Observation of the Clinical Efficacy and Safety of Reteplase in Prehospital Thrombolysis for ST-segment Elevation Acute Myocardial Infarction_West China Medical Journal

Authors：

 WANGAn-wei ,  LIJun-feng , GAOJin-quan , LIUYao , YANShi-hua

epartment of Cardiology, the People's Hospital of Chongzhou City, Chongzhou, Sichuan 611230, P. R. China;

Corresponding author：

LIJun-feng, Email: Ljfyisheng@sina.com

Keywords：

ST-segment elevation acute myocardial infarction; Reteplase; Prehospital thrombolysis

DOI：

10.7507/1002-0179.20140075

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To observe the clinical efficacy and safety of reteplase in prehospital thrombolysis for ST-segment elevation acute myocardial infarction. Methods We retrospectively analyzed the clinical data of 62 patients with acute ST-segment elevation myocardial infarction treated in our hospital between September 2010 and December 2012.They were randomly divided into two groups:the treatment group with 22 patients given reteplase thrombolysis therapy in the prehospital ambulance and/or emergency department,and the control group with 40 patients receiving thrombolytic therapy in the hospital.Then,we compared 60-minute and 120-minute recanalization rate,the rate of complicating with various kinds of adverse reactions and the composite end-point event rate between the two groups. Results Sixty minutes and 120 minutes after thrombolysis,the clinical judgment recanalization rate in the treatment group was significantly higher than that in the control group (P<0.05).Four weeks after hospitalization,the rate of complicating with various kinds of hemorrhage,hypotension and death rate in the two groups had no statistical difference (P>0.05). Conclusion Prehospital thrombolysis treatment for ST-segment elevation acute myocardial infarction has a better clinical efficacy and is worth popularizing in basic unit hospitals.

Citation： WANGAn-wei, LIJun-feng, GAOJin-quan, LIUYao, YANShi-hua. Observation of the Clinical Efficacy and Safety of Reteplase in Prehospital Thrombolysis for ST-segment Elevation Acute Myocardial Infarction. West China Medical Journal, 2014, 29(2): 243-245. doi: 10.7507/1002-0179.20140075 Copy

1.	刘书山,胡大一,杨进刚,等.节假日对ST段抬高心肌梗死院内再灌注延迟的影响[J].中国介入心脏病学杂志,2008,16(2):91-94.
2.	黎淑珍,程玉薇.急性心肌梗死患者早期活动的探讨[J].现代医院,2007,7(3):154-155.
3.	中华医学会心血管病分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断与治疗指南[J].中华心血管病杂志,2010,38(8):675-690.
4.	Tiandrawidjaja MC,Fu Y,Westerhout CM,et al.Resolution of ST-segment depression:a new prognestie marker in ST-segment elevation myocardial infarction[J].Eur Heart J,2010,31(5):573-581.
5.	邵耕.现代冠心病[M].北京:北京医科大学,中国协和医科大学联合出版社,1994:331-338.
6.	European Society of Cardiology,European Resuscitation Council.The pre-hospital management of acute heart attacks.Recommendations of a task force of the European Society of Cardiology and the European Resuscitation Council[J].Eur Heart J,1998,19(8):1140-1164.
7.	Simes RJ,Topol EJ,Homes DR,et al.Link between the angiographic substudy and mortality outcomes in alarge randomized trial of myocardial reperfusion:importance of early and complete infarct artery reperfusionl[J].Circulation,1995,91(7):1923-1928.
8.	Di Mario,Dudek D,Piscione F,et al.Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the combined abciximab reteplase stent study in acute myocardial infarction (CARESS-in-AMI):an open,prospective,randomized,multicentre trial[J].Lancet,2008,371(9612):559-568.
9.	李亚萍.急性心肌梗死的药物溶栓治疗进展[J].实用老年医学,2000,14(2):85-87.
10.	周红.第三代溶栓剂的作用特点及其研究现状[J].国外医学·心血管疾病分册,2000,27(5):274-276.
11.	Hanson TC,Williamson D.Identifying barriers to prehospital thrombolysis in the treatment of acute myocardial infarction[J].Emerg Med J,2006,23(8):650-653.
12.	蔡继锐,刘东亮,杨春香,等.国产瑞替普酶和进口阿替普酶对ST段抬高型心肌梗死的溶栓疗效比较[J].中国心血管病研究杂志,2011,9(3):181-183.
13.	Bode C,Smalling RW,Berg G,et al.Randomized comparison of coronary thrombolysis achieved with double-bolus reteplase (recombinant plasminogen activator) and front-loaded,accelerated alteplase (recombinant tissue plasminogen activator) in patients with acute myocardial infarction[J].Circulation,1996,94(5):891-898.

1. 刘书山,胡大一,杨进刚,等.节假日对ST段抬高心肌梗死院内再灌注延迟的影响[J].中国介入心脏病学杂志,2008,16(2):91-94.
2. 黎淑珍,程玉薇.急性心肌梗死患者早期活动的探讨[J].现代医院,2007,7(3):154-155.
3. 中华医学会心血管病分会,中华心血管病杂志编辑委员会.急性ST段抬高型心肌梗死诊断与治疗指南[J].中华心血管病杂志,2010,38(8):675-690.
4. Tiandrawidjaja MC,Fu Y,Westerhout CM,et al.Resolution of ST-segment depression:a new prognestie marker in ST-segment elevation myocardial infarction[J].Eur Heart J,2010,31(5):573-581.
5. 邵耕.现代冠心病[M].北京:北京医科大学,中国协和医科大学联合出版社,1994:331-338.
6. European Society of Cardiology,European Resuscitation Council.The pre-hospital management of acute heart attacks.Recommendations of a task force of the European Society of Cardiology and the European Resuscitation Council[J].Eur Heart J,1998,19(8):1140-1164.
7. Simes RJ,Topol EJ,Homes DR,et al.Link between the angiographic substudy and mortality outcomes in alarge randomized trial of myocardial reperfusion:importance of early and complete infarct artery reperfusionl[J].Circulation,1995,91(7):1923-1928.
8. Di Mario,Dudek D,Piscione F,et al.Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the combined abciximab reteplase stent study in acute myocardial infarction (CARESS-in-AMI):an open,prospective,randomized,multicentre trial[J].Lancet,2008,371(9612):559-568.
9. 李亚萍.急性心肌梗死的药物溶栓治疗进展[J].实用老年医学,2000,14(2):85-87.
10. 周红.第三代溶栓剂的作用特点及其研究现状[J].国外医学·心血管疾病分册,2000,27(5):274-276.
11. Hanson TC,Williamson D.Identifying barriers to prehospital thrombolysis in the treatment of acute myocardial infarction[J].Emerg Med J,2006,23(8):650-653.
12. 蔡继锐,刘东亮,杨春香,等.国产瑞替普酶和进口阿替普酶对ST段抬高型心肌梗死的溶栓疗效比较[J].中国心血管病研究杂志,2011,9(3):181-183.
13. Bode C,Smalling RW,Berg G,et al.Randomized comparison of coronary thrombolysis achieved with double-bolus reteplase (recombinant plasminogen activator) and front-loaded,accelerated alteplase (recombinant tissue plasminogen activator) in patients with acute myocardial infarction[J].Circulation,1996,94(5):891-898.

West China Medical Journal

Observation of the Clinical Efficacy and Safety of Reteplase in Prehospital Thrombolysis for ST-segment Elevation Acute Myocardial Infarction

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