Gender Difference of the Relationship between Serum Uric Acid and Metabolic Syndrome_West China Medical Journal

Authors：

CHEN Jingjing , HE Hongyan , WAN Liyan , LI Longxin , ZHAO Liming ,  CHEN Xiaoping. China

Department of Cardiology, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, P. R.;

Corresponding author：

CHEN Xiaoping. China, Email: 532778449@qq.com

Keywords：

尿酸; 代谢综合征; 性别差异

DOI：

10.7507/1002-0179.20130057

Video：

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目的　探讨中老年人群血清尿酸水平与代谢综合征（MS）及其各组分的关系。方法　采用横断面研究，对2007年49～80岁成都成华区711例人群进行调查，并测量身高、体重、血压、空腹血糖、三酰甘油、高密度脂蛋白、低密度脂蛋白、血清尿酸等指标，采用SPSS 16.0软件分析尿酸与MS及MS各组分之间的关系。结果　在中老年人群中，MS的发生率为25.60%，高尿酸血症的发生率为21.24%。女性MS、腹型肥胖、高三酰甘油血症和低高密度脂蛋白胆固醇血症的发生率均明显高于男性。尿酸与腰围、收缩压、三酰甘油、舒张压、高密度脂蛋白水平的相关系数分别为0.311、0.140、0.118、0.106和?0.147，均有统计学意义（P＜0.05）。男、女性尿酸与腰围的相关系数分别为0.173和?0.321，均有统计学意义（P＜0.05）。男、女性尿酸与空腹血糖的相关系数分别为?0.049和0.183，均有统计学意义（P＜0.05）。结论　血清尿酸水平与MS及其各组分关系密切，血清尿酸水平和MS及其各组分间的关系存在性别差异。

Citation： CHEN Jingjing,HE Hongyan,WAN Liyan,LI Longxin,ZHAO Liming,CHEN Xiaoping. China. Gender Difference of the Relationship between Serum Uric Acid and Metabolic Syndrome. West China Medical Journal, 2013, 28(2): 175-178. doi: 10.7507/1002-0179.20130057 Copy

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10.	Ebrahimpour P, Fakhrzadeh H, Heshmat R, et al. Serum uric acid levels and risk of metabolic syndrome in healthy adults[J]. Endocr Pract, 2008, 14(3): 298-304.
11.	Miao Z, Yan S, Wang J, et al. Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions[J]. Inflamm Res, 2009, 58(10): 659-668.
12.	Bedir A, Topbas M, Tanyeri F, et al．Leptin might be a regulator of serum uric acid concentrations in human[J]. Jpn Heart J, 2003, 44(4): 527-536.

1. 　Zhang W, Liang S, Wu J, et al. Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr-1+ myeloid-derived suppressor cells that promote long-term survival of allografts[J]. Transplantation, 2008, 86(8): 1125-1134.
2. 　熊建平, 欧利民, 谭学瑞. 尿酸及白细胞计数与代谢综合征的相关性研究[J].热带医学杂志, 2012, 12(2): 136-141.
3. 　Chiou WK, Wang MH, Huang DH, et al. The relationship between serum uric acid level and metabolic syndrome:difference by sex and age in Taiwanese[J]. J Epidemiol, 2010, 20(3): 219-224.
4. 　Onat A ,Uyarel H, Hergenc G, et al. Serum uric acid is a determinant of metabolic syndrome in a population-based study[J]. Am J Hypertens, 2006, 19(10 ): 1055-1062.
5. 　Yamada T，Fukatsu M, Suzuki S，et al．Elevated serum uric acid predicts impaired fasting glucose and type 2 diabetes only among Japanese women undergoing health checkups[J]. Diabetes Metab, 2011, 37(3): 252-258.
6. 　Tamba S, Nishizawa H, Funahashi T, et al. Relationship between the serum uric acid level ,visceral fat accumulation and serum adiponectin concentration in Japanese men[J]. Intern Med, 2008, 47(13): 1175-1180.
7. 　Bock G, Dalla C, Campioni M, et al. Pathog enesis of pre-diabetes mechanisms of fasting and postprandial hyperglycemia in people wit h impaired fasting glucose and/ or impaired glucose tolerance[J]. Diabetes, 2006, 55(11): 3536-3538.
8. 　庞建华, 周亚茹, 王战建. 2型糖尿病与胰岛素抵抗[J]. 河北医药, 2004, 26(4): 292.
9. 　张永能, 程继东. 高尿酸血症及相关代谢性疾病的病理生理学研究进展[J]. 广东医学, 2012, 33(1): 134-136.
10. 　Ebrahimpour P, Fakhrzadeh H, Heshmat R, et al. Serum uric acid levels and risk of metabolic syndrome in healthy adults[J]. Endocr Pract, 2008, 14(3): 298-304.
11. 　Miao Z, Yan S, Wang J, et al. Insulin resistance acts as an independent risk factor exacerbating high-purine diet induced renal injury and knee joint gouty lesions[J]. Inflamm Res, 2009, 58(10): 659-668.
12. 　Bedir A, Topbas M, Tanyeri F, et al．Leptin might be a regulator of serum uric acid concentrations in human[J]. Jpn Heart J, 2003, 44(4): 527-536.

West China Medical Journal

Gender Difference of the Relationship between Serum Uric Acid and Metabolic Syndrome

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