ω-3脂肪酸在胃肠道肿瘤患者中的临床作用效果_West China Medical Journal

Authors：

胡艳杰 ^1,2 ,  李卡 ² , 黄明君 ² , 汪晓东 ²

Corresponding author：

李卡, Email: xiaohu19901013@163.com

Keywords：

ω-3脂肪酸; 胃肠道肿瘤; 免疫营养制剂

DOI：

10.7507/1002-0179.20130348

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

近年来，研究证明ω-3脂肪酸具有抑制炎症反应、调节机体免疫功能、改善胃肠道术后患者肝功能损害及一定的抗肿瘤作用，这与其调节机体免疫因子、调控细胞内信号转导途径等有关。现就ω-3脂肪酸的来源、特点及在胃肠道肿瘤术前对患者机体的免疫营养作用、术后对患者肝功能恢复的临床效果和抗肿瘤等方面的相关作用作一综述。

Citation： 胡艳杰,李卡,黄明君,汪晓东. ω-3脂肪酸在胃肠道肿瘤患者中的临床作用效果. West China Medical Journal, 2013, 28(7): 1120-1122. doi: 10.7507/1002-0179.20130348 Copy

1.	刘鑫, 辛福泽, 张彦波. ω-3鱼油脂肪乳对胃肠道肿瘤患者术后免疫功能和炎性反应的影响[J]. 肠内与肠外营养, 2009, 16(5): 280-282.
2.	Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans[J]. Crit Care Med, 2002, 30(8): 1753-1761.
3.	陈博, 伍晓汀. 肠内免疫营养及其临床应用[J]. 中国普外基础与临床杂志, 2009, 16(12): 978-981.
4.	Calder PC. Immunomodulation by omega-3 fatty acids[J]. Prostag Leukotr Ess, 2007, 77(6): 327-335.
5.	Hofmanová J, Vaculová A, Kozubík A. Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis[J]. Cancer Lett, 2005, 218(1): 33-41.
6.	Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery[J]. Clin Nutr, 2004, 23(3): 325-330.
7.	Nakamura K, Kariyazono H, Komokata T, et al. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for Cancer[J]. Nutrition, 2005, 21(6): 639-649.
8.	梁尚游, 徐亮, 余利坚, 等. 肠内免疫营养对创伤Wistar大鼠肠屏障功能的影响[J]. 现代医药卫生, 2008(20): 3013-3015.
9.	Braga M, Vignali A, Gianotti L, et al. Immune and nutrional effects of enteral nutrition after major abdominal operations[J]. Eur J Surg, 1996, 162(2): 105-112.
10.	Stehr SN, Heller AR. Omega-3 fatty acid effects on biochemical indices following Cancer surgery[J]. Clin Chim Acta, 2006, 373(1-2): 1-8.
11.	Caglayan K, Oner I, Gunerhan Y, et al. The impact of preoperative immunonutrition and other nutrition models on tumor infiltrative lymphocytes in colorectal Cancer patients[J]. Am J Surg, 2012, 204(4): 416-421.
12.	张斌, 姬社青, 陈小兵. ω-3脂肪酸对胃癌新辅助放化疗患者术后康复的作用研究[J]. 中国当代医药, 2011, 18(25): 13-16.
13.	孟凡杰. ω-3鱼油脂肪乳对恶性肿瘤术后的影响[J]. 医药论坛杂志, 2009, 30(21): 80-82.
14.	Galbán C, Montejo JC, Mesejo A, et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients[J]. Crit Care Med, 2000, 28(3): 643-648.
15.	Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects[J]. Br J Nutr, 2003, 89(5): 679-689.
16.	张维康, 龙跃平, 陈俊华. ω-3鱼油脂肪乳对胃肠道恶性肿瘤患者术后恢复的作用[J]. 临床外科杂志, 2007, 15(9): 606-608.
17.	Marciniak R, Majewski P, Biczysko M. Effects of gastrectomy or colectomy on liver metabolism and liver morphology in an experimental rat model[J]. Med Sci Monit, 2004, 10(2): 34-40.
18.	Giger U, Büchler M, Farhadi J, et al. Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study[J]. Ann Surg Oncol, 2007, 14(10): 2798-2806.
19.	Rhoden D, Matheson PJ, Carricato ND, et al. Immune-enhancing enteral diet selectively augments ileal blood flow in the rat[J]. J Surg Res, 2002, 106(1): 25-30.
20.	Kirimlioglu V, Kirimlioglu H, Yilmaz S, et al. Effect of fish oil, olive oil, and vitamin E on liver pathology, cell proliferation, and antioxidant defense system in rats subjected to partial hepatectomy[J]. Transplant Proc, 2006, 38(2): 564-567.
21.	Heller AR, Rössel T, Gottschlich B, et al. Omega-3 fatty acids improve liver and pancreas function in postoperative Cancer patients[J]. Int J Cancer, 2004, 111(4): 611-616.
22.	Parker HM, Johnson NA, Burdon CA, et al. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis[J]. J Hepatol, 2012, 56(4): 944-951.
23.	谈谈, 仇毓东, 王萌, 等. ω-3不饱和脂肪酸对肝部分切除大鼠残肝的保护作用及机制[J]. 中国普通外科杂志, 2012, 21(1): 35-40.
24.	邱孝全, 沈月平. ω-3脂肪酸的抗癌研究[J]. 疾病控制杂志, 1997, 1(3): 211-213.
25.	Cockbain AJ, Toogood GJ, Hull MA. Omega-3 poly acids for the treatment and prevention of colorectal Cancer[J]. Gut, 2012, 61(1): 135-149.
26.	Fearon K. The anticancer and anticachectic effects of ω?3 fatty acids[J]. Clin Nutr, 2002, 21(sup2): 73-77.
27.	Latham P, Lund EK, Brown JC, et al. Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo[J]. Gut, 2001, 49(1): 97-105.
28.	Li M, Kong ZM, Liu ZL. Antioxidant enzyme activities and lipid peroxidation induced by eicosapentaenoic acid (EPA) in PC12 cells[J]. Cell Biol Toxicol, 2006, 22(5): 331-337.
29.	王向群, 陈丽娟. ω-3多不饱和脂肪酸抗肿瘤机制的研究进展[J]. 实用癌症杂志, 2011, 26(3): 321-324.
30.	王席娟. ω-3多不饱和脂肪酸的肿瘤治疗作用及其机制[J]. 肿瘤防治研究, 2010, 37(8): 967-970.
31.	Palmer AJ, Ho CK, Ajibola O, et al. The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis[J]. Crit Care Med, 2013, 41(1): 307-316.

1. 　刘鑫, 辛福泽, 张彦波. ω-3鱼油脂肪乳对胃肠道肿瘤患者术后免疫功能和炎性反应的影响[J]. 肠内与肠外营养, 2009, 16(5): 280-282.
2. 　Pratt VC, Tredget EE, Clandinin MT, et al. Alterations in lymphocyte function and relation to phospholipid composition after burn injury in humans[J]. Crit Care Med, 2002, 30(8): 1753-1761.
3. 　陈博, 伍晓汀. 肠内免疫营养及其临床应用[J]. 中国普外基础与临床杂志, 2009, 16(12): 978-981.
4. 　Calder PC. Immunomodulation by omega-3 fatty acids[J]. Prostag Leukotr Ess, 2007, 77(6): 327-335.
5. 　Hofmanová J, Vaculová A, Kozubík A. Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis[J]. Cancer Lett, 2005, 218(1): 33-41.
6. 　Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery[J]. Clin Nutr, 2004, 23(3): 325-330.
7. 　Nakamura K, Kariyazono H, Komokata T, et al. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for Cancer[J]. Nutrition, 2005, 21(6): 639-649.
8. 　梁尚游, 徐亮, 余利坚, 等. 肠内免疫营养对创伤Wistar大鼠肠屏障功能的影响[J]. 现代医药卫生, 2008(20): 3013-3015.
9. 　Braga M, Vignali A, Gianotti L, et al. Immune and nutrional effects of enteral nutrition after major abdominal operations[J]. Eur J Surg, 1996, 162(2): 105-112.
10. 　Stehr SN, Heller AR. Omega-3 fatty acid effects on biochemical indices following Cancer surgery[J]. Clin Chim Acta, 2006, 373(1-2): 1-8.
11. 　Caglayan K, Oner I, Gunerhan Y, et al. The impact of preoperative immunonutrition and other nutrition models on tumor infiltrative lymphocytes in colorectal Cancer patients[J]. Am J Surg, 2012, 204(4): 416-421.
12. 　张斌, 姬社青, 陈小兵. ω-3脂肪酸对胃癌新辅助放化疗患者术后康复的作用研究[J]. 中国当代医药, 2011, 18(25): 13-16.
13. 　孟凡杰. ω-3鱼油脂肪乳对恶性肿瘤术后的影响[J]. 医药论坛杂志, 2009, 30(21): 80-82.
14. 　Galbán C, Montejo JC, Mesejo A, et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients[J]. Crit Care Med, 2000, 28(3): 643-648.
15. 　Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects[J]. Br J Nutr, 2003, 89(5): 679-689.
16. 　张维康, 龙跃平, 陈俊华. ω-3鱼油脂肪乳对胃肠道恶性肿瘤患者术后恢复的作用[J]. 临床外科杂志, 2007, 15(9): 606-608.
17. 　Marciniak R, Majewski P, Biczysko M. Effects of gastrectomy or colectomy on liver metabolism and liver morphology in an experimental rat model[J]. Med Sci Monit, 2004, 10(2): 34-40.
18. 　Giger U, Büchler M, Farhadi J, et al. Preoperative immunonutrition suppresses perioperative inflammatory response in patients with major abdominal surgery-a randomized controlled pilot study[J]. Ann Surg Oncol, 2007, 14(10): 2798-2806.
19. 　Rhoden D, Matheson PJ, Carricato ND, et al. Immune-enhancing enteral diet selectively augments ileal blood flow in the rat[J]. J Surg Res, 2002, 106(1): 25-30.
20. 　Kirimlioglu V, Kirimlioglu H, Yilmaz S, et al. Effect of fish oil, olive oil, and vitamin E on liver pathology, cell proliferation, and antioxidant defense system in rats subjected to partial hepatectomy[J]. Transplant Proc, 2006, 38(2): 564-567.
21. 　Heller AR, Rössel T, Gottschlich B, et al. Omega-3 fatty acids improve liver and pancreas function in postoperative Cancer patients[J]. Int J Cancer, 2004, 111(4): 611-616.
22. 　Parker HM, Johnson NA, Burdon CA, et al. Omega-3 supplementation and non-alcoholic fatty liver disease: a systematic review and meta-analysis[J]. J Hepatol, 2012, 56(4): 944-951.
23. 　谈谈, 仇毓东, 王萌, 等. ω-3不饱和脂肪酸对肝部分切除大鼠残肝的保护作用及机制[J]. 中国普通外科杂志, 2012, 21(1): 35-40.
24. 　邱孝全, 沈月平. ω-3脂肪酸的抗癌研究[J]. 疾病控制杂志, 1997, 1(3): 211-213.
25. 　Cockbain AJ, Toogood GJ, Hull MA. Omega-3 poly acids for the treatment and prevention of colorectal Cancer[J]. Gut, 2012, 61(1): 135-149.
26. 　Fearon K. The anticancer and anticachectic effects of ω?3 fatty acids[J]. Clin Nutr, 2002, 21(sup2): 73-77.
27. 　Latham P, Lund EK, Brown JC, et al. Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivo[J]. Gut, 2001, 49(1): 97-105.
28. 　Li M, Kong ZM, Liu ZL. Antioxidant enzyme activities and lipid peroxidation induced by eicosapentaenoic acid (EPA) in PC12 cells[J]. Cell Biol Toxicol, 2006, 22(5): 331-337.
29. 　王向群, 陈丽娟. ω-3多不饱和脂肪酸抗肿瘤机制的研究进展[J]. 实用癌症杂志, 2011, 26(3): 321-324.
30. 　王席娟. ω-3多不饱和脂肪酸的肿瘤治疗作用及其机制[J]. 肿瘤防治研究, 2010, 37(8): 967-970.
31. 　Palmer AJ, Ho CK, Ajibola O, et al. The role of ω-3 fatty acid supplemented parenteral nutrition in critical illness in adults: a systematic review and meta-analysis[J]. Crit Care Med, 2013, 41(1): 307-316.

Previous Article
腺相关病毒介导的基因治疗在临床试验中的应用进展
Next Article
多靶点酪氨酸激酶抑制剂的临床应用进展

West China Medical Journal

ω-3脂肪酸在胃肠道肿瘤患者中的临床作用效果

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content