Experience of Infliximab Infusion Management for Crohn’s Disease_West China Medical Journal

Authors：

LI Luohong , LUO Ou , TANG Li ,  ZHANG Mingguang.

Department of Digestion, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

ZHANG Mingguang., Email: xhkllh80@163.com

Keywords：

英夫利西单抗; 克罗恩病; 护理管理

DOI：

10.7507/1002-0179.20130391

Video：

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目的　探讨英夫利西单抗治疗克罗恩病（CD）在临床护理中的有效管理措施。方法　对2011年9月—2012年8月静脉输注英夫利西单抗的25例住院患者，在药物配伍、输注流程、配制方法等方面予以严格管理，并严密观察药物不良反应和积极做好健康宣教。结果　经过精心的观察、护理和有效的护理管理措施，25例患者用药6周后体温恢复正常，大便次数1～2次/d，大便隐血试验阴性，腹痛、腹胀症状缓解，体重增加2～7 kg。结论　在英夫利西单抗药物临床输注过程中，实施有效的输注护理管理措施是确保患者治疗安全以及提高护理质量的重要保障。

Citation： LI Luohong,LUO Ou,TANG Li,ZHANG Mingguang.. Experience of Infliximab Infusion Management for Crohn’s Disease. West China Medical Journal, 2013, 28(8): 1247-1249. doi: 10.7507/1002-0179.20130391 Copy

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2.	Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial[J]. Lancet, 2002, 359(9317): 1541-1549.
3.	Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis[J]. New Engl J Med , 2005, 353(23): 2462-2476.
4.	孙怡燕, 吴永发, 徐灿, 等. 英夫利西单抗治疗克罗恩病的疗效观察[J]. 第二军医大学学报, 2010, 31(3): 338-339.
5.	Schnitzler F, Fidder H, Ferrante M, et al. Long-term outcome of treatment with infliximab in 614 patients with Crohn’s disease: results from a single-centre cohort[J]. Gut, 2009, 58(4): 492-500.
6.	Kraemer M, Kirschmeier A, Marth T. Perioperative adjuvant therapy with infliximab in complicated anal Crohn’s disease[J]. Int J Colorectal Dis, 2008, 23(10): 965-969.
7.	De Ridder L, Rings EH, Damen GM, et al. Infliximab dependency in pediatric Crohn’s disease: long-term follow-up of an unselected cohort[J]. Inflamm Bowel Dis, 2008, 14(3): 353-358.
8.	马东梅, 张春燕. 56例类风湿关节炎病人输注类克药物的观察和护理[J]. 护理研究, 2009, 23(20): 1837-1838.
9.	冯楠, 戈之铮. 英夫利昔单抗在炎症性肠病治疗中的应用[J]. 国际消化病杂志, 2008, 28(4): 273-276.
10.	Arhur B, Miguel R. Biologic therapy in the management of extraint estinal manifestations of inflammatory bowel disease[J]. Inf lam m Bow el Dis, 2007, 13: 1424-1429.
11.	翁雪玲, 张海嫦, 陈燕. 临床输注英夫利西单抗不良反应的预防及护理[J].解放军护理杂志, 2011, 28(1B): 57-58.

1. 　Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn’s disease. Crohn’s Disease cA2 Study Group[J]. N Engl J Med, 1997, 337(15): 1029-1035.
2. 　Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial[J]. Lancet, 2002, 359(9317): 1541-1549.
3. 　Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis[J]. New Engl J Med , 2005, 353(23): 2462-2476.
4. 　孙怡燕, 吴永发, 徐灿, 等. 英夫利西单抗治疗克罗恩病的疗效观察[J]. 第二军医大学学报, 2010, 31(3): 338-339.
5. 　Schnitzler F, Fidder H, Ferrante M, et al. Long-term outcome of treatment with infliximab in 614 patients with Crohn’s disease: results from a single-centre cohort[J]. Gut, 2009, 58(4): 492-500.
6. 　Kraemer M, Kirschmeier A, Marth T. Perioperative adjuvant therapy with infliximab in complicated anal Crohn’s disease[J]. Int J Colorectal Dis, 2008, 23(10): 965-969.
7. 　De Ridder L, Rings EH, Damen GM, et al. Infliximab dependency in pediatric Crohn’s disease: long-term follow-up of an unselected cohort[J]. Inflamm Bowel Dis, 2008, 14(3): 353-358.
8. 　马东梅, 张春燕. 56例类风湿关节炎病人输注类克药物的观察和护理[J]. 护理研究, 2009, 23(20): 1837-1838.
9. 　冯楠, 戈之铮. 英夫利昔单抗在炎症性肠病治疗中的应用[J]. 国际消化病杂志, 2008, 28(4): 273-276.
10. 　Arhur B, Miguel R. Biologic therapy in the management of extraint estinal manifestations of inflammatory bowel disease[J]. Inf lam m Bow el Dis, 2007, 13: 1424-1429.
11. 　翁雪玲, 张海嫦, 陈燕. 临床输注英夫利西单抗不良反应的预防及护理[J].解放军护理杂志, 2011, 28(1B): 57-58.

West China Medical Journal

Experience of Infliximab Infusion Management for Crohn’s Disease

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