Analysis of the Relative Factors of Lymph-nodes Metastasis in Patients with Cervical Cancer_West China Medical Journal

Authors：

 LIAOYun ,  WANXiao-li , XIAXiu-ying , XUHong-mei

Department of gynaecology and obstetrics, the People's Hospital of Leshan, Leshan, Sichuan 614000, P. R. China;

Corresponding author：

WANXiao-li, Email: 82208064@qq.com

Keywords：

Cervical cancer; Lymph-nodes metastasis; Clinic staging; Histologic subtype; Depth of stromal invasion

DOI：

10.7507/1002-0179.20140279

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To analyze the relative factors of lymph-nodes metastasis (LM) in patients with cervical cancer. Methods The clinico-pathological data of 136 patients with stageⅠ A-Ⅱ A of cervical cancer who underwent surgical therapy from January 2005 to December 2010 were retrospectively analyzed. The correlation between clinico-pathological parameters and LM was analyzed by univariable χ² analysis and multivariable logistic analysis. Results The total LM rate (LMR) was 14.0% (19/136). The rate of LM in obturator was the highest (63.2%), and then the rate between the external and internal iliac was 42.1%. The rate of deep inguinal lymph nodes and para-aortic lymph node was 0.0%. There was correlation between the clinic staging, depth of stromal invasion, histologic subtype, parametrial invasion, vaginal invasion and LM in univariable analysis (P<0.05). While in multivariable analysis, the correlation with LM was only existed between the clinic staging, histologic subtype, depth of stromal invasion and LM. Conclusion Clinic staging, histologic subtype, depth of stromal invasion are high risk factors of LM.

Citation： LIAOYun, WANXiao-li, XIAXiu-ying, XUHong-mei. Analysis of the Relative Factors of Lymph-nodes Metastasis in Patients with Cervical Cancer. West China Medical Journal, 2014, 29(5): 921-924. doi: 10.7507/1002-0179.20140279 Copy

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13.	李相生, 周纯武. 综合评价CT、MRI及PET在子宫颈癌术前分期及术后随访中的作用[J]. 癌症进展, 2006, 4(2):119-123.
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15.	Kobierski J, Emerich J, KrÓlikowska B, et al. Lymph node metastasis as a prognostic factor in cervical carcinoma[J]. Ginekol Pol, 2002, 73(11):925-929.
16.	Chandacham A, Charoenkwan K, Siriaunkgul S, et al. Extent of lymphovascular space invasion and risk of pelvic lymph node metastases in stage IB1 cervical cancer[J]. J Med Assoc Thai, 2005, 88(Suppl 2):S31-S36.
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18.	Milam MR, Frumovitz M, dos Reis R, et al. Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer[J]. Gynecol Oncol, 2007, 106(1):12-15.

1. 卞美璐. WHO (2006年)宫颈癌综合防治实践指南简介[J]. 中国实用妇科与产科杂志, 2007, 23(7):557-560.
2. 杨玲, 李连弟, 陈育德, 等. 中国2000年及2005年恶性肿瘤发病死亡的估计与预测[J]. 中国卫生统计, 2005, 22(4):218-221, 231.
3. 连利娟. 林巧稚妇科肿瘤学[M]. 4版. 北京:人民卫生出版社, 2006:342-349.
4. 曹泽毅. 中华妇产科学[M]. 2版. 北京:人民卫生出版社, 1999:2033-2034.
5. Benedet JL, Odicino F, Maisonneuve P, et al. Carcinoma of the cervix uteri[J]. J Epidemiol Biostat, 2001, 6(1):7-43.
6. 万晓丽, 郄明蓉, 张健, 等. 宫颈鳞癌临床分期和淋巴结转移高危因素分析[J]. 现代妇产科进展, 2009, 18(1):31-34.
7. Torabi M, Aquino SL, Harisinghani MG. Current concepts in lymph node imaging[J]. J Nucl Med, 2004, 45(9):1509-1518.
8. Chung HH, Kang SB, Cho JY, et al. Can preoperative MRI accurately evaluate nodal and parametrial invasion in early stage cervical cancer?[J]. Jpn J Clin Oncol, 2007, 37(5):370-375.
9. Sheu MH, Chang CY, Wang JH, et al. Preoperative staging of cervical carcinoma with Mr imaging:a reappraisal of diagnostic accuracy and pitfalls[J]. Eur Radiol, 2001, 11(9):1828-1833.
10. Bellomi M, Bonomo G, Landoni F, et al. Accuracy of computed tomography and magnetic resonance imaging in the detection of lymph node involvement in cervix carcinoma[J]. Eur Radiol, 2005, 15(12):2469-2474.
11. Park W, Park YJ, Huh SJ, et al. The usefulness of MRI and PET imaging for the detection of parametrial involvement and lymph node metastasis in patients with cervical cancer[J]. Jpn J Clin Oncol, 2005, 35(5):260-264.
12. Yang WT, Lam WW, Yu MY, et al. Comparison of dynamic helical CT and dynamic Mr imaging in the evaluation of pelvic lymph nodes in cervical carcinoma[J]. AJR Am J Roentgenol, 2000, 175(3):759-766.
13. 李相生, 周纯武. 综合评价CT、MRI及PET在子宫颈癌术前分期及术后随访中的作用[J]. 癌症进展, 2006, 4(2):119-123.
14. Popa I, Plante M, Renaud MC, et al. Negative sentinel lymph node accurately predicts negative status of pelvic lymph nodes in uterine cervix carcinoma[J]. Gynecol Oncol, 2006, 103(2):649-653.
15. Kobierski J, Emerich J, KrÓlikowska B, et al. Lymph node metastasis as a prognostic factor in cervical carcinoma[J]. Ginekol Pol, 2002, 73(11):925-929.
16. Chandacham A, Charoenkwan K, Siriaunkgul S, et al. Extent of lymphovascular space invasion and risk of pelvic lymph node metastases in stage IB1 cervical cancer[J]. J Med Assoc Thai, 2005, 88(Suppl 2):S31-S36.
17. Gao P, Zhou GY, Yin G, et al. Lymphatic vessel density as a prognostic indicator for patients with stage Ⅰ cervical carcinoma[J]. Hum Pathol, 2006, 37(6):719-725.
18. Milam MR, Frumovitz M, dos Reis R, et al. Preoperative lymph-vascular space invasion is associated with nodal metastases in women with early-stage cervical cancer[J]. Gynecol Oncol, 2007, 106(1):12-15.

West China Medical Journal

Analysis of the Relative Factors of Lymph-nodes Metastasis in Patients with Cervical Cancer

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