Progressing the White Matter Alteration Associated with Surgery on Right Temporal Lobe Epilepsy Patients: A Longitudinal Diffusion Tensor Imaging Study_West China Medical Journal

Authors：

YU Xiaofeng ¹ , CHEN Qin ¹ , ZHOU Bo ² , TANG Yingying ¹ , LUO Chunyan ¹ , XIAO Fenglai ¹ , ZENG Yuqin ³ , WANG Yuqing ⁴ , TANG Hehan ⁵ , LEI Ding ⁶ , GONG Qiyong ⁴ ,  ZHOU Dong. ¹

1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China; 2. Department of Psychosomatic Medicine, Sichuan Province People’s Hospital, Chengdu, Sichuan 610031, P. R. China; 3. Department of Neurology, Xiangya Hospital of Central-south University, Changsha, Hunan 410013, P. R. China; 4. Huaxi MR Research Center,;

Corresponding author：

ZHOU Dong., Email: yu446953030@163.com

Keywords：

颞叶癫痫; 磁共振弥散成像技术; 各向异性分数; 手术

DOI：

10.7507/1002-0179.20130495

Video：

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目的　利用磁共振弥散张量成像技术（DTI）对右侧难治性颞叶癫痫（TLE）患者术前及术后脑白质各向异性分数（FA）进行纵向随访研究，并对其与病程等临床症状之间的相关性进行分析，探讨右侧TLE患者的脑白质FA变化模式。方法　2008年7月－2009年8月纳入10例右侧难治性TLE患者。对每个受试者采用GE 3.0 T磁共振及8通道头线圈扫描，所有DTI图像通过单次回波平面成像序列采集。采用基于体素分析的SPM8软件对受试患者术前术后FA图进行配对t检验，观察难治性TLE患者脑白质变化模式。采用Pearson相关计算FA变化幅度与病程等临床症状之间的相关性，经比较校正后P值＜0.05的区域为有统计学意义的区域。结果　右侧TLE患者FA值降低的区域包括左侧颞下回、双侧额中回及左侧壳核、右侧楔叶。FA升高的区域包括左侧海马旁回、左侧颞叶、右侧额下回和左侧中央旁小叶。相关分析发现，右侧TLE患者右侧额下回FA变化值与发病年龄呈负相关，左侧颞下回FA变化值与术后随访间隔时间呈负相关。结论　右侧难治性TLE患者手术治疗后大脑白质变化不仅局限于颞叶，还涉及颞叶外结构。

Citation： YU Xiaofeng,CHEN Qin,ZHOU Bo,TANG Yingying,LUO Chunyan,XIAO Fenglai,ZENG Yuqin,WANG Yuqing,TANG Hehan,LEI Ding,GONG Qiyong,ZHOU Dong.. Progressing the White Matter Alteration Associated with Surgery on Right Temporal Lobe Epilepsy Patients: A Longitudinal Diffusion Tensor Imaging Study. West China Medical Journal, 2013, 28(10): 1569-1574. doi: 10.7507/1002-0179.20130495 Copy

1.	Wiebe S, Blume WT, Girvin JP, et al. A randomized, controlled trial of surgery for temporal-lobe epilepsy[J]. N Engl J Med, 2001, 345(5): 311-318.
2.	Binder JR, Bellgowan PS, Hammeke TA, et al. A comparison of two FMRI protocols for eliciting hippocampal activation[J]. Epilepsia, 2005, 46(7): 1061-1070.
3.	Brázdil M, Chlebus P, Mikl M, et al. Reorganization of language-related neuronal networks in patients with left temporal lobe epilepsy: an fMRI study [J]. Eur J Neurol, 2005, 12(4): 268-275.
4.	Téllez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis[J]. Brain, 2005, 128(5): 1188-1198.
5.	Concha L, Beaulieu C, Collins DL, et al. White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis[J]. J Neurol Neurosurg Psychiatry, 2009, 80(3): 312-319.
6.	Gotman J. Epileptic networks studied with EEG-MRI[J]. Epilepsia, 2008, 49(Suppl 3): 42-51.
7.	Henry TR, Mazziotta JC, Engel J, et al. Quantifying interictal metabolic activity in human temporal lobe epilepsy[J]. J Cereb Blood Flow Metab, 1990, 10(5): 748-757.
8.	Kim JH, Lee JM, Kang E, et al. Functional reorganization associated with semantic language processing in temporal lobe epilepsy patients after anterior temporal lobectomy: a longitudinal functional magnetic resonance image study[J]. J Korean Neurosurg Soc, 2010, 47(1): 17-25.
9.	Labate A, Cerasa A, Gambardella A, et al. Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study[J]. Neurology, 2008, 71(14): 1094-1101.
10.	Shon YM, Kim YI, Koo BB, et al. Group-specific regional white matter abnormality revealed in diffusion tensor imaging of medial temporal lobe epilepsy without hippocampal sclerosis[J]. Epilepsia, 2010, 51(4): 529-535.
11.	Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review[J]. NMR Biomed, 2002, 15(7-8): 435-455.
12.	Arfanakis K, Hermann BP, Rogers BP, et al. Diffusion tensor MRI in temporal lobe epilepsy[J]. Magn Reson Imaging, 2002, 20(7): 511-519.
13.	Concha L, Beaulieu C, Gross DW. Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy[J]. Ann Neurol, 2005, 57(2): 188-196.
14.	Thivard L, Lehéricy S, Krainik A, et al. Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis[J]. Neuroimage, 2005, 28(3): 682-690.
15.	Gross DW, Concha L, Beaulieu C. Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging[J]. Epilepsia, 2006, 47(8): 1360-1363.
16.	Focke NK, Yogarajah M, Bonelli SB, et al. Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis[J]. Neuroimage, 2008, 40(2): 728-737.
17.	Lin JJ, Riley JD, Juranek J, et al. Vulnerability of the frontal-temporal connections in temporal lobe epilepsy[J]. Epilepsy Res, 2008, 82(2-3): 162-170.
18.	Nilsson D, Go C, Rutka JT, et al. Bilateral diffusion tensor abnormalities of temporal lobe and cingulate gyrus white matter in children with temporal lobe epilepsy[J]. Epilepsy Res, 2008, 81(2-3): 128-135.
19.	Govindan RM, Makki MI, Sundaram SK, et al. Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy[J]. Epilepsy Res, 2008, 80(1): 30-41.
20.	Concha L, Gross DW, Wheatley BM, et al. Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients[J]. Neuroimage, 2006, 32(3): 1090-1099.
21.	Ahmadi ME, Hagler DJ, McDonald CR, et al. Side matters: diffusion tensor imaging tractography in left and right temporal lobe epilepsy[J]. AJNR Am J Neuroradiol, 2009, 30(9): 1740-1747.
22.	Concha L, Livy DJ, Beaulieu C, et al. In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy[J]. J Neurosci, 2010, 30(3): 996-1002.
23.	Nguyen D, Vargas MI, Khaw N, et al. Diffusion tensor imaging analysis with tract-based spatial statistics of the white matter abnormalities after epilepsy surgery[J]. Epilepsy Res, 2011, 94(3): 189-197.
24.	Riley JD, Franklin DL, Choi V, et al. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles[J]. Epilepsia, 2010, 51(4): 536-545.
25.	Schoene-Bake JC, Faber J, Elger CE, et al. White matter changes in post-surgical temporal lobe epilepsy[J]. Neurophysiol Clin, 2009, 120(1): e59-e60.
26.	Concha L, Beaulieu C, Wheatley BM, et al. Bilateral white matter diffusion changes persist after epilepsy surgery[J]. Epilepsia, 2007, 48(5): 931-940.
27.	Yogarajah M, Focke NK, Bonelli SB, et al. The structural plasticity of white matter networks following anterior temporal lobe resection[J]. Brain, 2010, 133(Pt 8): 2348-2364.
28.	Backes WH, Deblaere K, Vonck K, et al. Language activation distributions revealed by fMRI in post-operative epilepsy patients: differences between left- and right-sided resections[J]. Epilepsy Res, 2005, 66(1-3): 1-12.
29.	Hugg JW, Kuzniecky RI, Gilliam FG, et al. Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging[J]. Ann Neurol, 1996, 40(2): 236-239.
30.	Spanaki MV, Kopylev L, DeCarli C, et al. Postoperative changes in cerebral metabolism in temporal lobe epilepsy[J]. Arch Neurol, 2000, 57(10): 1447-1452.
31.	Jansen JF, Aldenkamp AP, Marian Majoie HJ, et al. Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy[J]. Epilepsy Behav, 2006, 9(1): 181-185.

1. 　Wiebe S, Blume WT, Girvin JP, et al. A randomized, controlled trial of surgery for temporal-lobe epilepsy[J]. N Engl J Med, 2001, 345(5): 311-318.
2. 　Binder JR, Bellgowan PS, Hammeke TA, et al. A comparison of two FMRI protocols for eliciting hippocampal activation[J]. Epilepsia, 2005, 46(7): 1061-1070.
3. 　Brázdil M, Chlebus P, Mikl M, et al. Reorganization of language-related neuronal networks in patients with left temporal lobe epilepsy: an fMRI study [J]. Eur J Neurol, 2005, 12(4): 268-275.
4. 　Téllez-Zenteno JF, Dhar R, Wiebe S. Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis[J]. Brain, 2005, 128(5): 1188-1198.
5. 　Concha L, Beaulieu C, Collins DL, et al. White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis[J]. J Neurol Neurosurg Psychiatry, 2009, 80(3): 312-319.
6. 　Gotman J. Epileptic networks studied with EEG-MRI[J]. Epilepsia, 2008, 49(Suppl 3): 42-51.
7. 　Henry TR, Mazziotta JC, Engel J, et al. Quantifying interictal metabolic activity in human temporal lobe epilepsy[J]. J Cereb Blood Flow Metab, 1990, 10(5): 748-757.
8. 　Kim JH, Lee JM, Kang E, et al. Functional reorganization associated with semantic language processing in temporal lobe epilepsy patients after anterior temporal lobectomy: a longitudinal functional magnetic resonance image study[J]. J Korean Neurosurg Soc, 2010, 47(1): 17-25.
9. 　Labate A, Cerasa A, Gambardella A, et al. Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study[J]. Neurology, 2008, 71(14): 1094-1101.
10. 　Shon YM, Kim YI, Koo BB, et al. Group-specific regional white matter abnormality revealed in diffusion tensor imaging of medial temporal lobe epilepsy without hippocampal sclerosis[J]. Epilepsia, 2010, 51(4): 529-535.
11. 　Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review[J]. NMR Biomed, 2002, 15(7-8): 435-455.
12. 　Arfanakis K, Hermann BP, Rogers BP, et al. Diffusion tensor MRI in temporal lobe epilepsy[J]. Magn Reson Imaging, 2002, 20(7): 511-519.
13. 　Concha L, Beaulieu C, Gross DW. Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy[J]. Ann Neurol, 2005, 57(2): 188-196.
14. 　Thivard L, Lehéricy S, Krainik A, et al. Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis[J]. Neuroimage, 2005, 28(3): 682-690.
15. 　Gross DW, Concha L, Beaulieu C. Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging[J]. Epilepsia, 2006, 47(8): 1360-1363.
16. 　Focke NK, Yogarajah M, Bonelli SB, et al. Voxel-based diffusion tensor imaging in patients with mesial temporal lobe epilepsy and hippocampal sclerosis[J]. Neuroimage, 2008, 40(2): 728-737.
17. 　Lin JJ, Riley JD, Juranek J, et al. Vulnerability of the frontal-temporal connections in temporal lobe epilepsy[J]. Epilepsy Res, 2008, 82(2-3): 162-170.
18. 　Nilsson D, Go C, Rutka JT, et al. Bilateral diffusion tensor abnormalities of temporal lobe and cingulate gyrus white matter in children with temporal lobe epilepsy[J]. Epilepsy Res, 2008, 81(2-3): 128-135.
19. 　Govindan RM, Makki MI, Sundaram SK, et al. Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy[J]. Epilepsy Res, 2008, 80(1): 30-41.
20. 　Concha L, Gross DW, Wheatley BM, et al. Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients[J]. Neuroimage, 2006, 32(3): 1090-1099.
21. 　Ahmadi ME, Hagler DJ, McDonald CR, et al. Side matters: diffusion tensor imaging tractography in left and right temporal lobe epilepsy[J]. AJNR Am J Neuroradiol, 2009, 30(9): 1740-1747.
22. 　Concha L, Livy DJ, Beaulieu C, et al. In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy[J]. J Neurosci, 2010, 30(3): 996-1002.
23. 　Nguyen D, Vargas MI, Khaw N, et al. Diffusion tensor imaging analysis with tract-based spatial statistics of the white matter abnormalities after epilepsy surgery[J]. Epilepsy Res, 2011, 94(3): 189-197.
24. 　Riley JD, Franklin DL, Choi V, et al. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles[J]. Epilepsia, 2010, 51(4): 536-545.
25. 　Schoene-Bake JC, Faber J, Elger CE, et al. White matter changes in post-surgical temporal lobe epilepsy[J]. Neurophysiol Clin, 2009, 120(1): e59-e60.
26. 　Concha L, Beaulieu C, Wheatley BM, et al. Bilateral white matter diffusion changes persist after epilepsy surgery[J]. Epilepsia, 2007, 48(5): 931-940.
27. 　Yogarajah M, Focke NK, Bonelli SB, et al. The structural plasticity of white matter networks following anterior temporal lobe resection[J]. Brain, 2010, 133(Pt 8): 2348-2364.
28. 　Backes WH, Deblaere K, Vonck K, et al. Language activation distributions revealed by fMRI in post-operative epilepsy patients: differences between left- and right-sided resections[J]. Epilepsy Res, 2005, 66(1-3): 1-12.
29. 　Hugg JW, Kuzniecky RI, Gilliam FG, et al. Normalization of contralateral metabolic function following temporal lobectomy demonstrated by 1H magnetic resonance spectroscopic imaging[J]. Ann Neurol, 1996, 40(2): 236-239.
30. 　Spanaki MV, Kopylev L, DeCarli C, et al. Postoperative changes in cerebral metabolism in temporal lobe epilepsy[J]. Arch Neurol, 2000, 57(10): 1447-1452.
31. 　Jansen JF, Aldenkamp AP, Marian Majoie HJ, et al. Functional MRI reveals declined prefrontal cortex activation in patients with epilepsy on topiramate therapy[J]. Epilepsy Behav, 2006, 9(1): 181-185.

West China Medical Journal

Progressing the White Matter Alteration Associated with Surgery on Right Temporal Lobe Epilepsy Patients: A Longitudinal Diffusion Tensor Imaging Study

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