A Meta-analysis of the Relationship between Interleukin-1beta and Epileptic Seizure_West China Medical Journal

Authors：

WEI Tongguo , ZHANG Bingli ,  YE Hongtao.

Department of Epilepsy, People’s Hospital of Meizhou, Meizhou, Guangdong 514031, P. R. China;

Corresponding author：

YE Hongtao., Email: weitongguosysu@163.com

Keywords：

Meta分析; 白细胞介素1β; 癫痫; 炎症反应

DOI：

10.7507/1002-0179.20130580

Video：

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目的　系统评价白细胞介素1β（IL-1β）与癫痫发作的相关性。方法　2012年5月－2013年10月检索PubMed数据库（1985年1月－2013年7月）、Medline数据库（1985年1月－2013年7月）、中国知网（1998年1月－2013年7月）和万方数据库（1996年1月－2013年7月），并辅以谷歌学术搜索引擎进行手工检索。由两名研究者按照研究的纳入与排除标准进行病例对照研究的选择，对入选文献的质量参照“非随机对照临床试验质量评价标准与计分表”进行评价和计分，评估纳入研究的方法学质量并对有效的信息进行数据提取。然后采用RevMan 5.0统计软件进行Meta分析，以加权均数差（WMD）为效应指标。结果　共纳入5个研究，包括82例癫痫发作的患者和471例正常对照。所纳入的研究未描述详细的抽样方法及其检测方法的特异性。Meta分析结果显示：癫痫发作72 h以内的患者与正常对照人群之间血浆IL-1β的浓度差异无统计学意义[WMD=0.04 pg/mL，95%CI（−0.07，0.16）pg/mL，P=0.46]。结论　IL-1β可能没有直接参与癫痫的发作，而是通过与其他炎性因子之间的相互作用来实现。因此，需要进一步的研究来证明IL-1β在癫痫发作中的作用。

Citation： WEI Tongguo,ZHANG Bingli,YE Hongtao.. A Meta-analysis of the Relationship between Interleukin-1beta and Epileptic Seizure. West China Medical Journal, 2013, 28(12): 1832-1836. doi: 10.7507/1002-0179.20130580 Copy

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2.	Walker AE. Allergic phenomenon as basic mechanisms in epilepsy[M]//Jaspar HH, Ward AA Jr, Pope A. Basic mechanisms of the epilepsies. London: Churchill, 1969: 812-814.
3.	Vezzani A, Janigro D. Leukocyte-endothelial adhesion mechanisms in epilepsy: cheers and jeers[J]. Epilepsy Curr, 2009, 9(4): 118-121.
4.	Ravizza T, Gagliardi B, Noé F, et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy[J]. Neurobiol Dis, 2008, 29(1): 142-160.
5.	Vezzani A, Balosso S, Ravizza T. The role of cytokines in the pathophysiology of epilepsy[J]. Brain Behav Immun, 2008, 22(6): 797-803.
6.	江明庆. 癫痫患者血清中IL-1β、TNF-α含量变化研究[J]. 当代医学, 2011, 17(33): 8-9.
7.	Sinha S, Patil S, Jayalekshmy V, et al. Do cytokines have any role in epilepsy?[J]. Epilepsy Res, 2008, 82(2-3): 171-176.
8.	Ravizza T, Boer K, Redeker S, et al. The IL-1beta system in epilepsy-associated malformations of cortical development[J]. Neurobiol Dis, 2006, 24(1): 128-143.
9.	Pernot F, Heinrich C, Barbier L, et al. Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy[J]. Epilepsia, 2011, 52(12): 2315-2325.
10.	Alapirtti T, Rinta S, Hulkkonen J, et al. Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: a video-EEG study[J]. J Neurol Sci, 2009, 280(1-2): 94-97.
11.	Lehtimäki KA, Keränen T, Palmio J, et al. Increased plasma levels of cytokines after seizures in localization-related epilepsy[J]. Acta Neurol Scand, 2007, 116(4): 226-230.
12.	Hulkkonen J, Koskikallio E, Rainesalo S, et al. The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients[J]. Epilepsy Res, 2004, 59(2-3): 199-205.
13.	Peltola J, Palmio J, Korhonen L, et al. Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures[J]. Epilepsy Res, 2000, 41(3): 205-211.
14.	Bauer S, Cepok S, Todorova-Rudolph A, et al. Etiology and site of temporal lobe epilepsy influence postictal cytokine release[J]. Epilepsy Res, 2009, 86(1): 82-88.
15.	刘建平. 非随机研究的系统评价方法[J]. 中国循证医学, 2001, 1(4): 239-243.
16.	Choi J, Koh S. Role of brain inflammation in epileptogenesis[J]. Yonsei Med J, 2008, 49(1): 1-18.
17.	Peltola J, Hurme M, Miettinen A, et al. Elevated levels of interleukin-6 May occur in cerebrospinal fluid from patients with recent epileptic seizures[J]. Epilepsy Res, 1998, 31(2): 129-133.
18.	Fukuda M, Suzuki Y, Ishizaki Y, et al. Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats[J]. Seizure, 2009, 18(3): 211-214.
19.	Haspolat S, Baysal Y, Duman O, et al. Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures[J]. J Child Neurol, 2005, 20(7): 565-568.
20.	Tomoum HY, Badawy NM, Mostafa AA, et al. Plasma interleukin-1beta levels in children with febrile seizures[J]. J Child Neurol, 2007, 22(6): 689-692.
21.	Jauneau AC, Ischenko A, Chatagner A, et al. Interleukin-1beta and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes[J]. J Neuroinflammation, 2006, 3: 8.
22.	Bartfai T, Sanchez-Alavez M, Andell-Jonsson S, et al. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma[J]. Ann N Y Acad Sci, 2007, 1113: 173-177.
23.	Rijkers K, Majoie HJ, Hoogland G, et al. The role of interleukin-1 in seizures and epilepsy: a critical review[J]. Exp Neurol, 2009, 216(2): 258-271.
24.	Steinman L. Elaborate interactions between the immune and nervous systems[J]. Nat Immunol, 2004, 5(6): 575-581.
25.	Vezzani A, Ravizza T, Balosso S, et al. Glia as a source of cytokines: implications for neuronal excitability and survival[J]. Epilepsia, 2008, 49(Suppl 2): 24-32.

1. 　Baxendale S, O’Toole A. Epilepsy myths: alive and foaming in the 21st century[J]. Epilepsy Behav, 2007, 11(2): 192-196.
2. 　Walker AE. Allergic phenomenon as basic mechanisms in epilepsy[M]//Jaspar HH, Ward AA Jr, Pope A. Basic mechanisms of the epilepsies. London: Churchill, 1969: 812-814.
3. 　Vezzani A, Janigro D. Leukocyte-endothelial adhesion mechanisms in epilepsy: cheers and jeers[J]. Epilepsy Curr, 2009, 9(4): 118-121.
4. 　Ravizza T, Gagliardi B, Noé F, et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy[J]. Neurobiol Dis, 2008, 29(1): 142-160.
5. 　Vezzani A, Balosso S, Ravizza T. The role of cytokines in the pathophysiology of epilepsy[J]. Brain Behav Immun, 2008, 22(6): 797-803.
6. 　江明庆. 癫痫患者血清中IL-1β、TNF-α含量变化研究[J]. 当代医学, 2011, 17(33): 8-9.
7. 　Sinha S, Patil S, Jayalekshmy V, et al. Do cytokines have any role in epilepsy?[J]. Epilepsy Res, 2008, 82(2-3): 171-176.
8. 　Ravizza T, Boer K, Redeker S, et al. The IL-1beta system in epilepsy-associated malformations of cortical development[J]. Neurobiol Dis, 2006, 24(1): 128-143.
9. 　Pernot F, Heinrich C, Barbier L, et al. Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy[J]. Epilepsia, 2011, 52(12): 2315-2325.
10. 　Alapirtti T, Rinta S, Hulkkonen J, et al. Interleukin-6, interleukin-1 receptor antagonist and interleukin-1beta production in patients with focal epilepsy: a video-EEG study[J]. J Neurol Sci, 2009, 280(1-2): 94-97.
11. 　Lehtimäki KA, Keränen T, Palmio J, et al. Increased plasma levels of cytokines after seizures in localization-related epilepsy[J]. Acta Neurol Scand, 2007, 116(4): 226-230.
12. 　Hulkkonen J, Koskikallio E, Rainesalo S, et al. The balance of inhibitory and excitatory cytokines is differently regulated in vivo and in vitro among therapy resistant epilepsy patients[J]. Epilepsy Res, 2004, 59(2-3): 199-205.
13. 　Peltola J, Palmio J, Korhonen L, et al. Interleukin-6 and interleukin-1 receptor antagonist in cerebrospinal fluid from patients with recent tonic-clonic seizures[J]. Epilepsy Res, 2000, 41(3): 205-211.
14. 　Bauer S, Cepok S, Todorova-Rudolph A, et al. Etiology and site of temporal lobe epilepsy influence postictal cytokine release[J]. Epilepsy Res, 2009, 86(1): 82-88.
15. 　刘建平. 非随机研究的系统评价方法[J]. 中国循证医学, 2001, 1(4): 239-243.
16. 　Choi J, Koh S. Role of brain inflammation in epileptogenesis[J]. Yonsei Med J, 2008, 49(1): 1-18.
17. 　Peltola J, Hurme M, Miettinen A, et al. Elevated levels of interleukin-6 May occur in cerebrospinal fluid from patients with recent epileptic seizures[J]. Epilepsy Res, 1998, 31(2): 129-133.
18. 　Fukuda M, Suzuki Y, Ishizaki Y, et al. Interleukin-1beta enhances susceptibility to hyperthermia-induced seizures in developing rats[J]. Seizure, 2009, 18(3): 211-214.
19. 　Haspolat S, Baysal Y, Duman O, et al. Interleukin-1alpha, interleukin-1beta, and interleukin-1Ra polymorphisms in febrile seizures[J]. J Child Neurol, 2005, 20(7): 565-568.
20. 　Tomoum HY, Badawy NM, Mostafa AA, et al. Plasma interleukin-1beta levels in children with febrile seizures[J]. J Child Neurol, 2007, 22(6): 689-692.
21. 　Jauneau AC, Ischenko A, Chatagner A, et al. Interleukin-1beta and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes[J]. J Neuroinflammation, 2006, 3: 8.
22. 　Bartfai T, Sanchez-Alavez M, Andell-Jonsson S, et al. Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma[J]. Ann N Y Acad Sci, 2007, 1113: 173-177.
23. 　Rijkers K, Majoie HJ, Hoogland G, et al. The role of interleukin-1 in seizures and epilepsy: a critical review[J]. Exp Neurol, 2009, 216(2): 258-271.
24. 　Steinman L. Elaborate interactions between the immune and nervous systems[J]. Nat Immunol, 2004, 5(6): 575-581.
25. 　Vezzani A, Ravizza T, Balosso S, et al. Glia as a source of cytokines: implications for neuronal excitability and survival[J]. Epilepsia, 2008, 49(Suppl 2): 24-32.

West China Medical Journal

A Meta-analysis of the Relationship between Interleukin-1beta and Epileptic Seizure

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