• 1. Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 2. Department of Rheumatology, Luzhou Medical College, Luzhou, Sichuan 646000, P. R. China;
LIU Yi., Email: lhacd@163.com
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目的  检测类风湿关节炎(RA)患者血清和关节液白细胞介素17A(IL-17A)的变化,探讨其与临床炎症指标、疾病活动性的关系。 方法  2011年6月-2012年6月采用酶联免疫吸附试验检测30例活动性RA患者和20例健康对照血清IL-17A水平,其中18例有膝关节积液RA患者同时检测配对血清和关节液IL-17A水平。 结果  RA组患者血清IL-17A水平显著高于健康对照组[(40.651 ± 16.402)、(23.799 ± 10.693) pg/mL,P<0.05]。RA患者关节液IL-17A水平明显高于其血清中水平[(63.555 ± 23.405)、(43.727 ± 17.212) pg/mL,P<0.05]。RA患者血清IL-17A水平只与疾病活动性评分(DAS28)呈正相关(r=0.498,P=0.020),而RA患者关节液IL-17A水平与DAS28和血清C反应蛋白有相关性(r=0.515,P=0.029;r=0.498,P=0.035)。 结论  RA患者血清和关节液IL-17A水平与疾病活动性显著相关,提示IL-17A可作为衡量疾病活动和关节损伤的标志之一。

Citation: LIN Hui,CHEN Yongtao,ZHOU Yanli,LIU Yi.. Serum and Synovial Fluid Levels of Interleukin-17A in Correlation with Disease Activity in Patients with Rheumatoid Arthritis. West China Medical Journal, 2013, 28(10): 1521-1524. doi: 10.7507/1002-0179.20130482 Copy

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