Study on the Compatible Stability of Brevescapine Injection in Common Solvents_West China Medical Journal

Authors：

 WANGXia , MEILing

Pharmacy of Chengdu Fifth People's Hospital, Chengdu, Sichuan 611137, P. R. China;

Corresponding author：

Keywords：

Breviscapine; Scutellarin; Compatible; Stability

DOI：

10.7507/1002-0179.20140089

Video：

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Objective To study on the compatible stability of brevescapine injection in common solvents. Methods Brevescapine injection was added into 0.9% sodium chloride injection,5% glucose injection,10% glucose injection (100,250,and 500 mL) respectively at room temperature.The pH value and visual appearance of the admixture were observed at immediate 0,1,2,4,6 hours after Brevescapine injection was added into the solvents.Scutellarin concentration was determined by the method of high performance liquid chromatography (HPLC). Results No significant change was found in appearance and pH value of the admixture.And Scutellarin concentration changed obviously in the admixture of 100 mL 0.9% sodium chloride injection,100 mL 10% glucose injection and the three types of 5% glucose injection. Conclusion Brevescapine injections have better compatibility with 250 mL and 500 mL 0.9% sodium chloride injection,and it is incompatible with 5% glucose injection.In addition,the admixture injection should be finished within six hours.

Citation： WANGXia, MEILing. Study on the Compatible Stability of Brevescapine Injection in Common Solvents. West China Medical Journal, 2014, 29(2): 293-296. doi: 10.7507/1002-0179.20140089 Copy

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2. Chai WS,Zhai SP,Wu SL,et al.The effect of breviseapine on pulmonary fibrosis induced by bleomycin in rats[J].China Phartrmcol Bull,2008,24(1):113-116.
3. 林潮炫.灯盏花素对促进骨性关节炎治愈的临床疗效观察[J].吉林医学,2013,34(6):1073.
4. Tan ZH,Yu LH,Wei HL,et al.The protective action of scutellarin against immunological liver injury induced by concanavalin A and its effect on pro-inflammatory cytokines in mice[J].J Pharm Pharmacol,2007,59(1):115-121.
5. 吴静,钟慧菊,孙志湘,等.灯盏花素治疗糖尿病周围神经病变的疗效观察[J].湖南医科大学学报,2002,27(4):337-340.
6. 张虹,苏小勇,张雪芳.灯盏花素与黄芪联合应用治疗糖尿病肾病临床观察[J].中国医药导报,2009,6(29):63-63,66.
7. Lin LL,Liu AJ,Liu JG,et al.Protective effects of scutellarin and breviscapine on brain and heart ischemia in rats[J].J Cardiovasc Pharmacol,2007,50(3):327-332.
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9. 覃树先.黄芩甙水溶液性稳定性研究[J].广西医学,2000,22(4):920-922.
10. 石森林,徐莲英,毛展凯,等.灯盏花素的理化性质及其稳定性影响因素研究[J].中国中药杂志,2009,34(7):843-847.
11. 李煜.不同pH值对注射液灯盏花素的稳定性影响[J].航空航天医院杂志,2013,24(4):401-402.
12. 熊魏,彭红,廖夫生.HPLC法测定灯盏花素胶囊中野黄芩苷的含量[J].广州化工,2013,41(4):138-139.
13. 杨强,杨俊毅,李思成,等.灯盏花素缓释片在Beagle犬体内相对生物利用度的研究[J].华西药学杂志,2004,19(3):175-178.
14. 陈大为,张彦青,邹艳霜,等.灯盏花素缓释微丸在家兔体内药效学和药动学研究[J].中国药剂学杂志,2003,1(2):63-67.
15. 陈国广,张柯萍,李学明,等.灯盏花素缓释固体分散体的制备及溶出度的研究[J].华西药学杂志,2007,22(2):169-171.
16. 张利平,吴海雯.灯盏花素注射液致不良反应8例[J].医药导报,2009,28(5):677-678.

West China Medical Journal

Study on the Compatible Stability of Brevescapine Injection in Common Solvents

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