Serum levels of Selenium and Fluorine in Patients with Adult Kashin-Beck Disease_West China Medical Journal

Authors：

TANG Xin ,  ZHOU Zongke , SHEN Bin , KANG Pengde , YANG Jing , LI Jian , LI Qi , PEI Fuxin.

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China.;

Corresponding author：

ZHOU Zongke, Email: zongke@126.com

Keywords：

大骨节病; 血清; 硒; 氟

DOI：

10.7507/1002-0179.20130070

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　了解成人大骨节病（KBD）患者血清中硒和氟的含量及其与大骨节病分度的相关性。方法　2008年8月－2009年10月，采集四川阿坝壤塘县大骨节病区成人KBD患者血清标本37例，四川非大骨节病区健康成人血清39例作为对照组。血清硒的含量采用石墨炉原子吸收分光光度法进行检测，氟采用氟离子选择电极法进行检测。统计学分析组间差异有无统计学意义，同时分析硒和氟的表达水平与大骨节病分度的相关性。结果　大骨节病组患者血清硒的表达水平明显低于健康对照组（P＜0.05）；血清氟的表达水平虽略低于健康对照组，但无统计学意义（P＞0.05）。大骨节病组患者Ⅰ度和Ⅱ、Ⅲ度间硒和氟的表达水平无统计学差异（P＞0.05）。结论　成人大骨节病患者血清中硒水平偏低，血清氟水平与健康人无统计学差异；血清硒和氟含量与大骨节病的分度并无明显相关性。

Citation： TANG Xin,ZHOU Zongke,SHEN Bin,KANG Pengde,YANG Jing,LI Jian,LI Qi,PEI Fuxin.. Serum levels of Selenium and Fluorine in Patients with Adult Kashin-Beck Disease. West China Medical Journal, 2013, 28(2): 221-223. doi: 10.7507/1002-0179.20130070 Copy

1.	Schepman K, Engelbert RH, Visser MM, et al. Kashin Beck disease: more than just osteoarthrosis: a crosssectional study regarding the influence of body function-structures and activities on level of participation [J]. Int Orthop, 2011, 35(5): 767-776.
2.	Guo X. Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China[J]. Int Orthop, 2001, 25(3): 147-150.
3.	Chasseur C, Suetens C, Michel V, et al. A 4-year study of the mycological aspects of Kashin-Beck disease in Tibet[J]. Int Orthop, 2001, 25 (3): 154-158.
4.	Haubruge E, Chasseur C, Debouck C, et al. The prevalence of mycotoxins in Kashin-Beck disease[J]. Int Orthop, 2001, 25(3): 159-162.
5.	Moreno-Reyes R, Suetens C, Mathieu F, et al. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status[J]. N Engl J Med, 1998, 339(16): 1112-1120.
6.	Malaisse F, Mathieu F. Big bone disease: a multidisciplinary approach of KBD in Tibet Autonomous Region (P.R. China)[M]. Presse Agronom Gembloux, 2008: 70-78.
7.	La Grange M, Mathieu F, Begaux F, et al. Kashin-Beck disease and drinking water in Central Tibet [J]. Int Orthop, 2001; 25(3): 167-169.
8.	Yang C, Niu C, Bodo M, et al. Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue [J]. Biochem J, 1993, 289(Pt3):829-835.
9.	Zou K, Liu G, Wu T, et al. Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis[J]. Osteoarthritis Cartilage, 2009,17(2): 144-151.
10.	Jirong Y, Huiyun P, Zhongzhe Y, et al. Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials[J]. Osteoarthritis Cartilage. 2012, 20(7): 605-613.
11.	李端生. 大骨节病低氟说的诠释[J]. 吉林地质, 2007, 26(4): 100-104.
12.	何锦, 安永会, 贾小丰,等. 阿坝州饮水中硒和氟元素与大骨节病关系研究[J]. 地下水, 2012, 34(2): 9-10.
13.	李富忠, 邓佳云, 周定友, 等. 2005年四川省大骨节病监测结果分析[J]. 预防医学情报杂志, 2005, 21(6): 666-668.
14.	GB16003-1995. 大骨节病诊断标准中华人民共和国国家标准[S].
15.	张宝军, 杨林生, 王五一, 等. 壤塘县大骨节病病区环境中硒的分布特征[J]. 地理科学进展, 2009, 28(6): 886-891.
16.	李亮, 安永会, 李旭峰, 等. 四川若尔盖大骨节病区地质环境特征分析[J]. 水文地质工程地质, 2010, 37(4): 126-129, 134.
17.	李顺江, 李巍, 胡霞, 等. 西藏土壤-植物-动物(人)系统中硒含量与大骨节病的关系[J]. 生态学杂志, 2008, 27(12): 2167-2170.
18.	邓佳云, 李德云, 梁代华, 等．从四川省大骨节病与硒的关系看硒在病因学中的地位[J]. 中国地方病防治杂志, 1999, 14(4)：249-251．.
19.	李顺江, 杨林生, 王五一, 等．西藏大骨节病与饮水硒关系研究[J]. 中国地方病学杂志, 2006, 25(4): 428-429．.
20.	王洪艳, 陈昭. 大骨节病与发中微量元素硒含量关系的配对研究[J]. 中国地方病防治杂志, 2008, 23(1): 59-60.
21.	Dhar V, Bhatnagar M．Physiology and toxicity of fluoride[J]．Indian J Dent Res, 2009, 20(3): 350-355.
22.	邓佳云, 杨小静, 周定友, 等. 四川藏区居民饮用砖茶中氟含量检测结果分析[J]. 职业卫生与病伤, 2009, 24(5): 306-308.

1. 　Schepman K, Engelbert RH, Visser MM, et al. Kashin Beck disease: more than just osteoarthrosis: a crosssectional study regarding the influence of body function-structures and activities on level of participation [J]. Int Orthop, 2011, 35(5): 767-776.
2. 　Guo X. Diagnostic, clinical and radiological characteristics of Kashin-Beck disease in Shaanxi Province, PR China[J]. Int Orthop, 2001, 25(3): 147-150.
3. 　Chasseur C, Suetens C, Michel V, et al. A 4-year study of the mycological aspects of Kashin-Beck disease in Tibet[J]. Int Orthop, 2001, 25 (3): 154-158.
4. 　Haubruge E, Chasseur C, Debouck C, et al. The prevalence of mycotoxins in Kashin-Beck disease[J]. Int Orthop, 2001, 25(3): 159-162.
5. 　Moreno-Reyes R, Suetens C, Mathieu F, et al. Kashin-Beck osteoarthropathy in rural Tibet in relation to selenium and iodine status[J]. N Engl J Med, 1998, 339(16): 1112-1120.
6. 　Malaisse F, Mathieu F. Big bone disease: a multidisciplinary approach of KBD in Tibet Autonomous Region (P.R. China)[M]. Presse Agronom Gembloux, 2008: 70-78.
7. 　La Grange M, Mathieu F, Begaux F, et al. Kashin-Beck disease and drinking water in Central Tibet [J]. Int Orthop, 2001; 25(3): 167-169.
8. 　Yang C, Niu C, Bodo M, et al. Fulvic acid supplementation and selenium deficiency disturb the structural integrity of mouse skeletal tissue [J]. Biochem J, 1993, 289(Pt3):829-835.
9. 　Zou K, Liu G, Wu T, et al. Selenium for preventing Kashin-Beck osteoarthropathy in children: a meta-analysis[J]. Osteoarthritis Cartilage, 2009,17(2): 144-151.
10. 　Jirong Y, Huiyun P, Zhongzhe Y, et al. Sodium selenite for treatment of Kashin-Beck disease in children: a systematic review of randomised controlled trials[J]. Osteoarthritis Cartilage. 2012, 20(7): 605-613.
11. 　李端生. 大骨节病低氟说的诠释[J]. 吉林地质, 2007, 26(4): 100-104.
12. 　何锦, 安永会, 贾小丰,等. 阿坝州饮水中硒和氟元素与大骨节病关系研究[J]. 地下水, 2012, 34(2): 9-10.
13. 　李富忠, 邓佳云, 周定友, 等. 2005年四川省大骨节病监测结果分析[J]. 预防医学情报杂志, 2005, 21(6): 666-668.
14. 　 GB16003-1995. 大骨节病诊断标准中华人民共和国国家标准[S].
15. 　张宝军, 杨林生, 王五一, 等. 壤塘县大骨节病病区环境中硒的分布特征[J]. 地理科学进展, 2009, 28(6): 886-891.
16. 　李亮, 安永会, 李旭峰, 等. 四川若尔盖大骨节病区地质环境特征分析[J]. 水文地质工程地质, 2010, 37(4): 126-129, 134.
17. 　李顺江, 李巍, 胡霞, 等. 西藏土壤-植物-动物(人)系统中硒含量与大骨节病的关系[J]. 生态学杂志, 2008, 27(12): 2167-2170.
18. 　邓佳云, 李德云, 梁代华, 等．从四川省大骨节病与硒的关系看硒在病因学中的地位[J]. 中国地方病防治杂志, 1999, 14(4)：249-251．.
19. 　李顺江, 杨林生, 王五一, 等．西藏大骨节病与饮水硒关系研究[J]. 中国地方病学杂志, 2006, 25(4): 428-429．.
20. 　王洪艳, 陈昭. 大骨节病与发中微量元素硒含量关系的配对研究[J]. 中国地方病防治杂志, 2008, 23(1): 59-60.
21. 　Dhar V, Bhatnagar M．Physiology and toxicity of fluoride[J]．Indian J Dent Res, 2009, 20(3): 350-355.
22. 　邓佳云, 杨小静, 周定友, 等. 四川藏区居民饮用砖茶中氟含量检测结果分析[J]. 职业卫生与病伤, 2009, 24(5): 306-308.

West China Medical Journal

Serum levels of Selenium and Fluorine in Patients with Adult Kashin-Beck Disease

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content