharmacol Exp Ther, 2008, 324(2): 409-415.
3.	Segerdahl M, Ekblom A, Sandelin K, et al. Peroperative adenosine infusion reduces the requirements for isoflurane and postoperative analgesics[J]. Anesth Analg, 1995, 80(6): 1145-1149.
4.	Seitz PA, ter Riet M, Rush W, et al. Adenosine decreases the minimum alveolar concentration of halothane in dogs[J]. Anesthesiology, 1990, 73(5): 990-994.
5.	Mantz J, Lecharny JB, Laudenbach V, et al. Anesthetics affect the uptake but not the depolarization-evoked release of GABA in rat striatal synaptosomes[J]. Anesthesiology, 1995, 82(2): 502-511.
6.	Yue L, Xie A, Bruzik KS, et al. Potentiating action of propofol at GABAA receptors of retinal bipolar cells[J]. Invest Ophthalmol Vis Sci, 2011, 52(5): 2497-2509.
7.	Fischer MJ, Leffler A, Niedermirtl F, et al. The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors[J]. J Biol Chem, 2010, 285(45): 34781-34792.
8.	Strieker M, Nolan EM, Walsh CT, et al. Stereospecific synthesis of threo-and erythro-β-Hydroxyglutamic acid during kutzneride biosynthesis[J]. J Am Chem Soc, 2009, 131(37): 13523-13530.
9.	Ralevic V, Burnstock G. Receptors for purines and pyrimidines[J]. Pharmacol Rev, 1998, 50(3): 413-492.
10.	王任烨, 狄枫, 徐英, 等. 腺苷及其受体在神经系统中的生物学作用[J]. 国外医学·药学分册, 2006, 33(4): 279-282.
11.	Deng Q, Terunuma M, Fellin T, et al. Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a Src kinase dependent pathway[J]. Glia, 2011, 59(7): 1084-1093.
12.	曲卫敏, 孙宇, 许奇, 等. 腺苷和睡眠觉醒调节[J]. 生物物理学报, 2011, 27(1): 5-17.
13.	赵静, 米文丽. 毛应启梁.腺苷及其受体参与外周痛觉信息调控的机制[J]. 国际病理科学与临床杂志, 2011, 31(4): 301-303.
14.	Zárate E, Sá Rêgo MM, White PF, et al. Comparison of adenosine and remifentanil infusions as adjuvants to desflurane anesthesia[J]. Anesthesiology, 1999, 90(4): 956-963.
15.	Fukunaga AF, Alexander GE, Stark CW. Characterization of the analgesic actions of adenosine: comparison of adenosine and remifentanil infusions in patients undergoing major surgical procedures[J]. Pain, 2003, 101(1-2): 129-138.

1. 　Sawynok J, Zarrindast MR, Reid AR, et al. Adenosine a3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine[J]. Eur J Pharmacol, 1997, 333(1): 1-7.
2. 　Donnelly-Roberts D, Mcgaraughty S, Shieh CC, et al. Painful purinergic receptors[J]. J Pharmacol Exp Ther, 2008, 324(2): 409-415.
3. 　Segerdahl M, Ekblom A, Sandelin K, et al. Peroperative adenosine infusion reduces the requirements for isoflurane and postoperative analgesics[J]. Anesth Analg, 1995, 80(6): 1145-1149.
4. 　Seitz PA, ter Riet M, Rush W, et al. Adenosine decreases the minimum alveolar concentration of halothane in dogs[J]. Anesthesiology, 1990, 73(5): 990-994.
5. 　Mantz J, Lecharny JB, Laudenbach V, et al. Anesthetics affect the uptake but not the depolarization-evoked release of GABA in rat striatal synaptosomes[J]. Anesthesiology, 1995, 82(2): 502-511.
6. 　Yue L, Xie A, Bruzik KS, et al. Potentiating action of propofol at GABAA receptors of retinal bipolar cells[J]. Invest Ophthalmol Vis Sci, 2011, 52(5): 2497-2509.
7. 　Fischer MJ, Leffler A, Niedermirtl F, et al. The general anesthetic propofol excites nociceptors by activating TRPV1 and TRPA1 rather than GABAA receptors[J]. J Biol Chem, 2010, 285(45): 34781-34792.
8. 　Strieker M, Nolan EM, Walsh CT, et al. Stereospecific synthesis of threo-and erythro-β-Hydroxyglutamic acid during kutzneride biosynthesis[J]. J Am Chem Soc, 2009, 131(37): 13523-13530.
9. 　Ralevic V, Burnstock G. Receptors for purines and pyrimidines[J]. Pharmacol Rev, 1998, 50(3): 413-492.
10. 　王任烨, 狄枫, 徐英, 等. 腺苷及其受体在神经系统中的生物学作用[J]. 国外医学·药学分册, 2006, 33(4): 279-282.
11. 　Deng Q, Terunuma M, Fellin T, et al. Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a Src kinase dependent pathway[J]. Glia, 2011, 59(7): 1084-1093.
12. 　曲卫敏, 孙宇, 许奇, 等. 腺苷和睡眠觉醒调节[J]. 生物物理学报, 2011, 27(1): 5-17.
13. 　赵静, 米文丽. 毛应启梁.腺苷及其受体参与外周痛觉信息调控的机制[J]. 国际病理科学与临床杂志, 2011, 31(4): 301-303.
14. 　Zárate E, Sá Rêgo MM, White PF, et al. Comparison of adenosine and remifentanil infusions as adjuvants to desflurane anesthesia[J]. Anesthesiology, 1999, 90(4): 956-963.
15. 　Fukunaga AF, Alexander GE, Stark CW. Characterization of the analgesic actions of adenosine: comparison of adenosine and remifentanil infusions in patients undergoing major surgical procedures[J]. Pain, 2003, 101(1-2): 129-138.

West China Medical Journal

Effect of Adenosine on Propofol Consumption in Total Intravenous Anesthesia

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