• Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
HELi, Email: heli2003new@126.com
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Objective To investigate the current situation of randomized controlled trials (RCTs) of thrombin like enzyme research and the ability to provide a reliable basis for the clinical practice. Methods RCTs identified from four Chinese databases up to the year 2012 were assessed according to international standard, including SinoMed (1978-2012), CNKI (1979-2012), Wanfang Data (1986-2012), and VIP (1989-2012). Results A total of 2358 articles were searched and 53 RCTs were identified. The results showed that the quality of these articles was not high enough to meet the needs of clinical practice in China. Conclusion In China, current quantity and quality of RCTs of thrombin like enzyme can not meet the need of clinical practice. In order to improve the prevention and treatment of hemorrhagic diseases, and surgical bleeding, especially for patients lacking clotting factor, more high-quality RCTs are required.

Citation: HUWen-ting, QINFeng-qin, CHENNing, GUOJian, FANGJing-huan, GUOJiang, ZHOUDong, HELi. Preliminary Analysis of Randomized Controlled Trials on Thrombin Like Enzyme in China. West China Medical Journal, 2014, 29(3): 488-491. doi: 10.7507/1002-0179.20140146 Copy

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