Magnetic Resonance Imaging Features and Pathologic Basis of Primary Central Nervous System Lymphoma_West China Medical Journal

Authors：

WANG Chenglong , ZHAI Shaohua , ZHOU Haiying.

Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding author：

Keywords：

原发性脑淋巴瘤; 磁共振成像; 诊断; 病理

DOI：

10.7507/1002-0179.20130538

Video：

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目的　探讨原发性脑淋巴瘤的MRI表现及病理基础，提高对脑原发性淋巴瘤的认识。方法　回顾分析2010年1月－2012年5月28例确诊为脑原发性淋巴瘤的MRI影像特征及临床病理资料。结果　28例患者，共发现36个病灶，幕上病灶34个，幕下病灶2个；MRI平扫；32个病灶在T1WI、T2WI肿瘤实质表现为等信号；4个病灶内出现液化坏死（其中1个病灶呈明显囊变），信号不均。MRI增强扫描：35个肿瘤病灶实质部分均匀强化，1个病灶呈环形强化。病理类型均为弥漫性大B细胞非霍奇金淋巴瘤。结论　原发性脑淋巴瘤具有较典型的MRI影像特征，可在术前明确诊断。

Citation： WANG Chenglong,ZHAI Shaohua,ZHOU Haiying.. Magnetic Resonance Imaging Features and Pathologic Basis of Primary Central Nervous System Lymphoma. West China Medical Journal, 2013, 28(11): 1704-1707. doi: 10.7507/1002-0179.20130538 Copy

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2.	Hartmann M, Sailor K. Primary malignant lymphoma of the brain[J]. Radiol, 1997, 37(1): 42-50．.
3.	孙文勇, 楼瑛, 张谷. 原发性中枢神经系统淋巴瘤临床病理与免疫组化研究[J]. 中国肿瘤, 2003, 12(7): 427-428.
4.	项威, 赵刚, 李彬, 等. 原发性中枢神经系统恶性淋巴瘤的诊断及治疗[J]. 现代肿瘤学, 2010, 11(1): 152-154.
5.	康庄 , 邹艳, 唐文杰. 免疫正常人原发性脑淋巴瘤的MRI表现[J]. 中华神经医学杂志, 2009, 7(18): 712-714.
6.	Schlegel U. Primary CNS lymphoma[J]. Ther Adv Neurol Disord, 2009, 2(2): 93-104.
7.	Shenkier TN, Blay JY, O’ neill BP, et al. Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group[J]. J Clin Oncol, 2005, 23(10): 2233-2239.
8.	Sierra del Rio M, Rousseau A, Soussain C, et al. Primary CNS lymphoma in immunocompetent patients[J]. Oncologist, 2009, 14(5): 526-539.
9.	张卫东, 吴沛宏, 谢穿淼, 等. 9例脑原发性淋巴瘤的MRI影像特征[J]. 癌症杂志, 2007, 26(7): 775-777.
10.	Schwaighofer BW, Hesselink JR, Press GA. Primary intracranial CNS lymphoma: MR manifeatations[J]. AJNR Am J Neuroradiol, 1989, 10(4): 725-729.
11.	刘玲, 邓开鸿, 宁刚. 原发性中枢神经系统淋巴瘤的CT及MRI表现[J]. 华西医学, 2010, 25(3): 560-563.
12.	Nakamura M, Shimada K, Ishida E, et al. Histopathology, pathogenesis and molecular genetics in primary central nervous system lymphomas[J]. Histol Histopathol, 2004, 19(1): 211-219.

1. 　Coré TR, Manns A, Hardy CR, et al. Epidemiology of brain lymphoma among people with or without acquired immunodeficiency syndrome. AIDS/Cancer Study Group[J]. J Natl Cancer Inst, 1996, 88(3): 675-679.
2. 　Hartmann M, Sailor K. Primary malignant lymphoma of the brain[J]. Radiol, 1997, 37(1): 42-50．.
3. 　孙文勇, 楼瑛, 张谷. 原发性中枢神经系统淋巴瘤临床病理与免疫组化研究[J]. 中国肿瘤, 2003, 12(7): 427-428.
4. 　项威, 赵刚, 李彬, 等. 原发性中枢神经系统恶性淋巴瘤的诊断及治疗[J]. 现代肿瘤学, 2010, 11(1): 152-154.
5. 　康庄 , 邹艳, 唐文杰. 免疫正常人原发性脑淋巴瘤的MRI表现[J]. 中华神经医学杂志, 2009, 7(18): 712-714.
6. 　Schlegel U. Primary CNS lymphoma[J]. Ther Adv Neurol Disord, 2009, 2(2): 93-104.
7. 　Shenkier TN, Blay JY, O’ neill BP, et al. Primary CNS lymphoma of T-cell origin: a descriptive analysis from the international primary CNS lymphoma collaborative group[J]. J Clin Oncol, 2005, 23(10): 2233-2239.
8. 　Sierra del Rio M, Rousseau A, Soussain C, et al. Primary CNS lymphoma in immunocompetent patients[J]. Oncologist, 2009, 14(5): 526-539.
9. 　张卫东, 吴沛宏, 谢穿淼, 等. 9例脑原发性淋巴瘤的MRI影像特征[J]. 癌症杂志, 2007, 26(7): 775-777.
10. 　Schwaighofer BW, Hesselink JR, Press GA. Primary intracranial CNS lymphoma: MR manifeatations[J]. AJNR Am J Neuroradiol, 1989, 10(4): 725-729.
11. 　刘玲, 邓开鸿, 宁刚. 原发性中枢神经系统淋巴瘤的CT及MRI表现[J]. 华西医学, 2010, 25(3): 560-563.
12. 　Nakamura M, Shimada K, Ishida E, et al. Histopathology, pathogenesis and molecular genetics in primary central nervous system lymphomas[J]. Histol Histopathol, 2004, 19(1): 211-219.

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West China Medical Journal

Magnetic Resonance Imaging Features and Pathologic Basis of Primary Central Nervous System Lymphoma

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