The Relationship between Serum Uric Acid and Insulin Release and Sensitivity_West China Medical Journal

Authors：

ZHOU Hong , ZHONG Li , LI Ke , WANG Min , ZENG Zhenghong.

Department of Endocrinology and Metabolism, the First People’s Hospital of Longquanyi District, Chengdu, Sichuan 610100, P. R. China;

Corresponding author：

Keywords：

血尿酸; 胰岛素分泌; 胰岛素敏感性

DOI：

10.7507/1002-0179.20130371

Video：

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目的　探讨血尿酸与胰岛素分泌和敏感性的关系。方法　对成都市龙泉驿区2007年6月－7月间20～75岁常住自然人群565人进行人口学、腰围、臀围、血压、75 g葡萄糖耐量及胰岛素测定（0、30、120 min），血脂、血肌酐及血尿酸检测。以早期胰岛素分泌功能指数（△I30/△G30）和葡萄糖处置指数（DIo）代表胰岛素分泌功能，以Matsuda 指数代表胰岛素敏感性，分别与血尿酸进行相关性研究。结果　男性的血尿酸与年龄呈负相关，与舒张压、葡萄糖负荷后120 min胰岛素和甘油三酯呈正相关。女性的血尿酸与甘油三酯、低密度脂蛋白、血肌酐呈正相关，与高密度脂蛋白、Matsuda指数呈负相关。无论男性和女性，均未发现血尿酸与△I30/△G30、DIo相关。结论　女性的胰岛素敏感性下降与血尿酸升高有关。未发现血尿酸与胰岛素分泌有相关关系。

Citation： ZHOU Hong,ZHONG Li,LI Ke,WANG Min,ZENG Zhenghong.. The Relationship between Serum Uric Acid and Insulin Release and Sensitivity. West China Medical Journal, 2013, 28(8): 1191-1194. doi: 10.7507/1002-0179.20130371 Copy

1.	Nan H, Pang Z, Wang S, et al. Serum uric acid, plasma glucose and diabetes[J]. Diab Vasc Dis Res, 2010, 7(1): 40-46.
2.	Yuan HJ, Yang XG, Shi XY, et al. Association of serum uric acid with different levels of glucose and related factors[J]. Chin Med J, 2011, 124(10): 1443-1448.
3.	Heinig M, Johnson RJ. Role of uric acid in hypertension, renal disease, and metabolic syndrome[J]. Cleve Clin J Med, 2006, 73(12): 1059-1064.
4.	Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010, 362(12): 1090-1101.
5.	Wareham NJ, Phillips DI, Byrne CD, et al. The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion[J]. Diabet Med, 1995, 12(10): 931.
6.	Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp[J]. Diabetes Care, 1999, 22(9): 1462-1470.
7.	Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans[J]. Diabetes, 1995, 44(12): 1386-1391.
8.	Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling[J]. Diabetes Care, 2004, 27(6): 1487-1495.
9.	Aloulou I, Brun JF, Mercier J. Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test[J]. Metabolism, 2006, 55(5): 676-690.
10.	Kadowaki T, Miyake Y, Hagura R, et al. Risk factors for worsening to diabetes in subjects with impaired glucose tolerance[J]. Diabetologia, 1984, 26(1): 44-49.
11.	Utzschneider KM, Prigeon RL, Faulenbach MV, et al. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels[J]. Diabetes Care, 2009, 32(2): 335-341.
12.	Meshkani R, Zargari M, Larijani B. The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects[J]. Acta Diabetol, 2011, 48(1): 79-88.
13.	Lorenzo C, Hazuda HP, Haffner SM. Insulin resistance and excess risk of diabetes in Mexican-Americans: the san antonio heart study[J]. J Clin Endocrinol Metab, 2012, 97(3): 793-799.
14.	Yang T, Chu CH, Bai CH, et al. Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study[J]. Atherosclerosis, 2012, 220(2): 525-531.
15.	Rodrigues SL, Baldo MP, Capingana P, et al. Gender distribution of serum uric acid and cardiovascular risk factors: population based study[J]. Arq Bras Cardiol, 2012, 98(1): 13-21.
16.	Stancáková A, Javorský M, Kuulasmaa T, et al. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6 414 Finnish men[J]. Diabetes, 2009, 58(5): 1212-1221.
17.	Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function[J]. Diabetes, 1993, 42(11): 1663-1672.

1. 　Nan H, Pang Z, Wang S, et al. Serum uric acid, plasma glucose and diabetes[J]. Diab Vasc Dis Res, 2010, 7(1): 40-46.
2. 　Yuan HJ, Yang XG, Shi XY, et al. Association of serum uric acid with different levels of glucose and related factors[J]. Chin Med J, 2011, 124(10): 1443-1448.
3. 　Heinig M, Johnson RJ. Role of uric acid in hypertension, renal disease, and metabolic syndrome[J]. Cleve Clin J Med, 2006, 73(12): 1059-1064.
4. 　Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010, 362(12): 1090-1101.
5. 　Wareham NJ, Phillips DI, Byrne CD, et al. The 30 minute insulin incremental response in an oral glucose tolerance test as a measure of insulin secretion[J]. Diabet Med, 1995, 12(10): 931.
6. 　Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp[J]. Diabetes Care, 1999, 22(9): 1462-1470.
7. 　Haffner SM, Miettinen H, Gaskill SP, et al. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans[J]. Diabetes, 1995, 44(12): 1386-1391.
8. 　Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling[J]. Diabetes Care, 2004, 27(6): 1487-1495.
9. 　Aloulou I, Brun JF, Mercier J. Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test[J]. Metabolism, 2006, 55(5): 676-690.
10. 　Kadowaki T, Miyake Y, Hagura R, et al. Risk factors for worsening to diabetes in subjects with impaired glucose tolerance[J]. Diabetologia, 1984, 26(1): 44-49.
11. 　Utzschneider KM, Prigeon RL, Faulenbach MV, et al. Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels[J]. Diabetes Care, 2009, 32(2): 335-341.
12. 　Meshkani R, Zargari M, Larijani B. The relationship between uric acid and metabolic syndrome in normal glucose tolerance and normal fasting glucose subjects[J]. Acta Diabetol, 2011, 48(1): 79-88.
13. 　Lorenzo C, Hazuda HP, Haffner SM. Insulin resistance and excess risk of diabetes in Mexican-Americans: the san antonio heart study[J]. J Clin Endocrinol Metab, 2012, 97(3): 793-799.
14. 　Yang T, Chu CH, Bai CH, et al. Uric acid level as a risk marker for metabolic syndrome: a Chinese cohort study[J]. Atherosclerosis, 2012, 220(2): 525-531.
15. 　Rodrigues SL, Baldo MP, Capingana P, et al. Gender distribution of serum uric acid and cardiovascular risk factors: population based study[J]. Arq Bras Cardiol, 2012, 98(1): 13-21.
16. 　Stancáková A, Javorský M, Kuulasmaa T, et al. Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6 414 Finnish men[J]. Diabetes, 2009, 58(5): 1212-1221.
17. 　Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function[J]. Diabetes, 1993, 42(11): 1663-1672.

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