Relationship between Plasma Homocysteine Level and Intracranial Artery Atherosclerosis in Patients with Cerebral Infarction_West China Medical Journal

Authors：

 GUCheng-wu , GUOWei-peng , JIANGShi-jie , YUMing

Department of Neurology, Central Hospital of Suining City, Suining, Sichuan 629000, P. R. China;

Corresponding author：

Keywords：

Homocysteine; Atherosclerosis; Cerebral infarction

DOI：

10.7507/1002-0179.20140063

Video：

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Objective To explore the relationship between plasma homocysteine level and intracranial artery atherosclerosis in patients with cerebral infarction. Methods A total of 120 patients with cerebral infarction diagnosed between January and December 2013 were selected.Plasma homocysteine level was analyzed and intracranial artery was detected by DSA. Results Intracranial artery atherosclerosis can be found in most of patients with cerebral infarction.Moreover,Plasma Hcy level of patients with large cerebral artery atherosclerosis was much higher than others (P<0.05).The much higher Plasma Hcy level,the severe intracranial artery atherosclerosis were found in internal carotid artery and cerebral middle artery (P<0.05). Conclusion Intracranial artery atherosclerosis is common in patients with cerebral infarction.Occurrence of intracranial artery atherosclerosis is positively correlated with plasma homocysteine level.Plasma homocysteine level may be a risk factor of intracranial artery atherosclerosis in patients with cerebral infarction.

Citation： GUCheng-wu, GUOWei-peng, JIANGShi-jie, YUMing. Relationship between Plasma Homocysteine Level and Intracranial Artery Atherosclerosis in Patients with Cerebral Infarction. West China Medical Journal, 2014, 29(2): 207-209. doi: 10.7507/1002-0179.20140063 Copy

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12.	王桂红,王拥军,何耀,等.血浆同型半胱氨酸水平与脑大动脉粥样硬化性病变的相关性分析[J].中华内科杂志,2006,45(9):744-747.
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16.	Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease and stroke:a meta-analysis[J].JAMA,2002,288(16):2015-2022.

1. 高晶,郭玉璞,赵庆杰,等.颅内动脉粥样硬化的分布及炎性因素探讨[J].中华神经科杂志,2006,39(7):459-462.
2. 易兴阳,潘光强,余昌明,等.颈动脉粥样硬化与脑梗死复发的关系探讨[J].中华神经科杂志,2002,35(2):68-70.
3. 顾炳权,王多宁.血浆同型半胱氨酸水平及临床诊断意义[J].中国血液流变学杂志,2004,14(4):630-634,638.
4. 中华医学会神经病学分会脑血管病学组缺血性脑卒中二级预防指南撰写组.中国缺血性脑卒中和短暂性脑缺血发作二级预防指南(2010)[J].中国临床医生,2011,2(11):68-74.
5. 淦作松,倪修红,唐尤佳,等.全脑血管造影术在诊断脑血管病的应用[J].江西医药,2008,43(8):834-835.
6. Manninen AL,Isokangas JM,Karttunen A,et al.A comparison of radiation exposure between diagnostic CTA and DSA examinations of cerebral and cervicocerebral vessels[J].AJNR Am J Neuroradiol,2012,33(11):2038-2042.
7. 张志勇,李慎茂,魏嘉平,等.粥样硬化性颅内-外动脉狭窄与冠状动脉狭窄的关系[J].中国脑血管病杂志,2007,4(6):241-245.
8. 陈东,智睿,丁朝兵,等.颈动脉粥样硬化斑块及其相关因素与脑梗死的关系[J].临床神经病学杂志,2007,20(6):468-470.
9. 刘文军,姜萍,张宗权,等.低场磁共振弥散加权成像在急性脑梗死诊断中的应用价值[J].华西医学,2010,25(8):1499-1501.
10. 刘新通,王伟,王丽娟,等.伴有颅内外动脉狭窄或闭塞的急性脑梗死后侧支循环建立与预后的关系[J].中华医学杂志,2011,91(11):766-768.
11. Tan NC,Venketasubramanian N,Saw SM,et al.Hyperhomocyst (e) inemia and risk of ischemic stroke among young Asian adults[J].Stroke,2002,33(8):1956-1962.
12. 王桂红,王拥军,何耀,等.血浆同型半胱氨酸水平与脑大动脉粥样硬化性病变的相关性分析[J].中华内科杂志,2006,45(9):744-747.
13. Sen S,Hinderliter A,Sen PK,et al.Aortic arch atheroma progression and recurrent vascular events in patients with stroke or transient ischemic attack[J].Circulation,2007,116(8):928-935.
14. Wald DS,Wald NJ,Morris JK,et al.Folic acid,homocysteine,and cardiovascular disease:judging causality in the face of inconclusive trial evidence[J].BMJ,2006,333(7578):1114-1117.
15. 王普清,罗韵文,张贵斌,等.进展性脑梗死危险因素Logistic回归分析[J].卒中与神经疾病,2007,14(6):368-372.
16. Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease and stroke:a meta-analysis[J].JAMA,2002,288(16):2015-2022.

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Relationship between Plasma Homocysteine Level and Intracranial Artery Atherosclerosis in Patients with Cerebral Infarction

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