阻塞性睡眠呼吸暂停低通气综合征与2型糖尿病的关系_West China Medical Journal

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2型糖尿病; 阻塞性睡眠呼吸暂停; 低通气综合征

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10.7507/1002-0179.20130245

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近年来越来越多的研究显示睡眠参与了包括血糖调节在内的多种生理功能调节。作为常见睡眠疾患之一，阻塞性睡眠呼吸暂停低通气综合征不仅在2型糖尿病患者中有着较高的发病率，而且还可能直接促使了体内糖代谢异常的发生，有证据表明通过有效治疗阻塞性睡眠呼吸暂停低通气综合征可以明显改善患者血糖调节水平。

Citation： 任蓉,黄国平. 阻塞性睡眠呼吸暂停低通气综合征与2型糖尿病的关系. West China Medical Journal, 2013, 28(5): 792-794. doi: 10.7507/1002-0179.20130245 Copy

1.	Sicree RJ, Shaw J, Zimmet P. The global burden, diabetes and impaired glucose tolerance[M]. In: IDF diabetes atlas4th ed. Brussels: International Diabetes Federation, 2009: 1-105.
2.	Punjabi NM. The epidemiology of adult obstructive sleep apnea[J]. Proc Am Thorac Soc, 2008, 5(2): 136-143.
3.	Einhorn D, Stewart DA, Erman MK, et al. Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus[J]. Endocr Pract, 2007, 13(4): 355-362.
4.	Schober AK, Neurath MF, Harsch IA. Prevalence of sleep apnoea in diabetic patients[J]. Clin Respir J, 2011, 5(3): 165-172.
5.	Foster GD, Sanders MH, Millman R, et al. Obstructive sleep apnea among obese patients with type 2 diabetes[J]. Diabetes Care, 2009, 32(6): 1017-1019.
6.	Punjabi NM, Sorkin JD, Katzel LI, et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men[J]. Am J Respir Crit Care Med, 2002, 165(5): 677-682.
7.	Ip MS, Lam B, Ng MM, et al. Obstructive sleep apnea is independently associated with insulin resistance[J]. Am J Respir Crit Care Med, 2002, 165(5): 670-676.
8.	Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes[J]. Am J Med, 2009, 122(12): 1122-1127.
9.	Marshall NS, Wong KK, Phillips CL, et al. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the busselton health study?[J]. J Clin Sleep Med, 2009, 5(1): 15-20.
10.	Ronksley PE, Hemmelgarn BR, Heitman SJ, et al. Obstructive sleep apnoea is associated with diabetes in sleepy subjects[J]. Thorax, 2009, 64(10): 834-839.
11.	Aronsohn RS, Whitmore H, van Cauter E, et al. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes[J]. Am J Respir Crit Care Med, 2010, 181(5): 507-513.
12.	Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers[J]. J Appl Physiol, 2009, 106(5): 1538-1544.
13.	Iiyori N, Alonso LC, Li J, et al. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity[J]. Am J Respir Crit Care Med, 2007, 175(8): 851-857.
14.	Stamatakis KA, Punjabi NM. Effects of experimental sleep fragmentation on glucose metabolism in normal subjects[J]. Chest, 2010, 137(1): 95-101.
15.	Punjabi NM, Beamer BA. Alterations in glucose disposal in sleep-disordered breathing[J]. Am J Respir Crit Care Med .2009, 179(3): 235-240.
16.	Punjabi NM, Workshop Participants. Do sleep disorders and associated treatments impact glucose metabolism?[J]. Drugs, 2009, 69(suppl 2): 13-27.
17.	Lam JC, Lam B, Yao TJ, et al. A randomized controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnea[J]. Eur Respir J, 2010, 35(1): 138-145.
18.	Patruno V, Aiolfi S, Costantino G, et al. Fixed and autoadjusting continuous positive airway pressure treatments are not similar in educing cardiovascular risk factors in patients with obstructive sleep apnea[J]. Chest, 2007, 131(5): 1393-1399.
19.	魏翠英, 王慧玲 , 李静, 等. CPAP治疗对OSA HS合并糖尿病患者2 4小时动态血糖影响的初步研究[G]. 2008年中国睡眠研究会第五届学术年会论文摘要汇编. 北京: 中国睡眠研究会, 2008.
20.	Coughlin SR, Mawdsley L, Mugarza JA, et al. Cardiovascularand metabolic effects of CPAP in obese males with OSA[J]. Eur Respir J, 2007, 29(4): 720-727.
21.	West SD, Nicoll DJ, Wallace TM, et al. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes[J]. Thorax, 2007, 62(11): 969-974.
22.	Yang D, Liu Z, Yang H, et al. Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis[J]. Sleep Breath, 2013, 17(1): 33-38.
23.	Hecht L, Möhler R, Meyer G. Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis[J]. Ger Med Sci, 2011, 9: 20.
24.	Kosseifi S, Bailey B, Price R, et al. The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients[J]. Mil Med, 2010, 175(11): 913-916.

1. 　Sicree RJ, Shaw J, Zimmet P. The global burden, diabetes and impaired glucose tolerance[M]. In: IDF diabetes atlas4th ed. Brussels: International Diabetes Federation, 2009: 1-105.
2. 　Punjabi NM. The epidemiology of adult obstructive sleep apnea[J]. Proc Am Thorac Soc, 2008, 5(2): 136-143.
3. 　Einhorn D, Stewart DA, Erman MK, et al. Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus[J]. Endocr Pract, 2007, 13(4): 355-362.
4. 　Schober AK, Neurath MF, Harsch IA. Prevalence of sleep apnoea in diabetic patients[J]. Clin Respir J, 2011, 5(3): 165-172.
5. 　Foster GD, Sanders MH, Millman R, et al. Obstructive sleep apnea among obese patients with type 2 diabetes[J]. Diabetes Care, 2009, 32(6): 1017-1019.
6. 　Punjabi NM, Sorkin JD, Katzel LI, et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men[J]. Am J Respir Crit Care Med, 2002, 165(5): 677-682.
7. 　Ip MS, Lam B, Ng MM, et al. Obstructive sleep apnea is independently associated with insulin resistance[J]. Am J Respir Crit Care Med, 2002, 165(5): 670-676.
8. 　Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes[J]. Am J Med, 2009, 122(12): 1122-1127.
9. 　Marshall NS, Wong KK, Phillips CL, et al. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the busselton health study?[J]. J Clin Sleep Med, 2009, 5(1): 15-20.
10. 　Ronksley PE, Hemmelgarn BR, Heitman SJ, et al. Obstructive sleep apnoea is associated with diabetes in sleepy subjects[J]. Thorax, 2009, 64(10): 834-839.
11. 　Aronsohn RS, Whitmore H, van Cauter E, et al. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes[J]. Am J Respir Crit Care Med, 2010, 181(5): 507-513.
12. 　Louis M, Punjabi NM. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers[J]. J Appl Physiol, 2009, 106(5): 1538-1544.
13. 　Iiyori N, Alonso LC, Li J, et al. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity[J]. Am J Respir Crit Care Med, 2007, 175(8): 851-857.
14. 　Stamatakis KA, Punjabi NM. Effects of experimental sleep fragmentation on glucose metabolism in normal subjects[J]. Chest, 2010, 137(1): 95-101.
15. 　Punjabi NM, Beamer BA. Alterations in glucose disposal in sleep-disordered breathing[J]. Am J Respir Crit Care Med .2009, 179(3): 235-240.
16. 　Punjabi NM, Workshop Participants. Do sleep disorders and associated treatments impact glucose metabolism?[J]. Drugs, 2009, 69(suppl 2): 13-27.
17. 　Lam JC, Lam B, Yao TJ, et al. A randomized controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnea[J]. Eur Respir J, 2010, 35(1): 138-145.
18. 　Patruno V, Aiolfi S, Costantino G, et al. Fixed and autoadjusting continuous positive airway pressure treatments are not similar in educing cardiovascular risk factors in patients with obstructive sleep apnea[J]. Chest, 2007, 131(5): 1393-1399.
19. 　魏翠英, 王慧玲 , 李静, 等. CPAP治疗对OSA HS合并糖尿病患者2 4小时动态血糖影响的初步研究[G]. 2008年中国睡眠研究会第五届学术年会论文摘要汇编. 北京: 中国睡眠研究会, 2008.
20. 　Coughlin SR, Mawdsley L, Mugarza JA, et al. Cardiovascularand metabolic effects of CPAP in obese males with OSA[J]. Eur Respir J, 2007, 29(4): 720-727.
21. 　West SD, Nicoll DJ, Wallace TM, et al. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes[J]. Thorax, 2007, 62(11): 969-974.
22. 　Yang D, Liu Z, Yang H, et al. Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis[J]. Sleep Breath, 2013, 17(1): 33-38.
23. 　Hecht L, Möhler R, Meyer G. Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis[J]. Ger Med Sci, 2011, 9: 20.
24. 　Kosseifi S, Bailey B, Price R, et al. The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients[J]. Mil Med, 2010, 175(11): 913-916.

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阻塞性睡眠呼吸暂停低通气综合征与2型糖尿病的关系

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