Meta-analysis on the Association of <i>CYP11B2</i> Gene Polymorphism and Left Ventricular Hypertrophy in Chinese Hypertensive Patients_West China Medical Journal

Authors：

 MABao-xin ¹ , LIUXian-liang ² , LIHua ¹ , LIZong-qing ¹

1. Department of Cardiology, Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P. R. China;
2. Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P. R. China;

Corresponding author：

Keywords：

Hypertension; Left ventricular hypertrophy; Aldosterone synthase; Gene polymorphism; Meta-analysis

DOI：

10.7507/1002-0179.20140074

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Objective To investigate the association between CYP11B2 gene polymorphism and left ventricular hypertrophy in Chinese hypertensive patients by the means of meta-analysis. Methods Literatures about case control study on the association of CYP11B2 gene polymorphism and left ventricular hypertrophy were searched from January 1980 to December 2012.The electronic databases searched included China national knowledge internet,Chinese biological medicine disk,Vip fulltext database,Wanfang fulltext database and Pubmed.Odds ratio (OR) of CYP11B2 genotype distributions in left ventricular hypertrophy (LVH) patients against NLVH patients were analyzed.RevMan 5.1 software was applied for investigating heterogeneity among individual studies and summarizing effects across studies by proper statistical methods. Results Six case-control studies were selected finally.A total of 1 791 hypertensive patients were included.The pooled OR (95% CI) of CC vs.TT+TC genotype was 1.21(0.80,1.81)(Z=0.91,P=0.36),the pooled OR (95% CI) of (TC+CC) vs.TT genotype was 1.16(0.68,1.98)(Z=0.54,P=0.59),and the pooled OR (95% CI) of C vs.T allele was 1.09(0.78,1.54)(Z=0.51,P=0.61). Conclusion The genotype of CYP11B2 polymorphism is not associated with an increase risk of left ventricular hypertrophy in Chinese hypertensive patients.

Citation： MABao-xin, LIUXian-liang, LIHua, LIZong-qing. Meta-analysis on the Association of CYP11B2 Gene Polymorphism and Left Ventricular Hypertrophy in Chinese Hypertensive Patients. West China Medical Journal, 2014, 29(2): 239-242. doi: 10.7507/1002-0179.20140074 Copy

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8.	周永,高春香,张瑞志,等.醛固酮合成酶基因多态性(C/T)与高血压患者左室肥厚相关性研究[J].高血压杂志,2004,12(4):315-318.
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1. Delles C,Erdmann J,Jacobi J,et al.Aldosterone synthase (CYP11B2)-344C/T polymorphism is associated with left ventricular structure in human arterial hypertension[J].J Am Coll Cardiol,2001,37(3):878-884.
2. Stella P,Bigatti G,Tizzoni L,et al.Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension[J].J Am Coll Cardiol,2004,43(2):265-270.
3. Kupari M,Hautanen A,Lankinen L,et al.Associations between human aldosterone synthase (CYP11B2) gene polymorphisms and left ventricular size,mass,and function[J].Circulation,1998,97(6):569-575.
4. Kurbanova D,Eliseyeva M.Genetic background of left ventricular hypertrophy in Uzbek hypertensive men[J].Turk Kardiyol Dern Ars,2010,38(7):466-472.
5. Isaji M,Mune T,Takada N,et al.Correlation between left ventricular mass and urinary sodium excretion in specific genotypes of CYP11B2[J].J Hypertens,2005,23(6):1149-1157.
6. 崔俊彪,王曦云,盛莉,等.醛固酮合成酶基因-344C/T多态性与高血压左室肥厚相关性研究[J].中国心血管病研究杂志,2006,4(3):190-193.
7. 孙晓健,刘少荣,刘文波,等.醛固酮合成酶基因-344T/C多态性与高血压性左室肥厚相关性研究[J].临床心血管病杂志,2004,20(7):386-388.
8. 周永,高春香,张瑞志,等.醛固酮合成酶基因多态性(C/T)与高血压患者左室肥厚相关性研究[J].高血压杂志,2004,12(4):315-318.
9. 陈丹.醛固酮合成酶CYP11B2基因C-344T多态性与原发性高血压发病关系的研究[D].大连:大连医科大学,2004:18.
10. 李庆祥.高血压及其靶器官损害的相关基因研究[D].北京:北京协和医科大学,2003.
11. 陈爱华,张文秀,唐晓明,等.醛固酮合成酶基因多态性与高血压及左室肥厚的关系[J].中华内科杂志,2002,41(5):298-301.
12. 邹茜婷,安振梅.醛固酮对心血管系统的不良影响与治疗[J].华西医学,2007,22(3):551-552.
13. 邓珏琳,高云,黄德嘉,等.原发性高血压与血管紧张素转换酶基因多态性的相关性研究[J].华西医学,2000,15(2):164-166.
14. 杨静,张泉,李江津,等.中国汉族人群醛固酮合成酶CYP11B2基因多态性与原发性高血压相关性的荟萃分析[J].中华高血压杂志,2011,19(7):673-677.

West China Medical Journal

Meta-analysis on the Association of CYP11B2 Gene Polymorphism and Left Ventricular Hypertrophy in Chinese Hypertensive Patients

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