Efficacy and Safety of Compound Flumetasone Ointment for Neurodermatitis and Chronic Eczema:A Systematic Review_West China Medical Journal

Authors：

 XIAOBi-huan , WUYan , SUNYan ,  GAOXing-hua

Department of Dermatology, the First Hospital of China Medical University, Key Laboratory of Immunodermatology, Ministry of Health, Shenyang, Liaoning 110001, P. R. China;

Corresponding author：

GAOXing-hua, Email: gaobarry@hotmail.com

Keywords：

Compound flumetasone ointment; Dermatitis; Eczema; Randomized controlled trials; Systematic review

DOI：

10.7507/1002-0179.20140209

Video：

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Objective To assess the efficacy and safety of compound flumetasone ointment for neurodermatitis and chronic eczema. Methods We searched the Medline, Cochrane Central Register of Controlled Trials, EMbase, CBM, CNKI and Wanfang Data to collect randomized controlled trials (RCTs) of compound flumetasone ointment for neurodermatitis and chronic eczema; the retrieval time started from founded date to December 2012. The language was confined to English and Chinese. We performed meta-analyses using the Cochrane Collaboration's RevMan 5.0 Software. Results A total of 22 RCTs involving 2 049 patients with neurodermatitis and chronic eczema were included and assessed. At the end of the 2nd, 3rd and 4th week, the efficacy of topical compound flumetasone ointment (or combined with oral antihistamines) was obviously higher than that of other topical corticosteroid preparations[RR=1.39, 95%CI(1.30, 1.50), P<0.000 01; RR=1.25, 95%CI(1.15, 1.37), P<0.000 01; RR=1.21, 95%CI(1.11, 1.33), P<0.000 1]. Only temporary and slight adverse effects, such as erythema, desquamation, burning and tingling were observed, whereas no serious adverse effects were reported. Conclusion The limited evidence demonstrates that topical compound flumetasone ointment (or combined with oral antihistamines) is safe and efficient. More large sampled and multiple central RCTs are required to verify these conclusions owing to the limitations of the present study.

Citation： XIAOBi-huan, WUYan, SUNYan, GAOXing-hua. Efficacy and Safety of Compound Flumetasone Ointment for Neurodermatitis and Chronic Eczema:A Systematic Review. West China Medical Journal, 2014, 29(4): 692-701. doi: 10.7507/1002-0179.20140209 Copy

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24.	多守元. 卤米松三氯生软膏和复方氟米松治疗慢性湿疹疗效对比[J]. 西南军医, 2011, 13(6):1021-1022.
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26.	王云娜, 黎波, 杜元灏, 等. 针灸治疗神经性皮炎临床随机对照试验疗效及安全性评价[J]. 辽宁中医杂志, 2009, 36(12):2160-2163.
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28.	陈建宏, 黄妙珠, 关倩雅, 等. 中药内服治疗湿疹的随机对照试验的系统评价[J]. 中国现代医生, 2010, 48(13):83-84.
29.	杨志波, 赖彬, 黄迎玉. 中药洗剂治疗湿疹的系统评价[J]. 中医药导报, 2010, 16(9):21-25.
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32.	Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, et al. Probiotics for the treatment of eczema:a systematic review[J]. Clin Exp Allergy, 2009, 39(8):1117-1127.
33.	Boyle RJ, Both-Hextall FJ, Leonardi-Bee J, et al. Probiotics for treating eczema[J]. Cochrane Database Syst Rev, 2008, 8(4):CD006135.
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35.	Wienert V, Heusinger JH. Local treatment of hemorrhoidal disease and perianal eczema-Meta-analysis of the efficacy and safety of an Escherichia coli culture suspension alone or in combination with hydrocortisone[J]. Arzneimittelforschung, 2002, 52(7):515-523.
36.	Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema-a systematic review and meta-analysis[J]. J Eur Acad Dermatol Venereol, 2007, 21(5):606-619.
37.	Kerscher MJ, Korting HC. Treatment of atopic eczema with evening primrose oil:rationale and clinical results[J]. Clin Investig, 1992, 70(2):167-171.
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40.	吴满平, 蒋惠平, 王雪萍. 复方氟米松软膏治疗慢性湿疹、神经性皮炎的临床疗效观察[J]. 中国医院用药评价与分析, 2009, 9(9):704-705.
41.	颜艳, 鞠梅, 于建斌, 等. 复方氟米松软膏治疗湿疹皮炎类皮肤病临床疗效观察[J]. 中华皮肤科杂志, 2006, 39(2):116-117.
42.	Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region[J]. Dermatol Ther, 2004, 17(1):8-19.

1. 张石革. 皮炎与糖皮质激素[J]. 中国药房, 2002, 13(9):575.
2. 陈小红, 彭世瑜. 水杨酸在银屑病治疗中的作用[J]. 国外医学·皮肤性病学分册, 2000, 26(3):172-175.
3. 董玲英. 复方氟米松软膏治疗播散型神经性皮炎60例[J]. 中国药业, 2009, 18(17):59.
4. 李世林. 复方氟米松软膏治疗神经性皮炎临床观察[J]. 中国药房, 2008, 19(11):852-853.
5. 屈雅丽. 复方氟米松软膏治疗慢性湿疹及神经性皮炎的临床观察[J]. 中外医疗, 2008(25):77.
6. 李鸿国. 复方氟米松软膏治疗慢性湿疹临床观察及实验研究[D]. 大连:大连医科大学, 2009.
7. 梁静. 复方氟米松软膏治疗慢性手部湿疹42例疗效观察[D]. 大连:大连医科大学, 2009.
8. 彭安厚. 复方氟米松软膏治疗掌跖部慢性湿疹临床观察[J]. 中国皮肤性病学杂志, 2008, 22(5):318-319.
9. 左娟, 王雅芳, 李英弟. 复方氟米松软膏治疗慢性湿疹效果观察[J]. 宁夏医学杂志, 2009, 31(2):167-168.
10. 李莲花, 金哲虎. 复方氟米松软膏治疗皮炎湿疹疗效观察[J]. 中国皮肤性病学杂志, 2009, 23(10):687-688.
11. 余兵, 肖文. 阿维A胶囊联合复方氟米松软膏治疗掌跖角化性湿疹的临床研究[J]. 广西医学, 2009, 31(11):1640-1641.
12. 赵玮. 奥深联合左西替利嗪治疗慢性湿疹40例临床观察[J]. 中国医药导报, 2009, 6(16):76-77.
13. 伦振新, 苏伟团, 戚志东. 复方氟米松软膏治疗慢性肥厚型湿疹60例临床观察[J]. 海南医学, 2010, 21(5):50-51.
14. 孙玉娥, 孙亚琴, 崔斌, 等. 复方氟米松软膏治疗慢性单纯性苔藓和皲裂性湿疹临床观察[J]. 江苏医药, 2010, 36(18):2221-2222.
15. 杨越楠, 焦林君, 徐凌忠. 复方氟米松软膏治疗神经性皮炎的疗效观察[J]. 包头医学院学报, 2009, 25(6):62-63.
16. 何秋波. 复方氟米松软膏治疗手足角化性湿疹临床观察[J]. 医药论坛杂志, 2010, 31(8):116.
17. 徐洁. 氯雷他定联合复方氟米松治疗慢性湿疹的临床观察[J]. 临床合理用药杂志, 2010, 3(9):87.
18. 吴波, 余振东, 刘颜. 复方氟米松软膏治疗慢性四肢及掌跖部湿疹临床观察[J]. 海南医学, 2009, 20(7):94-95.
19. 叶霞, 黄丹. 复方氟米松软膏联合地氯雷他定治疗慢性湿疹临床观察[J]. 中国现代医生, 2010, 48(22):145.
20. 刘纯卉. 复方氟米松软膏治疗慢性湿疹及神经性皮炎的临床观察[J]. 中国煤炭工业医学杂志, 2008, 11(9):1356.
21. 柯丹, 刁庆春, 伍津津, 等. 复方氟米松软膏治疗108例神经性皮炎患者的临床疗效和安全性评价[J]. 重庆医学, 2010, 39(23):3219-3220.
22. 王秀峰, 刘红霞, 张玉仙. 复方氟米松软膏治疗慢性湿疹和神经性皮炎的疗效观察[J].临床合理用药, 2010, 3(21):42.
23. 张海萍. 复方氟米松软膏治疗慢性湿疹疗效观察[J]. 中国社区医师·医学专业, 2011, 13(272):140.
24. 多守元. 卤米松三氯生软膏和复方氟米松治疗慢性湿疹疗效对比[J]. 西南军医, 2011, 13(6):1021-1022.
25. 曹素芬. 复方氟米松软膏联合紫外负离子喷雾治疗神经性皮炎疗效观察[J]. 重庆医学, 2010, 39(3):377-378.
26. 王云娜, 黎波, 杜元灏, 等. 针灸治疗神经性皮炎临床随机对照试验疗效及安全性评价[J]. 辽宁中医杂志, 2009, 36(12):2160-2163.
27. 杨芳, 王义亮, 郭强, 等. 针灸治疗神经性皮炎的文献系统评价[J]. 针灸临床杂志, 2010, 26(8):1-7.
28. 陈建宏, 黄妙珠, 关倩雅, 等. 中药内服治疗湿疹的随机对照试验的系统评价[J]. 中国现代医生, 2010, 48(13):83-84.
29. 杨志波, 赖彬, 黄迎玉. 中药洗剂治疗湿疹的系统评价[J]. 中医药导报, 2010, 16(9):21-25.
30. Ashcroft DM, Chen LC, Garside R. Topical pimecrolimus for eczema[J]. Cochrane Database Syst Rev, 2007(4):CD005500.
31. Stege H. Ultraviolet therapy in patients with chronic hand eczema[J]. Hautarzt, 2008, 59(9):696-702.
32. Boyle RJ, Bath-Hextall FJ, Leonardi-Bee J, et al. Probiotics for the treatment of eczema:a systematic review[J]. Clin Exp Allergy, 2009, 39(8):1117-1127.
33. Boyle RJ, Both-Hextall FJ, Leonardi-Bee J, et al. Probiotics for treating eczema[J]. Cochrane Database Syst Rev, 2008, 8(4):CD006135.
34. Bath-Hextall FJ, Birnie AJ, Ravenscroft JC, et al. Interventions to reduce Staphylococcus aureus in the management of atopic eczema:an updated Cochrane review[J]. Br J Dermatol, 2010, 163(1):12-26.
35. Wienert V, Heusinger JH. Local treatment of hemorrhoidal disease and perianal eczema-Meta-analysis of the efficacy and safety of an Escherichia coli culture suspension alone or in combination with hydrocortisone[J]. Arzneimittelforschung, 2002, 52(7):515-523.
36. Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema-a systematic review and meta-analysis[J]. J Eur Acad Dermatol Venereol, 2007, 21(5):606-619.
37. Kerscher MJ, Korting HC. Treatment of atopic eczema with evening primrose oil:rationale and clinical results[J]. Clin Investig, 1992, 70(2):167-171.
38. Morse NL, Clough PM. A meta-analysis of randomized, placebo-controlled clinical trials of Efamol(R)evening primrose oil in atopic eczema. Where do we go from here in light of more recent discoveries?[J]. Curr Pharmaceut Biotechnol, 2006, 7(6):503-524.
39. Armstrong NC, Ernst E. The treatment of eczema with Chinese herbs:a systematic review of randomized clinical trials[J]. Br J Clin Pharmacol, 1999, 48(2):262-264.
40. 吴满平, 蒋惠平, 王雪萍. 复方氟米松软膏治疗慢性湿疹、神经性皮炎的临床疗效观察[J]. 中国医院用药评价与分析, 2009, 9(9):704-705.
41. 颜艳, 鞠梅, 于建斌, 等. 复方氟米松软膏治疗湿疹皮炎类皮肤病临床疗效观察[J]. 中华皮肤科杂志, 2006, 39(2):116-117.
42. Lynch PJ. Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region[J]. Dermatol Ther, 2004, 17(1):8-19.

West China Medical Journal

Efficacy and Safety of Compound Flumetasone Ointment for Neurodermatitis and Chronic Eczema:A Systematic Review

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