Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy_West China Medical Journal

Authors：

 WANGLi-ying , CHENXiao-man , WUYong-yue , CHENJun-qi

Department of Clinical Laboratory, the People's Hospital of Leizhou City, Leizhou, Guangdong 524200, P. R. China;

Corresponding author：

Keywords：

Hypertensive disorder complicating pregnancy; Cystatin-C; Renal damage; Diagnosis; Clinical value

DOI：

10.7507/1002-0179.20140334

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Objective To investigate the diagnostic value of serum cystatin-C (Cys-C) detection in hypertensive disorder complicating pregnancy patients. Methods A hundred patients with pregnancy induced hypertension (PIH) were chosen as the research object from February 2012 to March 2013, and they were divided into mild group, moderate group and severe group according to the severity of the disease. The other 40 healthy pregnant women were selected as the controls (the control group). We compared the four groups in terms of Cys-C, serum urea nitrogen (BUN) and creatinine level, as well as the positive rate of Cys-C, BUN, and creatinine. Results Cys-C, BUN, and creatinine in the PIH group were significantly higher than those in the control group (P<0.05). Cys-C and creatinine in preeclampsia mild group were significantly higher than those in the control group (P<0.05), but BUN level between the two was not statistically significant (P>0.05). Cys-C, BUN, and creatinine in the PIH moderate and severe groups were significantly higher than those in the control group (P<0.05). The abnormal rate of Cys-C in the PIH mild group was significantly higher than that of Cys-C and creatinine (P<0.05). Conclusion Cys-C, BUN and creatinine can all show renal damage in PIH patients, but the Cys-C value in early diagnosis is better than that of BUN and creatinine. It can be used as a monitoring index of pregnancy-induced hypertension prevention and early treatment.

Citation： WANGLi-ying, CHENXiao-man, WUYong-yue, CHENJun-qi. Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy. West China Medical Journal, 2014, 29(6): 1096-1098. doi: 10.7507/1002-0179.20140334 Copy

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11.	廖小清, 阮珍. 妊娠期高血压疾病患者血清超敏C-反应蛋白和尿微量白蛋白的检测意义[J]. 吉林医学, 2011, 32(21): 4323-4324.
12.	高桂华, 满冬亮, 蔡晶. 妊娠高血压综合征患者血清胱抑素C水平变化及与其他肾功能指标的相关性[J]. 检验医学与临床, 2011, 8(16): 1976-1977.
13.	向明, 王莉平. 血清8-isoPGF2α、Cys-C及CRP检测在妊娠期高血压综合征诊断中的意义[J]. 国际检验医学杂志, 2012, 33(14): 1677-1678, 1681.
14.	欧阳清, 刘健, 石青峰, 等. 血清胱抑素C及尿微量白蛋白对妊娠期糖尿病患者肾功能评价的临床意义[J]. 山东医药, 2011, 51(28): 29-30.
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1. 蒋亚萍. 妊娠高血压综合征患者血清胱抑素C测定的临床意义[J]. 检验医学与临床, 2008, 5(7): 432-433.
2. 杨蔚洁, 顾敏娟, 夏洪, 等. 血清胱抑素C诊断早期糖尿病肾病肾损害[J]. 中国临床医学, 2008, 15(2): 223-224.
3. 刘硕, 徐东强, 孙丽丽. 胱抑素C、尿素、肌酐在肾脏疾病检测和诊断中的应用研究[J]. 临床合理用药杂志, 2010, 3(24): 11-12.
4. 方颖, 于景云, 王亚男, 等. 血清胱抑素C在妊娠期高血压早期肾损害中的意义[J]. 实用预防医学, 2011, 18(6): 1108-1109.
5. 乐杰. 妇产科学[M]. 7版. 北京: 人民卫生出版社, 2008: 128-129.
6. 余秀琼, 戴玫. 妊娠期高血压疾病诊断及治疗进展[J]. 心血管病学进展, 2012, 33(6): 777-781.
7. 陈朝霞, 王祥珍. 妊娠高血压疾病患者免疫功能和C-反应蛋白水平变化及其临床意义[J]. 广东医学院学报, 2011, 29(3): 263-265.
8. 安自民, 高绍华. 评价肾功能损害患者中血清胱抑素C测定的临床价值[J]. 中国中西医结合肾病杂志, 2009, 10(12): 1102-1103.
9. 全晖. 血清胱抑素C在肾功能损伤中的诊断价值[J]. 四川医学, 2009, 30(8): 1320-1321.
10. 孙雪荣, 李海峰, 于春冬, 等. Cysc的动态变化对妊高症的早期预防及临床诊疗价值[J]. 中国优生与遗传杂志, 2011, 19(12): 66-67.
11. 廖小清, 阮珍. 妊娠期高血压疾病患者血清超敏C-反应蛋白和尿微量白蛋白的检测意义[J]. 吉林医学, 2011, 32(21): 4323-4324.
12. 高桂华, 满冬亮, 蔡晶. 妊娠高血压综合征患者血清胱抑素C水平变化及与其他肾功能指标的相关性[J]. 检验医学与临床, 2011, 8(16): 1976-1977.
13. 向明, 王莉平. 血清8-isoPGF2α、Cys-C及CRP检测在妊娠期高血压综合征诊断中的意义[J]. 国际检验医学杂志, 2012, 33(14): 1677-1678, 1681.
14. 欧阳清, 刘健, 石青峰, 等. 血清胱抑素C及尿微量白蛋白对妊娠期糖尿病患者肾功能评价的临床意义[J]. 山东医药, 2011, 51(28): 29-30.
15. 李毅, 祁成, 袁鹏, 等. 血清胱抑素C在妊娠期高血压疾病早期肾损伤中的意义[J]. 中国妇幼保健, 2012, 27(15): 2256-2258.

West China Medical Journal

Clinical Value of Serum Cystatin-C Detection in Hypertensive Disorder Complicating Pregnancy

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