Clinical Study of the Treatment of Knee Osteoarthritis with Arthroscopic Debridement and Glucosamine Hydrochloride_West China Medical Journal

Authors：

CHEN Xiaobing , CUI Jing.

Department of Orthopedics, People’s Hospital of Xinjiang District of Aletai, Aletai, Xinjiang 836500, P. R. China;

Corresponding author：

Keywords：

关节镜清理术; 盐酸氨基葡萄糖; 骨关节炎，膝

DOI：

10.7507/1002-0179.20130487

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　探讨关节镜清理术配合盐酸氨基葡萄糖对膝骨关节炎的治疗作用。方法　2009年6月－2011年6月纳入轻度膝骨关节炎（AhlbackⅠ级）患者135例，随机分成3组。A组（n=45）接受关节镜清理术治疗；B组（n=45）口服盐酸氨基葡萄糖胶囊治疗；C组（（n=45）先行关节镜清理术治疗，术后口服盐酸氨基葡萄糖胶囊。观察3组Lequesne评分和WOMAC指数，用以评价治疗效果。结果　成功随访患者123例，随访时间8个月。治疗后各组Lequesne评分和WOMAC指数较治疗前均显著好转（P＜0.01），其中治疗后C组好转较A组和B组具有显著性（P＜0.01），但B组和C组之间差异无统计学意义（P＞0.05）。结论　关节镜清理术配合盐酸氨基葡萄糖，较之单用关节镜清理术或盐酸氨基葡萄糖，对膝骨关节炎的治疗有更好的效果。

Citation： CHEN Xiaobing,CUI Jing.. Clinical Study of the Treatment of Knee Osteoarthritis with Arthroscopic Debridement and Glucosamine Hydrochloride. West China Medical Journal, 2013, 28(10): 1541-1544. doi: 10.7507/1002-0179.20130487 Copy

1.	Calamia V, Ruiz-Romero C, Rocha B, et al. Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes[J]. Arthritis Res Ther, 2010, 12(4): R138.
2.	Berenbaum F. New horizons and perspectives in the treatment of osteoarthritis[J]. Arthritis Res Ther, 2008, 10 (Suppl 2): 1.
3.	Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
4.	Moseley JB, O’malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002, 347(2): 81-88.
5.	苏江, 张晶, 吴侗, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的随机对照研究[J]. 华西医学, 2012, 14(12): 34.
6.	McAlindon T, Formica M, LaValley M, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial[J]. Am J Med, 2004, 117(9): 643-649.
7.	Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12): 1145-1155.
8.	Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18): 2113-2123.
9.	Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial[J]. Lancet, 2001, 357(9252): 251-256.
10.	Spahn G, Mückley T, Kahl E, et al. Factors affecting the outcome of arthroscopy in medial-compartment osteoarthritis of the knee[J]. Arthroscopy, 2006, 22(11): 1233-1240.
11.	Aaron RK, Skolnick AH, Reinert SE. Arthroscopic debridement for osteoarthritis of the knee[J]. J Bone Jt Surg Am, 2006, 88(5): 936-943.
12.	Dervin GF, Stiell IG, Rody K, et al. Effect of arthroscopic débridement for osteoarthritis of the knee on health-related quality of Life[J]. J Bone Joint Surg Am, 2003, 85-A(1): 10-19.
13.	Siparsky P, Ryzewicz M, Peterson B, et al. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications?[J]. Clin Orthop Relat Res, 2007, 455: 107-112.
14.	Dervin GF, Stiell IG, Wells GA, et al. Physicians’ accuracy and interrator reliability for the diagnosis of unstable meniscal tears in patients having osteoarthritis of the knee[J]. Can J Surg, 2001, 44(4): 267-274.
15.	Bernard J, Lemon M, Patterson MH. Arthroscopic washout of the knee: a 5-year survival analysis[J]. Knee, 2004, 11(3): 233-235.
16.	Harrison MM, Morrell J, Hopman WM. Influence of obesity on outcome after knee arthroscopy[J]. Arthroscopy, 2004, 20(7): 691-695.
17.	Fond J, Rodin D, Ahmad S, et al. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2-and 5-year results[J]. Arthroscopy, 2002, 18(8): 829-834.
18.	Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up[J]. Arthroscopy, 2003, 19(1): 13-20.

1. 　Calamia V, Ruiz-Romero C, Rocha B, et al. Pharmacoproteomic study of the effects of chondroitin and glucosamine sulfate on human articular chondrocytes[J]. Arthritis Res Ther, 2010, 12(4): R138.
2. 　Berenbaum F. New horizons and perspectives in the treatment of osteoarthritis[J]. Arthritis Res Ther, 2008, 10 (Suppl 2): 1.
3. 　Toda Y, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a lateral-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10): 3129-3136.
4. 　Moseley JB, O’malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee[J]. N Engl J Med, 2002, 347(2): 81-88.
5. 　苏江, 张晶, 吴侗, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的随机对照研究[J]. 华西医学, 2012, 14(12): 34.
6. 　McAlindon T, Formica M, LaValley M, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial[J]. Am J Med, 2004, 117(9): 643-649.
7. 　Jordan KM, Arden NK, Doherty M, et al. EULAR recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the Standing Committee for international clinical studies including therapeutic trials (ESCISIT)[J]. Ann Rheum Dis, 2003, 62(12): 1145-1155.
8. 　Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study[J]. Arch Intern Med, 2002, 162(18): 2113-2123.
9. 　Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial[J]. Lancet, 2001, 357(9252): 251-256.
10. 　Spahn G, Mückley T, Kahl E, et al. Factors affecting the outcome of arthroscopy in medial-compartment osteoarthritis of the knee[J]. Arthroscopy, 2006, 22(11): 1233-1240.
11. 　Aaron RK, Skolnick AH, Reinert SE. Arthroscopic debridement for osteoarthritis of the knee[J]. J Bone Jt Surg Am, 2006, 88(5): 936-943.
12. 　Dervin GF, Stiell IG, Rody K, et al. Effect of arthroscopic débridement for osteoarthritis of the knee on health-related quality of Life[J]. J Bone Joint Surg Am, 2003, 85-A(1): 10-19.
13. 　Siparsky P, Ryzewicz M, Peterson B, et al. Arthroscopic treatment of osteoarthritis of the knee: are there any evidence-based indications?[J]. Clin Orthop Relat Res, 2007, 455: 107-112.
14. 　Dervin GF, Stiell IG, Wells GA, et al. Physicians’ accuracy and interrator reliability for the diagnosis of unstable meniscal tears in patients having osteoarthritis of the knee[J]. Can J Surg, 2001, 44(4): 267-274.
15. 　Bernard J, Lemon M, Patterson MH. Arthroscopic washout of the knee: a 5-year survival analysis[J]. Knee, 2004, 11(3): 233-235.
16. 　Harrison MM, Morrell J, Hopman WM. Influence of obesity on outcome after knee arthroscopy[J]. Arthroscopy, 2004, 20(7): 691-695.
17. 　Fond J, Rodin D, Ahmad S, et al. Arthroscopic debridement for the treatment of osteoarthritis of the knee: 2-and 5-year results[J]. Arthroscopy, 2002, 18(8): 829-834.
18. 　Jackson RW, Dieterichs C. The results of arthroscopic lavage and debridement of osteoarthritic knees based on the severity of degeneration: a 4-to 6-year symptomatic follow-up[J]. Arthroscopy, 2003, 19(1): 13-20.

West China Medical Journal

Clinical Study of the Treatment of Knee Osteoarthritis with Arthroscopic Debridement and Glucosamine Hydrochloride

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content